{ "source": "ClinicalTrials.gov: studies with a site in Ireland", "attribution": "Source: ClinicalTrials.gov, U.S. National Library of Medicine.", "licence": "Public data; see ClinicalTrials.gov Terms and Conditions", "retrieved": "2026-10-13T06:01:56+00:00", "count": 2698, "records": [ { "nct_id": "NCT00002755", "title": "Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Scottish Cancer Therapy Network", "conditions": [ "Breast Cancer" ], "start_date": "1995-11", "last_update": "2013-11-06" }, { "nct_id": "NCT00002895", "title": "Early Chemotherapy Based on CA 125 Level Alone Compared With Delayed Chemotherapy in Treating Patients With Recurrent Ovarian Epithelial , Fallopian Tube, or Primary Peritoneal Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Medical Research Council", "conditions": [ "Fallopian Tube Cancer", "Ovarian Cancer", "Primary Peritoneal Cavity Cancer" ], "start_date": "1996-06", "last_update": "2013-12-04" }, { "nct_id": "NCT00003031", "title": "Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Infection", "Pulmonary Complications" ], "start_date": "1997-06", "last_update": "2012-07-02" }, { "nct_id": "NCT00003122", "title": "Surgery in Treating Patients With Neuroblastoma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Societe Internationale d'Oncologie Pediatrique", "conditions": [ "Neuroblastoma" ], "start_date": "1994-12", "last_update": "2013-08-26" }, { "nct_id": "NCT00003636", "title": "Chemotherapy Plus Surgery in Treating Patients With Stage III or Stage IV Ovarian, Peritoneal, or Fallopian Tube Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Fallopian Tube Cancer", "Ovarian Cancer", "Primary Peritoneal Cavity Cancer" ], "start_date": "1998-09", "last_update": "2015-08-05" }, { "nct_id": "NCT00003734", "title": "Combination Hormone Therapy Followed by Radiation Therapy in Treating Patients With Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. Luke's Hospital, Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "1998-12", "last_update": "2016-07-21" }, { "nct_id": "NCT00003854", "title": "Prognostic Study of Sentinel Lymph Node and Bone Marrow Metastases in Women With Stage I or Stage IIA Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alliance for Clinical Trials in Oncology", "conditions": [ "Breast Cancer" ], "start_date": "1999-04", "last_update": "2016-07-13" }, { "nct_id": "NCT00003855", "title": "Lymph Node Removal in Treating Women Who Have Stage I or Stage IIA Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alliance for Clinical Trials in Oncology", "conditions": [ "Breast Cancer" ], "start_date": "1999-04", "last_update": "2020-04-29" }, { "nct_id": "NCT00004218", "title": "Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Leukemia Research Fund", "conditions": [ "Leukemia" ], "start_date": "1999-10", "last_update": "2013-12-18" }, { "nct_id": "NCT00004978", "title": "An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "conditions": [ "HIV Infections" ], "start_date": "2000-03", "last_update": "2021-11-05" }, { "nct_id": "NCT00005583", "title": "Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Nordic Society of Gynaecological Oncology - Clinical Trials Unit", "conditions": [ "Endometrial Cancer" ], "start_date": "2000-01", "last_update": "2013-08-02" }, { "nct_id": "NCT00015873", "title": "Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Dutch Childhood Oncology Group", "conditions": [ "Leukemia" ], "start_date": "1999-05", "last_update": "2014-02-17" }, { "nct_id": "NCT00021255", "title": "Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Breast Neoplasms" ], "start_date": "2001-04", "last_update": "2016-11-15" }, { "nct_id": "NCT00021450", "title": "Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Prostate Cancer" ], "start_date": "2001-04", "last_update": "2016-09-02" }, { "nct_id": "NCT00024336", "title": "Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "1999-08", "last_update": "2013-08-07" }, { "nct_id": "NCT00024453", "title": "Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Infection" ], "start_date": "1999-02", "last_update": "2013-08-07" }, { "nct_id": "NCT00025064", "title": "Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Lymphoma" ], "start_date": "2000-01", "last_update": "2013-08-07" }, { "nct_id": "NCT00025077", "title": "Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2000-01", "last_update": "2013-08-02" }, { "nct_id": "NCT00025103", "title": "Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Kidney Cancer" ], "start_date": "2001-05", "last_update": "2013-08-02" }, { "nct_id": "NCT00025441", "title": "Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Societe Internationale d'Oncologie Pediatrique", "conditions": [ "Ovarian Cancer", "Sarcoma", "Small Intestine Cancer" ], "start_date": "1998-11", "last_update": "2013-12-04" }, { "nct_id": "NCT00027352", "title": "A Comparison of Two Ways to Manage Anti-HIV Treatment (The SMART Study)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "conditions": [ "HIV Infections" ], "start_date": "", "last_update": "2009-11-25" }, { "nct_id": "NCT00030719", "title": "Combination Chemotherapy With or Without Filgrastim Before Surgery, High-Dose Chemotherapy, and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Leicester", "conditions": [ "Neuroblastoma" ], "start_date": "2001-12", "last_update": "2014-06-24" }, { "nct_id": "NCT00036088", "title": "Olanzapine Versus An Active Comparator in the Treatment of Schizophrenia", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Schizophrenia" ], "start_date": "2001-08", "last_update": "2006-07-19" }, { "nct_id": "NCT00036543", "title": "A Study of Atrasentan in Men With Metastatic, Hormone-Refractory Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott", "conditions": [ "Prostate Cancer" ], "start_date": "2001-05", "last_update": "2006-08-15" }, { "nct_id": "NCT00036556", "title": "Study of Atrasentan in Men With Non-Metastatic, Hormone-Refractory Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2001-06", "last_update": "2007-08-15" }, { "nct_id": "NCT00038467", "title": "Randomized Trial Of Exemestane Versus Continued Tamoxifen In Postmenopausal Women With Early Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms" ], "start_date": "1998-02", "last_update": "2014-05-07" }, { "nct_id": "NCT00045032", "title": "Herceptin (Trastuzumab) in Treating Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Primary Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Breast Cancer" ], "start_date": "2001-11", "last_update": "2017-04-27" }, { "nct_id": "NCT00048230", "title": "PS-341 (VELCADE™) Versus High-Dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Millennium Pharmaceuticals, Inc.", "conditions": [ "Multiple Myeloma" ], "start_date": "2002-06", "last_update": "2012-01-13" }, { "nct_id": "NCT00048659", "title": "YM598 Added to Mitoxantrone/Prednisone to Control Pain in Metastatic Prostate Cancer Patients No Longer Responding to Hormone Therapy", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Hormone-Refractory Prostate Cancer", "Prostatic Neoplasms" ], "start_date": "", "last_update": "2012-06-07" }, { "nct_id": "NCT00050830", "title": "A Phase 2, Randomized, Open-Label Study Of Single Agent CI-1033 In Patients With Advanced Non-Small Cell Lung Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Lung Neoplasms" ], "start_date": "2003-01", "last_update": "2006-11-08" }, { "nct_id": "NCT00051051", "title": "A Phase II Study of CI-1033 in Treating Patients With Metastatic (Stage IV) Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms" ], "start_date": "2002-12", "last_update": "2007-05-04" }, { "nct_id": "NCT00052130", "title": "Vaccine Therapy for Patients With Stage III Melanoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "CancerVax Corporation", "conditions": [ "Malignant Melanoma" ], "start_date": "", "last_update": "2005-06-24" }, { "nct_id": "NCT00052156", "title": "Vaccine Therapy for Patients With Stage IV Melanoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "CancerVax Corporation", "conditions": [ "Malignant Melanoma" ], "start_date": "", "last_update": "2005-06-24" }, { "nct_id": "NCT00056407", "title": "\"REDUCE\" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Prostate" ], "start_date": "2003-03", "last_update": "2016-09-23" }, { "nct_id": "NCT00057564", "title": "A Study of Combination Thalidomide Plus Dexamethasone Therapy vs. Dexamethasone Therapy Alone in Previously Untreated Subjects With Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene Corporation", "conditions": [ "Multiple Myeloma" ], "start_date": "2003-02", "last_update": "2015-09-11" }, { "nct_id": "NCT00057720", "title": "TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Telik", "conditions": [ "Ovarian Neoplasms" ], "start_date": "2003-06", "last_update": "2011-07-25" }, { "nct_id": "NCT00062660", "title": "Tipranavir in Patients With Progressive, Systemic HIV-1 Disease Who Have Failed or Are Intolerant to Currently Approved Treatments for HIV Infection", "phases": [], "overall_status": "APPROVED_FOR_MARKETING", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "HIV Infections" ], "start_date": "2003-05", "last_update": "2016-11-30" }, { "nct_id": "NCT00063726", "title": "A Study of PS-341 Given to Patients With Multiple Myeloma Who Experienced Progressive Disease After Receiving Dexamethasone in M34101-039", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Millennium Pharmaceuticals, Inc.", "conditions": [ "Multiple Myeloma" ], "start_date": "2002-04", "last_update": "2012-01-13" }, { "nct_id": "NCT00068042", "title": "A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Acromegaly" ], "start_date": "2003-04", "last_update": "2008-04-07" }, { "nct_id": "NCT00069095", "title": "A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Colorectal Cancer" ], "start_date": "2003-07", "last_update": "2016-10-06" }, { "nct_id": "NCT00069121", "title": "A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Colorectal Cancer" ], "start_date": "2003-04-18", "last_update": "2020-03-06" }, { "nct_id": "NCT00069784", "title": "The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Non-Insulin-Dependent" ], "start_date": "2003-08", "last_update": "2013-01-31" }, { "nct_id": "NCT00072462", "title": "Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Queen Mary University of London", "conditions": [ "Breast Cancer" ], "start_date": "2003-09", "last_update": "2024-09-19" }, { "nct_id": "NCT00073528", "title": "Study Comparing Lapatinib (GW572016) And Letrozole Versus Letrozole In Subjects With Advanced Or Metastatic Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Neoplasms" ], "start_date": "2003-12-09", "last_update": "2021-02-24" }, { "nct_id": "NCT00077389", "title": "Intensive Neoadjuvant Chemotherapy in Treating Young Patients Undergoing Surgical Resection for High-Risk Hepatoblastoma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Leicester", "conditions": [ "Liver Cancer" ], "start_date": "2004-01", "last_update": "2014-06-24" }, { "nct_id": "NCT00077792", "title": "Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction - Study 25 (ExTRACT-TIMI25)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Myocardial Infarction", "Acute ST-Segment Elevation" ], "start_date": "2002-10", "last_update": "2009-04-20" }, { "nct_id": "NCT00078832", "title": "Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Queen Mary University of London", "conditions": [ "Breast Cancer" ], "start_date": "2003-09", "last_update": "2021-10-06" }, { "nct_id": "NCT00082433", "title": "Epothilone (Ixabepilone) Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "R-Pharm", "conditions": [ "Cancer", "Breast Cancer" ], "start_date": "2003-11", "last_update": "2020-11-02" }, { "nct_id": "NCT00095238", "title": "Irbesartan in Heart Failure With Preserved Systolic Function (I-Preserve)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Congestive Heart Failure" ], "start_date": "2002-06", "last_update": "2015-04-07" }, { "nct_id": "NCT00096473", "title": "Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Inc.", "conditions": [ "Alzheimer's Disease", "Dementia" ], "start_date": "2001-01", "last_update": "2011-04-01" }, { "nct_id": "NCT00099502", "title": "BEYOND: Betaferon/Betaseron Efficacy Yielding Outcomes of a New Dose in Multiple Sclerosis (MS) Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "start_date": "2003-11", "last_update": "2008-12-19" }, { "nct_id": "NCT00101660", "title": "Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinib", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Chronic Myeloid Leukemia", "Philadelphia-Positive Myeloid Leukemia" ], "start_date": "2005-02", "last_update": "2012-03-02" }, { "nct_id": "NCT00103181", "title": "Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "NSABP Foundation Inc", "conditions": [ "Breast Cancer" ], "start_date": "2005-03", "last_update": "2022-04-14" }, { "nct_id": "NCT00103844", "title": "Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Chronic Myeloid Leukemia", "Philadelphia-Positive Myeloid Leukemia" ], "start_date": "2005-02", "last_update": "2010-08-10" }, { "nct_id": "NCT00104403", "title": "Study Of Prevention of Chemo-Induced Nausea and Vomiting Caused By Moderately Emetogenic Chemotherapy", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Nausea and Vomiting, Chemotherapy-Induced", "Chemotherapy-Induced Nausea and Vomiting" ], "start_date": "2004-12", "last_update": "2015-04-16" }, { "nct_id": "NCT00113308", "title": "COX-2 Inhibitor Study In Patients With Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Arthritis, Rheumatoid" ], "start_date": "2005-06", "last_update": "2017-03-14" }, { "nct_id": "NCT00122304", "title": "Study of Safety in Hemolytic Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Treated With Eculizumab", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Hemoglobinuria, Paroxysmal" ], "start_date": "2004-12", "last_update": "2007-02-21" }, { "nct_id": "NCT00122317", "title": "Extension Study of Eculizumab in Patients With Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Paroxysmal Hemoglobinuria, Nocturnal" ], "start_date": "2005-05", "last_update": "2018-03-13" }, { "nct_id": "NCT00122330", "title": "Study Using Eculizumab in Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Hemoglobinuria, Paroxysmal" ], "start_date": "2004-10", "last_update": "2006-12-04" }, { "nct_id": "NCT00123474", "title": "Chronic Myelogenous Leukemia (CML) - Follow on: Study of BMS-354825 in Subjects With CML", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Myeloid Leukemia, Chronic, Chronic-Phase" ], "start_date": "2005-07", "last_update": "2016-08-25" }, { "nct_id": "NCT00123487", "title": "Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CML", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Myeloid Leukemia, Chronic, Accelerated Phase", "Leukemia, Lymphoblastic, Acute, Philadelphia-Positive" ], "start_date": "2005-06", "last_update": "2014-11-03" }, { "nct_id": "NCT00124982", "title": "Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2005-04", "last_update": "2012-02-27" }, { "nct_id": "NCT00125567", "title": "Stalevo in Early Wearing-Off Patients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Orion Corporation, Orion Pharma", "conditions": [ "Idiopathic Parkinson's Disease" ], "start_date": "2005-08", "last_update": "2009-06-22" }, { "nct_id": "NCT00128167", "title": "Trivalent, Live, Cold Adapted Influenza Vaccine (CAIV-T) Against Inactivated Influenza Vaccine (TIV) in Children 6-59 Months of Age", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "MedImmune LLC", "conditions": [ "Influenza" ], "start_date": "2004-10", "last_update": "2021-09-13" }, { "nct_id": "NCT00129038", "title": "Modified-release Dipyridamole/Aspirin (200mg/25mg bd) Versus Aspirin (75mg) in Aspirin-resistant Patients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Coronary Arteriosclerosis" ], "start_date": "2004-04-01", "last_update": "2025-01-23" }, { "nct_id": "NCT00130897", "title": "Treatment Use Study With Sunitinib (SU011248) For Patients With Cytokine-Refractory Metastatic Renal Cell Carcinoma", "phases": [], "overall_status": "APPROVED_FOR_MARKETING", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2005-07", "last_update": "2012-03-09" }, { "nct_id": "NCT00141193", "title": "Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Colorectal Adenoma" ], "start_date": "2001-02", "last_update": "2008-08-06" }, { "nct_id": "NCT00141323", "title": "Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Ligand Pharmaceuticals", "conditions": [ "Osteoporosis" ], "start_date": "2001-11", "last_update": "2011-08-15" }, { "nct_id": "NCT00144170", "title": "Tipranavir/Ritonavir vs. Genotypically Defined Protease Inhibitor/Ritonavir in HIV Patients (RESIST-2)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "HIV Infections" ], "start_date": "2003-02", "last_update": "2014-07-02" }, { "nct_id": "NCT00144339", "title": "Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2002-12", "last_update": "2014-05-20" }, { "nct_id": "NCT00144794", "title": "Mucopolysaccharidosis I (MPS I) Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Genzyme, a Sanofi Company", "conditions": [ "Mucopolysaccharidosis I (MPS I)" ], "start_date": "2003-11-20", "last_update": "2026-02-27" }, { "nct_id": "NCT00147199", "title": "Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "United Therapeutics", "conditions": [ "Pulmonary Hypertension" ], "start_date": "2005-06", "last_update": "2024-01-02" }, { "nct_id": "NCT00148798", "title": "Study of Cisplatin/Vinorelbine +/- Cetuximab as First-line Treatment of Advanced Non Small Cell Lung Cancer (FLEX)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck KGaA, Darmstadt, Germany", "conditions": [ "Non Small Cell Lung Cancer (NSCLC)" ], "start_date": "2004-10", "last_update": "2014-06-25" }, { "nct_id": "NCT00150267", "title": "A 5-Year Postmarketing Safety Study Of Xalcom In Patients With Open Angle Glaucoma Or Ocular Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Glaucoma, Open-Angle", "Ocular Hypertension" ], "start_date": "2002-02", "last_update": "2008-11-05" }, { "nct_id": "NCT00151450", "title": "Comparison of Pregabalin Versus Venlafaxine XR and Placebo in the Treatment of Generalized Anxiety Disorder", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Anxiety" ], "start_date": "2005-03", "last_update": "2021-01-22" }, { "nct_id": "NCT00153062", "title": "PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Stroke" ], "start_date": "2003-08", "last_update": "2014-05-13" }, { "nct_id": "NCT00153101", "title": "Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2001-11", "last_update": "2014-05-20" }, { "nct_id": "NCT00160693", "title": "Open Label Long-Term Safety Study of Certolizumab Pegol (CZP) for Patients With Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2003-03", "last_update": "2018-08-01" }, { "nct_id": "NCT00162266", "title": "Abatacept With Methotrexate- Phase IIB", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2000-10", "last_update": "2012-06-01" }, { "nct_id": "NCT00163527", "title": "Efficacy and Safety of Oral Roflumilast Taken With Low Dose Inhaled Corticosteroids in Patients With Asthma (12 to 70 y) (BY217/M2-013)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Asthma" ], "start_date": "2003-04", "last_update": "2016-12-02" }, { "nct_id": "NCT00165815", "title": "The Efficacy, Tolerability and Safety of Donepezil (Aricept) in Parkinson's Disease Patients With Dementia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Limited", "conditions": [ "Dementia With Parkinson's Disease" ], "start_date": "2002-08", "last_update": "2013-05-10" }, { "nct_id": "NCT00168792", "title": "A Trial Evaluating the Efficacy and Safety of Tenecteplase Together With Unfractionated Heparin Prior to Early Percutaneous Coronary Intervention (PCI) as Compared to Standard Primary PCI in Patients With Acute Myocardial Infarction (ASSENT 4 PCI)", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Myocardial Infarction" ], "start_date": "2003-11", "last_update": "2013-10-29" }, { "nct_id": "NCT00168831", "title": "Tiotropium / Respimat One-Year Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2003-02", "last_update": "2014-05-20" }, { "nct_id": "NCT00174304", "title": "Open Label Study To Assess The Effectiveness Of Amlodipine-Atorvastatin Combination In Hypertension And Dyslipidemia.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Hypertension", "Hyperlipidemia" ], "start_date": "2004-10", "last_update": "2021-01-27" }, { "nct_id": "NCT00174642", "title": "Opposing Step-by-step Insulin Reinforcement to Intensified Strategy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2004-12", "last_update": "2009-09-15" }, { "nct_id": "NCT00174655", "title": "BIG 02/98 Docetaxel - Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Breast Neoplasms" ], "start_date": "1998-06", "last_update": "2011-11-10" }, { "nct_id": "NCT00175903", "title": "Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed Epilepsy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma", "conditions": [ "Epilepsy" ], "start_date": "2005-02", "last_update": "2015-03-17" }, { "nct_id": "NCT00182715", "title": "Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Velindre NHS Trust", "conditions": [ "Colorectal Cancer" ], "start_date": "2005-03", "last_update": "2013-09-17" }, { "nct_id": "NCT00184600", "title": "Comparison of Insulin Detemir, Insulin Aspart and Biphasic Insulin Aspart 30 With OAD Treatment in Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2004-11", "last_update": "2017-03-09" }, { "nct_id": "NCT00185198", "title": "Efficacy and Safety of Testogel® in Men With Partial Androgen Deficiency of Aging Males (PADAM)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Androgens (Deficiency)", "Male" ], "start_date": "2004-09", "last_update": "2014-04-02" }, { "nct_id": "NCT00189826", "title": "A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Liver Transplantation.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Liver Transplantation" ], "start_date": "2004-08", "last_update": "2014-07-09" }, { "nct_id": "NCT00189839", "title": "A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Kidney Transplantation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Kidney Transplantation" ], "start_date": "2004-08", "last_update": "2014-07-09" }, { "nct_id": "NCT00191932", "title": "Switching to Duloxetine From Other Antidepressants", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Major Depressive Disorder" ], "start_date": "2004-08", "last_update": "2006-07-25" }, { "nct_id": "NCT00195663", "title": "Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie (prior sponsor, Abbott)", "conditions": [ "Early Rheumatoid Arthritis" ], "start_date": "2000-12", "last_update": "2013-07-12" }, { "nct_id": "NCT00196794", "title": "A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated Diarrhea", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Genzyme, a Sanofi Company", "conditions": [ "Clostridium Enterocolitis", "Diarrhea" ], "start_date": "2005-04", "last_update": "2014-03-19" }, { "nct_id": "NCT00203372", "title": "Neoadjuvant TAC Plus or Minus Bevacizumab(AVF3299)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Translational Oncology Research International", "conditions": [ "Breast Cancer" ], "start_date": "2005-05", "last_update": "2015-10-12" }, { "nct_id": "NCT00206310", "title": "Crestor Versus Placebo in Subjects With Heart Failure", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Heart Failure" ], "start_date": "2003-09", "last_update": "2010-11-19" }, { "nct_id": "NCT00207142", "title": "Induction-Maintenance With Atazanavir in HIV Naïve Patients (The INDUMA Study)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "HIV Infections" ], "start_date": "2005-11", "last_update": "2010-01-12" }, { "nct_id": "NCT00214773", "title": "Mucopolysaccharidosis (MPS) VI Clinical Surveillance Program (CSP)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "BioMarin Pharmaceutical", "conditions": [ "Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy Syndrome)" ], "start_date": "2005-07", "last_update": "2021-04-05" }, { "nct_id": "NCT00216476", "title": "A Study of Relapse Prevention and the Effectiveness of Long-acting Injectable Risperidone and Quetiapine Tablets in the Treatment of Patients With Schizophrenia or Schizoaffective Disorder", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen-Cilag International NV", "conditions": [ "Schizophrenia", "Psychotic Disorders" ], "start_date": "2004-10", "last_update": "2014-04-16" }, { "nct_id": "NCT00216619", "title": "The Prolonged Use of Topiramate for Preventing Migraine Headaches", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Pharmaceutica N.V., Belgium", "conditions": [ "Migraine" ], "start_date": "2003-11", "last_update": "2014-07-02" }, { "nct_id": "NCT00232180", "title": "A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Heart Failure" ], "start_date": "2006-03", "last_update": "2020-12-22" }, { "nct_id": "NCT00239369", "title": "Telmisartan80/HCTZ25 Versus Telmisartan80/HCTZ12.5 in Hypertension Not Responding to Telmisartan80/HCTZ12.5", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hypertension" ], "start_date": "2005-10", "last_update": "2017-12-28" }, { "nct_id": "NCT00240331", "title": "AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Renal Failure" ], "start_date": "2003-01", "last_update": "2011-05-19" }, { "nct_id": "NCT00240474", "title": "A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hypertension" ], "start_date": "2002-12", "last_update": "2013-11-01" }, { "nct_id": "NCT00241449", "title": "A Trial Comparing the Efficacy and Tolerability of Faslodex With Nolvadex in Postmenopausal Women With Advanced Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Breast Cancer", "Metastasis" ], "start_date": "1998-11", "last_update": "2012-06-06" }, { "nct_id": "NCT00241722", "title": "Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)", "conditions": [ "Bowel Dysfunction", "Constipation" ], "start_date": "2005-08-01", "last_update": "2017-08-30" }, { "nct_id": "NCT00242801", "title": "Iressa vs Best Supportive Care - 2nd/3rd Line Survival Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "NSCLC" ], "start_date": "2003-07", "last_update": "2009-04-23" }, { "nct_id": "NCT00244465", "title": "Observational Study to Evaluate Risks of Side Effects, Drug Abuse and Dependence in Patients Who Received Xyrem ® on Prescription", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma", "conditions": [ "Narcolepsy" ], "start_date": "2006-05", "last_update": "2016-09-07" }, { "nct_id": "NCT00247962", "title": "Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Wyeth is now a wholly owned subsidiary of Pfizer", "conditions": [ "Ankylosing Spondylitis" ], "start_date": "2005-12", "last_update": "2012-11-08" }, { "nct_id": "NCT00248170", "title": "Comparison