Hyperpolarized Xenon-129 MRI of the lungsComputed Tomography (CT)Pulmonary Function Tests (PFTs)Six Minute Walk Test (6MWT)Cardiopulmonary exercise testing (CPET)Sputum analysisBlood analysis
Hyperpolarized Xenon-129 MRI of the lungs: Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas
Computed Tomography (CT): Participants will undergo a CT scan of the thoracic cavity
Pulmonary Function Tests (PFTs): Participants will have their lung function evaluated using PFTs
Six Minute Walk Test (6MWT): Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity
Cardiopulmonary exercise testing (CPET): Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity
Sputum analysis: Participants will provide a sputum sample that will be analysed for eosinophils
Blood analysis: Participants will have their blood drawn and analysed for eosinophil count.
Study summary
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Eligibility
Sex
ALL
Min age
18 Years
Max age
85 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature
* Provision of written, informed consent prior to any study specific procedures
* Males and females aged 18-85
* Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history
* Participant is able to perform reproducible pulmonary function testing (i.e. the 3 best acceptable spirograms have Forced Expiratory Volume in 1 second (FEV1) values that do not vary more than 150 millilitres)
* Participant is able to perform a breathhold for 16s
* FEV1 \> 25% predicted
* Forced Vital Capacity (FVC) \> 25% predicted and \>0.5 litres
Exclusion Criteria:
* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material
* Participant is medically unstable in the opinion of the Principal Investigator
* Participant has a daytime room air oxygen saturation \<90% while lying supine
* Participant is unable to perform spirometry or plethysmography maneuvers
* Patient is pregnant at time of enrolment
* In the opinion of the investigator, patient suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia
* Patient has implanted mechanically, electrically or magnetically activated device or any metal in their body, which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) - at the discretion of the MRI Technologist.
Primary outcome measure(s)
Changes in airways over time — 3 years Measured using Xenon-129 (129-Xe) MRI
Changes in parenchyma over time — 3 years Measured using Xenon-129 (129-Xe) MRI
Differences in lung ventilation in cannabis smokers compared to never-smokers and tobacco smokers — 3 years Measured using 129-Xe MRI
Differences in perfusion in cannabis smokers compared to never-smokers and tobacco smokers — 3 years Measured using 129-Xe MRI
Differences in parenchyma integrity in cannabis smokers compared to never-smokers and tobacco smokers — 3 years Measured using 129-Xe MRI
Differences in airways between cannabis-only smokers and cannabis and tobacco smokers — 3 years Measured using 129-Xe MRI
Differences in parenchyma between cannabis-only smokers and cannabis and tobacco smokers — 3 years Measured using 129-Xe MRI
Dose-response of cannabis use to changes in airways over time — 3 years Measured using 129-Xe MRI
Dose-response of cannabis use to changes in parenchyma over time — 3 years Measured using 129-Xe MRI
Trial sites (1)
Facility
City
Region
Status
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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