Clinical Efficacy and Survival Prediction Analysis of Transjugular Intrahepatic Portosystemic Shunt in Patients With Liver Cirrhosis

NCT07437638 · tracked via the Priya Life Science China tracker

Sponsor

The Second Affiliated Hospital of Chongqing Medical University

Phase

—

Started

2024-09-01

Last updated

2026-02-27

Condition(s) studied

Liver CirrhosisHepatic EncephalopathyTIPS

Study summary

This study aims to develop a practical tool for identifying cirrhotic patients at high risk of hepatic encephalopathy following transjugular intrahepatic portosystemic shunt (TIPS) placement. A retrospective analysis will be conducted on medical records of 624 cirrhotic patients who underwent TIPS from 2011 to 2021. Statistical methods will be applied to screen preoperative routine indicators associated with post-TIPS hepatic encephalopathy risk. A predictive nomogram will be constructed incorporating the screened indicators to estimate individual preoperative risk. The predictive performance will be compared with conventional clinical scoring systems. This tool is intended to facilitate preoperative risk evaluation and targeted management of high-risk patients undergoing TIPS

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: * Age 18-80 years, regardless of gender * Diagnosis of decompensated cirrhosis meeting clinical guidelines * Complete preoperative baseline data available, with regular postoperative follow-up for at least 3 months to assess endpoint events * Absence of absolute contraindications for TIPS Exclusion Criteria: * Age \< 18 or \> 80 years * Non-cirrhotic portal hypertension * Hepatocellular carcinoma or other systemic malignancies * Severe cardiopulmonary disease * Prior liver transplantation or portosystemic shunt surgery * Death or liver transplantation within 30 days post-TIPS * Missing key baseline data or loss to follow-up

Primary outcome measure(s)

Occurrence of hepatic encephalopathy within 3 months after TIPS — 3-month follow-up after TIPS
The development of hepatic encephalopathy, diagnosed based on clinical assessment and medical records during follow-up outpatient visits or hospital readmissions within 3 months after the TIPS procedure. All HE cases in this study occurred within this period.

Trial sites (1)

Facility	City	Region	Status
Chongqing	Chongqing	China

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07437638 on ClinicalTrials.gov ↗ ← All trials in China