Trial of Letrozole to Anastrozole in the Adjuvant Treatment of Postmenopausal Women With Hormone Receptor and Node Positive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Cancer" ], "start_date": "2005-12", "last_update": "2016-04-19" }, { "nct_id": "NCT00251433", "title": "GW572016 With Docetaxel and Trastuzumab for the Treatment Of Untreated ErbB2 Over-Expressing Metastatic Breast Cancer", "phases": [ "PHASE1" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Neoplasms, Breast" ], "start_date": "2005-09-26", "last_update": "2023-03-31" }, { "nct_id": "NCT00255606", "title": "Docetaxel and Prednisone in Treating Patients With Hormone-Refractory Metastatic Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Tampere University", "conditions": [ "Prostate Cancer" ], "start_date": "2005-08", "last_update": "2013-06-26" }, { "nct_id": "NCT00256932", "title": "Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)", "conditions": [ "Bowel Dysfunction", "Constipation" ], "start_date": "2005-08", "last_update": "2015-09-02" }, { "nct_id": "NCT00256997", "title": "A Study of Risperidone Long-Acting Injection Versus Oral Antipsychotics in Schizophrenia Participants With a History of Being Poorly Compliant With Taking Their Medication", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Janssen-Ortho Inc., Canada", "conditions": [ "Schizophrenia" ], "start_date": "2006-01", "last_update": "2013-12-05" }, { "nct_id": "NCT00261833", "title": "Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "CSL Behring", "conditions": [ "Alpha1-proteinase Inhibitor Deficiency", "Emphysema" ], "start_date": "2006-03", "last_update": "2015-01-19" }, { "nct_id": "NCT00261976", "title": "A Long-term Safety Study of Infliximab (Remicade)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Centocor, Inc.", "conditions": [ "Arthritis, Rheumatoid", "Crohn Disease", "Psoriasis" ], "start_date": "2002-02", "last_update": "2014-03-18" }, { "nct_id": "NCT00262522", "title": "Study of Lopinavir/Ritonavir Tablets Versus Soft Gel Capsules and Once Daily Versus Twice Daily Administration, When Coadministered With Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Naive Human Immunodeficiency Virus Type 1 Infected Subjects", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott", "conditions": [ "Human Immunodeficiency Virus Infections" ], "start_date": "2005-11", "last_update": "2012-02-06" }, { "nct_id": "NCT00263042", "title": "Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Sanofi", "conditions": [ "Cardiovascular Disease" ], "start_date": "2005-12", "last_update": "2016-05-20" }, { "nct_id": "NCT00263718", "title": "Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Psoriasis Vulgaris", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "LEO Pharma", "conditions": [ "Psoriasis Vulgaris" ], "start_date": "2005-12", "last_update": "2025-02-24" }, { "nct_id": "NCT00264849", "title": "Omalizumab in Adult and Adolescent Patients With Severe Persistent Allergic Asthma", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis", "conditions": [ "Asthma" ], "start_date": "2005-11", "last_update": "2018-06-29" }, { "nct_id": "NCT00267943", "title": "Open-label Follow-up Trial of Fixed Dose Combination of Telmisartan + Hydrochlorothiazide in Hypertensive Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hypertension" ], "start_date": "2006-01", "last_update": "2013-11-13" }, { "nct_id": "NCT00271154", "title": "REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Cardiac Rhythm and Heart Failure", "conditions": [ "Heart Failure" ], "start_date": "2004-09", "last_update": "2012-01-30" }, { "nct_id": "NCT00272948", "title": "Pediatric Trial Investigating the Incidence & Outcome of Veno-Occlusive Disease With the Prophylactic Use of Defibrotide", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "European Society for Blood and Marrow Transplantation", "conditions": [ "Hepatic Veno-Occlusive Disease" ], "start_date": "2005-12", "last_update": "2011-06-09" }, { "nct_id": "NCT00273377", "title": "The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "The Cleveland Clinic", "conditions": [ "Surgical Wound Infection", "Surgery, Colon" ], "start_date": "2002-05", "last_update": "2016-06-29" }, { "nct_id": "NCT00273988", "title": "Pharmacokinetic Study of Interaction Between Nevirapine and Methadone in HIV-1 Infected, Opioid-dependent Adults", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Acquired Immunodeficiency Syndrome" ], "start_date": "2002-04", "last_update": "2013-10-31" }, { "nct_id": "NCT00274911", "title": "Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal Tumors", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2004-02", "last_update": "2013-08-02" }, { "nct_id": "NCT00274950", "title": "Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Childhood Germ Cell Tumor", "Extragonadal Germ Cell Tumor", "Ovarian Cancer" ], "start_date": "2005-05", "last_update": "2013-09-17" }, { "nct_id": "NCT00275106", "title": "Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Lymphoma" ], "start_date": "2004-09", "last_update": "2013-07-10" }, { "nct_id": "NCT00276666", "title": "Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2001-11", "last_update": "2013-09-17" }, { "nct_id": "NCT00276679", "title": "Temozolomide in Treating Young Patients With High-Risk Relapsed or Refractory Neuroblastoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Neuroblastoma" ], "start_date": "2003-04", "last_update": "2013-09-17" }, { "nct_id": "NCT00276692", "title": "Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Sarcoma" ], "start_date": "2003-08", "last_update": "2013-06-26" }, { "nct_id": "NCT00276705", "title": "Combination Chemotherapy and Thalidomide in Treating Younger Patients Undergoing Surgery For Newly Diagnosed Liver Cancer", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Liver Cancer" ], "start_date": "2005-06", "last_update": "2013-09-17" }, { "nct_id": "NCT00276718", "title": "Etoposide, Carboplatin, and Bleomycin in Treating Young Patients Undergoing Surgery For Malignant Germ Cell Tumors", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors", "Childhood Germ Cell Tumor", "Extragonadal Germ Cell Tumor", "Ovarian Cancer" ], "start_date": "1989-04", "last_update": "2013-09-17" }, { "nct_id": "NCT00276731", "title": "Combination Chemotherapy Followed By Surgery With or Without Radiation Therapy in Treating Young Patients With Stage II or Stage III Neuroblastoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Neuroblastoma" ], "start_date": "1995-03", "last_update": "2013-09-17" }, { "nct_id": "NCT00276757", "title": "Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Histiocyte Society", "conditions": [ "Childhood Langerhans Cell Histiocytosis" ], "start_date": "2001-04", "last_update": "2014-01-10" }, { "nct_id": "NCT00278239", "title": "Quality of Life in Patients Who Have Undergone Previous Treatment for Primitive Neuroectodermal Tumors", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors", "Cognitive/Functional Effects", "Long-term Effects Secondary to Cancer Therapy in Children", "Psychosocial Effects of Cancer and Its Treatment" ], "start_date": "2002-06", "last_update": "2013-09-20" }, { "nct_id": "NCT00279045", "title": "Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2000-01-03", "last_update": "2017-11-29" }, { "nct_id": "NCT00279760", "title": "Phase I/II Multiple-Dose LEA29Y vs CTLAG4Ig vs Placebo in Rheumatoid Arthritis", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "", "last_update": "2016-09-16" }, { "nct_id": "NCT00280059", "title": "Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Epilepsy, Partial" ], "start_date": "2006-08", "last_update": "2021-01-28" }, { "nct_id": "NCT00281905", "title": "Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors", "Neuroblastoma" ], "start_date": "1992-06", "last_update": "2013-09-20" }, { "nct_id": "NCT00283751", "title": "Comparison of Insulin Detemir or Insulin Glargine as Add on to Oral Antidiabetic Drugs in Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2003-03", "last_update": "2017-01-27" }, { "nct_id": "NCT00286507", "title": "Full Thickness Macular Hole and Internal Limiting Membrane Peeling Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Aberdeen", "conditions": [ "Stage 2 or 3 Full Thickness Macular Hole" ], "start_date": "2005-07", "last_update": "2012-06-06" }, { "nct_id": "NCT00287924", "title": "High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2005-03", "last_update": "2013-09-17" }, { "nct_id": "NCT00287950", "title": "Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Infants With Neuroblastoma", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Neuroblastoma" ], "start_date": "1992-09", "last_update": "2013-09-17" }, { "nct_id": "NCT00287976", "title": "Irinotecan in Treating Young Patients With Refractory or Recurrent Hepatoblastoma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Liver Cancer" ], "start_date": "2003-04", "last_update": "2013-09-17" }, { "nct_id": "NCT00293358", "title": "Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "1997-01", "last_update": "2013-09-17" }, { "nct_id": "NCT00296387", "title": "Effects in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Acute Coronary Syndrome" ], "start_date": "2006-01", "last_update": "2007-12-17" }, { "nct_id": "NCT00297232", "title": "Natalizumab (Tysabri) Re-Initiation of Dosing", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2006-03", "last_update": "2016-07-15" }, { "nct_id": "NCT00302016", "title": "Expanded Access Program of AMN107 in Imatinib-resistant or Intolerant Adult Patients With Chronic Myeloid Leukemia", "phases": [], "overall_status": "NO_LONGER_AVAILABLE", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Myeloid Leukemia" ], "start_date": "2006-01", "last_update": "2011-08-26" }, { "nct_id": "NCT00310180", "title": "Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Breast Adenocarcinoma", "Hormone Receptor Positive", "Stage IA Breast Cancer AJCC v7", "Stage IB Breast Cancer AJCC v7", "Stage IIA Breast Cancer AJCC v6 and v7", "Stage IIB Breast Cancer AJCC v6 and v7", "Stage IIIB Breast Cancer AJCC v7" ], "start_date": "2006-04-07", "last_update": "2026-10-01" }, { "nct_id": "NCT00312156", "title": "Comparison of Efficacy and Safety of Insulin Detemir and NPH Insulin in Children and Adolescents With Type 1 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2002-08", "last_update": "2017-01-27" }, { "nct_id": "NCT00312208", "title": "Docetaxel in Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Breast Cancer" ], "start_date": "2001-11", "last_update": "2013-12-30" }, { "nct_id": "NCT00316771", "title": "A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2005-11", "last_update": "2016-11-02" }, { "nct_id": "NCT00317408", "title": "Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma", "conditions": [ "Lymphoma" ], "start_date": "2004-04", "last_update": "2015-09-25" }, { "nct_id": "NCT00318461", "title": "To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2006-05", "last_update": "2017-03-07" }, { "nct_id": "NCT00321919", "title": "A Study of Treatment With NeoRecormon (Epoetin Beta) in Patients With Chronic Renal Anemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Anemia" ], "start_date": "2000-07", "last_update": "2016-06-29" }, { "nct_id": "NCT00322218", "title": "Study Comparing Zevalin Regimen With no Further Treatment in Patients With Diffuse Large B-cell Lymphoma.", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Spectrum Pharmaceuticals, Inc", "conditions": [ "Lymphoma, Large Cell, Diffuse" ], "start_date": "2006-05", "last_update": "2022-01-19" }, { "nct_id": "NCT00324155", "title": "Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2006-08", "last_update": "2014-11-03" }, { "nct_id": "NCT00324805", "title": "Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Stage IB Lung Non-Small Cell Carcinoma AJCC v7", "Stage IIA Lung Non-Small Cell Carcinoma AJCC v7", "Stage IIB Lung Non-Small Cell Carcinoma AJCC v7", "Stage IIIA Lung Non-Small Cell Cancer AJCC v7" ], "start_date": "2007-07-19", "last_update": "2026-06-23" }, { "nct_id": "NCT00325442", "title": "FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "United Therapeutics", "conditions": [ "Pulmonary Hypertension" ], "start_date": "2006-10", "last_update": "2017-08-02" }, { "nct_id": "NCT00326248", "title": "Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Nausea and Vomiting, Postoperative" ], "start_date": "2006-03", "last_update": "2016-10-26" }, { "nct_id": "NCT00327691", "title": "A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Cardiovascular Disease", "Cerebrovascular Accident", "Coronary Heart Disease" ], "start_date": "1998-04", "last_update": "2007-05-03" }, { "nct_id": "NCT00328068", "title": "Assessment of SpondyloArthritis Society (ASAS) Classification and Diagnostic Criteria for Early Axial Spondyloarthritis (SpA)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Charite University, Berlin, Germany", "conditions": [ "Spondyloarthritis", "Spondylarthropathy", "Spondylitis, Ankylosing" ], "start_date": "2006-07", "last_update": "2013-02-13" }, { "nct_id": "NCT00334282", "title": "Safety and Efficacy of GW786034 (Pazopanib) In Metastatic Renal Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2006-04", "last_update": "2016-02-05" }, { "nct_id": "NCT00334854", "title": "Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "European Paediatric Soft Tissue Sarcoma Study Group", "conditions": [ "Childhood Malignant Fibrous Histiocytoma of Bone", "Sarcoma" ], "start_date": "2006-03", "last_update": "2013-08-12" }, { "nct_id": "NCT00335452", "title": "Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Acute Coronary Disease", "Angina Unstable" ], "start_date": "2006-06", "last_update": "2010-11-18" }, { "nct_id": "NCT00338247", "title": "EAP (Expanded Access Protocol) Of Lapatinib Combined With Capecitabine In Metastatic Breast Cancer", "phases": [], "overall_status": "APPROVED_FOR_MARKETING", "lead_sponsor": "Novartis", "conditions": [ "Neoplasms, Breast" ], "start_date": "2006-07", "last_update": "2016-04-06" }, { "nct_id": "NCT00340080", "title": "Clinical Utility Of Genetic Screening For HLA-B*5701, On Susceptibility To Abacavir Hypersensitivity", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "HIV Infection" ], "start_date": "2006-04", "last_update": "2010-01-25" }, { "nct_id": "NCT00340366", "title": "Influence of Genetics on Vitamin Metabolism in Pregnant Women", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "National Human Genome Research Institute (NHGRI)", "conditions": [ "Pregnancy", "Birth Defects" ], "start_date": "2003-12-16", "last_update": "2017-07-02" }, { "nct_id": "NCT00348712", "title": "Efficacy and Safety of Inhaled Pre-prandial Human Insulin in Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2006-10-30", "last_update": "2017-03-01" }, { "nct_id": "NCT00348959", "title": "An Evaluation of the Effect of 'Open Window' on Psychological Well-being and Experience of Stem Cell Transplantation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Hematological Malignancies" ], "start_date": "2006-08", "last_update": "2012-06-13" }, { "nct_id": "NCT00349024", "title": "Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors", "Chordoma", "Kidney Cancer", "Leukemia", "Lymphoma", "Mucositis", "Neuroblastoma", "Pain", "Sarcoma", "Unspecified Childhood Solid Tumor, Protocol Specific" ], "start_date": "2005-07", "last_update": "2013-09-20" }, { "nct_id": "NCT00349531", "title": "A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Restless Legs Syndrome" ], "start_date": "2006-07", "last_update": "2012-05-21" }, { "nct_id": "NCT00354562", "title": "A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small Cell Lung Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Abbott", "conditions": [ "Lung Cancer", "Non-Small Cell Lung Cancer" ], "start_date": "2007-02", "last_update": "2011-01-07" }, { "nct_id": "NCT00355901", "title": "An Observational Follow-up Study for Subjects Receiving Salvage Therapy After Previous Treatment in a Visilizumab Study for Intravenous Steroid-Refractory Ulcerative Colitis", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "PDL BioPharma, Inc.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2006-09", "last_update": "2008-08-05" }, { "nct_id": "NCT00356096", "title": "Phase IV Trial With Pramipexole to Evaluate Safety and Efficacy in Patients With RLS Associated With Mood Disturbances", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Restless Legs Syndrome", "Depression" ], "start_date": "2006-07", "last_update": "2012-05-21" }, { "nct_id": "NCT00356421", "title": "A Clinical Trial Comparing Efficacy and Safety of Exubera® and Humalog®", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Diabetes Mellitus, Type 1" ], "start_date": "2006-11", "last_update": "2009-09-02" }, { "nct_id": "NCT00358566", "title": "GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pharmexa A/S", "conditions": [ "Advanced Unresectable Pancreatic Cancer" ], "start_date": "2006-06", "last_update": "2008-05-19" }, { "nct_id": "NCT00359112", "title": "AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Non-Insulin-Dependent Diabetes Mellitus" ], "start_date": "2004-02", "last_update": "2009-05-18" }, { "nct_id": "NCT00359762", "title": "Exenatide Versus Glimepiride in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes Mellitus" ], "start_date": "2006-09", "last_update": "2015-09-15" }, { "nct_id": "NCT00360854", "title": "Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma", "phases": [ "PHASE1" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2005-05", "last_update": "2013-09-20" }, { "nct_id": "NCT00360945", "title": "Cisplatin and Temozolomide in Treating Young Patients With Malignant Glioma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2004-04", "last_update": "2013-09-17" }, { "nct_id": "NCT00362765", "title": "Fenofibrate and Metformin Insulin Sensitivity in Type 2 Diabetics Study", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Solvay Pharmaceuticals", "conditions": [ "Type 2 Diabetes", "Dyslipidemia" ], "start_date": "2006-10", "last_update": "2008-08-13" }, { "nct_id": "NCT00365170", "title": "Efficacy and Safety of Insulin Aspart vs. Human Insulin During Pregnancy by Women With Type 1 Diabetes", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2002-09", "last_update": "2016-12-21" }, { "nct_id": "NCT00366834", "title": "Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Vomiting", "Nausea", "Nausea and Vomiting, Chemotherapy-Induced" ], "start_date": "2006-07", "last_update": "2012-09-10" }, { "nct_id": "NCT00375674", "title": "A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Kidney Neoplasms" ], "start_date": "2007-08-01", "last_update": "2018-09-21" }, { "nct_id": "NCT00379457", "title": "Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "European Paediatric Soft Tissue Sarcoma Study Group", "conditions": [ "Sarcoma" ], "start_date": "2006-06", "last_update": "2013-08-12" }, { "nct_id": "NCT00382070", "title": "Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "NSABP Foundation Inc", "conditions": [ "Breast Cancer" ], "start_date": "2006-08", "last_update": "2024-03-22" }, { "nct_id": "NCT00384202", "title": "A Conversion Study to Assess Safety and Efficacy of a MR4 Based Immunosuppressive Regimen in Stable Liver Recipients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Transplantation" ], "start_date": "2006-10", "last_update": "2014-07-09" }, { "nct_id": "NCT00387088", "title": "Tiotropium / Respimat One Year Study in COPD.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2006-09", "last_update": "2014-05-16" }, { "nct_id": "NCT00391287", "title": "Surveillance Study to Estimate the Incidence of Pure Red Blood Cell Aplasia Among Patients With Chronic Kidney Failure", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "conditions": [ "Pure Red-Cell Aplasia", "Chronic Kidney Failure" ], "start_date": "2006-06", "last_update": "2014-10-03" }, { "nct_id": "NCT00391612", "title": "EASE Trial: Exhale Airway Stents for Emphysema", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Broncus Technologies", "conditions": [ "Emphysema" ], "start_date": "2006-05", "last_update": "2011-01-12" }, { "nct_id": "NCT00393198", "title": "Bleeding Pattern and User Satisfaction During Second Consecutive MIRENA® in Contraception and Treatment of Menorrhagia", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Contraception", "Menorrhagia" ], "start_date": "2006-10", "last_update": "2014-11-03" }, { "nct_id": "NCT00393939", "title": "Study Of Sunitinib In Combination With Docetaxel Vs Docetaxel In Patients With Advanced Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms" ], "start_date": "2007-02", "last_update": "2012-07-19" }, { "nct_id": "NCT00402272", "title": "SPIRIT V: Post-marketing Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System in Europe", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Coronary Disease", "Coronary Artery Disease", "Coronary Restenosis" ], "start_date": "2006-11", "last_update": "2010-10-14" }, { "nct_id": "NCT00402727", "title": "Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Abscess", "Wound Infection", "Diabetic Foot", "Ulcer" ], "start_date": "2006-09", "last_update": "2014-11-07" }, { "nct_id": "NCT00405418", "title": "Lantus Versus Levemir Treat-To-Target", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2006-11", "last_update": "2009-09-15" }, { "nct_id": "NCT00405756", "title": "A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene Corporation", "conditions": [ "Newly Diagnosed Multiple Myeloma" ], "start_date": "2007-01", "last_update": "2017-01-11" }, { "nct_id": "NCT00405808", "title": "Rimonabant in Abdominally Obese Patients With Impaired Fasting Blood Glucose", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Sanofi", "conditions": [ "Obesity" ], "start_date": "2006-12", "last_update": "2011-01-26" }, { "nct_id": "NCT00409188", "title": "Cancer Vaccine Study for Unresectable Stage III Non-small Cell Lung Cancer (START)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "EMD Serono", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2007-01", "last_update": "2015-11-20" }, { "nct_id": "NCT00409617", "title": "Study of Adalimumab Treatment for Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott", "conditions": [ "Crohn's Disease" ], "start_date": "2006-12", "last_update": "2011-10-10" }, { "nct_id": "NCT00410410", "title": "A Study of Abatacept in Patients With Active Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Ulcerative Colitis" ], "start_date": "2006-12", "last_update": "2015-03-24" }, { "nct_id": "NCT00411424", "title": "Safety, Tolerability and Efficacy Study of the New Medication ASK8007 to Treat Patients With Rheumatoid Arthritis", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2007-09", "last_update": "2013-03-21" }, { "nct_id": "NCT00412698", "title": "European Trial About Effect of RimoNabant on Abdominal Obese Patients With dysLipidemia", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Sanofi", "conditions": [ "Obesity", "Dyslipidemias" ], "start_date": "2006-12", "last_update": "2010-12-10" }, { "nct_id": "NCT00413283", "title": "Dose/ Schedule Finding Trial of Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT) in Non-Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Lung Cancer", "Chemotherapy-Induced Thrombocytopenia", "Non-Small Cell Lung Cancer", "Cancer", "Lung Neoplasms", "Oncology", "Solid Tumors", "Thrombocytopenia" ], "start_date": "2006-12", "last_update": "2013-10-24" }, { "nct_id": "NCT00413699", "title": "Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Arthritis, Rheumatoid" ], "start_date": "2007-02-05", "last_update": "2018-10-30" }, { "nct_id": "NCT00414583", "title": "Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "CENTOGENE GmbH Rostock", "conditions": [ "Cerebrovascular Accident" ], "start_date": "2008-01", "last_update": "2021-04-09" }, { "nct_id": "NCT00418457", "title": "Regional Anesthesia and Breast Cancer Recurrence", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "The Cleveland Clinic", "conditions": [ "Breast Neoplasms" ], "start_date": "2007-01", "last_update": "2020-06-16" }, { "nct_id": "NCT00420849", "title": "A Multicentre, Single-arm, Open-label Safety Study of Lenalidomide Plus Dexamethasone in Previously Treated Subjects With Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene Corporation", "conditions": [ "Multiple Myeloma" ], "start_date": "2006-11", "last_update": "2012-05-21" }, { "nct_id": "NCT00424047", "title": "A Study of CC-5013 Plus Dexamethasone Versus Dexamethasone Alone in Previously Treated Subjects With Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2003-01-01", "last_update": "2017-10-19" }, { "nct_id": "NCT00424255", "title": "Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Head and Neck" ], "start_date": "2006-12", "last_update": "2014-07-18" }, { "nct_id": "NCT00426660", "title": "Expanded Access Program for Maraviroc At Multiple Centers", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ViiV Healthcare", "conditions": [ "HIV Infections" ], "start_date": "2007-02", "last_update": "2016-06-29" }, { "nct_id": "NCT00428129", "title": "Microplasmin Administered Via the Trellis-8 Infusion System for Treatment of Acute Iliofemoral DVT", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "ThromboGenics", "conditions": [ "Deep Vein Thrombosis" ], "start_date": "2007-03", "last_update": "2014-04-07" }, { "nct_id": "NCT00429195", "title": "The Effect of Dietary Fat Modification on Risk Factors Associated With the Metabolic Syndrome", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Metabolic Syndrome" ], "start_date": "2004-02", "last_update": "2013-01-21" }, { "nct_id": "NCT00430781", "title": "Pazopanib Plus Lapatinib Compared to Lapatinib Alone and Pazopanib Alone In Subjects With Metastatic Cervical Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Uterine Cervix", "Metastatic Cervical Cancer" ], "start_date": "2006-11", "last_update": "2015-05-08" }, { "nct_id": "NCT00431236", "title": "A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Nausea and Vomiting, Chemotherapy-Induced" ], "start_date": "2006-11-06", "last_update": "2017-08-22" }, { "nct_id": "NCT00431353", "title": "VICTOR Study - A Study of Valcyte (Valganciclovir po) Compared to Ganciclovir iv in Patients With Cytomegalovirus (CMV) Disease Who Are Solid Organ Transplant Recipients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Cytomegalovirus Infections" ], "start_date": "2004-04", "last_update": "2016-11-02" }, { "nct_id": "NCT00433212", "title": "Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "McMaster University", "conditions": [ "Respiratory Insufficiency of