Abdominal Compression Garments: Abdominal compression garment compressing the abdomen, buttocks, and upper thighs.
Medications that modulate heart rate and blood pressure: Medications that modulate heart rate and blood pressure that participants regularly take. These medications include beta-blockers, midodrine, ivabradine and stimulants.
Study summary
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting. It is not known if commercially available compression garments that participants wear in their every day lives are effective at improving heart rate and reducing symptoms in POTS. This trial will evaluate the use of commercially available waist-high and abdominal compression garments in adults diagnosed with POTS in a community setting.
Eligibility
Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria:
* Physician diagnosis of Postural Tachycardia Syndrome (POTS)
* Resident of Canada
* Owns waist-high compression garment: medical grade or commercially available tights with a pressure rating provided (e.g. 15-18 mmHg, 20-30 mmHg, 30-40 mmHg)
* Optional Sub-Study: owns an abdominal compression garment (e.g. abdominal shapewear, waist high shorts)
* Able to participate in a 4-day study (2x2 day segments with a 5-day washout period)
Exclusion Criteria:
* Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease) that precludes POTS diagnosis
* Not a resident of Canada
* Participants with somatization or severe anxiety symptoms will be excluded
* Pregnant (self-reported)
* Inability to tolerate compression garments for the duration of the study
* Does not own a waist-high compression garment
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies
Primary outcome measure(s)
WHC Heart Rate — 10 minutes The primary outcome is the delta HR (standing HR - supine HR) in orthostatic vital signs (OVS) #1 (prior to the WHC) and OVS #2 (30min after WHC is applied), in the "Without Medication" phase.
AC Heart Rate — 10 minutes The primary outcome is the delta HR (standing HR - supine HR) in orthostatic vital signs (OVS) #1 (prior to the AC) and OVS #2 (30min after AC is applied), in the "Without Medication" phase.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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