Dapagliflozin (DAPA): Dapagliflozin 10mg orally once a day for 12 months
Placebo: Participants will receive a matching placebo taken once daily by mouth for 12 months.
Study summary
This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* 18 years of age or older and willing and able to provide informed consent
* Patients with a history of positive COVID-19 test (polymerase chain reaction or rapid test) or have been diagnosed with COVID-19 by a health care provider.
* New or persistent symptoms at least 12 weeks from infection and present for at least 8 weeks that is not explained by an alternative diagnosis (64).
* Women of childbearing potential (WOCBP) who, if sexually active, are willing to use to use at least one highly effective methods of contraception throughout the study.
Exclusion Criteria:
* History of diabetes
* Prior heart failure
* Weight loss treatment with glucagon-like peptide-1 receptor agonists (e.g. liraglutide, semaglutide)
* Pregnancy or planned pregnancy in the next 12 months. We will ask WOCBP about the possibility of pregnancy at the time of screening and if so, then pregnancy testing will be offered. If testing is declined in this instance, then they will be excluded from the study.
* Women who are breastfeeding
* Severe renal impairment (eGFR\<30mL/min1.73m2)
* Known history of allergy or hypersensitivity to dapagliflozin
Exclusion for optional MRI portion of the protocol:
\- Any contraindication to MRI
Primary outcome measure(s)
6 month change in EQ-5D derived utility score. — 6 months The 6 month change in EQ-5D derived utility score will be compared between the dapagliflozin and placebo arms within a multiple regression model.
Trial sites (1)
Facility
City
Region
Status
University of Ottawa Heart Institute
Ottawa
Ontario
More Ottawa Heart Institute Research Corporation trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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