Prematurity" ], "start_date": "2007-04", "last_update": "2014-12-05" }, { "nct_id": "NCT00435409", "title": "A Study Of Sunitinib In Combination With Capecitabine Compared With Capecitabine In Patients With Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms" ], "start_date": "2007-02", "last_update": "2012-06-26" }, { "nct_id": "NCT00436774", "title": "Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Childhood Germ Cell Tumor", "Extragonadal Germ Cell Tumor", "Gastrointestinal Complications", "Infertility", "Long-term Effects Secondary to Cancer Therapy in Children", "Neurotoxicity", "Ovarian Cancer", "Pulmonary Complications", "Sexual Dysfunction", "Urinary Complications" ], "start_date": "2006-06", "last_update": "2013-08-12" }, { "nct_id": "NCT00439777", "title": "Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Pulmonary Embolism - The EINSTEIN PE Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Pulmonary Embolism" ], "start_date": "2007-03", "last_update": "2014-02-27" }, { "nct_id": "NCT00442325", "title": "Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Coronary Arteriosclerosis", "Diabetes Mellitus, Type 2", "Cerebrovascular Accident", "Dyslipidemia", "Peripheral Vascular Disease" ], "start_date": "2003-01", "last_update": "2021-02-18" }, { "nct_id": "NCT00446680", "title": "Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Syntara", "conditions": [ "Cystic Fibrosis" ], "start_date": "2007-03", "last_update": "2010-06-25" }, { "nct_id": "NCT00447278", "title": "A Study Comparing the Effect of Atomoxetine Versus Other Standard Care Therapy on the Long Term Functioning in Attention-Deficit/Hyperactivity Disorder (ADHD) Children and Adolescents", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Attention Deficit Hyperactivity Disorder" ], "start_date": "2007-03", "last_update": "2010-04-27" }, { "nct_id": "NCT00451451", "title": "Efficacy and Safety Study of Oral BG00012 With Active Reference in Relapsing-Remitting Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2007-06", "last_update": "2015-01-26" }, { "nct_id": "NCT00454389", "title": "A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "NeoVista", "conditions": [ "Macular Degeneration" ], "start_date": "2007-04", "last_update": "2011-07-27" }, { "nct_id": "NCT00457691", "title": "Study Of FOLFIRI Chemotherapy With Or Without Sunitinib In Patients With Metastatic Colorectal Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Metastatic Colorectal Cancer" ], "start_date": "2007-06", "last_update": "2015-03-30" }, { "nct_id": "NCT00459667", "title": "BEYOND Follow-up: Betaferon®/Betaseron® Efficacy Yielding Outcomes of a New Dose", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "start_date": "2007-05", "last_update": "2015-04-23" }, { "nct_id": "NCT00460408", "title": "Ocular Safety Of Patients Receiving Macugen For Neovascular Age Related Macular Degeneration", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Macular Degeneration" ], "start_date": "2006-08", "last_update": "2012-12-11" }, { "nct_id": "NCT00463788", "title": "Cetuximab and Cisplatin in the Treatment of \"Triple Negative\" (Estrogen Receptor [ER] Negative, Progesterone Receptor [PgR] Negative, and Human Epidermal Growth Factor Receptor 2 [HER2] Negative) Metastatic Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck KGaA, Darmstadt, Germany", "conditions": [ "Breast Neoplasm" ], "start_date": "2007-06", "last_update": "2014-02-13" }, { "nct_id": "NCT00463866", "title": "Local Phase 4 Pan-European SMART Study", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Asthma" ], "start_date": "2007-03", "last_update": "2010-03-22" }, { "nct_id": "NCT00468546", "title": "A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2003-05", "last_update": "2016-10-25" }, { "nct_id": "NCT00470236", "title": "Radiation Doses and Fractionation Schedules in Non-low Risk Ductal Carcinoma In Situ (DCIS) of the Breast", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Trans Tasman Radiation Oncology Group", "conditions": [ "Carcinoma, Ductal, Breast" ], "start_date": "2007-06", "last_update": "2023-03-22" }, { "nct_id": "NCT00471146", "title": "Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine For Advanced Pancreatic Cancer.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Pancreatic Ductal" ], "start_date": "2007-07", "last_update": "2012-07-16" }, { "nct_id": "NCT00472199", "title": "Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Restless Legs Syndrome" ], "start_date": "2007-05", "last_update": "2014-06-27" }, { "nct_id": "NCT00473460", "title": "Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Lung Diseases", "Bronchitis, Chronic" ], "start_date": "2004-10", "last_update": "2014-10-28" }, { "nct_id": "NCT00474045", "title": "Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2007-05", "last_update": "2017-03-10" }, { "nct_id": "NCT00475605", "title": "A Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Protopic for the Treatment of Atopic Dermatitis", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "LEO Pharma", "conditions": [ "Atopic Dermatitis" ], "start_date": "2005-05-25", "last_update": "2019-12-18" }, { "nct_id": "NCT00476892", "title": "Multi-centre Randomised Controlled Trial of Pelvic Floor Muscle Training for Prolapse", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Glasgow Caledonian University", "conditions": [ "Pelvic Organ Prolapse" ], "start_date": "2007-06", "last_update": "2011-03-23" }, { "nct_id": "NCT00478660", "title": "An Open-Label Study to Evaluate the Response to Adalimumab in Patients With Active Ankylosing Spondylitis Who Have Failed Standard Therapy or TNF-Alpha Inhibitors (RHAPSODY)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott", "conditions": [ "Ankylosing Spondylitis" ], "start_date": "2006-02", "last_update": "2007-10-10" }, { "nct_id": "NCT00479739", "title": "CONCEPT: A 1-Year Comparison Of A Stable Dose Of SERETIDE® Inhaler With An Adjustable Maintenance Dose Of SYMBICORT® Inhaler. SERETIDE® Inhaler is a Trademark of GSK Group of Companies. SYMBICORT® Inhaler is a Trademark of Astra Zeneca.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Asthma" ], "start_date": "2002-11", "last_update": "2016-09-15" }, { "nct_id": "NCT00480025", "title": "GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Lung Cancer, Non-Small Cell" ], "start_date": "2007-10-04", "last_update": "2020-12-22" }, { "nct_id": "NCT00481390", "title": "Prospective Epidemiological Study Of The Prevalence Of HLA-B*5701 In HIV-1 Infected Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Infection, Human Immunodeficiency Virus I", "HIV Infection", "HIV-1 Infection" ], "start_date": "2007-06", "last_update": "2011-06-08" }, { "nct_id": "NCT00490139", "title": "ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Neoplasms, Breast" ], "start_date": "2007-05-16", "last_update": "2025-03-21" }, { "nct_id": "NCT00499070", "title": "Assessing Immune Function in Young Patients With Cytopenia That Did Not Respond to Treatment", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital Freiburg", "conditions": [ "Dyskeratosis Congenita", "Fanconi Anemia", "Myelodysplastic Syndromes", "Pearson Marrow-pancreas Syndrome", "Shwachman-diamond Syndrome" ], "start_date": "2007-01", "last_update": "2015-01-16" }, { "nct_id": "NCT00501059", "title": "A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Moderate Risk of CVD" ], "start_date": "2007-07-05", "last_update": "2018-10-26" }, { "nct_id": "NCT00505336", "title": "The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Diastolic Heart Failure" ], "start_date": "2006-04", "last_update": "2009-02-11" }, { "nct_id": "NCT00510978", "title": "Probiotics in GastroIntestinal Disorders", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Ulcerative Colitis", "Crohn's Disease" ], "start_date": "2002-01", "last_update": "2011-06-14" }, { "nct_id": "NCT00513877", "title": "Bortezomib in Treating Patients With Malignant Pleural Mesothelioma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Malignant Mesothelioma" ], "start_date": "2006-05", "last_update": "2014-12-31" }, { "nct_id": "NCT00513981", "title": "High-Dose Methotrexate in Treating Young Patients With Solid Tumors", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors", "Sarcoma", "Unspecified Childhood Solid Tumor, Protocol Specific" ], "start_date": "2007-03", "last_update": "2013-06-26" }, { "nct_id": "NCT00514345", "title": "CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With Ifosfamide", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Chemotherapeutic Agent Toxicity", "Sarcoma", "Unspecified Childhood Solid Tumor, Protocol Specific" ], "start_date": "2007-07", "last_update": "2013-08-12" }, { "nct_id": "NCT00514397", "title": "Temozolomide and Radiation Therapy in Treating Young Patients With Pontine Glioma", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Brain and Central Nervous System Tumors" ], "start_date": "2008-01", "last_update": "2013-08-12" }, { "nct_id": "NCT00514683", "title": "Safety And Efficacy of BIBF 1120 in Idiopathic Pulmonary Fibrosis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Fibrosis" ], "start_date": "2007-08", "last_update": "2015-01-06" }, { "nct_id": "NCT00518882", "title": "Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2007-08", "last_update": "2017-03-08" }, { "nct_id": "NCT00519961", "title": "A Prospective Study to Assess the Screening Value of N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) for the Identification of Patients That Benefit From Additional Cardiac Testing Prior to Vascular Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Peripheral Vascular Disease" ], "start_date": "2007-02", "last_update": "2011-03-16" }, { "nct_id": "NCT00520741", "title": "Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB BIOSCIENCES, Inc.", "conditions": [ "Epilepsy" ], "start_date": "2007-08", "last_update": "2018-07-19" }, { "nct_id": "NCT00531362", "title": "Enteric Coating as a Factor in Aspirin Resistance", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cardiovascular Disease" ], "start_date": "2007-09", "last_update": "2009-09-29" }, { "nct_id": "NCT00534508", "title": "Distribution of Tacrolimus in Skin, Atopic Dermatitis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Dermatitis, Atopic" ], "start_date": "2000-12", "last_update": "2014-09-18" }, { "nct_id": "NCT00535691", "title": "Tacrolimus Ointment Pharmacokinetics in Infants With Atopic Dermatitis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Dermatitis, Atopic" ], "start_date": "2003-04", "last_update": "2014-09-01" }, { "nct_id": "NCT00537459", "title": "A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Premature Ejaculation" ], "start_date": "2006-12", "last_update": "2012-03-19" }, { "nct_id": "NCT00545909", "title": "BEATRIS Study: A Study of Adherence to Bonviva (Ibandronate) Once Monthly in Women With Post-Menopausal Osteoporosis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Postmenopausal Osteoporosis" ], "start_date": "2006-03", "last_update": "2016-11-02" }, { "nct_id": "NCT00549198", "title": "KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Infection, Human Immunodeficiency Virus I", "HIV Infection" ], "start_date": "2007-06", "last_update": "2011-04-12" }, { "nct_id": "NCT00549302", "title": "Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Hypertension, Pulmonary" ], "start_date": "2005-12", "last_update": "2013-04-09" }, { "nct_id": "NCT00551616", "title": "Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "HRA Pharma", "conditions": [ "Contraception" ], "start_date": "2007-04", "last_update": "2022-05-03" }, { "nct_id": "NCT00552799", "title": "RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Nottingham", "conditions": [ "Cellulitis/Erysipelas of the Leg" ], "start_date": "2006-07", "last_update": "2012-07-24" }, { "nct_id": "NCT00553267", "title": "Telmisartan/Amlodipine (80/10) vs. Telmisartan/Amlodipine (40/10) vs. amlodipine10 in Resistant Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hypertension" ], "start_date": "2007-11", "last_update": "2014-02-13" }, { "nct_id": "NCT00553553", "title": "Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Liver Dysfunction", "Pain" ], "start_date": "2007-09", "last_update": "2008-12-31" }, { "nct_id": "NCT00557466", "title": "A Dose Ranging Trial of 4 Doses of Indacaterol Delivered Via the TWISTHALER® Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis", "conditions": [ "COPD" ], "start_date": "2007-10", "last_update": "2013-01-18" }, { "nct_id": "NCT00559585", "title": "Methotrexate-Inadequate Response Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Rheumatoid Arthritis (RA)" ], "start_date": "2008-01", "last_update": "2015-11-09" }, { "nct_id": "NCT00560326", "title": "Tacrolimus Ointment Long Term Safety in Young Children With Atopic Dermatitis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Dermatitis, Atopic" ], "start_date": "2003-06", "last_update": "2014-09-01" }, { "nct_id": "NCT00560378", "title": "Long-term Safety of Protopic in Atopic Eczema", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Dermatitis, Atopic", "Eczema, Atopic" ], "start_date": "1998-06", "last_update": "2014-09-18" }, { "nct_id": "NCT00560573", "title": "Study Of CP-751,871 In Combination With Cisplatin And Gemcitabine In Chemotherapy-Naïve Patients With Advanced Non-Small Cell Lung Cancer", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2007-11", "last_update": "2013-03-21" }, { "nct_id": "NCT00561171", "title": "Phase IIa Study to Investigate the Efficacy and Safety of SPP635 in Diabetic and Hypertensive Patients With Albuminuria", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Speedel Pharma Ltd.", "conditions": [ "Hypertension", "Type II Diabetes Mellitus" ], "start_date": "2007-11", "last_update": "2008-11-21" }, { "nct_id": "NCT00561925", "title": "VERxVE Study on Efficacy and Safety of Nevirapine XR in Comparison to Nevirapine IR With Truvada in Naive HIV+ Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "HIV Infections" ], "start_date": "2007-11", "last_update": "2014-04-07" }, { "nct_id": "NCT00567502", "title": "Safety and Pregnancy Outcomes in Thrombocythemia Patients Exposed to XAGRID® (Anagrelide Hydrochloride) Compared to Other Treatments", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Thrombocythemia, Essential" ], "start_date": "2005-05-31", "last_update": "2021-06-09" }, { "nct_id": "NCT00594828", "title": "Patient Self Testing of Warfarin Therapy", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Warfarin" ], "start_date": "2006-07", "last_update": "2008-01-16" }, { "nct_id": "NCT00596700", "title": "Capsule Endoscopy Crohn's Disease Activity Index - Validation Multi Center Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Rabin Medical Center", "conditions": [ "Crohn's Disease" ], "start_date": "2007-01", "last_update": "2014-04-29" }, { "nct_id": "NCT00611026", "title": "Clinical Trial to Evaluate the Efficacy and Safety of Fesoterodine in Comparison to Tolterodine Extended Release(ER)in Patients With Overactive Bladder.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Overactive Bladder" ], "start_date": "2008-02", "last_update": "2011-02-02" }, { "nct_id": "NCT00621855", "title": "RE-DEEM Dose Finding Study for Dabigatran Etexilate in Patients With Acute Coronary Syndrome", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Coronary Disease" ], "start_date": "2008-03", "last_update": "2014-03-12" }, { "nct_id": "NCT00622284", "title": "Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2008-02", "last_update": "2014-01-29" }, { "nct_id": "NCT00622869", "title": "Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Liver Transplantation" ], "start_date": "2008-01", "last_update": "2013-05-27" }, { "nct_id": "NCT00624052", "title": "26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hypertension" ], "start_date": "2008-03", "last_update": "2014-05-20" }, { "nct_id": "NCT00625898", "title": "BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "NSABP Foundation Inc", "conditions": [ "Breast Cancer" ], "start_date": "2008-04", "last_update": "2020-09-10" }, { "nct_id": "NCT00626106", "title": "QUILT-2.015: A Study of AMG 479 With Exemestane or Fulvestrant in Postmenopausal Women With Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "NantCell, Inc.", "conditions": [ "Breast Cancer", "Breast Tumors", "Metastatic Cancer" ], "start_date": "2008-03-27", "last_update": "2024-09-19" }, { "nct_id": "NCT00626548", "title": "A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic Hormone Resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "AstraZeneca", "conditions": [ "Prostate Cancer" ], "start_date": "2008-01", "last_update": "2012-09-03" }, { "nct_id": "NCT00636064", "title": "A Study Comparing the Efficacy and Safety of Valdecoxib Plus Parecoxib Versus Valdecoxib Plus Placebo for the Treatment of Pain After Coronary Artery Bypass Surgery", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Pain" ], "start_date": "2003-01", "last_update": "2008-10-10" }, { "nct_id": "NCT00638690", "title": "Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cougar Biotechnology, Inc.", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2008-05", "last_update": "2014-04-30" }, { "nct_id": "NCT00656747", "title": "Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Chronic Bronchitis" ], "start_date": "2008-03", "last_update": "2014-12-01" }, { "nct_id": "NCT00658515", "title": "A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Coronary Heart Disease" ], "start_date": "2008-04", "last_update": "2020-01-03" }, { "nct_id": "NCT00659295", "title": "Observational Study to Evaluate the Safety of Levemir® in Diabetes", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2" ], "start_date": "2004-06", "last_update": "2017-03-10" }, { "nct_id": "NCT00661206", "title": "Safety and Efficacy of Six Months Dual Antiplatelet Therapy After Drug-Eluting Stenting", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Deutsches Herzzentrum Muenchen", "conditions": [ "Coronary Artery Disease" ], "start_date": "2008-09", "last_update": "2014-10-09" }, { "nct_id": "NCT00661700", "title": "A Double-blind \"Preferred\" Vardenafil Dose Study of QoL and Functional Outcomes in Males With Erectile Dysfunction", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Erectile Dysfunction" ], "start_date": "2003-04", "last_update": "2014-11-18" }, { "nct_id": "NCT00662649", "title": "Long-term Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing-remitting Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis", "conditions": [ "Multiple Sclerosis" ], "start_date": "2008-02", "last_update": "2012-07-12" }, { "nct_id": "NCT00666744", "title": "A Randomised Controlled Trial of Family Mediated Exercises (FAME) Following Stroke", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Weakness", "Balance" ], "start_date": "2008-04", "last_update": "2008-10-29" }, { "nct_id": "NCT00670007", "title": "Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "CSL Behring", "conditions": [ "Emphysema", "Alpha 1-proteinase Inhibitor Deficiency" ], "start_date": "2008-04", "last_update": "2016-08-15" }, { "nct_id": "NCT00672334", "title": "Sodium Bicarbonate in Cardiac Surgery Study", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Austin Health", "conditions": [ "Cardiac Surgery", "Cardiopulmonary Bypass" ], "start_date": "2008-05", "last_update": "2012-08-01" }, { "nct_id": "NCT00673049", "title": "Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Large Cell", "Carcinoma, Non-Small-Cell Lung", "Carcinoma, Squamous Cell", "Carcinoma, Adenosquamous Cell" ], "start_date": "2008-05", "last_update": "2013-07-24" }, { "nct_id": "NCT00673205", "title": "(Bicalutamide) Casodex vs Placebo in Non-metastatic Early Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Non-Metastatic Prostate Cancer" ], "start_date": "1995-09", "last_update": "2010-12-10" }, { "nct_id": "NCT00678288", "title": "A Study to Assess Sorafenib Alone and in Combination With Low-Dose Interferon Following Unsuccessful Treatment With Sunitinib in Patients With Advanced Renal Cell Cancer.", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2008-04", "last_update": "2014-12-11" }, { "nct_id": "NCT00678392", "title": "Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Kidney Neoplasms" ], "start_date": "2008-09-03", "last_update": "2019-01-09" }, { "nct_id": "NCT00686959", "title": "Chemotherapy and Radiation in Treating Participants With Stage 3 Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Non Small Cell Lung Cancer" ], "start_date": "2008-09", "last_update": "2016-06-28" }, { "nct_id": "NCT00688688", "title": "Study to Test the Long Term Safety and Efficacy of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Urinary Bladder, Overactive" ], "start_date": "2008-04-25", "last_update": "2024-11-20" }, { "nct_id": "NCT00689104", "title": "Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Urinary Bladder, Overactive" ], "start_date": "2008-04-28", "last_update": "2024-11-20" }, { "nct_id": "NCT00689936", "title": "Study to Determine Efficacy and Safety of Lenalidomide Plus Low-dose Dexamethasone Versus Melphalan, Prednisone, Thalidomide in Patients With Previously Untreated Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2008-08-21", "last_update": "2019-11-20" }, { "nct_id": "NCT00694382", "title": "Evaluation of AVE5026 in the Prevention of Venous Thromboembolism in Cancer Patients Undergoing Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Venous Thromboembolism", "Cancer" ], "start_date": "2008-06", "last_update": "2013-01-23" }, { "nct_id": "NCT00699998", "title": "A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Acute Coronary Syndrome" ], "start_date": "2008-06", "last_update": "2013-05-07" }, { "nct_id": "NCT00700817", "title": "The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes Mellitus", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2008-06", "last_update": "2017-03-08" }, { "nct_id": "NCT00703326", "title": "Phase III Study of Docetaxel + Ramucirumab or Placebo in Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Breast Cancer" ], "start_date": "2008-08-06", "last_update": "2021-12-06" }, { "nct_id": "NCT00709566", "title": "EMPART - Exercise and Manual Physiotherapy Arthritis Research Trial", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Hip Osteoarthritis" ], "start_date": "2008-04", "last_update": "2010-07-23" }, { "nct_id": "NCT00712387", "title": "Trial of Proficiency- Based Simulation Training for General Surgical Trainees", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Education", "Training", "Computer Simulation" ], "start_date": "2008-07", "last_update": "2009-02-24" }, { "nct_id": "NCT00714961", "title": "Clopidogrel as Adjunctive Reperfusion Therapy - Thrombolysis in Myocardial Infarction", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Acute Coronary Syndromes" ], "start_date": "2003-02", "last_update": "2009-03-25" }, { "nct_id": "NCT00716144", "title": "Dose Ranging Study of the Safety and Efficacy of R115966 in Plaque Psoriasis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Stiefel, a GSK Company", "conditions": [ "Psoriasis" ], "start_date": "2006-06-01", "last_update": "2018-01-29" }, { "nct_id": "NCT00717470", "title": "A Study in Kidney Transplant Subjects to Investigate the Optimal Suppression of Immunity to Help Prevent Kidney Rejection", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Kidney Transplantation" ], "start_date": "2008-05-14", "last_update": "2024-11-01" }, { "nct_id": "NCT00718523", "title": "Study of Adding AMG 479 to First Line Chemotherapy in Patients With Optimally Debulked Epithelial Ovarian Cancer", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Translational Research in Oncology", "conditions": [ "Ovarian Neoplasms" ], "start_date": "2009-01", "last_update": "2016-01-12" }, { "nct_id": "NCT00719212", "title": "Study of AMG 479 as Second Line Therapy in Patients With Recurrent Platinum-sensitive Ovarian Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Translational Research in Oncology", "conditions": [ "Ovarian Neoplasms" ], "start_date": "2009-01", "last_update": "2016-01-11" }, { "nct_id": "NCT00720915", "title": "D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "McMaster University", "conditions": [ "Deep Vein Thrombosis", "Pulmonary Embolism" ], "start_date": "2008-09", "last_update": "2016-12-13" }, { "nct_id": "NCT00720941", "title": "Pazopanib Versus Sunitinib in the Treatment of Locally Advanced and/or Metastatic Renal Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2008-08-14", "last_update": "2025-03-30" }, { "nct_id": "NCT00721409", "title": "Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Cancer" ], "start_date": "2008-09-15", "last_update": "2019-11-04" }, { "nct_id": "NCT00722267", "title": "European Non-interventional Study in Chronic Obstructive Pulmonary Disease (COPD) Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2008-07", "last_update": "2020-01-22" }, { "nct_id": "NCT00726492", "title": "An Examination of the Value of Shortwave Diathermy and Hydrotherapy for Patients With Osteoarthritis of Their Knees", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Knee Osteoarthritis" ], "start_date": "2001-06", "last_update": "2008-08-01" }, { "nct_id": "NCT00727467", "title": "A Randomised Controlled Trial (RCT) to Evaluate Use of an Individual Auditory Cueing Device's (IACD's) on Freezing and Gait in People With Parkinson's Disease (PD)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Parkinson's Disease" ], "start_date": "2008-09", "last_update": "2008-12-31" }, { "nct_id": "NCT00733499", "title": "A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "DePuy International", "conditions": [ "Osteoarthritis" ], "start_date": "2006-09-01", "last_update": "2020-01-14" }, { "nct_id": "NCT00733915", "title": "Long-term Study of the DePuy Low Contact Stress (LCS) Complete Total Knee System", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "DePuy International", "conditions": [ "Arthroplasty, Replacement, Knee" ], "start_date": "2002-03-01", "last_update": "2025-09-12" }, { "nct_id": "NCT00743795", "title": "Safety, Tolerability, and Antiviral Activity of 24 or 48 Weeks of GS-9190 in Combination With Peginterferon Alfa 2a and Ribavirin for the Treatment of Genotype-1 Chronic HCV Infection", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "HCV Infection" ], "start_date": "2008-10", "last_update": "2013-11-05" }, { "nct_id": "NCT00744497", "title": "Randomized Study Comparing Docetaxel Plus Dasatinib to Docetaxel Plus Placebo in Castration-resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2008-10", "last_update": "2016-10-17" }, { "nct_id": "NCT00748189", "title": "Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Leukaemia, Lymphocytic, Chronic" ], "start_date": "2008-12-22", "last_update": "2019-06-25" }, { "nct_id": "NCT00750880", "title": "An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2008-09", "last_update": "2015-07-22" }, { "nct_id": "NCT00752817", "title": "Creating