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Advil vs Tylenol

Ibuprofen  ·  Acetaminophen

The two most common painkillers in the world. One reduces inflammation, the other does not — and they carry entirely different risks, to the stomach and to the liver respectively.

At a glance

AdvilIbuprofen
TylenolAcetaminophen
Brand names
Advil / Motrin
Tylenol / Panadol
Drug class
NSAID
Analgesic and antipyretic
Route
Not listed
Not listed
Marketed by
Haleon
Johnson & Johnson
First FDA approval
18 May 1984
26 May 1976
US shortage
Not listed
Not listed

Key differences

What each one treats

AdvilIbuprofen

Uses temporarily relieves minor aches and pains due to: headache toothache backache menstrual cramps the common cold muscular aches minor pain of arthritis temporarily reduces fever

TylenolAcetaminophen

An oral or rectal medication used to relieve mild-to-moderate pain and reduce fever.

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Deltasone VS Advil

Read more

Advil profile Tylenol profile All comparisons
This is not medical advice, and not a recommendation of one drug over the other.

Which medicine is right for a given person depends on their diagnosis, other conditions, other medicines, kidney and liver function, pregnancy, and cost or reimbursement — none of which this page knows. Two drugs in the same class are not automatically interchangeable. Never start, stop or switch a prescription medicine on the basis of a web page; that decision belongs to you and your clinician or pharmacist.

Class and summary text is written by the Priya Life Science editorial team. Label, mechanism, route, manufacturer and approval data come from the U.S. FDA via the openFDA API; shortage status from the FDA Drug Shortage Database. Approvals, indications and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions — a drug approved in one may not be approved, or may carry a different name, in another.