Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy

NCT07168213 · tracked via the Priya Life Science Canada tracker

Sponsor

Laval University

Phase

Not applicable

Started

2025-10-21

Last updated

2026-03-09

Condition(s) studied

Oxygen DeliveryAcute Respiratory FailureHigh Flow Oxygen TherapyHypoxemic Acute Respiratory Failure

Investigational drug(s) / intervention(s)

Manual FiO2 titration with Philips oximeter (SpO2 target 90%)Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)Manual FiO2 titration with Philips oximeter (SpO2 target 94%)Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)

Manual FiO2 titration with Philips oximeter (SpO2 target 90%): FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter

Manual FiO2 titration with Nonin oximeter (SpO2 target 90%): FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter

Manual FiO2 titration with Philips oximeter (SpO2 target 94%): FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter

Manual FiO2 titration with Nonin oximeter (SpO2 target 94%): FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter

Study summary

Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * ≥ 18 years of age * Admiitted in intensive care unit * Presence of an arterial catheter * Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter . Exclusion Criteria: * No SpO2 signal with oximeter in use * False nails or nail polish * Methemoglobinemia \>0.015 on last available arterial gas * Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...) * Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)

Primary outcome measure(s)

FiO2 — Mean FiO2 in the two last minute of each study period between minute 8 and 10
FiO2 at the end of each study period (last minute average) to reach SpO2 target to reach SpO2 target with specific oximeter

Trial sites (1)

Facility	City	Region	Status
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval	Québec	Quebec	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07168213 on ClinicalTrials.gov ↗ ← All trials in Canada