Cardiovascular training (CT)Resistance training (RT)Multimodal training (MT)
Cardiovascular training (CT): 12 weeks of CT
Resistance training (RT): 12 weeks of RT
Multimodal training (MT): 12 weeks of MT
Study summary
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.
Eligibility
Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5);
* On a stable dosage of medication during the previous month;
* Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;
Exclusion Criteria:
* Having atypical parkinsonism, dementia, stroke, or any other neurological condition;
* Presenting severe untreated obstructive sleep apnea (OSA);
* Having a Montreal Cognitive Assessment (MoCA) score \<18
* Having a Beck Depression Inventory score \>31;
* Having absolute contraindications to exercise;
* Having severe osteoporosis;
* Participating in an exercise or drug trial during the period of the study;
* Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.
Primary outcome measure(s)
Changes in objective sleep quality — 12 weeks (post-intervention) and 8 weeks (follow-up) Sleep efficiency (SE) measured with polysomnography; SE (%) = Time asleep while in bed \* 100; values = 0-100%; higher values reflect better SE.
Changes in subjective sleep quality — 12 weeks (post-intervention) and 8 weeks (follow-up) PD Sleep Scale version 2 (PDSS-2); values = 0-60; higher values reflect worse sleep quality.
Changes in sleep architecture — 12 weeks (post-intervention) and 8 weeks (follow-up) Changes in slow-wave power measured with polysomnography.
Changes in sleep architecture — 12 weeks (post-intervention) and 8 weeks (follow-up) Changes in sleep spindles density measured with polysomnography.
Changes in sleep architectures — 12 weeks (post-intervention) and 8 weeks (follow-up) Changes in REM sleep duration (%) measured with polysomnography.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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