@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms

NCT05526352 · tracked via the Priya Life Science Canada tracker

Sponsor

University Hospital, Geneva

Phase

Observational

Started

2015-06-01

Last updated

2026-01-16

Condition(s) studied

Intracranial Aneurysm

Study summary

The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).

The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database.

The purpose for populating the database are to:

* Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as markers the following: genetics factors, microbiota, environmental factors, congenital factors (ie: cerebrovascular anatomical variants), transcriptomics signature, proteomics signature,shape characteristics, haemodynamics characteristics.
* Screen for and evaluate prognostic factors of outcome regarding different management strategies including watchful observation, microsurgical treatment, endovascular treatment or any combination thereof.
* Implement and evaluate patient-specific management protocols integrating all available information.
* Evaluate the impact of the database and use of tools to improve care, reduce costs, support knowledge discovery and promote new industrial developments.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * able to provide consent or, in the event that a patient is incapable of providing consent, that a person is legally authorized to do so on behalf of the patient according to legal and ethical requirements of the country where the clinical centre is located. Patients: * must have an angiographically proven intracranial aneurysm (MRA\< CTA\< DSA accepted).The determination of SAH requires the presence of a subarachnoid haemorrhage be verified on CT or by lumbar puncture. MRA: Magnetic Resonance Angiography CTA: Computed Tomography Angiography DSA: Digital Subtracted Angiography Exclusion Criteria: * failure of a candidate to contribute clinical data, * refusal to provide informed consent.

Primary outcome measure(s)

Disease model validation — 5 years
Validation and improvement of the holistic disease model

Trial sites (22)

Facility	City	Region	Status
University of California	San Francisco	California	Recruiting
University of Cincinnati College of Medicine	Cincinnati	Ohio	Recruiting
University of Virginia	Virginia Beach	Virginia	Recruiting
Montreal Neurological Institute and Hospital, McGill University	Montreal	Canada	Recruiting
Helsinki University Central Hospital	Helsinki	Finland	Recruiting
Kuopio University Hospital	Kuopio	Finland	Recruiting
ICAN	Nantes	France	Recruiting
Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich	Munich	Germany	Recruiting
University of Pecs	Pécs	Hungary	Completed
Erasmus Medical Center	Rotterdam	Netherlands	Completed
University Medical Center Utrecht	Utrecht	Netherlands	Recruiting
Jagiellonian University Medical College	Krakow	Poland	Recruiting
Barcelona Hospital General de Cataluna	Barcelona	Spain	Completed
Hospital Clinic Barcelona	Barcelona	Spain	Completed
IMIM - Hospital del Mar	Barcelona	Spain	Recruiting
Neurochirurgie / Hôpitaux Universitaire de Genève	Geneva	Switzerland	Recruiting
University Hospital of Lausanne (CHUV), CoLaus Datacenter	Lausanne	Switzerland	Recruiting
Department of Neurosurgery, Cantonal Hospital St. Gallen	Sankt Gallen	Switzerland	Recruiting
Klinik Hirslanded	Zurich	Switzerland	Not Yet Recruiting
University College London	London	United Kingdom	Recruiting
Radcliffe Infirmary	Oxford	United Kingdom	Completed
Royal Hallamshire Hospital	Sheffield	United Kingdom	Completed

Other trials for the same condition

Pivotal Study of the Silk Vista Baby Flow Diverters in the Treatment of Unruptured Intracranial Aneurysms (PIONEER) Recruiting

Comprehensive Aneurysm Management Trial Recruiting

Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial Starting soon

International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF) Recruiting

Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05526352 on ClinicalTrials.gov ↗ ← All trials in Canada