a Proficiency-Based Virtual Reality Simulation Training Programme for Laparoscopic Assisted Colectomy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Colorectal Disease" ], "start_date": "2008-09", "last_update": "2008-10-07" }, { "nct_id": "NCT00753207", "title": "Lapatinib and Epirubicin in Treating Patients With Metastatic Breast Cancer. ICORG 06-30", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2007-10", "last_update": "2016-02-15" }, { "nct_id": "NCT00755976", "title": "Sulindac and Epirubicin in Treating Patients With Metastatic Malignant Melanoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Melanoma (Skin)" ], "start_date": "2007-08", "last_update": "2014-12-31" }, { "nct_id": "NCT00757055", "title": "If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure", "phases": [ "PHASE2" ], "overall_status": "WITHDRAWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Diastolic Heart Failure" ], "start_date": "2012-12", "last_update": "2014-11-25" }, { "nct_id": "NCT00757237", "title": "Aztreonam for Inhalation Solution vs Tobramycin Inhalation Solution in Patients With Cystic Fibrosis & Pseudomonas Aeruginosa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Cystic Fibrosis" ], "start_date": "2008-08", "last_update": "2011-07-04" }, { "nct_id": "NCT00760929", "title": "A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on Progression-Free Survival in Patients With Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC).", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Squamous Non-Small Cell Lung Cancer" ], "start_date": "2008-11-10", "last_update": "2021-01-05" }, { "nct_id": "NCT00764686", "title": "A Study Investigating an Exercise and Education Programme for Individuals With Ankylosing Spondylitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Spondylitis, Ankylosing" ], "start_date": "2008-06", "last_update": "2009-09-29" }, { "nct_id": "NCT00767520", "title": "Safety and Efficacy of Exemestane Plus Dasatinib Versus Placebo for Advanced ER+ Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Breast Cancer" ], "start_date": "2009-02", "last_update": "2013-02-28" }, { "nct_id": "NCT00768300", "title": "(ARTEMIS-IPF) Randomized, Placebo-Controlled Study to Evaluate Safety and Effectiveness of Ambrisentan in IPF", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2008-12", "last_update": "2014-04-08" }, { "nct_id": "NCT00774345", "title": "A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "B-cell Chronic Lymphocytic Leukemia" ], "start_date": "2009-01-27", "last_update": "2021-12-02" }, { "nct_id": "NCT00781885", "title": "A Multi-Center, Open-Label, Multiple Dose, Dose Finding Study Exploring the Safety and Tolerability of Beraprost Sodium Modified Release in PAH Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lung Biotechnology PBC", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2009-01-31", "last_update": "2020-06-09" }, { "nct_id": "NCT00782171", "title": "Evaluation of Immediate Versus Delayed Loading of Dental Implants With a Modified Surface", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Institut Straumann AG", "conditions": [ "Partial Edentulism" ], "start_date": "2004-07", "last_update": "2017-06-20" }, { "nct_id": "NCT00789971", "title": "Triamcinolone Versus Topical Treatment in Post Operative Phacoemulsification", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sligo General Hospital", "conditions": [ "Ocular Inflammation" ], "start_date": "2007-03", "last_update": "2008-11-13" }, { "nct_id": "NCT00790140", "title": "Trial of Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) in Upper Gastrointestinal Cancer Surgery", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Esophageal Cancer" ], "start_date": "2005-07", "last_update": "2008-11-13" }, { "nct_id": "NCT00792571", "title": "An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lung Biotechnology PBC", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2009-02-28", "last_update": "2019-12-26" }, { "nct_id": "NCT00795561", "title": "Management of Nausea and Vomiting of Pregnancy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Hyperemesis Gravidarum", "Nausea", "Vomiting", "Pregnancy" ], "start_date": "2009-04", "last_update": "2014-01-15" }, { "nct_id": "NCT00795912", "title": "A Study Of The Usage Of Statins In A Community Heart Failure Population", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Heart Failure" ], "start_date": "2003-05", "last_update": "2008-11-21" }, { "nct_id": "NCT00796445", "title": "A Phase III Study to Test the Benefit of a New Kind of Anti-cancer Treatment in Patients With Melanoma, After Surgical Removal of Their Tumor", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Melanoma" ], "start_date": "2008-12-01", "last_update": "2021-03-05" }, { "nct_id": "NCT00799877", "title": "Chronic Plaque Psoriasis (Ps) Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Chronic Plaque Psoriasis" ], "start_date": "2008-09-26", "last_update": "2024-03-15" }, { "nct_id": "NCT00802711", "title": "3-Dimensional Conformal Radiation Therapy or Internal Radiation Therapy After Breast-Conserving Surgery in Treating Women With Stage I or Stage II Breast Cancer", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2009-10", "last_update": "2026-04-13" }, { "nct_id": "NCT00806819", "title": "Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2008-12", "last_update": "2017-02-02" }, { "nct_id": "NCT00809211", "title": "Nilotinib in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Leukemia" ], "start_date": "2008-10", "last_update": "2018-07-24" }, { "nct_id": "NCT00812669", "title": "CLL-Irl Study. CTRIAL-IE (ICORG) 07-01, V7", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Leukemia" ], "start_date": "2008-08-18", "last_update": "2025-07-08" }, { "nct_id": "NCT00814541", "title": "PAD. ICORG 05-01, V11", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Multiple Myeloma and Plasma Cell Neoplasm" ], "start_date": "2005-12", "last_update": "2014-12-31" }, { "nct_id": "NCT00819520", "title": "Ivermectin in the Treatment of Head Lice", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "conditions": [ "Lice Infestations" ], "start_date": "2004-02", "last_update": "2011-08-22" }, { "nct_id": "NCT00821431", "title": "Compression Device Versus 4-layer Compression System", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ConvaTec Inc.", "conditions": [ "Leg Ulcers" ], "start_date": "2006-05", "last_update": "2015-01-09" }, { "nct_id": "NCT00825929", "title": "Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Radboud University Medical Center", "conditions": [ "HIV Infections" ], "start_date": "2009-02", "last_update": "2025-01-13" }, { "nct_id": "NCT00828854", "title": "Study of the Effect of the Addition of SNDX-275 (Entinostat) to Continued Aromatase Inhibitor (AI) Therapy in Postmenopausal Women With ER+ Breast Cancer Whose Disease is Progressing", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Syndax Pharmaceuticals", "conditions": [ "ER+ Breast Cancer" ], "start_date": "2008-10-01", "last_update": "2022-06-30" }, { "nct_id": "NCT00830102", "title": "Single-dose Crossover Study to Compare the Safety and Efficacy of FlutiForm With Fluticasone and Formoterol Concurrently or Alone in Asthma Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "SkyePharma AG", "conditions": [ "Asthma" ], "start_date": "2004-10", "last_update": "2011-06-23" }, { "nct_id": "NCT00830934", "title": "Trial for the Treatment of Pelvic and Back Pain in Pregnancy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Pelvic Girdle Pain", "Symphysio Pubic Dysfunction" ], "start_date": "2009-04", "last_update": "2009-01-28" }, { "nct_id": "NCT00833612", "title": "Counterpulsation Reduces Infarct Size Pre-PCI for AMI", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Datascope Corp.", "conditions": [ "Acute Myocardial Infarction (AMI)" ], "start_date": "2008-12", "last_update": "2011-06-27" }, { "nct_id": "NCT00835770", "title": "BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (MS)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2009-02-03", "last_update": "2020-12-31" }, { "nct_id": "NCT00842712", "title": "Cilengitide and Cetuximab in Combination With Platinum-based Chemotherapy as First-line Treatment for Subjects With Advanced Non Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck KGaA, Darmstadt, Germany", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2009-02", "last_update": "2017-01-13" }, { "nct_id": "NCT00842829", "title": "Study of Breakthrough Cancer Pain: Assessment of Fentanyl Buccal Tablets Titration and Treatment in Opioid-Tolerant Patients", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Cephalon", "conditions": [ "Cancer Pain", "Breakthrough Pain" ], "start_date": "2009-01", "last_update": "2012-10-01" }, { "nct_id": "NCT00846807", "title": "Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Arthroplasty, Replacement", "Thromboembolism" ], "start_date": "2009-02", "last_update": "2012-09-18" }, { "nct_id": "NCT00853658", "title": "Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Heart Failure" ], "start_date": "2009-03", "last_update": "2016-11-25" }, { "nct_id": "NCT00855322", "title": "Study Examining the Effect of Exercise in People With Rheumatoid Arthritis Taking Anti-TNFalpha Medication", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Arthritis, Rheumatoid" ], "start_date": "2008-01", "last_update": "2009-03-04" }, { "nct_id": "NCT00856661", "title": "Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "H. Lundbeck A/S", "conditions": [ "Stroke" ], "start_date": "2009-04", "last_update": "2017-03-16" }, { "nct_id": "NCT00858364", "title": "Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Amgen", "conditions": [ "Non-Small Cell Lung Cancer", "Anemia", "Cancer", "Lung Cancer" ], "start_date": "2009-07-17", "last_update": "2022-11-30" }, { "nct_id": "NCT00861614", "title": "Study of Immunotherapy to Treat Advanced Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Prostate Cancer" ], "start_date": "2009-05", "last_update": "2016-09-30" }, { "nct_id": "NCT00866697", "title": "Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Ovarian Cancer" ], "start_date": "2009-05-26", "last_update": "2021-02-16" }, { "nct_id": "NCT00867048", "title": "Strategic Timing of Antiretroviral Treatment", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Minnesota", "conditions": [ "HIV Infection" ], "start_date": "2009-04-15", "last_update": "2024-03-04" }, { "nct_id": "NCT00876395", "title": "Everolimus in Combination With Trastuzumab and Paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Cancer" ], "start_date": "2009-09-10", "last_update": "2018-12-19" }, { "nct_id": "NCT00877292", "title": "A New Prenatal Blood Test for Down Syndrome", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Women and Infants Hospital of Rhode Island", "conditions": [ "Down Syndrome", "Trisomy 21" ], "start_date": "2009-02", "last_update": "2015-06-03" }, { "nct_id": "NCT00882778", "title": "PROPACT: Retrospective Prophylaxis Patient Case Collection", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Congenital Bleeding Disorder", "Haemophilia A With Inhibitors", "Haemophilia B With Inhibitors" ], "start_date": "2009-04", "last_update": "2017-01-09" }, { "nct_id": "NCT00883402", "title": "Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Oxford", "conditions": [ "Carotid Stenosis" ], "start_date": "2008-01", "last_update": "2024-12-09" }, { "nct_id": "NCT00887536", "title": "A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "NSABP Foundation Inc", "conditions": [ "Breast Cancer" ], "start_date": "2009-05", "last_update": "2022-04-20" }, { "nct_id": "NCT00887549", "title": "A Study of Thymidylate Synthase Expression in Patients With Non-Small Cell Lung Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2009-04", "last_update": "2012-06-19" }, { "nct_id": "NCT00897871", "title": "Evaluating the Side Effects and How Well Anticancer Drugs Work in Very Young Patients With Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Unspecified Childhood Solid Tumor, Protocol Specific" ], "start_date": "2007-02", "last_update": "2013-08-12" }, { "nct_id": "NCT00900354", "title": "Pharmacokinetics of Dactinomycin in Young Patients With Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Cancer and Leukaemia Group", "conditions": [ "Unspecified Childhood Solid Tumor, Protocol Specific" ], "start_date": "2006-06", "last_update": "2013-08-12" }, { "nct_id": "NCT00905294", "title": "Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "University College Cork", "conditions": [ "Coronary Artery Disease" ], "start_date": "2009-08", "last_update": "2013-06-19" }, { "nct_id": "NCT00909532", "title": "Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2009-06", "last_update": "2013-01-18" }, { "nct_id": "NCT00909727", "title": "Study of Ivacaftor in Cystic Fibrosis Subjects Aged 6 to 11 Years With the G551D Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2009-08", "last_update": "2012-08-21" }, { "nct_id": "NCT00911170", "title": "PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Cancer", "Colon Cancer", "Colorectal Cancer", "Fever", "Locally Advanced", "Metastatic Colorectal Cancer", "Neutropenia", "Rectal Cancer" ], "start_date": "2009-11-03", "last_update": "2017-12-29" }, { "nct_id": "NCT00911716", "title": "TC Avastin. ICORG 08-10, V6", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2008-10", "last_update": "2019-08-01" }, { "nct_id": "NCT00913458", "title": "Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid Arthritis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Active Rheumatoid Arthritis", "Arthritis, Rheumatoid", "Rheumatoid Arthritis" ], "start_date": "2009-09", "last_update": "2014-07-17" }, { "nct_id": "NCT00915655", "title": "A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected Adolescents", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Tibotec Pharmaceuticals, Ireland", "conditions": [ "HIV-1 Infection" ], "start_date": "2009-07", "last_update": "2012-09-03" }, { "nct_id": "NCT00915824", "title": "Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Healthy" ], "start_date": "2007-11", "last_update": "2009-10-29" }, { "nct_id": "NCT00916513", "title": "Quality of Life and Treatment Satisfaction of People With Type 2 Diabetes: A European Survey", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Diabetes" ], "start_date": "2009-05", "last_update": "2010-04-27" }, { "nct_id": "NCT00921154", "title": "Ivermectin Solution Bioequivalence Study - Fasted", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "conditions": [ "Healthy" ], "start_date": "2005-03", "last_update": "2011-10-06" }, { "nct_id": "NCT00921544", "title": "Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Retinopathy of Prematurity" ], "start_date": "2008-08", "last_update": "2009-06-16" }, { "nct_id": "NCT00921830", "title": "Pharmacokinetics of 3 Formulations of Ibuprofen Suppositories", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide", "conditions": [ "Healthy" ], "start_date": "2004-04", "last_update": "2011-10-06" }, { "nct_id": "NCT00921960", "title": "St. Vincent's Screening To Prevent Heart Failure Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Left Ventricular Dysfunction", "Myocardial Infarction", "Hypertension", "Diabetes", "Obesity" ], "start_date": "2005-01", "last_update": "2018-07-27" }, { "nct_id": "NCT00924443", "title": "A Study of Clofarabine in Older Patients With Acute Myeloid Leukemia (AML) for Whom Chemotherapy Is Not Suitable", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Genzyme, a Sanofi Company", "conditions": [ "Acute Myeloid Leukemia" ], "start_date": "2004-06", "last_update": "2015-04-01" }, { "nct_id": "NCT00927875", "title": "A Study of BMS-833923 With Carboplatin and Etoposide Followed by BMS-833923 Alone in Subjects With Extensive-Stage Small Cell Lung Cancer", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Small Cell Lung Carcinoma" ], "start_date": "2010-02", "last_update": "2013-06-03" }, { "nct_id": "NCT00931463", "title": "A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Kirby Institute", "conditions": [ "HIV Infections" ], "start_date": "2009-09", "last_update": "2026-03-27" }, { "nct_id": "NCT00931827", "title": "Acceptability of Long-term Progestin-only Contraception in Europe", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Contraception" ], "start_date": "2008-01", "last_update": "2013-12-24" }, { "nct_id": "NCT00932451", "title": "An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2010-01", "last_update": "2017-01-13" }, { "nct_id": "NCT00932893", "title": "An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2009-09", "last_update": "2017-01-02" }, { "nct_id": "NCT00941707", "title": "An Efficacy and Safety Study of JNJ-38518168 in Adult Participants With Rheumatoid Arthritis", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2010-02", "last_update": "2013-04-23" }, { "nct_id": "NCT00942162", "title": "A Study to Test the Benefit of a New Anti-cancer Treatment in Patients With Unresectable Advanced Melanoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Melanoma" ], "start_date": "2009-08-14", "last_update": "2020-12-08" }, { "nct_id": "NCT00949286", "title": "Action in Diabetes and Vascular Disease Preterax and Diamicron MR Controlled Evaluation Post Trial Observational Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "The George Institute", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2010-01", "last_update": "2014-05-19" }, { "nct_id": "NCT00949338", "title": "Comparing Two Sets of Bladder-Filling Instructions in Treating Patients Undergoing Radiation Therapy For Prostate Cancer. ICORG 05-04", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "2006-03", "last_update": "2014-12-31" }, { "nct_id": "NCT00949650", "title": "BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Carcinoma, Non-Small-Cell Lung", "Adenocarcinoma" ], "start_date": "2009-08-14", "last_update": "2018-04-06" }, { "nct_id": "NCT00949910", "title": "An Expanded Access Program of Tarceva (Erlotinib) in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2004-11", "last_update": "2016-10-05" }, { "nct_id": "NCT00951535", "title": "A Prospective Phase II Dose Escalation Study Using IMRT for High Risk N0 M0 Prostate Cancer. ICORG 08-17", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "2009-07-20", "last_update": "2026-04-17" }, { "nct_id": "NCT00955175", "title": "Hypofractionated 3-Dimensional Radiation Therapy in Treating Patients With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer. ICORG 99-09", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Lung Cancer" ], "start_date": "2000-11", "last_update": "2016-02-17" }, { "nct_id": "NCT00955435", "title": "Study of Blood and Urine Samples in Patients With Newly Diagnosed Localized Prostate Cancer Treated With Hormone Therapy and Radiation Therapy. ICORG 06-15", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "2006-02", "last_update": "2021-02-18" }, { "nct_id": "NCT00958321", "title": "Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery. ICORG 06-35", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Lung Cancer", "Metastatic Cancer" ], "start_date": "2007-03", "last_update": "2017-05-24" }, { "nct_id": "NCT00959855", "title": "Long-term Impact of Pulmonary Rehabilitation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2009-09", "last_update": "2019-07-23" }, { "nct_id": "NCT00960128", "title": "Observational Prospective Study on Patients Treated With Norditropin®", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Growth Hormone Disorder", "Growth Hormone Deficiency in Children", "Adult Growth Hormone Deficiency", "Genetic Disorder", "Turner Syndrome", "Foetal Growth Problem", "Small for Gestational Age", "Chronic Kidney Disease", "Chronic Renal Insufficiency", "Noonan Syndrome" ], "start_date": "2006-04-01", "last_update": "2017-10-12" }, { "nct_id": "NCT00960440", "title": "Study of CP-690,550 Versus Placebo In Rheumatoid Arthritis Patients On Background Methotrexate With Inadequate Response To Tumor Necrosis Factor (TNF) Inhibitors", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Arthritis, Rheumatoid" ], "start_date": "2009-10", "last_update": "2018-12-19" }, { "nct_id": "NCT00962312", "title": "Lapatinib Ditosylate and Capecitabine in Treating Patients With Metastatic Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pancreatic Cancer" ], "start_date": "2009-01", "last_update": "2014-12-31" }, { "nct_id": "NCT00968643", "title": "Spinal Cord Compression. ICORG 05-03, V6", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Spinal Cord Compression", "Unspecified Adult Solid Tumor, Protocol Specific" ], "start_date": "2006-01", "last_update": "2014-12-31" }, { "nct_id": "NCT00968682", "title": "CADY Study ICORG 08-01", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer", "Cardiac Toxicity" ], "start_date": "2008-04", "last_update": "2014-12-31" }, { "nct_id": "NCT00971217", "title": "Exploring the Effectiveness of the 'Back of the Net' Intervention on Indices of Physical and Psychological Measures", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dublin City University", "conditions": [ "Self Concept", "Body Fat Composition", "Depression", "Perceived Social Support" ], "start_date": "2010-08", "last_update": "2011-08-01" }, { "nct_id": "NCT00972283", "title": "Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2009-09-01", "last_update": "2017-04-06" }, { "nct_id": "NCT00973947", "title": "Customized Headrest or Standard Headrest in Holding Patients Still While Undergoing Radiation Therapy for Head and Neck Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Head and Neck Cancer" ], "start_date": "2008-01", "last_update": "2014-12-31" }, { "nct_id": "NCT00974168", "title": "Spinal Cord Compression Re-Treat Study", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pain", "Radiation Toxicity", "Spinal Cord Compression", "Unspecified Adult Solid Tumor, Protocol Specific" ], "start_date": "2007-10", "last_update": "2019-07-29" }, { "nct_id": "NCT00974610", "title": "Study of Blood Samples From Patients With Malignant Melanoma, Metastatic Breast Cancer, Advanced Lung Cancer, Pancreatic Cancer, or Colorectal Cancer.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer", "Colorectal Cancer", "Lung Cancer", "Melanoma (Skin)", "Pancreatic Cancer" ], "start_date": "2008-08", "last_update": "2017-05-24" }, { "nct_id": "NCT00974883", "title": "Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Oxford", "conditions": [ "Giant Cell Arteritis" ], "start_date": "2010-06", "last_update": "2015-07-17" }, { "nct_id": "NCT00975793", "title": "Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Belinda Howe", "conditions": [ "Severe Sepsis" ], "start_date": "2008-10", "last_update": "2014-04-24" }, { "nct_id": "NCT00979745", "title": "Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Clinuvel Pharmaceuticals Limited", "conditions": [ "Erythropoietic Protoporphyria" ], "start_date": "2009-09", "last_update": "2021-10-12" }, { "nct_id": "NCT00981773", "title": "The St. Marys and The Mater Switch Study", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Imperial College London", "conditions": [ "HIV Infections" ], "start_date": "2009-09", "last_update": "2019-09-12" }, { "nct_id": "NCT00982488", "title": "Long-term Safety of Dasatinib in Patients With Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Leukemia" ], "start_date": "2007-10", "last_update": "2016-01-22" }, { "nct_id": "NCT00987454", "title": "Erythropoietin in Traumatic Brain Injury (EPO-TBI)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Traumatic Brain Injury" ], "start_date": "2010-05", "last_update": "2016-07-26" }, { "nct_id": "NCT00989963", "title": "Dose-response Study of the Safety and Efficacy of Beraprost Sodium Modified Release (BPS-MR) in Patients With Pulmonary Arterial Hypertension (PAH)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lung Biotechnology PBC", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2010-02-01", "last_update": "2020-09-30" }, { "nct_id": "NCT00990314", "title": "Extension of BPS-MR-PAH-203 in Pulmonary Arterial Hypertension (PAH) Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lung Biotechnology PBC", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2009-11-30", "last_update": "2019-09-16" }, { "nct_id": "NCT00996177", "title": "A Study to Compare Patient-controlled Pain Medications Delivered Either Through the Skin or Intravenously", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen-Cilag International NV", "conditions": [ "Pain", "Analgesia, Patient-Controlled", "Pain, Postoperative" ], "start_date": "2004-06", "last_update": "2014-01-29" }, { "nct_id": "NCT00996398", "title": "Cold Water Immersion Does Not Reduce Knee Joint Position Sense in Healthy Participants: a Randomised Cross-over Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Knee Joint Position Sense" ], "start_date": "2009-05", "last_update": "2009-10-16" }, { "nct_id": "NCT01002248", "title": "Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "AEterna Zentaris", "conditions": [ "Multiple Myeloma" ], "start_date": "2009-12", "last_update": "2018-02-09" }, { "nct_id": "NCT01003184", "title": "Efficacy of Once-Weekly Exenatide Versus Once or Twice Daily Insulin Detemir in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes Mellitus" ], "start_date": "2009-10", "last_update": "2015-04-07" }, { "nct_id": "NCT01007435", "title": "A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2009-10-31", "last_update": "2017-07-26" }, { "nct_id": "NCT01007487", "title": "Plastic Wound Retractors and Bacterial Translocation in Abdominal Surgery", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Bacterial Translocation", "Surgical Site Infection", "Abdominal Surgery", "Wound Infection" ], "start_date": "2008-01", "last_update": "2011-07-20" }, { "nct_id": "NCT01011205", "title": "Phase 3b Study to Evaluate Advagraf in Combination With Mycophenolate Mofetil and Basiliximab in Liver Transplantation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Liver Transplantation" ], "start_date": "2009-09-30", "last_update": "2024-11-01" }, { "nct_id": "NCT01011738", "title": "An Observational Cohort Study in Patients With Chronic Hepatitis B Receiving Pegasys", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hepatitis B, Chronic" ], "start_date": "2009-04-11", "last_update": "2017-04-10" }, { "nct_id": "NCT01011868", "title": "Efficacy and Safety of BI 10773 in Combination With Insulin in Patients With Type 2 Diabetes", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2009-11", "last_update": "2014-09-30" }, { "nct_id": "NCT01014208", "title": "Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy Followed by Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B Cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Lymphoma, Large-Cell, Diffuse" ], "start_date": "2010-03", "last_update": "2015-08-07" }, { "nct_id": "NCT01018953", "title": "Study to Assess the Efficacy and Safety of Different Doses of BIM 23A760 in Patients With Carcinoid Syndrome", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Ipsen", "conditions": [ "Carcinoid Syndrome" ], "start_date": "2010-02", "last_update": "2020-11-20" }, { "nct_id": "NCT01019239", "title": "LapLAND Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Diverticulitis" ], "start_date": "2010-01", "last_update": "2009-12-01" }, { "nct_id": "NCT01027949", "title": "An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "United Therapeutics", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2007-01-16", "last_update": "2021-05-10" }, { "nct_id": "NCT01030380", "title": "Determination of the Efficacy of Slendertone® Face to Tone the Muscles of the Face and Reduce the Signs of Facial Aging", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bio-Medical Research, Ltd.", "conditions": [ "Facial Muscle Toning" ], "start_date": "2009-02", "last_update": "2009-12-11" }, { "nct_id": "NCT01030432", "title": "Study of BMS-650032 With Peginterferon Alfa-2a Plus Ribavirin", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hepatitis C Virus" ], "start_date": "2010-02", "last_update": "2015-10-09" }, { "nct_id": "NCT01030887", "title": "PEACH Trial: Prescribed Exercise After Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer" ], "start_date": "2010-01", "last_update": "2011-08-15" }, { "nct_id": "NCT01031940", "title": "CMAC® Versus Airtraq® and Macintosh Laryngoscope in Difficult Tracheal Intubation.", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Airway", "Difficult Intubation", "Airway Device" ], "start_date": "2010-01", "last_update": "2012-06-19" }, { "nct_id": "NCT01032460", "title": "Comparison of Two Novel Indirect Laryngoscopes to the Macintosh Laryngoscope in Patients With Cervical Spine Immobilization.