Low-dose Atropine Eye Drops to Reduce Progression of Myopia in Children in the United Kingdom

Condition(s) studied

Investigational drug(s) / intervention(s)

Atropine Sulfate: Atropine sulfate 0.01% eye drops which consist of 10mls of a clear colourless solution of atropine sulfate 0.01% w/v and benzalkonium chloride 0.01% w/v in sterile water.

Placebo: Placebo eye drops which consist of 10mls of a clear colourless solution of benzalkonium chloride 0.01% w/v in sterile water.

Study summary

Short-sightedness, also called myopia, makes objects in the distance, such as the television, look blurred. This is caused by the eye growing too long, something that usually happens while children are also getting taller. People with myopia can see better with glasses or contact lenses, but this doesn't stop their eyes continuing to become more short-sighted. The CHAMP UK study is investigating a type of eye drop called atropine that might help to stop myopia getting worse as children get older.

Eligibility

Primary outcome measure(s)

• Spherical equivalent refractive error (i.e. myopia severity) — Baseline - 24-months
  Spherical equivalent refractive error (i.e., myopia severity) of both eyes measured by autorefractor under cycloplegia (adjusted for baseline).

Trial sites (4)