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Clinical Trials in Canada / NCT06907251
Starting soon Phase 3

Dapagliflozin for Long COVID Syndrome

NCT06907251 · tracked via the Priya Life Science Canada tracker
Phase
Phase 3
Started
2026-09-01
Last updated
2026-07-01

Condition(s) studied

COVID - 19Long COVID SyndromeSARS CoV-2

Investigational drug(s) / intervention(s)

Dapagliflozin (DAPA) →Placebo

Dapagliflozin (DAPA): Dapagliflozin 10mg orally once a day for 12 months

Placebo: Participants will receive a matching placebo taken once daily by mouth for 12 months.

Study summary

This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * 18 years of age or older and willing and able to provide informed consent * Patients with a history of positive COVID-19 test (polymerase chain reaction or rapid test) or have been diagnosed with COVID-19 by a health care provider. * New or persistent symptoms at least 12 weeks from infection and present for at least 8 weeks that is not explained by an alternative diagnosis (64). * Women of childbearing potential (WOCBP) who, if sexually active, are willing to use to use at least one highly effective methods of contraception throughout the study. Exclusion Criteria: * History of diabetes * Prior heart failure * Weight loss treatment with glucagon-like peptide-1 receptor agonists (e.g. liraglutide, semaglutide) * Pregnancy or planned pregnancy in the next 12 months. We will ask WOCBP about the possibility of pregnancy at the time of screening and if so, then pregnancy testing will be offered. If testing is declined in this instance, then they will be excluded from the study. * Women who are breastfeeding * Severe renal impairment (eGFR\<30mL/min1.73m2) * Known history of allergy or hypersensitivity to dapagliflozin Exclusion for optional MRI portion of the protocol: \- Any contraindication to MRI

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University of Ottawa Heart Institute Ottawa Ontario

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Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06907251 on ClinicalTrials.gov ↗ ← All trials in Canada