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Immobilization" ], "start_date": "2010-01", "last_update": "2010-11-09" }, { "nct_id": "NCT01033305", "title": "Oral Ciclosporin for Colonic Release in Ulcerative Colitis (CyCol™)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Sigmoid Pharma", "conditions": [ "Mild to Moderate Ulcerative Colitis" ], "start_date": "2010-03", "last_update": "2012-04-19" }, { "nct_id": "NCT01034969", "title": "Firazyr® Patient Registry (Icatibant Outcome Survey - IOS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Hereditary Angioedema (HAE)" ], "start_date": "2009-07-10", "last_update": "2024-10-28" }, { "nct_id": "NCT01037868", "title": "Usefulness of Supportive Text Messages in the Treatment of Depressed Alcoholics", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Depression", "Alcohol Use Disorder" ], "start_date": "2009-09", "last_update": "2013-03-28" }, { "nct_id": "NCT01038804", "title": "A Study of YM155 Plus Docetaxel as First-Line Treatment in Subjects With HER2 Negative Metastatic Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Breast Cancer" ], "start_date": "2009-12", "last_update": "2013-09-18" }, { "nct_id": "NCT01042769", "title": "A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Diabetes Mellitus Type 2" ], "start_date": "2010-02", "last_update": "2016-11-02" }, { "nct_id": "NCT01045603", "title": "Instanyl® Non-Interventional Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Takeda", "conditions": [ "Breakthrough Cancer Pain" ], "start_date": "2009-12", "last_update": "2012-10-29" }, { "nct_id": "NCT01054339", "title": "Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Beacon Therapeutics", "conditions": [ "Alpha-1 Antitrypsin Deficiency" ], "start_date": "2010-06", "last_update": "2019-03-28" }, { "nct_id": "NCT01056120", "title": "Long Term Safety Profile of the PRO-Kinetic ENERGY Coronary Stent System in Daily Clinical Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biotronik AG", "conditions": [ "De Novo and Re-stenosed Coronary Artery Lesions" ], "start_date": "2010-03", "last_update": "2016-02-01" }, { "nct_id": "NCT01057537", "title": "UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Imperial College London", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2010-06", "last_update": "2012-11-27" }, { "nct_id": "NCT01058174", "title": "Liver Transplant European Study Into the Prevention of Fungal Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Liver Transplantation", "Mycoses" ], "start_date": "2009-12-15", "last_update": "2024-11-18" }, { "nct_id": "NCT01064037", "title": "A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF)", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Heart Failure", "Heart Decompensation" ], "start_date": "2010-04", "last_update": "2015-10-08" }, { "nct_id": "NCT01064401", "title": "Efficacy and Safety of BIIB019 (Daclizumab High Yield Process) Versus Interferon β 1a in Participants With Relapsing-Remitting Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2010-05", "last_update": "2016-07-11" }, { "nct_id": "NCT01066208", "title": "American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Oxford", "conditions": [ "Wegener's Granulomatosis", "Microscopic Polyangiitis", "Churg Strauss Syndrome", "Polyarteritis Nodosa", "Giant Cell Arteritis", "Takayasu Arteritis" ], "start_date": "2011-01", "last_update": "2016-08-19" }, { "nct_id": "NCT01066793", "title": "PROPHESYS 2: An Observational Study on Predictors of Response in Treatment-naïve Patients With Chronic Hepatitis C Treated With Pegasys (Peginterferon Alfa-2a) or Peginterferon-alfa-2b", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hepatitis C, Chronic" ], "start_date": "2007-10", "last_update": "2016-05-09" }, { "nct_id": "NCT01066962", "title": "Study of Darunavir/r + Tenofovir/Emtricitabine vs. Darunavir/r + Raltegravir in HIV-infected Antiretroviral naïve Subjects", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ANRS, Emerging Infectious Diseases", "conditions": [ "HIV Infections" ], "start_date": "2010-08", "last_update": "2013-11-06" }, { "nct_id": "NCT01067859", "title": "A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Acute Heart Failure" ], "start_date": "2010-03", "last_update": "2015-10-08" }, { "nct_id": "NCT01068665", "title": "Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2010-03", "last_update": "2017-03-06" }, { "nct_id": "NCT01070771", "title": "Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital Southampton NHS Foundation Trust", "conditions": [ "Coronary Artery Disease" ], "start_date": "2008-06", "last_update": "2019-05-22" }, { "nct_id": "NCT01077154", "title": "Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Amgen", "conditions": [ "Breast Cancer" ], "start_date": "2010-06-02", "last_update": "2021-09-28" }, { "nct_id": "NCT01078597", "title": "A Study on the Prevalence of the Modified Citrullinated Vimentin Anti-body (Anti-MCV) in an Irish Rheumatoid Arthritis (RA) Population and to Assess the Impact of Anti-MCV and the Anti-cyclic-citrullinated Peptide Antibody (Anti-CCP) Status on the Management of Irish Patients With Early RA", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie (prior sponsor, Abbott)", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2010-09", "last_update": "2013-08-20" }, { "nct_id": "NCT01082770", "title": "Randomised Controlled Trial of Needle Free Access Devices in Preventing Hemodialysis Blood Stream Infection", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Hemodialysis Catheter Blood Stream Infection", "Central Line Infection", "Dialysis Line Thrombosis" ], "start_date": "2010-03", "last_update": "2010-03-09" }, { "nct_id": "NCT01087788", "title": "Certolizumab Pegol in Subjects With Adult Onset Active and Progressive Psoriatic Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB BIOSCIENCES GmbH", "conditions": [ "Arthritis, Psoriatic" ], "start_date": "2010-03", "last_update": "2018-08-01" }, { "nct_id": "NCT01098266", "title": "NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AGC Biologics S.p.A.", "conditions": [ "Malignant Pleural Mesothelioma" ], "start_date": "2010-04-12", "last_update": "2019-09-17" }, { "nct_id": "NCT01101425", "title": "Male Breast Cancer: Understanding the Biology for Improved Patient Care", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Breast Cancer" ], "start_date": "2010-12", "last_update": "2026-05-12" }, { "nct_id": "NCT01102426", "title": "Aplidin - Dexamethasone in Relapsed/Refractory Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "PharmaMar", "conditions": [ "Relapsed/Refractory Multiple Myeloma" ], "start_date": "2010-06", "last_update": "2020-11-10" }, { "nct_id": "NCT01102712", "title": "Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Uptake Medical Corp", "conditions": [ "Emphysema", "Chronic Obstructive Pulmonary Disease" ], "start_date": "2009-11", "last_update": "2012-02-23" }, { "nct_id": "NCT01105611", "title": "Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "HIV Infections", "Hepatitis C" ], "start_date": "2010-08", "last_update": "2011-07-21" }, { "nct_id": "NCT01106001", "title": "Study to Test the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Orthopaedic Research and Innovation Foundation, Ireland", "conditions": [ "Osteoarthritis" ], "start_date": "2008-09", "last_update": "2010-04-19" }, { "nct_id": "NCT01106014", "title": "Selexipag (ACT-293987) in Pulmonary Arterial Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Actelion", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2009-12-01", "last_update": "2025-10-27" }, { "nct_id": "NCT01107912", "title": "Comparison of Prasugrel and Clopidogrel in Very Elderly and Non-Elderly Patients With Stable Coronary Artery Disease", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Coronary Artery Disease" ], "start_date": "2010-03", "last_update": "2012-10-26" }, { "nct_id": "NCT01107925", "title": "Comparison of Prasugrel and Clopidogrel in Low Body Weight Versus Higher Body Weight With Coronary Artery Disease", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Coronary Artery Disease" ], "start_date": "2010-03", "last_update": "2012-08-30" }, { "nct_id": "NCT01112306", "title": "ACT-293987 in Pulmonary Arterial Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Actelion", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2010-07-07", "last_update": "2025-03-30" }, { "nct_id": "NCT01112462", "title": "To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "McNeil AB", "conditions": [ "Respiratory Tract Infections" ], "start_date": "2010-03", "last_update": "2012-07-10" }, { "nct_id": "NCT01112943", "title": "Acupuncture Combined With Pulmonary Rehabilitation: Are There Additional Benefits?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2007-07", "last_update": "2012-08-14" }, { "nct_id": "NCT01113060", "title": "Aspirin Effectiveness Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Coronary Artery Disease" ], "start_date": "2010-04", "last_update": "2016-12-19" }, { "nct_id": "NCT01117012", "title": "Rollover Study of VX-770 in Cystic Fibrosis Subjects", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2010-07", "last_update": "2015-07-07" }, { "nct_id": "NCT01117350", "title": "Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2010-07", "last_update": "2014-04-11" }, { "nct_id": "NCT01120691", "title": "Effect of QVA149 Versus NVA237 and Tiotropium on Chronic Obstructive Pulmonary Disorder (COPD) Exacerbations", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2010-04", "last_update": "2013-12-02" }, { "nct_id": "NCT01122459", "title": "Evaluation of the Effect of Two Types of Fluid in the Recovery From Anaesthesia. Voluven 6% v Hartmanns", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Postoperative Nausea and Vomiting" ], "start_date": "2010-01", "last_update": "2011-07-21" }, { "nct_id": "NCT01124149", "title": "Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Ulcerative Colitis" ], "start_date": "2010-06-29", "last_update": "2021-06-09" }, { "nct_id": "NCT01125566", "title": "LUX-Breast 1: BIBW 2992 (Afatinib) in HER2-positive Metastatic Breast Cancer Patients After One Prior Herceptin Treatment", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Breast Neoplasms" ], "start_date": "2010-06-22", "last_update": "2019-07-18" }, { "nct_id": "NCT01126437", "title": "Comparison of Tiotropium in the HandiHaler Versus the Respimat in Chronic Obstructive Pulmonary Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2010-05", "last_update": "2014-06-20" }, { "nct_id": "NCT01127750", "title": "Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis", "conditions": [ "Relapsing Multiple Sclerosis" ], "start_date": "2010-05", "last_update": "2017-02-23" }, { "nct_id": "NCT01142427", "title": "Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Children's Oncology Group", "conditions": [ "Acute Lymphoblastic Leukemia" ], "start_date": "2010-08-09", "last_update": "2023-10-03" }, { "nct_id": "NCT01145859", "title": "Rivaroxaban Pharmacokinetics/Pharmacodynamics (PK/PD) Study in Pediatric Subjects", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Venous Thrombosis", "Pediatrics" ], "start_date": "2010-11", "last_update": "2015-08-06" }, { "nct_id": "NCT01147809", "title": "Safety and Efficacy Study for Solid Tumor Patients Treated With Eltrombopag", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Thrombocytopaenia" ], "start_date": "2010-06", "last_update": "2016-04-18" }, { "nct_id": "NCT01147939", "title": "Study of Elacytarabine Versus Investigator's Choice in Patients With Late Stage Acute Myeloid Leukaemia (AML)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Clavis Pharma", "conditions": [ "Acute Myeloid Leukemia (AML)" ], "start_date": "2010-06", "last_update": "2013-09-27" }, { "nct_id": "NCT01148329", "title": "PROMUS™ Element™ Everolimus-Eluting Coronary Stent System European Post-Approval Surveillance Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Coronary Heart Disease" ], "start_date": "2010-06", "last_update": "2017-02-02" }, { "nct_id": "NCT01150097", "title": "Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant Recipients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Liver Transplant Recipient" ], "start_date": "2010-03-31", "last_update": "2018-11-07" }, { "nct_id": "NCT01154140", "title": "A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Non Squamous Lung Cancer" ], "start_date": "2011-01-13", "last_update": "2017-11-06" }, { "nct_id": "NCT01158287", "title": "Sorafenib. ICORG 06-41, V4", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Esophageal Cancer", "Gastric Cancer" ], "start_date": "2009-02", "last_update": "2014-12-31" }, { "nct_id": "NCT01160705", "title": "Biomarkers of Response to Taxotere in HRPC. ICORG 08-08, V2", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Metastatic Cancer", "Prostate Cancer" ], "start_date": "2009-11", "last_update": "2020-11-17" }, { "nct_id": "NCT01164150", "title": "Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer. ICORG 09-06", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Endometrial Cancer", "Gastrointestinal Complications", "Radiation Toxicity", "Urinary Complications" ], "start_date": "2010-03", "last_update": "2026-04-13" }, { "nct_id": "NCT01169337", "title": "Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Light Chain Deposition Disease", "Smoldering Multiple Myeloma" ], "start_date": "2011-01-24", "last_update": "2026-10-01" }, { "nct_id": "NCT01169389", "title": "Analgesic Control Following Knee Arthroscopy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Orthopaedic Research and Innovation Foundation, Ireland", "conditions": [ "Knee", "Arthroscopy", "Analgesia" ], "start_date": "2009-01", "last_update": "2010-07-30" }, { "nct_id": "NCT01170065", "title": "Roll Over Study From 1199.30 BIBF 1120 in Idiopathic Pulmonary Fibrosis (IPF)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Fibrosis" ], "start_date": "2010-06-25", "last_update": "2019-06-06" }, { "nct_id": "NCT01171976", "title": "Efficacy and Safety of Ranibizumab in Two \"Treat and Extend\" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Diabetic Macular Edema" ], "start_date": "2010-09", "last_update": "2014-09-15" }, { "nct_id": "NCT01172860", "title": "Endoscopic Treatment of Inoperable Colorectal Cancer With the EndoVe System", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Mercy University Hospital, Cork, Ireland", "conditions": [ "Colorectal Cancer" ], "start_date": "2010-03", "last_update": "2017-11-09" }, { "nct_id": "NCT01172951", "title": "Nutrigenomics Investigation of the Body's Metabolic Response to 2 Different Meal Challenges", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Healthy Subjects" ], "start_date": "2008-12", "last_update": "2011-01-11" }, { "nct_id": "NCT01176487", "title": "Palliative 3-Dimensional Conformal Radiation Therapy in Reducing Radiation Side Effects in Patients With Lung Cancer. ICORG 06-34", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Lung Cancer" ], "start_date": "2010-06", "last_update": "2016-03-31" }, { "nct_id": "NCT01177813", "title": "Efficacy and Safety of Empagliflozin (BI 10773) Versus Placebo and Sitagliptin Over 24 Weeks in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2010-07", "last_update": "2014-06-16" }, { "nct_id": "NCT01179048", "title": "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2010-08-31", "last_update": "2019-07-17" }, { "nct_id": "NCT01179347", "title": "Tiotropium Bromide in Cystic Fibrosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Cystic Fibrosis" ], "start_date": "2010-09", "last_update": "2013-12-24" }, { "nct_id": "NCT01189669", "title": "n-3 Polyunsaturated Fatty Acids (PUFA) Supplementation in Young Women With Polycystic Ovary Syndrome (PCOS)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Adelaide and Meath Hospital", "conditions": [ "Polycystic Ovary Syndrome" ], "start_date": "2007-09", "last_update": "2010-09-13" }, { "nct_id": "NCT01190930", "title": "Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Oncology Group", "conditions": [ "Acute Lymphoblastic Leukemia", "Adult B Lymphoblastic Lymphoma", "Ann Arbor Stage I B Lymphoblastic Lymphoma", "Ann Arbor Stage II B Lymphoblastic Lymphoma", "Childhood B Acute Lymphoblastic Leukemia", "Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1", "Childhood B Lymphoblastic Lymphoma", "Down Syndrome", "Hypodiploid B Acute Lymphoblastic Leukemia", "Philadelphia Chromosome Positive" ], "start_date": "2010-08-11", "last_update": "2026-05-28" }, { "nct_id": "NCT01193244", "title": "Study Comparing Orteronel Plus Prednisone in Participants With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Millennium Pharmaceuticals, Inc.", "conditions": [ "Prostate Cancer" ], "start_date": "2010-10-01", "last_update": "2017-05-17" }, { "nct_id": "NCT01195142", "title": "Adipose Tissue Gene Expression Profiles in Women With Polycystic Ovary Syndrome (PCOS) Versus Controls", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "The Adelaide and Meath Hospital", "conditions": [ "Polycystic Ovary Syndrome" ], "start_date": "2007-12", "last_update": "2010-09-06" }, { "nct_id": "NCT01195155", "title": "Transcriptomic Profile of Adipose Tissue Following n-3 Polyunsaturated Fatty Acid (PUFA) Supplementation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Adelaide and Meath Hospital", "conditions": [ "Polycystic Ovary Syndrome" ], "start_date": "2007-12", "last_update": "2010-09-06" }, { "nct_id": "NCT01195168", "title": "Cardiovascular Risk Markers in Polycystic Ovary Syndrome (PCOS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "The Adelaide and Meath Hospital", "conditions": [ "Polycystic Ovary Syndrome" ], "start_date": "2006-11", "last_update": "2010-09-06" }, { "nct_id": "NCT01195662", "title": "A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Type 2 Diabetes" ], "start_date": "2010-10", "last_update": "2016-12-29" }, { "nct_id": "NCT01196195", "title": "KONCERT A Kaletra ONCE Daily Randomised Trial of the Pharmacokinetics, Safety and Efficacy of Twice-daily Versus Once-daily Lopinavir/Ritonavir Tablets Dosed by Weight as Part of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-1 (HIV-1) Infected Children (PENTA 18)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "PENTA Foundation", "conditions": [ "Antiretroviral Therapy in HIV-1 Infected Children" ], "start_date": "2010-08", "last_update": "2013-10-28" }, { "nct_id": "NCT01201356", "title": "Long-term Safety and Tolerability of 0.5 mg Fingolimod in Patients With Relapsing Forms of Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Relapsing Forms of Multiple Sclerosis" ], "start_date": "2010-09-13", "last_update": "2021-04-21" }, { "nct_id": "NCT01203605", "title": "European Surgical Outcomes Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Queen Mary University of London", "conditions": [ "Non-cardiac Surgery" ], "start_date": "2011-04", "last_update": "2012-09-05" }, { "nct_id": "NCT01212445", "title": "Dose-Finding Trial of Polyethylene Glycol 3350 Laxative Plus Electrolytes for the Treatment of Constipation (Protocol P07515)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Constipation" ], "start_date": "2010-10", "last_update": "2016-03-15" }, { "nct_id": "NCT01217671", "title": "International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Kamada, Ltd.", "conditions": [ "Emphysema" ], "start_date": "2009-12", "last_update": "2019-11-29" }, { "nct_id": "NCT01218373", "title": "The Clinical Evaluation of Continuous Assistance Offered to Older People Living Independently.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Him SA", "conditions": [ "Frailty" ], "start_date": "2010-12-01", "last_update": "2017-01-25" }, { "nct_id": "NCT01220141", "title": "Observational Study on Safety of Room Temperature Stable NovoSeven® in Patients With Haemophilia A or B", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Congenital Bleeding Disorder", "Haemophilia A", "Haemophilia B" ], "start_date": "2010-11", "last_update": "2015-04-16" }, { "nct_id": "NCT01227889", "title": "A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Cancer" ], "start_date": "2010-12-23", "last_update": "2017-10-04" }, { "nct_id": "NCT01232556", "title": "A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Lymphoma, Non-Hodgkin" ], "start_date": "2011-04-04", "last_update": "2019-01-08" }, { "nct_id": "NCT01234337", "title": "Phase III Trial Comparing Capecitabine in Combination With Sorafenib or Placebo in the Treatment of Locally Advanced or Metastatic HER2-Negative Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Breast Cancer" ], "start_date": "2011-02-21", "last_update": "2018-11-06" }, { "nct_id": "NCT01234350", "title": "A Safety Study in Patients With Advanced Prostate Cancer Treated With FIRMAGON", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Ferring Pharmaceuticals", "conditions": [ "Prostate Cancer" ], "start_date": "2011-01", "last_update": "2019-06-25" }, { "nct_id": "NCT01235325", "title": "The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Supplementation", "Bone Health", "Crohn's Disease" ], "start_date": "2008-07", "last_update": "2010-11-09" }, { "nct_id": "NCT01235962", "title": "A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Renal Cell Carcinoma (RCC)", "Cancer" ], "start_date": "2010-11-30", "last_update": "2020-11-23" }, { "nct_id": "NCT01239732", "title": "A Study of the Addition of Avastin (Bevacizumab) to Carboplatin and Paclitaxel Therapy in Patients With Ovarian Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Ovarian Cancer" ], "start_date": "2010-12", "last_update": "2016-06-10" }, { "nct_id": "NCT01239797", "title": "Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Relapsed or Refractory Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Lymphoma", "Multiple Myeloma" ], "start_date": "2011-06-20", "last_update": "2022-06-01" }, { "nct_id": "NCT01241760", "title": "VX-950-C211 - A Dosing Regimen Study (Twice Daily Versus Every 8 Hours) of Telaprevir in Treatment-naïve Participants With Genotype 1 Chronic Hepatitis C Virus Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Infectious Diseases BVBA", "conditions": [ "Genotype 1 Chronic Hepatitis C", "Treatment Naive" ], "start_date": "2010-12", "last_update": "2014-06-04" }, { "nct_id": "NCT01242696", "title": "TAXUS® Element™ Paclitaxel-Eluting Coronary Stent System European Post-Approval Surveillance Study (TE-Prove)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Coronary Heart Disease" ], "start_date": "2010-11", "last_update": "2017-02-03" }, { "nct_id": "NCT01242813", "title": "Efficacy and Safety Study of ACZ885 in Patients With Active Recurrent or Chronic TNF-receptor Associated Periodic Syndrome (TRAPS).", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "TNF-receptor Associated Periodic Syndromes (TRAPS)" ], "start_date": "2010-10", "last_update": "2016-02-04" }, { "nct_id": "NCT01243424", "title": "CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2010-11-11", "last_update": "2020-01-07" }, { "nct_id": "NCT01244386", "title": "Low-dose CT Using Iterative Reconstruction in Patients With Inflammatory Bowel Disease", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Inflammatory Bowel Disease", "Crohn's Disease", "Ulcerative Colitis" ], "start_date": "2010-06", "last_update": "2010-11-19" }, { "nct_id": "NCT01244490", "title": "Efficacy and Safety of Extended-release Guanfacine Hydrochloride in Children and Adolescents Aged 6-17 Years With Attention-Deficit/Hyperactivity Disorder (ADHD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Attention Deficit Hyperactivity Disorder" ], "start_date": "2011-01-17", "last_update": "2021-07-02" }, { "nct_id": "NCT01246635", "title": "Smith & Nephew's European Trufit Study", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Smith & Nephew, Inc.", "conditions": [ "Defect of Articular Cartilage" ], "start_date": "2008-04-15", "last_update": "2021-04-01" }, { "nct_id": "NCT01246882", "title": "Stroke Inpatient Rehabilitation Reinforcement of ACTivity", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of California, Los Angeles", "conditions": [ "Stroke" ], "start_date": "2011-01", "last_update": "2019-05-01" }, { "nct_id": "NCT01251861", "title": "Bicalutamide With or Without Akt Inhibitor MK2206 in Treating Patients With Previously Treated Prostate Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Recurrent Prostate Carcinoma", "Stage I Prostate Cancer AJCC v7", "Stage IIA Prostate Cancer AJCC v7", "Stage IIB Prostate Cancer AJCC v7", "Stage III Prostate Cancer AJCC v7" ], "start_date": "2011-03-17", "last_update": "2026-06-25" }, { "nct_id": "NCT01252160", "title": "Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "Neuralgia, Postherpetic" ], "start_date": "2010-10-28", "last_update": "2018-04-19" }, { "nct_id": "NCT01254279", "title": "Early