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Clinical Trials in the UK / NCT06618287
Recruiting Phase 1/Phase 2

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

NCT06618287 · tracked via the Priya Life Science UK tracker
Sponsor
Bristol-Myers Squibb
Phase
Phase 1/Phase 2
Started
2025-02-04
Last updated
2026-09-14

Condition(s) studied

Lung CancerBreast Cancer

Investigational drug(s) / intervention(s)

BMS-986507OsimertinibPembrolizumabNivolumabPumitamig

BMS-986507: Specified dose on specified days

Osimertinib: Specified dose on specified days

Pembrolizumab: Specified dose on specified days

Nivolumab: Specified dose on specified days

Pumitamig: Specified dose on specified days

Study summary

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria * Participants must have at least one measurable lesion per response evaluation criteria in solid tumors. * Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. * Participants must have a life expectancy of at least 3 months at the time of the first dose. * Group A: Participants must have pathologically confirmed locally advanced or metastatic NSCLC with an EGFR exon 19 deletion or L858R mutation in exon 21, either alone or in combination with other EGFR mutations, which may include T790M in exon 20. Participants with other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed * Group B: Participants must have pathologically confirmed locally advanced or metastatic NSCLC. * Group C: Participants must have pathologically confirmed locally-advanced, recurrent inoperable, or metastatic TNBC or ER-low, HER2-negative BC. * Group D: Participants must have pathologically confirmed locally-advanced, recurrent inoperable, or metastatic TNBC per ASCO/CAP criteria, based on the most recently analyzed biopsy or another pathology specimen. * Group E: Participants must have pathologically confirmed locally advanced or metastatic NSCLC, not amenable to treatment in curative intent. Exclusion Criteria * Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology. * Participants with known mutations in EGFR will be excluded (Group A,B and E). * Participants must not have a history of serious recurrent infections. * Participants must not have a history of severe heart disease. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (65)

FacilityCityRegionStatus
University of Alabama at Birmingham Birmingham Alabama Recruiting
University of Miami Hospital and Clinics, Sylvester Cancer Center Miami Florida Recruiting
Local Institution - 0065 Iowa City Iowa Not Yet Recruiting
Local Institution - 0140 St Louis Missouri Not Yet Recruiting
John Theurer Cancer Center at Hackensack University Medical Center Hackensack New Jersey Recruiting
Cleveland Clinic Cleveland Ohio Recruiting
Local Institution - 0102 Columbus Ohio Not Yet Recruiting
Providence Portland Medical Center Portland Oregon Recruiting
Providence St. Vincent Medical Center Portland Oregon Recruiting
Local Institution - 0052 Portland Oregon Not Yet Recruiting
Local Institution - 0014 Pittsburgh Pennsylvania Withdrawn
University of Tennessee Medical Center Knoxville Tennessee Recruiting
NEXT Oncology - Irving Irving Texas Recruiting
Swedish Medical Center Seattle Washington Recruiting
Liverpool Hospital Liverpool New South Wales Recruiting
Princess Alexandra Hospital Woolloongabba Queensland Recruiting
Peter MacCallum Cancer Centre Melbourne Victoria Recruiting
Local Institution - 0101 Subiaco Western Australia Not Yet Recruiting
Cross Cancer Institute Edmonton Alberta Recruiting
Local Institution - 0064 Newmarket Ontario Not Yet Recruiting
Local Institution - 0023 Ottawa Ontario Withdrawn
The Ottawa Hospital - General Campus Ottawa Ontario Recruiting
Centre Hospitalier de l'Université de Montréal Montreal Quebec Recruiting
Jewish General Hospital Montreal Quebec Recruiting
Local Institution - 0144 Montreal Quebec Not Yet Recruiting
Oncocentro Valdivia Valdivia Los Ríos Region Recruiting
FALP Santiago Santiago Metropolitan Recruiting
Pontificia Universidad Catolica de Chile Santiago Santiago Metropolitan Recruiting
Bradfordhill Santiago Santiago Metropolitan Recruiting
Oncocentro Apys Viña del Mar Valparaiso Recruiting
Local Institution - 0077 Nice Alpes-Maritimes Withdrawn
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux Aquitaine Recruiting
Centre Leon Berard Lyon Auvergne-Rhône-Alpes Recruiting
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone Marseille Bouches-du-Rhône Recruiting
Local Institution - 0076 Caen Calvados Withdrawn
Hôpital Arnaud de Villeneuve - CHU Montpellier Montpellier Hérault Recruiting
Gustave Roussy Villejuif Val-de-Marne Recruiting
Institut Curie Paris France Recruiting
Hôpital Tenon Paris France Recruiting
Cro-Irccs Aviano Friuli Venezia Giulia Recruiting

+ 25 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06618287 on ClinicalTrials.gov ↗ ← All trials in the UK