subgingival instrumentation: Subgingival instrumentation like scaling and root planing of the recruited subject shall be done.
Study summary
The goal of this interventional study is to assess the clinical and histopathological changes in Oral Lichen Planus patients with gingival involvement pre and post subgingival instrumentation.
Objective- Primary objective: To observe and evaluate the clinical signs and symptoms in Oral Lichen Planus with gingival involvement. Secondary objective: To observe and evaluate the Cluster of Differentiation (CD) 4+ and 8+T lymphocytes in Oral Lichen Planus with gingival involvement.
Study group: 30 cases of Oral Lichen Planus with gingival involvement
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria:
* Clinically and histopathologically confirmed cases of OLP.
* OLP predominantly involving the gingiva.
* Consent obtained.
Exclusion criteria:
* Cases which does not fulfil either clinical or histopathological criteria.
* Unwilling to participate in the study.
* Patients with recorded history of factors that might modify immune response (such as patient on corticosteroids or medically compromised patients or suffering from heart diseases).
* Cases undergoing treatment of OLP within past 6 months.
* Biopsies with inadequate or non-representative samples
* Cases histopathologically diagnosed as Lichenoid Dysplasia or Oral Lichenoid Lesions.
* Cases diagnosed with autoimmune disorders.
Primary outcome measure(s)
Change in clinical signs and symptoms in cases of oral lichen planus — At baseline and after end of treatment at 4 weeks Clinical signs and symptoms will be recorded using oral disease severity score criteria
Trial sites (1)
Facility
City
Region
Status
Post Graduate Institute of Dental Sciences
Rohtak
Haryana
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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