Access to Cabazitaxel in Patients With Metastatic Hormone Refractory Prostate Cancer Previously Treated With a Docetaxel-containing Regimen", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Prostate Cancer Metastatic" ], "start_date": "2010-12", "last_update": "2015-01-21" }, { "nct_id": "NCT01259297", "title": "A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Cardiovascular Events" ], "start_date": "2011-01", "last_update": "2014-04-08" }, { "nct_id": "NCT01260831", "title": "Evaluating Processes of Care & the Outcomes of Children in Hospital (EPOCH)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "The Hospital for Sick Children", "conditions": [ "Critically Ill Children" ], "start_date": "2011-01", "last_update": "2017-06-21" }, { "nct_id": "NCT01261273", "title": "e-NOBORI Observational Registry of Nobori DES", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Terumo Europe N.V.", "conditions": [ "Coronary Artery Disease" ], "start_date": "2010-08-25", "last_update": "2019-10-09" }, { "nct_id": "NCT01270347", "title": "Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Cystic Fibrosis" ], "start_date": "2011-01", "last_update": "2024-12-13" }, { "nct_id": "NCT01271530", "title": "Arm Cycling to Improve Fitness in Polio Survivors", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Postpoliomyelitis Syndrome" ], "start_date": "2010-07", "last_update": "2013-09-19" }, { "nct_id": "NCT01272037", "title": "Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Breast Ductal Carcinoma In Situ", "Invasive Breast Carcinoma", "Multicentric Breast Carcinoma", "Multifocal Breast Carcinoma", "Synchronous Bilateral Breast Carcinoma" ], "start_date": "2011-02-28", "last_update": "2026-10-01" }, { "nct_id": "NCT01272219", "title": "Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Metabolism and Nutrition Disorder", "Obesity" ], "start_date": "2011-06-01", "last_update": "2018-01-19" }, { "nct_id": "NCT01275677", "title": "Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "HER2/Neu Positive", "Progesterone Receptor Positive", "Recurrent Breast Carcinoma", "Stage IA Breast Cancer AJCC v7", "Stage IB Breast Cancer AJCC v7", "Stage IIA Breast Cancer AJCC v6 and v7", "Stage IIB Breast Cancer AJCC v6 and v7", "Stage IIIA Breast Cancer AJCC v7", "Stage IIIC Breast Cancer AJCC v7" ], "start_date": "2011-02-08", "last_update": "2025-07-14" }, { "nct_id": "NCT01281189", "title": "Phase 3 Study of Dexpramipexole in ALS", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Knopp Biosciences", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2011-03", "last_update": "2021-06-07" }, { "nct_id": "NCT01283477", "title": "Efficacy of Acupuncture for Prophylaxis of Intrathecal Morphine Induced Pruritis in Patients Undergoing Caesarean Delivery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Letterkenny General Hospital", "conditions": [ "Acupuncture", "Morphine Induced Pruritis" ], "start_date": "2010-10", "last_update": "2012-03-27" }, { "nct_id": "NCT01285479", "title": "The Gilenya Pregnancy Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Multiple Sclerosis" ], "start_date": "2011-10-15", "last_update": "2025-01-22" }, { "nct_id": "NCT01285609", "title": "Phase 3 Trial in Squamous Non Small Cell Lung Cancer Subjects Comparing Ipilimumab Versus Placebo in Addition to Paclitaxel and Carboplatin", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Lung Cancer - Non Small Cell Squamous" ], "start_date": "2011-01-16", "last_update": "2020-06-18" }, { "nct_id": "NCT01286779", "title": "BAX 326 (rFIX) Continuation Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Baxalta now part of Shire", "conditions": [ "Hemophilia B" ], "start_date": "2011-04-12", "last_update": "2021-05-20" }, { "nct_id": "NCT01287897", "title": "A Study To Assess The Efficacy And Safety Of PF-04236921 In Subjects With Crohn's Disease Who Failed Anti-TNF Therapy", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Crohn's Disease" ], "start_date": "2011-02", "last_update": "2016-01-21" }, { "nct_id": "NCT01288287", "title": "Long Term Effects of an Early Response to Certolizumab Pegol (CZP, Cimzia®) in Rheumatoid Arthritis (RA) Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma", "conditions": [ "Arthritis,Rheumatoid" ], "start_date": "2011-07", "last_update": "2016-09-16" }, { "nct_id": "NCT01289002", "title": "e-BioMatrix PostMarket Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biosensors Europe SA", "conditions": [ "Coronary Artery Disease" ], "start_date": "2008-04", "last_update": "2019-05-06" }, { "nct_id": "NCT01289990", "title": "Safety and Efficacy of Empagliflozin (BI 10773) and Sitagliptin Versus Placebo Over 76 Weeks in Patients With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2011-02", "last_update": "2014-07-15" }, { "nct_id": "NCT01291836", "title": "Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Alere San Diego", "conditions": [ "Acute Decompensated Heart Failure", "Acute Kidney Injury" ], "start_date": "2010-12", "last_update": "2024-01-03" }, { "nct_id": "NCT01295294", "title": "Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Uterine Hemorrhage" ], "start_date": "2011-03", "last_update": "2014-11-04" }, { "nct_id": "NCT01298570", "title": "Regorafenib+FOLFIRI Versus Placebo+FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "UNC Lineberger Comprehensive Cancer Center", "conditions": [ "Colorectal Cancer Metastatic" ], "start_date": "2011-04-07", "last_update": "2021-01-06" }, { "nct_id": "NCT01299168", "title": "Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Alberta", "conditions": [ "Validation Study of Molecular Diagnostic System", "Development of Reporting System for Molecular Diagnosis", "Incorporate Molecular Diagnosis Into Diagnostic Standards" ], "start_date": "2011-05", "last_update": "2026-06-02" }, { "nct_id": "NCT01302431", "title": "Nurse-Led Manualized Telephone Support Intervention", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Multiple Sclerosis" ], "start_date": "2011-04", "last_update": "2014-12-03" }, { "nct_id": "NCT01303172", "title": "A Trial Comparing Gemcitabine With and Without IMM-101 in Advanced Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Immodulon Therapeutics Ltd", "conditions": [ "Advanced Pancreatic Cancer" ], "start_date": "2011-06", "last_update": "2021-11-10" }, { "nct_id": "NCT01304355", "title": "An Assessment of Cognitive Function in Irritable Bowel Syndrome", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Irritable Bowel Syndrome" ], "start_date": "2011-01", "last_update": "2011-02-25" }, { "nct_id": "NCT01307397", "title": "A Study of Vemurafenib in Participants With Metastatic Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Malignant Melanoma" ], "start_date": "2011-03-01", "last_update": "2017-12-18" }, { "nct_id": "NCT01309087", "title": "Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS CLIA", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Allegro Diagnostics, Corp.", "conditions": [ "Lung Cancer" ], "start_date": "2009-01", "last_update": "2014-03-26" }, { "nct_id": "NCT01311648", "title": "BAY81-8973 Pediatric Safety and Efficacy Trial", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Haemophilia A" ], "start_date": "2011-06-09", "last_update": "2023-12-05" }, { "nct_id": "NCT01312077", "title": "The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Total Hip Arthroplasty" ], "start_date": "2010-10", "last_update": "2011-03-10" }, { "nct_id": "NCT01312415", "title": "The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Total Knee Replacement" ], "start_date": "2010-08", "last_update": "2011-03-10" }, { "nct_id": "NCT01313689", "title": "Ofatumumab vs Physician's Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Leukaemia" ], "start_date": "2011-04-14", "last_update": "2018-11-08" }, { "nct_id": "NCT01314144", "title": "Use of Continuous Wound Infusion of Bupivacaine for Analgesia Following Axillary Clearance Surgery", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Breast Cancer" ], "start_date": "2010-08", "last_update": "2011-03-14" }, { "nct_id": "NCT01315678", "title": "Study to Evaluate Arikayce™ in CF Patients With Chronic Pseudomonas Aeruginosa Infections", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Insmed Incorporated", "conditions": [ "Pseudomonas Aeruginosa Infection" ], "start_date": "2012-02-29", "last_update": "2020-06-16" }, { "nct_id": "NCT01316276", "title": "Extension Study of Liposomal Amikacin for Inhalation in Cystic Fibrosis (CF) Patients With Chronic Pseudomonas Aeruginosa (Pa) Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Insmed Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2012-10-05", "last_update": "2020-06-17" }, { "nct_id": "NCT01318941", "title": "Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion", "Wet Age Related Macular Degeneration", "Diabetic Macular Edema", "Retinal Vein Occlusion" ], "start_date": "2011-03", "last_update": "2016-05-23" }, { "nct_id": "NCT01319396", "title": "Performance Validation of a Non-contact Breathing Frequency Monitor (Model BM07)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "ResMed", "conditions": [ "Unspecified Threat to Breathing" ], "start_date": "2010-10", "last_update": "2021-04-01" }, { "nct_id": "NCT01319890", "title": "The 'SILVERMAN1' Trial Single Incision Laparoscopic Versus Existing Resection (Minimal Access) for Neoplasia", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Irish Clinical Outcomes in Research and Education", "conditions": [ "Right Colon Tumors" ], "start_date": "2011-07", "last_update": "2012-04-03" }, { "nct_id": "NCT01320397", "title": "Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "RostaQuo S.p.A.", "conditions": [ "Essential Hypertension" ], "start_date": "2011-05", "last_update": "2011-03-23" }, { "nct_id": "NCT01321281", "title": "A Study to Determine if Aquamin Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Andrea Doolan", "conditions": [ "Osteoarthritis" ], "start_date": "2011-03", "last_update": "2012-05-15" }, { "nct_id": "NCT01326676", "title": "Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial", "phases": [ "PHASE3" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Imperial College London", "conditions": [ "Cardiovascular Disease" ], "start_date": "2011-02", "last_update": "2023-09-28" }, { "nct_id": "NCT01335399", "title": "Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Newly Diagnosed, Previously Untreated Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Multiple Myeloma" ], "start_date": "2011-08-04", "last_update": "2022-09-30" }, { "nct_id": "NCT01335464", "title": "Safety and Efficacy of BIBF 1120 at High Dose in Idiopathic Pulmonary Fibrosis Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Fibrosis" ], "start_date": "2011-04", "last_update": "2016-07-25" }, { "nct_id": "NCT01336023", "title": "Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2011-05-23", "last_update": "2018-02-19" }, { "nct_id": "NCT01337661", "title": "A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "MedImmune LLC", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2011-04", "last_update": "2012-08-28" }, { "nct_id": "NCT01345019", "title": "Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Cancer", "Hematologic Malignancies", "Multiple Myeloma", "Oncology", "Bone Metastases", "Multiple Myeloma Bone Lesions" ], "start_date": "2012-05-17", "last_update": "2022-11-08" }, { "nct_id": "NCT01345318", "title": "B0151005 Open-Label Extension Study", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Crohn's Disease" ], "start_date": "2011-06", "last_update": "2024-01-12" }, { "nct_id": "NCT01347567", "title": "Heart Failure (HF) Outpatient Monitoring Evaluation (HOME) Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Alere San Diego", "conditions": [ "Heart Failure", "Systolic Heart Failure", "Acute Decompensated Heart Failure" ], "start_date": "2011-04", "last_update": "2024-01-03" }, { "nct_id": "NCT01347814", "title": "Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Diabetes Mellitus" ], "start_date": "2008-02", "last_update": "2011-05-04" }, { "nct_id": "NCT01349127", "title": "Trial to Assess Vitamin D Requirements in Lactating Women", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency", "Vitamin D Insufficiency" ], "start_date": "2008-08", "last_update": "2017-05-04" }, { "nct_id": "NCT01350284", "title": "The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Gastric Emptying", "Diabetes Mellitus" ], "start_date": "2009-06", "last_update": "2011-05-09" }, { "nct_id": "NCT01356108", "title": "Pulmonic Valve REplacement Multi-discIpline EMEA Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Edwards Lifesciences", "conditions": [ "Pulmonary Regurgitation", "Pulmonary Insufficiency", "Pulmonary Stenosis" ], "start_date": "2011-01", "last_update": "2018-11-20" }, { "nct_id": "NCT01358877", "title": "A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Breast Cancer" ], "start_date": "2011-11-08", "last_update": "2025-11-28" }, { "nct_id": "NCT01360554", "title": "ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2011-06-16", "last_update": "2017-05-24" }, { "nct_id": "NCT01364597", "title": "Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma SA", "conditions": [ "Epilepsy" ], "start_date": "2011-08-01", "last_update": "2025-10-20" }, { "nct_id": "NCT01365585", "title": "Evaluate The Clinical Effectiveness, Safety And Tolerability Of Sildenafil Used In Doses ≥20mg TID For The Treatment Of Pulmonary Arterial Hypertension", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2011-07", "last_update": "2021-02-01" }, { "nct_id": "NCT01367665", "title": "STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Basal Cell Carcinoma" ], "start_date": "2011-07-01", "last_update": "2019-06-06" }, { "nct_id": "NCT01369329", "title": "A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Crohn's Disease", "IBD", "Colitis", "Inflammatory Bowel Disease" ], "start_date": "2011-07", "last_update": "2016-12-07" }, { "nct_id": "NCT01369355", "title": "A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Crohn's Disease", "Colitis", "IBD", "Inflammatory Bowel Disease" ], "start_date": "2011-09-13", "last_update": "2025-02-04" }, { "nct_id": "NCT01369667", "title": "Vitamin D Supplementation in Adult Crohn's Disease", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Crohn's Disease" ], "start_date": "2012-04", "last_update": "2015-08-18" }, { "nct_id": "NCT01371825", "title": "Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Lysosomal Acid Lipase Deficiency", "Wolman Disease" ], "start_date": "2011-05-04", "last_update": "2019-01-30" }, { "nct_id": "NCT01374425", "title": "Study of Bevacizumab + mFOLFOX6 Versus Bevacizumab + FOLFIRI With Biomarker Stratification in Participants With Previously Untreated Metastatic Colorectal Cancer (mCRC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Genentech, Inc.", "conditions": [ "Colorectal Cancer" ], "start_date": "2011-08", "last_update": "2016-08-11" }, { "nct_id": "NCT01381874", "title": "A Study of Abiraterone Acetate Plus Prednisone With or Without Exemestane in Postmenopausal Women With Estrogen Receptor-Positive (ER+) Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Metastatic ER+ Her2- Breast Cancer", "Postmenopausal" ], "start_date": "2011-08-24", "last_update": "2019-04-11" }, { "nct_id": "NCT01384682", "title": "Maraviroc Switch Collaborative Study", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Kirby Institute", "conditions": [ "HIV" ], "start_date": "2011-08", "last_update": "2016-01-20" }, { "nct_id": "NCT01395017", "title": "Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "conditions": [ "Pancreatic Cancer" ], "start_date": "2011-06", "last_update": "2016-04-08" }, { "nct_id": "NCT01398202", "title": "Dietary Supplementation With 25-hydroxyvitamin D3 in Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Status as Reflected by Serum 25-hydroxyvitamin D" ], "start_date": "2011-01", "last_update": "2015-12-02" }, { "nct_id": "NCT01399528", "title": "A Pharmacogenomic Exploration of Lacosamide Response", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Epilepsy" ], "start_date": "2011-09", "last_update": "2012-12-07" }, { "nct_id": "NCT01412047", "title": "Paroxysmal Nocturnal Hemoglobinuria Human Anti-Human Antibodies Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Paroxysmal Nocturnal Hemoglobinuria", "PNH" ], "start_date": "2012-03", "last_update": "2017-10-18" }, { "nct_id": "NCT01412333", "title": "A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Relapsing Multiple Sclerosis" ], "start_date": "2011-09-20", "last_update": "2024-03-08" }, { "nct_id": "NCT01416116", "title": "Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Inc", "conditions": [ "or Peripheral Nerve Injury (PNI)", "Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)" ], "start_date": "2011-07-06", "last_update": "2018-04-23" }, { "nct_id": "NCT01416181", "title": "A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Biogen", "conditions": [ "Secondary Progressive Multiple Sclerosis" ], "start_date": "2011-09-13", "last_update": "2017-09-11" }, { "nct_id": "NCT01419665", "title": "GP2013 in the Treatment of Patients With Previously Untreated, Advanced Stage Follicular Lymphoma (ASSIST_FL)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sandoz", "conditions": [ "Follicular Lymphoma" ], "start_date": "2011-12-01", "last_update": "2021-05-14" }, { "nct_id": "NCT01420679", "title": "Pralatrexate vs Observation Following CHOP-based Chemotherapy in Undiagnosed Peripheral T-cell Lymphoma Patients", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Spectrum Pharmaceuticals, Inc", "conditions": [ "Peripheral T-cell Lymphoma" ], "start_date": "2011-08", "last_update": "2021-11-19" }, { "nct_id": "NCT01424267", "title": "Zenith® LP Abdominal Aortic Aneurysm (AAA) Post-Market Registry", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cook Group Incorporated", "conditions": [ "Abdominal Aortic Aneurysm", "Aorto-iliac Aneurysm" ], "start_date": "2010-07", "last_update": "2012-10-11" }, { "nct_id": "NCT01425723", "title": "Long-Term Safety and Efficacy of rFIXFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia B", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ Therapeutics Inc.", "conditions": [ "Severe Hemophilia B" ], "start_date": "2011-12-08", "last_update": "2020-12-19" }, { "nct_id": "NCT01428063", "title": "Study of pegInterferon Alfa-2a, Ribavirin, and Daclatasvir (BMS-790052) With or Without BMS-650032 for Participants in Some Hepatitis C Virus Trials", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hepatitis C Virus Infection" ], "start_date": "2011-09", "last_update": "2016-05-27" }, { "nct_id": "NCT01428492", "title": "Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis", "conditions": [ "Multiple Myeloma" ], "start_date": "2011-12", "last_update": "2018-08-08" }, { "nct_id": "NCT01431287", "title": "Tiotropium +Olodaterol Fixed Dose Combination (FDC) Versus Tiotropium and Olodaterol in Chronic Obstructive Pulmonary Disease (COPD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2011-09", "last_update": "2015-07-16" }, { "nct_id": "NCT01433445", "title": "Panobinostat and Ruxolitinib in Primary Myelofibrosis, Post-polycythemia Vera-myelofibrosis or Post-essential Thrombocythemia-myelofibrosis", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Idiopathic Myelofibrosis", "Post Essential Thrombocythemia Myelofibrosis", "Post Polycythemia-Vera Myelofibrosis" ], "start_date": "2011-11-01", "last_update": "2021-06-25" }, { "nct_id": "NCT01434225", "title": "NEMO1:NEonatal Seizure Using Medication Off-patent", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Great Ormond Street Hospital for Children NHS Foundation Trust", "conditions": [ "Neonatal Seizures" ], "start_date": "2011-08", "last_update": "2015-09-14" }, { "nct_id": "NCT01437787", "title": "Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hematopoietic Neoplasm" ], "start_date": "2011-12-31", "last_update": "2026-08-11" }, { "nct_id": "NCT01438086", "title": "Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Heart Failure", "Myocardial Infarction" ], "start_date": "2011-10", "last_update": "2017-03-30" }, { "nct_id": "NCT01440374", "title": "A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Thrombocytopaenia" ], "start_date": "2011-09", "last_update": "2017-06-05" }, { "nct_id": "NCT01440946", "title": "Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB029, in Previously Treated Pediatric Participants With Hemophilia B", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ Therapeutics Inc.", "conditions": [ "Hemophilia B" ], "start_date": "2012-06", "last_update": "2020-12-19" }, { "nct_id": "NCT01440985", "title": "A Study on the Effects of Two Nicotine Replacement Products on Tooth Staining", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "McNeil AB", "conditions": [ "Tobacco Dependence" ], "start_date": "2005-07", "last_update": "2012-07-10" }, { "nct_id": "NCT01442623", "title": "Conventional Versus Virtual Reality Based Vestibular Rehabilitation", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Peripheral Vestibular Disease" ], "start_date": "2011-02", "last_update": "2014-12-12" }, { "nct_id": "NCT01447043", "title": "Study to Assess the Effectiveness of Existing Anti vascUlar Endothelial Growth Factor (Anti VEGF) in Patients With Wet Age-related Macular Degeneration (wAMD) (AURA)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Ophthalmology, Macular Degeneration" ], "start_date": "2009-01", "last_update": "2014-01-27" }, { "nct_id": "NCT01447394", "title": "Safety and Efficacy Study of Pegylated Interferon Lambda Versus Pegylated Interferon Alfa, Plus Ribavirin in Subjects With Hepatitis C", "phases": [ "PHASE3" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hepatitis C Virus (HCV)" ], "start_date": "2012-03", "last_update": "2012-02-03" }, { "nct_id": "NCT01447446", "title": "An Observational Study on Dual And Triple Therapies Based on Peginterferon Alfa (e.g. Pegasys) in Patients With Chronic Hepatitis C", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hepatitis C, Chronic" ], "start_date": "2011-09", "last_update": "2017-03-30" }, { "nct_id": "NCT01448707", "title": "A Clinical Trial Comparing the Efficacy of Darunavir/Ritonavir Monotherapy Versus a Triple Combination Therapy Containing Darunavir/Ritonavir and 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Patients With Undetectable Plasma HIV-1 RNA on Current Treatment", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen-Cilag International NV", "conditions": [ "Human Immunodeficiency Virus (HIV) Infections", "Acquired Immunodeficiency Syndrome (AIDS) Virus" ], "start_date": "2012-03-15", "last_update": "2017-11-27" }, { "nct_id": "NCT01450280", "title": "Safety and Immunogenicity of New Malaria Vaccine Candidate ChAd63 CS Administered Alone and With MVA CS", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Oxford", "conditions": [ "Malaria" ], "start_date": "2011-12", "last_update": "2012-11-29" }, { "nct_id": "NCT01450449", "title": "Short Course vs. Standard Course Radiotherapy in Elderly and/or Frail Patients With Glioblastoma Multiforme", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "International Atomic Energy Agency", "conditions": [ "Glioblastoma Multiforme" ], "start_date": "2009-02", "last_update": "2015-03-24" }, { "nct_id": "NCT01450761", "title": "Trial in Extensive-Disease Small Cell Lung Cancer (ED-SCLC) Subjects Comparing Ipilimumab Plus Etoposide and Platinum Therapy to Etoposide and Platinum Therapy Alone", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Small Cell Lung Carcinoma" ], "start_date": "2011-12-13", "last_update": "2020-07-08" }, { "nct_id": "NCT01451346", "title": "Study in Patients With Mild to Moderate Psoriasis", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Alimentary Health Ltd", "conditions": [ "Psoriasis" ], "start_date": "2008-01", "last_update": "2011-10-13" }, { "nct_id": "NCT01452022", "title": "Performance of Inductigraft in Spinal Fusion", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Baxter Healthcare Corporation", "conditions": [ "Degenerative Disk Disease", "Spinal Stenosis of Lumbar Region" ], "start_date": "2011-10", "last_update": "2017-04-05" }, { "nct_id": "NCT01454284", "title": "A Study in Participants With Type I Diabetes Mellitus", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Diabetes Mellitus, Type 1" ], "start_date": "2012-01", "last_update": "2018-04-17" }, { "nct_id": "NCT01454739", "title": "Long-Term Safety and Efficacy of rFVIIIFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ Therapeutics Inc.", "conditions": [ "Hemophilia A" ], "start_date": "2011-12", "last_update": "2020-12-19" }, { "nct_id": "NCT01455675", "title": "Efficacy Study of IgY (Antibody Against Pseudomonas) in Cystic Fibrosis Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Mukoviszidose Institut gGmbH", "conditions": [ "Cystic Fibrosis" ], "start_date": "2011-10", "last_update": "2017-07-06" }, { "nct_id": "NCT01456325", "title": "A Study of Onartuzumab (MetMAb) in Combination With Tarceva (Erlotinib) in Participants With Met Diagnostic-Positive Non-Small Cell Lung Cancer Who Have Received Chemotherapy For Advanced or Metastatic Disease (MetLung)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Genentech, Inc.", "conditions": [ "Non-Squamous Non-Small Cell Lung Cancer" ], "start_date": "2012-01", "last_update": "2016-11-02" }, { "nct_id": "NCT01458106", "title": "Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ Therapeutics Inc.", "conditions": [ "Hemophilia A" ], "start_date": "2012-11", "last_update": "2020-12-19" }, { "nct_id": "NCT01465529", "title": "A Cross-over Study of OligoG in Subjects With Cystic Fibrosis. Fibrosis", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "AlgiPharma AS", "conditions": [ "Cystic Fibrosis" ], "start_date": "2011-05", "last_update": "2015-01-14" }, { "nct_id": "NCT01466660", "title": "LUX-Lung 7: A Phase IIb Trial of Afatinib(BIBW2992) Versus Gefitinib for the Treatment of 1st Line EGFR Mutation Positive Adenocarcinoma of the Lung", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Lung Neoplasms" ], "start_date": "2011-12-13", "last_update": "2020-04-07" }, { "nct_id": "NCT01467050", "title": "Prevention of Adverse Drug Events (ADEs) in Hospitalised Older Patients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Adverse Drug Reaction" ], "start_date": "2011-06", "last_update": "2012-06-06" }, { "nct_id": "NCT01467102", "title": "euCPSP: European Observational Study on Chronic Post Surgical Pain,PAIN-OUT Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "European Society of Anaesthesiology", "conditions": [ "Chronic Postoperative