Attenuating Calciprotein particles Transformation and Inhibiting Vascular calcification Evolution by Sodium ThioSulphate trial

Condition studied

Vascular Calcification

Investigational medicinal product(s)

Eligibility

Primary endpoint

Difference in pre to post-dialysis change in T₅₀ between the non-dosed session and the STS-dosed session in the same participant., Change in pre-dialysis T₅₀ from the non-dosed control session to each of the three STS-dosed sessions

Endpoint detail

Within subject differences in CPP amounts between non-dosed and STS-dosed sessions and the STS-dosed sessions, and in pre- to post-dialysis changes within each session., Correlations between changes in T₅₀ and CPP measures across session and timepoints., Within-subject changes in CRP, IL-6, TNF-α and NO/ROS related markers between sessions., Changes in P1NP, CTX, osteocalcin, ALP, bone-specific ALP, phosphate, calcium, PTH, and FGF23 between sessions and timepoints.