The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Restriction

Condition(s) studied

Investigational drug(s) / intervention(s)

Knee extension exercise: Maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion

Study summary

The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.

Participants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.

Eligibility

Primary outcome measure(s)

• Maximum repetitions performed during knee extension exercise — From enrollment to the end of the final study visit (~4 weeks)
  The primary outcome of the study will be the maximum number of knee extension repetitions that participants are able to perform at varying resistive exercise loads.

Trial sites (1)

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