Pain" ], "start_date": "2011-07", "last_update": "2014-07-17" }, { "nct_id": "NCT01467128", "title": "Adverse Drug Event Prevention Using Structured Pharmacist Review", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Adverse Drug Reactions" ], "start_date": "2011-06", "last_update": "2012-06-06" }, { "nct_id": "NCT01467323", "title": "Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 1 or Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2" ], "start_date": "1998-04", "last_update": "2017-01-04" }, { "nct_id": "NCT01476956", "title": "Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "CARE ARTHRITIS LTD.", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2011-10", "last_update": "2021-10-27" }, { "nct_id": "NCT01480063", "title": "An Observational Study to Collect Information on Safety and to Document the Drug Utilization of Fampyra (BIIB041) When Used In Routine Medical Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Multiple Sclerosis" ], "start_date": "2012-04-16", "last_update": "2019-06-05" }, { "nct_id": "NCT01482559", "title": "Management of Hypotension In the Preterm Infant", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "University College Cork", "conditions": [ "Hypotension", "Low Blood Pressure", "Intraventricular Hemorrhage of Prematurity" ], "start_date": "2015-02", "last_update": "2019-10-02" }, { "nct_id": "NCT01482650", "title": "Comparison of the BASKA Airway, a Novel Supraglottic Device, to the LMA Airway in Low Risk Female Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Performance and Safety of an Airway Management Device" ], "start_date": "2011-11", "last_update": "2012-06-19" }, { "nct_id": "NCT01485159", "title": "Airflow Limitation in Cardiac Diseases in Europe", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2011-10", "last_update": "2014-02-24" }, { "nct_id": "NCT01485926", "title": "A Phase II Neo-adjuvant Study Assessing TCH (Docetaxel, Carboplatin and Trastuzumab) and TCHL (Docetaxel, Carboplatin, Trastuzumab and Lapatinib) in HER-2 Positive Breast Cancer Patients.", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2010-10", "last_update": "2018-08-06" }, { "nct_id": "NCT01492504", "title": "Three-year Follow-up Study of Subjects Who Participated in a Previous Asunaprevir (BMS-650032) and/or Daclatasvir (BMS-790052) Chronic Hepatitis C Clinical Trial", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hepatitis C" ], "start_date": "2012-02-07", "last_update": "2019-11-27" }, { "nct_id": "NCT01493414", "title": "INC424 for Patients With Primary Myelofibrosis, Post Polycythemia Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Myelofibrosis" ], "start_date": "2011-08-16", "last_update": "2019-04-26" }, { "nct_id": "NCT01495884", "title": "The Myocet/Lapatinib Study. ICORG 10-03, V5", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Her2 Positive Metastatic Breast Cancer" ], "start_date": "2011-03", "last_update": "2015-10-26" }, { "nct_id": "NCT01496859", "title": "Observational Study of Baska Mask, a New Supraglottic Airway Device", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Performance and Safety of a New Supraglottic Airway Device" ], "start_date": "2011-08", "last_update": "2012-03-26" }, { "nct_id": "NCT01498965", "title": "The Cork BASELINE Birth Cohort Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "National Children's Research Centre, Ireland", "conditions": [ "Food Allergy", "Eczema", "Obesity" ], "start_date": "2008-08", "last_update": "2015-01-21" }, { "nct_id": "NCT01500278", "title": "Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma SA", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2011-12", "last_update": "2018-07-31" }, { "nct_id": "NCT01500616", "title": "Telaprevir Open-Label Study in Co-Infected Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen-Cilag International NV", "conditions": [ "Hepatitis C, Chronic" ], "start_date": "2012-06", "last_update": "2016-08-18" }, { "nct_id": "NCT01500694", "title": "Access to Extended Release Guanfacine HCl for Subjects Who Participated in Studies SPD503-315 or SPD503-316 in Europe", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Attention Deficit Hyperactivity Disorder (ADHD)" ], "start_date": "2012-03-20", "last_update": "2021-06-16" }, { "nct_id": "NCT01508767", "title": "Early Post-operative Removal of Urethral Catheter in Patients Undergoing Colorectal Surgery With Epidural Analgesia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Urinary Retention" ], "start_date": "2012-01", "last_update": "2013-08-19" }, { "nct_id": "NCT01510184", "title": "Study of Zevalin Versus Observation in Participants at Least 60 Years Old With Newly Diagnosed Diffuse Large B-cell Lymphoma in Positron Emission Tomography (PET)-Negative Complete Remission After Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) or R-CHOP-like Therapy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Spectrum Pharmaceuticals, Inc", "conditions": [ "Diffuse Large B-cell Lymphoma", "Follicle Center Lymphoma" ], "start_date": "2012-04-19", "last_update": "2021-12-16" }, { "nct_id": "NCT01510223", "title": "The Effect of Macronutrients in the Diet on Digestive and Cardiovascular Health", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Obesity", "Diabetes", "Cardiovascular Diseases" ], "start_date": "2010-08", "last_update": "2012-01-16" }, { "nct_id": "NCT01511913", "title": "A Multi-National, Prospective, Observational Study in Patients With Unresectable or Metastatic Melanoma", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Advanced Cutaneous Melanoma" ], "start_date": "2012-06-03", "last_update": "2021-12-28" }, { "nct_id": "NCT01515007", "title": "Phase 3 Study With Ciprofloxacin Dispersion for Inhalation in Non-CF Bronchiectasis (ORBIT-3)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Aradigm Corporation", "conditions": [ "Non Cystic Fibrosis Bronchiectasis" ], "start_date": "2014-03-31", "last_update": "2021-03-26" }, { "nct_id": "NCT01518543", "title": "Follow-up of Patient Implanted With the Staple ASTUS®", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Integra LifeSciences Services", "conditions": [ "Arthrodesis" ], "start_date": "2010-04", "last_update": "2014-09-11" }, { "nct_id": "NCT01519791", "title": "A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma SA", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2012-01", "last_update": "2026-08-25" }, { "nct_id": "NCT01520818", "title": "Comparison of Biphasic Human Insulin 30 With Biphasic Insulin Aspart in Subjects With Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2" ], "start_date": "2000-03", "last_update": "2017-01-04" }, { "nct_id": "NCT01521923", "title": "A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Pharma", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2012-01", "last_update": "2026-08-25" }, { "nct_id": "NCT01522443", "title": "Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Exelixis", "conditions": [ "Prostate Cancer", "Castration Resistant Prostate Cancer", "Pain", "Prostatic Neoplasms" ], "start_date": "2012-03", "last_update": "2018-05-23" }, { "nct_id": "NCT01523587", "title": "LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2012-03-05", "last_update": "2019-02-15" }, { "nct_id": "NCT01524276", "title": "Product Surveillance Registry", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Medtronic", "conditions": [ "Cardiac Rhythm Disorders", "Urological Disorders", "Neurological Disorders", "Cardiovascular Disorders", "Digestive Disorders", "Intracranial Aneurysm", "Mechanical Circulatory Support", "Respiratory Therapy", "Aortic, Peripheral Vascular and Venous Disorders", "Minimally Invasive Surgical Procedures", "Diagnostic Techniques and Procedures", "Surgical Procedures, Operative", "Renal Insufficiency", "Neurovascular", "Coronary Artery Disease", "Ear, Nose and Throat Disorder" ], "start_date": "2012-01", "last_update": "2026-09-18" }, { "nct_id": "NCT01526369", "title": "A Randomized Study of TH Versus THL in First Line Treatment of HER2-positive Metastatic Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Metastatic Breast Cancer" ], "start_date": "2012-02-13", "last_update": "2025-05-09" }, { "nct_id": "NCT01527812", "title": "Optimal Positioning of Local Anaesthetic in Femoral Nerve Block Prior to Hip Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Fractured Neck of Femur" ], "start_date": "2009-12", "last_update": "2012-04-03" }, { "nct_id": "NCT01529697", "title": "Prospective Study of the Feedback From an Adherence Monitor on Asthma Control", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Asthma" ], "start_date": "2012-02", "last_update": "2016-01-12" }, { "nct_id": "NCT01530139", "title": "Strategies for Personalised Nutrition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Newcastle University", "conditions": [ "Dietary Modification" ], "start_date": "2012-08", "last_update": "2016-02-26" }, { "nct_id": "NCT01530412", "title": "Long Term Evaluation of Activity Levels Post Pulmonary Rehabilitation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2007-06", "last_update": "2012-02-10" }, { "nct_id": "NCT01531894", "title": "Continuation Study of the Oral AKT Inhibitor GSK2110183", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Cancer" ], "start_date": "2012-02-08", "last_update": "2019-07-09" }, { "nct_id": "NCT01532453", "title": "Prevention of UV-induced Carcinogenic Skin Alterations in Immunosuppressed Solid Organ Transplanted Patients", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Spirig Pharma Ltd.", "conditions": [ "Actinic Keratoses", "Squamous Cell Carcinomas" ], "start_date": "2010-11", "last_update": "2016-01-08" }, { "nct_id": "NCT01535261", "title": "Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Macular Edema", "Central Retinal Vein Occlusion" ], "start_date": "2012-02", "last_update": "2016-10-27" }, { "nct_id": "NCT01538680", "title": "Regorafenib in Subjects With Metastatic Colorectal Cancer (CRC) Who Have Progressed After Standard Therapy", "phases": [], "overall_status": "NO_LONGER_AVAILABLE", "lead_sponsor": "Bayer", "conditions": [ "Colorectal Neoplasms" ], "start_date": "", "last_update": "2019-05-29" }, { "nct_id": "NCT01543477", "title": "Post-Authorisation Safety Cohort Observation of RetacritTM (Epoetin Zeta) Administered Subcutaneously for the Treatment of Renal Anaemia", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Renal Anemia", "Pregnancy", "Lactation" ], "start_date": "2010-07-07", "last_update": "2020-10-01" }, { "nct_id": "NCT01543906", "title": "Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65)", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "QLT Inc.", "conditions": [ "Retinitis Pigmentosa (RP)" ], "start_date": "2012-02", "last_update": "2014-12-15" }, { "nct_id": "NCT01545674", "title": "Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Natera, Inc.", "conditions": [ "Trisomy 13", "Trisomy 18", "Trisomy 21", "Aneuploidy" ], "start_date": "2012-01", "last_update": "2023-03-23" }, { "nct_id": "NCT01545791", "title": "Observational Study to Evaluate the Safety of Levemir® in Patients With Diabetes", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2" ], "start_date": "2006-05", "last_update": "2016-10-28" }, { "nct_id": "NCT01550146", "title": "Single Dose of Dexamethasone in Femur Fractures", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Fractured Neck of Femur" ], "start_date": "2009-07", "last_update": "2012-03-09" }, { "nct_id": "NCT01562028", "title": "BELIEF (Bevacizumab and ErLotinib In EGFR Mut+ NSCLC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Lung Cancer" ], "start_date": "2012-06", "last_update": "2026-08-26" }, { "nct_id": "NCT01566721", "title": "A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Breast Neoplasms" ], "start_date": "2012-05-17", "last_update": "2021-04-27" }, { "nct_id": "NCT01566747", "title": "Second-line Pazopanib Renal Cell Carcinoma (RCC) Study. CTRIAL-IE (ICORG) 10-01, V5", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2011-03", "last_update": "2021-12-23" }, { "nct_id": "NCT01569295", "title": "Study Evaluating the Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab for Previously Treated Chronic Lymphocytic Leukemia (CLL) (Tugela )", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Chronic Lymphocytic Leukemia" ], "start_date": "2012-06-15", "last_update": "2020-03-10" }, { "nct_id": "NCT01571284", "title": "Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Colorectal Cancer Metastatic" ], "start_date": "2012-05-30", "last_update": "2018-04-17" }, { "nct_id": "NCT01574053", "title": "Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "CHDI Foundation, Inc.", "conditions": [ "Huntington's Disease" ], "start_date": "2012-07", "last_update": "2024-02-28" }, { "nct_id": "NCT01574391", "title": "A Comparison Study Of Two Different Techniques For Identifying The Epidural Space In Parturients In Labour", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National Maternity Hospital, Ireland", "conditions": [ "Labouring Parturients Requiring/Requesting Epidural Analgesia as Part of Their Peri-partum Care" ], "start_date": "2012-03", "last_update": "2015-04-14" }, { "nct_id": "NCT01576718", "title": "A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Teva Branded Pharmaceutical Products R&D, Inc.", "conditions": [ "Asthma" ], "start_date": "2012-04", "last_update": "2018-05-08" }, { "nct_id": "NCT01578707", "title": "A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pharmacyclics LLC.", "conditions": [ "Relapsed or Refractory Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2012-06", "last_update": "2019-12-18" }, { "nct_id": "NCT01581203", "title": "Phase III Hallmark DUAL: ASV+DCV (Nulls/Partials, Intolerants/Ineligibles. Naives)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hepatitis C Virus" ], "start_date": "2012-05", "last_update": "2015-10-09" }, { "nct_id": "NCT01584258", "title": "Prostate Advances in Comparative Evidence", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Royal Marsden NHS Foundation Trust", "conditions": [ "Prostate Cancer" ], "start_date": "2012-08-07", "last_update": "2024-01-19" }, { "nct_id": "NCT01597908", "title": "Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Melanoma" ], "start_date": "2012-06-04", "last_update": "2021-02-24" }, { "nct_id": "NCT01598467", "title": "Prospective Assessment of Robotic Sacrocolpopexy: a European Multicentric Cohort (PARSEC)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Femke van Zanten", "conditions": [ "Pelvic Organ Prolapse" ], "start_date": "2011-08", "last_update": "2018-02-22" }, { "nct_id": "NCT01599650", "title": "Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Branch Retinal Vein Occlusion" ], "start_date": "2012-05", "last_update": "2016-11-10" }, { "nct_id": "NCT01599988", "title": "Study to Compare Milk Protein Isolate (MPI) With Caseinate in Terms of Protein Utilization", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Enteral Feeds" ], "start_date": "2011-10", "last_update": "2013-01-16" }, { "nct_id": "NCT01600482", "title": "Clinical Investigation for Safety and Efficacy Study of CELT ACD (Arterial ClosureDevice)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vasorum Ltd", "conditions": [ "Cardiac Disease", "Coronary Artery Disease" ], "start_date": "2012-05", "last_update": "2017-08-23" }, { "nct_id": "NCT01604278", "title": "Efficacy, Safety and Tolerability of the Co-administration of NVA237 Plus Indacaterol Once Daily Versus Indacaterol Once Daily in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2012-05", "last_update": "2014-11-14" }, { "nct_id": "NCT01605227", "title": "Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Exelixis", "conditions": [ "Prostate Cancer", "Castration Resistant Prostate Cancer", "Pain", "Prostatic Neoplasms" ], "start_date": "2012-07", "last_update": "2018-03-14" }, { "nct_id": "NCT01606995", "title": "Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Atrial Fibrillation" ], "start_date": "2012-06-12", "last_update": "2022-08-03" }, { "nct_id": "NCT01607957", "title": "Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Taiho Oncology, Inc.", "conditions": [ "Colorectal Cancer" ], "start_date": "2012-06-17", "last_update": "2024-09-19" }, { "nct_id": "NCT01608789", "title": "Virtue® European Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Coloplast A/S", "conditions": [ "Stress Urinary Incontinence" ], "start_date": "2012-08-27", "last_update": "2020-06-11" }, { "nct_id": "NCT01617668", "title": "A Randomized, Phase 2, Neoadjuvant Study of Weekly Paclitaxel With or Without LCL161 in Patients With Triple Negative Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Cancer" ], "start_date": "2012-08", "last_update": "2016-10-17" }, { "nct_id": "NCT01618370", "title": "Radium(223) Dichloride (Alpharadin) in Castration-Resistant (Hormone-Refractory) Prostate Cancer Patients With Bone Metastases", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2012-07-22", "last_update": "2017-03-31" }, { "nct_id": "NCT01619085", "title": "Extension Trial of the Long Term Safety of BIBF 1120 in Patients With Idiopathic Pulmonary Fibrosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2012-06-06", "last_update": "2022-03-25" }, { "nct_id": "NCT01622088", "title": "Phase 3 Extension Study of Dexpramipexole in ALS", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Knopp Biosciences", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2012-06", "last_update": "2022-05-03" }, { "nct_id": "NCT01625052", "title": "Determination of the Optimal Approach to Select the Best Size of BASKA Mask to Use in Male Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Determination of the Best Predictor for Correct Baska Mask Size" ], "start_date": "2012-01", "last_update": "2012-12-25" }, { "nct_id": "NCT01625078", "title": "Observational Study of Baska Mask, a New Supraglottic Airway Device in Children", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "John Laffey", "conditions": [ "Baska Mask Efficacy and Safety in Children" ], "start_date": "2012-03", "last_update": "2014-05-29" }, { "nct_id": "NCT01628146", "title": "Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Technolas Perfect Vision GmbH", "conditions": [ "Hyperopic Presbyopia" ], "start_date": "2012-09", "last_update": "2015-05-20" }, { "nct_id": "NCT01630759", "title": "Remote Monitoring of Diabetes in Pregnancy: a Feasibility Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Ulster", "conditions": [ "Gestational Diabetes" ], "start_date": "2012-01", "last_update": "2014-01-28" }, { "nct_id": "NCT01631214", "title": "Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Postmenopausal Women With Osteoporosis" ], "start_date": "2012-05-04", "last_update": "2025-02-21" }, { "nct_id": "NCT01632904", "title": "Randomized Switch Study From Hydroxyurea to Ruxolitinib for RELIEF of Polycythemia Vera Symptoms: The Relief Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Polycythemia Vera" ], "start_date": "2012-06", "last_update": "2017-11-14" }, { "nct_id": "NCT01633489", "title": "Lysosomal Acid Lipase (LAL) Deficiency Registry", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Lysosomal Acid Lipase Deficiency", "Cholesterol Ester Storage Disease", "Wolman Disease", "Acid Cholesteryl Ester Hydrolase Deficiency, Type 2", "Acid Lipase Deficiency", "LIPA Deficiency", "LAL-Deficiency" ], "start_date": "2013-05-30", "last_update": "2026-03-06" }, { "nct_id": "NCT01638000", "title": "A Study to Evaluate the Efficacy and Safety of Mirabegron Compared to Solifenacin in Patients With Overactive Bladder Who Were Previously Treated With Another Medicine But Were Not Satisfied With That Treatment.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Urologic Diseases", "Urinary Bladder, Overactive", "Urinary Bladder Diseases" ], "start_date": "2012-06-12", "last_update": "2024-11-21" }, { "nct_id": "NCT01638416", "title": "Standard Issue Transfusion Versus Fresher Red Blood Cell Use in Intensive Care- A Randomised Controlled Trial", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Transfusion", "Age of Blood" ], "start_date": "2012-10", "last_update": "2020-10-22" }, { "nct_id": "NCT01639794", "title": "Vesitirim™ in Men Postmarketing Observational Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Lower Urinary Tract Symptoms (LUTS)", "Overactive Bladder (OAB)" ], "start_date": "2012-02", "last_update": "2013-01-17" }, { "nct_id": "NCT01641016", "title": "BREATHER (PENTA 16) Short-Cycle Therapy (SCT) (5 Days on/2 Days Off) in Young People With Chronic HIV-infection", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "PENTA Foundation", "conditions": [ "HIV" ], "start_date": "2011-04", "last_update": "2015-03-02" }, { "nct_id": "NCT01642004", "title": "Study of BMS-936558 (Nivolumab) Compared to Docetaxel in Previously Treated Advanced or Metastatic Squamous Cell Non-small Cell Lung Cancer (NSCLC) (CheckMate 017)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Squamous Cell Non-small Cell Lung Cancer" ], "start_date": "2012-10-16", "last_update": "2022-12-28" }, { "nct_id": "NCT01642498", "title": "A Multicenter Study to Evaluate the ROX Arteriovenous Coupler in Patients With Treatment-Resistant Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ROX Medical, Inc.", "conditions": [ "Hypertension" ], "start_date": "2012-09-01", "last_update": "2019-05-10" }, { "nct_id": "NCT01646021", "title": "Study of Ibrutinib (a Bruton's Tyrosine Kinase Inhibitor), Versus Temsirolimus in Patients With Relapsed or Refractory Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Mantle Cell Lymphoma" ], "start_date": "2012-12-10", "last_update": "2018-01-19" }, { "nct_id": "NCT01649856", "title": "A Study of Subcutaneous Versus Intravenous MabThera/Rituxan (Rituximab) in Combination With CHOP Chemotherapy in Patients With Previously Untreated CD20-Positive Diffuse Large B-Cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Lymphoma, Large B-Cell, Diffuse" ], "start_date": "2012-08-24", "last_update": "2017-10-11" }, { "nct_id": "NCT01652469", "title": "Testing of Drugs Erlotinib and Docetaxel in Lung Cancer Patients Classified Regarding Their Outlook Using VeriStrat®.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2012-08", "last_update": "2026-08-26" }, { "nct_id": "NCT01658930", "title": "Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Canadian Cancer Trials Group", "conditions": [ "Cervical Cancer" ], "start_date": "2012-12-10", "last_update": "2024-12-17" }, { "nct_id": "NCT01659021", "title": "Efficacy and Safety of Idelalisib in Combination With Ofatumumab for Previously Treated Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Chronic Lymphocytic Leukemia" ], "start_date": "2012-12-04", "last_update": "2019-08-14" }, { "nct_id": "NCT01660451", "title": "Open-label, Uncontrolled Phase II Trial of Intravenous PI3K Inhibitor BAY80-6946 in Patients With Relapsed, Indolent or Aggressive Non-Hodgkin's Lymphomas", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Lymphoma, Non-Hodgkin" ], "start_date": "2012-11-19", "last_update": "2024-07-17" }, { "nct_id": "NCT01663051", "title": "Evaluation of the Zilver® Vena™ Venous Stent", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cook Group Incorporated", "conditions": [ "Iliofemoral Venous Outflow Obstruction" ], "start_date": "2012-11", "last_update": "2016-11-01" }, { "nct_id": "NCT01663623", "title": "Belimumab in Remission of VASculitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Human Genome Sciences Inc., a GSK Company", "conditions": [ "Vasculitis" ], "start_date": "2013-03-20", "last_update": "2018-04-17" }, { "nct_id": "NCT01665144", "title": "Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Secondary Progressive Multiple Sclerosis" ], "start_date": "2012-12-20", "last_update": "2024-06-05" }, { "nct_id": "NCT01665742", "title": "Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Overweight", "Obesity" ], "start_date": "2012-01", "last_update": "2014-12-09" }, { "nct_id": "NCT01667146", "title": "Open Lung Ventilation in ARDS: The PHARLAP Trial", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Acute Respiratory Distress Syndrome" ], "start_date": "2012-10", "last_update": "2024-07-18" }, { "nct_id": "NCT01667419", "title": "A Study of Vemurafenib Adjuvant Therapy in Participants With Surgically Resected Cutaneous BRAF-Mutant Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Melanoma" ], "start_date": "2012-09-24", "last_update": "2019-07-23" }, { "nct_id": "NCT01668784", "title": "Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Advanced or Metastatic (Medically or Surgically Unresectable) Clear-cell Renal Cell Carcinoma" ], "start_date": "2012-10-09", "last_update": "2022-08-09" }, { "nct_id": "NCT01671007", "title": "GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Stroke", "Atrial Fibrillation" ], "start_date": "2012-08-22", "last_update": "2020-12-31" }, { "nct_id": "NCT01674764", "title": "Surgical Treatment for Spinal Cord Injury", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AOSpine Europe", "conditions": [ "Acute Spinal Cord Injury of Traumatic Origin (tSCI)" ], "start_date": "2012-11", "last_update": "2020-05-13" }, { "nct_id": "NCT01675466", "title": "Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Non-specific Abdominal Pain" ], "start_date": "2012-08", "last_update": "2013-03-26" }, { "nct_id": "NCT01678859", "title": "Cervical Mucus - the Biochemical and Molecular Properties in Fertile and Subfertile Women (C-MIS Study)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Merrion Fertility Clinic", "conditions": [ "Infertility" ], "start_date": "2012-08", "last_update": "2013-09-06" }, { "nct_id": "NCT01680120", "title": "Dose Finding Study for Continuous Spinal Anaesthesia", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Femoral Fracture" ], "start_date": "2012-09", "last_update": "2012-09-06" }, { "nct_id": "NCT01682512", "title": "Efficacy, Pharmacokinetics, and Safety of BI 695500 in Patients With Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Arthritis, Rheumatoid" ], "start_date": "2012-09-05", "last_update": "2018-01-30" }, { "nct_id": "NCT01691911", "title": "Preconditioning Shields Against Vascular Events in Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Abdominal Aortic Aneurysm", "Carotid Atherosclerosis", "Critical Lower Limb Ischaemia" ], "start_date": "2012-02", "last_update": "2015-06-03" }, { "nct_id": "NCT01697267", "title": "Rituximab Vasculitis Maintenance Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cambridge University Hospitals NHS Foundation Trust", "conditions": [ "Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis", "Microscopic Polyangiitis", "Wegener Granulomatosis" ], "start_date": "2013-04", "last_update": "2022-03-18" }, { "nct_id": "NCT01702571", "title": "A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Who Have Received Prior Anti-HER2 And Chemotherapy-based Treatment", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Breast Cancer" ], "start_date": "2012-11-27", "last_update": "2022-04-04" }, { "nct_id": "NCT01704716", "title": "High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. Anna Kinderkrebsforschung", "conditions": [ "Neuroblastoma" ], "start_date": "2002-02", "last_update": "2020-10-23" }, { "nct_id": "NCT01709149", "title": "Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2012-10", "last_update": "2020-03-31" }, { "nct_id": "NCT01710592", "title": "A Phase II Trial of Epirubicin, Oxaliplatin and Capecitabine (EOX) Versus Docetaxel and Oxaliplatin (ElTax) in the Treatment of Advanced Gastro-oesophageal Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Gastro Oesophageal Cancer" ], "start_date": "2007-05", "last_update": "2013-01-10" }, { "nct_id": "NCT01712789", "title": "Evaluation of Safety of Pomalidomide in Combination With Dexamethasone (Low Dose) in Patients With Refractory or Relapsed and Refractory Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2012-11-06", "last_update": "2022-01-10" }, { "nct_id": "NCT01713946", "title": "A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Tuberous Sclerosis Complex-associated Refractory Seizures" ], "start_date": "2013-04-29", "last_update": "2018-11-07" }, { "nct_id": "NCT01719263", "title": "Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Uptake Medical Corp", "conditions": [ "Emphysema" ], "start_date": "2013-06", "last_update": "2015-10-29" }, { "nct_id": "NCT01721252", "title": "Tarceva. ICORG 08-41", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2009-12", "last_update": "2015-03-30" }, { "nct_id": "NCT01722487", "title": "Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pharmacyclics LLC.", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2013-03", "last_update": "2017-11-30" }, { "nct_id": "NCT01722851", "title": "Circulating miRNAs.