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Clinical Trials in Canada / NCT06091319
Recruiting Observational

Florbetaben for Imaging of Vascular Amyloid

NCT06091319 · tracked via the Priya Life Science Canada tracker
Phase
Observational
Started
2023-10-09
Last updated
2026-09-08

Condition(s) studied

Acute Coronary SyndromeStrokeTransient Ischemic AttackAtherosclerosis of Artery

Investigational drug(s) / intervention(s)

[18F]-Florbetaben PET and CT imaging

[18F]-Florbetaben PET and CT imaging: \[18F\]-Florbetaben imaging to compare uptake in the culprit and non-culprit arteries.

Study summary

The Primary Objective is to determine if a new nuclear tracer (named 18F-Florbetaben) used with nuclear imaging (PET imaging) can detect inflamed plaque in patients with recent ACS or stroke/TIA.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: 1. suffered a recent cardiovascular event (30-120 days post ACS (i.e. STEMI or NSTEMI) or TIA/stroke with ipsilateral large vessel atherosclerotic disease confirmed on US, CT or MRI; 2. stable symptoms and hemodynamics; 3. age \>/= 18 years; 4. given informed consent. Exclusion Criteria: 1. a recent CV event likely to have been embolic in the opinion of the neurologist or cardiologist; 2. severe LV dysfunction (EF\<30%); 3. severe valve disease requiring intervention; 4. decompensated heart failure; 5. pregnancy (all women of child bearing potential will have a negative BHCG test; 6. breastfeeding; 7. women of childbearing potential who refuse to use two forms of contraception (this includes at least one form of highly effective and one effective method of contraception) throughout the study OR men capable of fathering a child who refuse to use contraception;. 8. unable to give informed consent;. 9. Florbetaben allergy; 10. glomerular filtration rate (GFR) \<50 ml/min/1.72m2 Exclusion for CTA portion of the protocol: Patients with dye allergy, or those with GFR \<60, will not undergo CTA but will have PET/CT.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University of Ottawa Heart Institute Ottawa Ontario Recruiting

More Ottawa Heart Institute Research Corporation trials in Canada

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06091319 on ClinicalTrials.gov ↗ ← All trials in Canada