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer", "Newly Diagnosed Breast Cancer", "Recurrent Breast Cancer" ], "start_date": "2011-05", "last_update": "2025-07-08" }, { "nct_id": "NCT01722890", "title": "CharactHer. ICORG 12-09, V3", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "HER2-positive Breast Cancer", "TNM Stage II-IV Breast Cancer" ], "start_date": "2012-07", "last_update": "2025-07-08" }, { "nct_id": "NCT01724346", "title": "Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pharmacyclics LLC.", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2013-12-03", "last_update": "2024-09-19" }, { "nct_id": "NCT01725295", "title": "Neurostructural Integration Technique for Fibromyalgia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Fibromyalgia" ], "start_date": "2003-04", "last_update": "2012-11-12" }, { "nct_id": "NCT01726309", "title": "Single Nucleotide Polymorphism(SNP)Study. ICORG 08-40, V4", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Colorectal Cancer", "Non-Small Cell Lung Cancer" ], "start_date": "2011-05", "last_update": "2025-07-08" }, { "nct_id": "NCT01726322", "title": "Ovarian Reserve in Premenopausal Breast Cancer", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Premenopausal Breast Cancer", "Breast Cancer" ], "start_date": "2012-09", "last_update": "2025-07-08" }, { "nct_id": "NCT01726452", "title": "NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Adenocarcinoma of the Oesophagus", "Adenocarcinoma of the Oesophago-gastric Junction", "Oesophageal Tumours", "Junctional Tumours", "Oesophageal Cancer" ], "start_date": "2013-01-24", "last_update": "2022-09-30" }, { "nct_id": "NCT01727609", "title": "Speed of Increasing Milk Feeds Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Oxford", "conditions": [ "Premature Birth", "Late-onset Invasive Infection", "Necrotizing Enterocolitis" ], "start_date": "2013-06", "last_update": "2019-03-11" }, { "nct_id": "NCT01728558", "title": "Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Critical Illness and Mechanical Ventilation" ], "start_date": "2013-11", "last_update": "2019-08-20" }, { "nct_id": "NCT01728922", "title": "Dose-related Effects of Vitamin D3 on Immune Responses in Patients With Clinically Isolated Syndrome", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Clinically Isolated Syndrome", "Multiple Sclerosis" ], "start_date": "2012-11-06", "last_update": "2017-05-03" }, { "nct_id": "NCT01730404", "title": "Safety, Tolerability and Efficacy of 28-day Inhaled CHF 6001 DPI in COPD Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Chiesi Farmaceutici S.p.A.", "conditions": [ "COPD" ], "start_date": "2012-10", "last_update": "2017-03-29" }, { "nct_id": "NCT01732796", "title": "IFN-free Combination Therapy in HCV-infected Patients Treatment-naive:HCVerso1", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hepatitis C, Chronic" ], "start_date": "2012-12", "last_update": "2016-04-18" }, { "nct_id": "NCT01734928", "title": "Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2013-01-07", "last_update": "2023-06-06" }, { "nct_id": "NCT01737047", "title": "The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Imperial College London", "conditions": [ "HIV Positive", "Ageing" ], "start_date": "2013-04-01", "last_update": "2025-09-18" }, { "nct_id": "NCT01740427", "title": "A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms" ], "start_date": "2013-02-22", "last_update": "2024-11-14" }, { "nct_id": "NCT01741896", "title": "Can Remote Ischaemic Preconditioning Reduce Contrast Induced Nephropathy in Patients Receiving Contrast for Computed Tomography?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Contrast Induced Nephropathy", "Remote Ischaemic Preconditioning" ], "start_date": "2012-11", "last_update": "2013-09-13" }, { "nct_id": "NCT01746225", "title": "Schedules of Nab-Paclitaxel in Metastatic Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Metastatic Breastcancer" ], "start_date": "2013-04", "last_update": "2026-09-02" }, { "nct_id": "NCT01753635", "title": "Comparison of the Baska Mask Airway to a Single-use LMA Device in Low-risk Female Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "John Laffey", "conditions": [ "Performance and Safety of an Airway Management Device" ], "start_date": "2012-11", "last_update": "2013-03-19" }, { "nct_id": "NCT01756443", "title": "Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Open Reduction Internal Fixation(ORIF) of Lateral Malleolus" ], "start_date": "2011-08", "last_update": "2013-12-10" }, { "nct_id": "NCT01757509", "title": "A Randomized Controlled Feasibility Trial to Determine the Effectiveness of Set Dancing for People With Parkinson's Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Parkinson's Disease" ], "start_date": "2012-12", "last_update": "2013-08-27" }, { "nct_id": "NCT01757535", "title": "Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Leukemia, Myeloid, Acute" ], "start_date": "2013-04-24", "last_update": "2025-07-08" }, { "nct_id": "NCT01757977", "title": "A Comparison of the Performance of Standard Double Lumen Tubes With Vivasight DL™ Double Lumen Tubes for Lung Isolation in Patients Undergoing Thoracic Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "John Laffey", "conditions": [ "Performance and Safety of an Airway Management Device" ], "start_date": "2012-08", "last_update": "2013-03-19" }, { "nct_id": "NCT01759524", "title": "To Compare lidocaine2%/Clonidine in Combination, With Bupivacaine 0.5 % Alone in Equal Volumes for Combined Sciatic-saphenous Nerve Block in Terms of Selectivity of Blockade", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Bimalleolar Fractures of the Ankle.", "Sciatic Nerve Block.", "Saphenous Nerve Block.", "Post Operative Analgesia Duration." ], "start_date": "2011-10", "last_update": "2013-11-19" }, { "nct_id": "NCT01760005", "title": "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Washington University School of Medicine", "conditions": [ "Alzheimers Disease", "Dementia", "Alzheimers Disease, Familial" ], "start_date": "2012-12", "last_update": "2026-07-27" }, { "nct_id": "NCT01764633", "title": "Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Dyslipidemia" ], "start_date": "2013-02-08", "last_update": "2024-05-28" }, { "nct_id": "NCT01767155", "title": "Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AEterna Zentaris", "conditions": [ "Endometrial Cancer" ], "start_date": "2013-04", "last_update": "2018-07-31" }, { "nct_id": "NCT01770808", "title": "A Study to Determine if Aquamin (as AquaCal and AquaPT) Improves Digestive Discomfort", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Digestive System Disorders" ], "start_date": "2011-05", "last_update": "2013-01-18" }, { "nct_id": "NCT01772472", "title": "A Study of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy in Patients With HER2-Positive Breast Cancer Who Have Residual Tumor in the Breast or Axillary Lymph Nodes Following Preoperative Therapy (KATHERINE)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Breast Cancer" ], "start_date": "2013-04-03", "last_update": "2025-07-22" }, { "nct_id": "NCT01773746", "title": "Study of Room Air Versus 60% Oxygen for Resuscitation of Premature Infants", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Sharp HealthCare", "conditions": [ "Extreme Prematurity - Less Than 28 Weeks" ], "start_date": "2013-08", "last_update": "2018-09-12" }, { "nct_id": "NCT01774279", "title": "interNational Anaplastic Thyroid Cancer Tissue Bank and Database (iNATT)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Velindre NHS Trust", "conditions": [ "Anaplastic Thyroid Cancer" ], "start_date": "2013-06", "last_update": "2021-01-05" }, { "nct_id": "NCT01776424", "title": "Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Prevention & Control" ], "start_date": "2013-02-28", "last_update": "2022-11-28" }, { "nct_id": "NCT01776840", "title": "A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Mantle Cell Lymphoma" ], "start_date": "2013-05-16", "last_update": "2025-07-08" }, { "nct_id": "NCT01777022", "title": "Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Edinburgh", "conditions": [ "Decreased Fetal Movements Affecting Care of Mother", "Pregnancy", "Stillbirth" ], "start_date": "2014-01-01", "last_update": "2018-02-08" }, { "nct_id": "NCT01778361", "title": "HIV UPBEAT: Understanding the Pathology of Bone Disease in HIV-infected Patients.", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Osteoporosis" ], "start_date": "2011-02", "last_update": "2019-09-25" }, { "nct_id": "NCT01778374", "title": "Mater-Bronx Rapid HIV Testing Project.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Human Immunodeficiency Virus" ], "start_date": "2012-09", "last_update": "2020-03-25" }, { "nct_id": "NCT01780935", "title": "Efficacy and Safety of Two Treatment Regimens of 0.5 mg Ranibizumab Intravitreal Injections Guided by Functional and/or Anatomical Criteria, in Patients With Neovascular Age-related Macular Degeneration", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "start_date": "2013-06-03", "last_update": "2017-08-14" }, { "nct_id": "NCT01783444", "title": "A Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in Advance Breast Cancer.", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Cancer" ], "start_date": "2013-02-26", "last_update": "2021-02-26" }, { "nct_id": "NCT01784068", "title": "Nilotinib Treatment-free Remission Study in CML (Chronic Myeloid Leukemia) Patients", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Myelogenous Leukemia" ], "start_date": "2013-03-19", "last_update": "2026-08-13" }, { "nct_id": "NCT01785251", "title": "Neuromuscular Electrical Stimulation Following Total Hip Arthroplasty", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Deep Vein Thrombosis", "Total Hip Arthroplasty" ], "start_date": "2011-06", "last_update": "2013-02-07" }, { "nct_id": "NCT01786486", "title": "AMPLATZER Cardiac Plug (ACP) Registry-Long Term Follow-up Protocol", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Atrial Fibrillation", "Left Atrial Appendage", "Stroke" ], "start_date": "2009-08", "last_update": "2023-06-28" }, { "nct_id": "NCT01787552", "title": "A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Primary Myelofibrosis", "Thrombocytosis", "Essential Thrombocythemia", "Polycythemia Vera", "Myeloproliferative Disorders", "Bone Marrow Diseases", "Hematologic Diseases", "Blood Coagulation Disorders", "Blood Platelet Disorders", "Hemorrhagic Disorders" ], "start_date": "2013-05-08", "last_update": "2020-04-15" }, { "nct_id": "NCT01788527", "title": "Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mount Sinai Hospital, Canada", "conditions": [ "Type 1 Diabetics Who Are Pregnant or Planning Pregnancy" ], "start_date": "2013-03", "last_update": "2017-07-19" }, { "nct_id": "NCT01792388", "title": "Vitd and Barrier Function in IBD", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Crohn's Disease" ], "start_date": "2011-12", "last_update": "2014-07-22" }, { "nct_id": "NCT01796171", "title": "A Phase 1/2 Study of Betalutin for Treatment of Relapsed Non-Hodgkin Lymphoma", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Nordic Nanovector", "conditions": [ "Non-Hodgkin Lymphoma", "Follicular Lymphoma" ], "start_date": "2012-12", "last_update": "2024-06-21" }, { "nct_id": "NCT01797965", "title": "Long-Term Extension Study in Participants With Multiple Sclerosis Who Have Completed Study 205MS301 (NCT01064401) to Evaluate the Safety and Efficacy of BIIB019", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis", "Multiple Sclerosis" ], "start_date": "2013-02-15", "last_update": "2019-12-04" }, { "nct_id": "NCT01801891", "title": "Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Professor Stewart Walsh", "conditions": [ "Chronic Venous Disease" ], "start_date": "2013-05", "last_update": "2014-12-12" }, { "nct_id": "NCT01804686", "title": "A Long-term Extension Study of PCI-32765 (Ibrutinib)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma", "Mantle Cell Lymphoma", "Follicular Lymphoma", "Diffuse Large B-cell Lymphoma", "Waldenstrom Macroglobulinemia", "Chronic Graft Versus Host Disease" ], "start_date": "2013-09-09", "last_update": "2026-10-01" }, { "nct_id": "NCT01804855", "title": "Effectiveness of a Smartphone App for Adolescent Obesity Management", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Children's University Hospital, Ireland", "conditions": [ "Obesity", "Impaired Health", "Psychosocial Problem", "Physical Activity", "General Nutrition Disorder" ], "start_date": "2013-02", "last_update": "2017-10-25" }, { "nct_id": "NCT01804972", "title": "Efficacy of Patient Centred Information for Vascular Disease", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Vascular Disease" ], "start_date": "2013-05", "last_update": "2014-03-26" }, { "nct_id": "NCT01807923", "title": "A Study of Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis, Homozygous for the F508del CFTR Mutation" ], "start_date": "2013-05", "last_update": "2015-08-31" }, { "nct_id": "NCT01808573", "title": "A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Puma Biotechnology, Inc.", "conditions": [ "HER2+ Metastatic Breast Cancer (MBC)" ], "start_date": "2013-03-29", "last_update": "2021-06-11" }, { "nct_id": "NCT01809821", "title": "Sleep to Lower Elevated Blood Pressure", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Hypertension", "Sleep Disorders", "Insomnia", "Cardiovascular Diseases" ], "start_date": "2013-05", "last_update": "2014-09-03" }, { "nct_id": "NCT01813422", "title": "GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Hypercholesterolemia" ], "start_date": "2013-04-18", "last_update": "2019-02-20" }, { "nct_id": "NCT01813721", "title": "Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Chemotherapy-induced Febrile Neutropenia" ], "start_date": "2012-12", "last_update": "2017-03-15" }, { "nct_id": "NCT01822444", "title": "ANGIOPREDICT. ICORG 12-16, V3", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Advanced Colorectal Cancer" ], "start_date": "2012-11", "last_update": "2026-04-13" }, { "nct_id": "NCT01823120", "title": "Text Message Intervention to Reduce Repeat Self-harm", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Self-Injurious Behavior" ], "start_date": "2015-03", "last_update": "2014-09-11" }, { "nct_id": "NCT01828099", "title": "LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2013-07-09", "last_update": "2025-01-16" }, { "nct_id": "NCT01828112", "title": "LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2013-06-28", "last_update": "2025-02-07" }, { "nct_id": "NCT01828697", "title": "Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "conditions": [ "Deep Venous Thrombosis", "Pulmonary Embolism" ], "start_date": "2013-04-24", "last_update": "2022-05-26" }, { "nct_id": "NCT01829711", "title": "Moxetumomab Pasudotox for Advanced Hairy Cell Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "MedImmune LLC", "conditions": [ "Leukemia, Hairy Cell" ], "start_date": "2013-04-29", "last_update": "2020-04-08" }, { "nct_id": "NCT01830400", "title": "A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Inc.", "conditions": [ "Partial Onset Seizures" ], "start_date": "2012-04", "last_update": "2015-08-19" }, { "nct_id": "NCT01836523", "title": "The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2013-11", "last_update": "2017-03-06" }, { "nct_id": "NCT01840293", "title": "Breast Cancer Proteomics and Molecular Heterogeneity", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Primary Breast Cancer", "Recurrent/Metastatic Breast Cancer" ], "start_date": "2013-02", "last_update": "2025-12-19" }, { "nct_id": "NCT01840306", "title": "Exosomal and Free Extracellular RNAs and Proteins as Predictive Biomarkers for HER2 Therapies in Breast Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer", "HER2 Positive Breast Cancer", "HER2 Negative Breast Cancer" ], "start_date": "2012-10-12", "last_update": "2025-07-08" }, { "nct_id": "NCT01844505", "title": "Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Unresectable or Metastatic Melanoma" ], "start_date": "2013-06-11", "last_update": "2025-05-21" }, { "nct_id": "NCT01844778", "title": "Ease of Use and Microbial Contamination of Tobramycin Inhalation Powder (TIP) Versus Nebulised Tobramycin Inhalation Solution (TIS) and Nebulised Colistimethate (COLI)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Cystic Fibrosis" ], "start_date": "2013-08", "last_update": "2016-07-27" }, { "nct_id": "NCT01846767", "title": "Exogenous Glucose Oxidation Breath Test", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2012-04", "last_update": "2014-11-26" }, { "nct_id": "NCT01847313", "title": "The Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Karl Neff", "conditions": [ "Diabetic Kidney Disease" ], "start_date": "2013-04", "last_update": "2019-02-08" }, { "nct_id": "NCT01848561", "title": "A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis (UC)" ], "start_date": "2013-04-29", "last_update": "2025-07-16" }, { "nct_id": "NCT01849874", "title": "A Study of MEK162 vs. Physician's Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Low-grade Serous Ovarian Cancer", "Low-grade Serous Fallopian Tube Cancer", "Low-grade Serous Peritoneal Cancer" ], "start_date": "2013-06-27", "last_update": "2023-10-30" }, { "nct_id": "NCT01850212", "title": "A Phase 4 Cross-Sectional Study of Bone Mineral Density in HIV-1 Infected Subjects", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "HIV Infections" ], "start_date": "2013-02", "last_update": "2014-10-31" }, { "nct_id": "NCT01852292", "title": "Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum Therapy", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Head and Neck Squamous Cell Carcinoma" ], "start_date": "2013-10-01", "last_update": "2018-07-24" }, { "nct_id": "NCT01862471", "title": "Neuromuscular Electrical Stimulation Versus Intermittent Pneumatic Compression for Blood Flow", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Venous Thrombosis" ], "start_date": "2013-05", "last_update": "2013-06-20" }, { "nct_id": "NCT01864746", "title": "A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GBG Forschungs GmbH", "conditions": [ "Breast Cancer", "Hormonreceptor Positive", "Her2-normal", "Postneoadjuvant Treatment With CDK 4/6 Inhibitor", "CPS-EG Score" ], "start_date": "2013-10-30", "last_update": "2023-12-12" }, { "nct_id": "NCT01865747", "title": "A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Exelixis", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2013-06", "last_update": "2021-04-27" }, { "nct_id": "NCT01866059", "title": "Treatment of Root Caries in an Older Irish Population.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Active Root Caries", "Over Sixty-five Years of Age", ">=Two Carious Root Surfaces Per Patient" ], "start_date": "2012-07", "last_update": "2016-05-11" }, { "nct_id": "NCT01870778", "title": "Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Acute Heart Failure" ], "start_date": "2013-10-02", "last_update": "2018-03-30" }, { "nct_id": "NCT01871532", "title": "Low-dose Gonal-f® in Ovulation Induction", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck KGaA, Darmstadt, Germany", "conditions": [ "Infertility", "Monofollicular Development" ], "start_date": "2013-07", "last_update": "2016-08-11" }, { "nct_id": "NCT01872975", "title": "Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "NSABP Foundation Inc", "conditions": [ "Stage IB Breast Cancer", "Stage II Breast Cancer" ], "start_date": "2013-08", "last_update": "2023-12-27" }, { "nct_id": "NCT01874171", "title": "Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Warwick", "conditions": [ "Oropharyngeal Squamous Cell Carcinoma" ], "start_date": "2012-11-15", "last_update": "2017-05-08" }, { "nct_id": "NCT01877967", "title": "Investigating the Effect of Dietary Supplement VSL#3 on Cognition and Mood in Healthy Older Adults", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Alteration of Cognitive Function", "Disturbance in Affect (Finding)" ], "start_date": "2013-05", "last_update": "2015-05-27" }, { "nct_id": "NCT01878760", "title": "APRICOT: Anaesthesia PRactice In Children Observational Trial", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "European Society of Anaesthesiology", "conditions": [ "Anaesthesia", "Children" ], "start_date": "2014-03", "last_update": "2015-10-14" }, { "nct_id": "NCT01886612", "title": "A Comparison of Neuromuscular Electrical Stimulation and Intermittent Pneumatic Compression in Terms of Lower Limb Blood Flow", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Venous Thrombosis" ], "start_date": "2013-06", "last_update": "2013-08-02" }, { "nct_id": "NCT01889238", "title": "Safety and Efficacy Study of Enzalutamide in Patients With Advanced, Androgen Receptor-Positive, Triple Negative Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Advanced, Androgen Receptor Positive Triple Negative Breast Cancer" ], "start_date": "2013-06-12", "last_update": "2024-12-13" }, { "nct_id": "NCT01891240", "title": "IMproved PRegnancy Outcome by Early Detection", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Louise Kenny", "conditions": [ "Pre-eclampsia", "Pregnancy", "Pregnancy, High-risk", "Pregnancy Complications" ], "start_date": "2013-11", "last_update": "2016-11-08" }, { "nct_id": "NCT01892319", "title": "An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes Mellitus", "Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2" ], "start_date": "2013-09-30", "last_update": "2019-11-19" }, { "nct_id": "NCT01893008", "title": "Preoperative Inspiratory Muscle Training in Esophageal Resection", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "UMC Utrecht", "conditions": [ "Esophageal Resection Candidates" ], "start_date": "2013-09", "last_update": "2017-05-11" }, { "nct_id": "NCT01894997", "title": "A Comparison of the Effects of Neuromuscular Electrical Stimulation and Intermittent Pneumatic Compression on Blood Flow in the Lower Limb", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Venous Thrombosis" ], "start_date": "2014-01", "last_update": "2014-09-03" }, { "nct_id": "NCT01902290", "title": "Study of Efficacy and Safety of Brodalumab Compared With Placebo in Adults With Inadequately Controlled Asthma With High Bronchodilator Reversibility", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Amgen", "conditions": [ "Asthma" ], "start_date": "2013-05-22", "last_update": "2022-09-21" }, { "nct_id": "NCT01903707", "title": "Cognitive Remediation in Schizophrenia", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Schizophrenia", "Psychosis" ], "start_date": "2013-05", "last_update": "2014-12-05" }, { "nct_id": "NCT01905943", "title": "A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Chronic Lymphocytic Leukemia" ], "start_date": "2013-11-04", "last_update": "2019-10-28" }, { "nct_id": "NCT01907217", "title": "Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Depression" ], "start_date": "2008-05", "last_update": "2018-11-14" }, { "nct_id": "NCT01908426", "title": "Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Exelixis", "conditions": [ "Hepatocellular Carcinoma" ], "start_date": "2013-09-26", "last_update": "2021-05-06" }, { "nct_id": "NCT01908829", "title": "A Trial Comparing Combination Treatment (Solifenacin Plus Mirabegron) With One Treatment Alone (Solifenacin)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Urinary Bladder Diseases", "Urinary Bladder Overactive", "Urologic Diseases" ], "start_date": "2013-07-10", "last_update": "2024-10-31" }, { "nct_id": "NCT01910610", "title": "Multi-Line Therapy Trial in Unresectable Metastatic Colorectal Cancer", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "GERCOR - Multidisciplinary Oncology Cooperative Group", "conditions": [ "Colorectal Cancer Metastatic" ], "start_date": "2013-10-30", "last_update": "2024-03-12" }, { "nct_id": "NCT01911767", "title": "Biogen Multiple Sclerosis Pregnancy Exposure Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Multiple Sclerosis", "Exposure During Pregnancy" ], "start_date": "2013-10-30", "last_update": "2022-06-21" }, { "nct_id": "NCT01913860", "title": "Supporting the Improvement and Management of Prescribing for Urinary Tract Infections (SIMPle)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Uncomplicated Urinary Tract Infection" ], "start_date": "2013-09", "last_update": "2014-12-05" }, { "nct_id": "NCT01914575", "title": "Dipole Density Mapping of Right and Left Atrial Supraventricular Tachycardia", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Acutus Medical", "conditions": [ "Supraventricular Tachycardia" ], "start_date": "2014-01-22", "last_update": "2019-01-31" }, { "nct_id": "NCT01917630", "title": "Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Alvine Pharmaceuticals Inc.", "conditions": [ "Celiac Disease" ], "start_date": "2013-08", "last_update": "2014-12-17" }, { "nct_id": "NCT01922622", "title": "Minimum Effective Intrathecal Dose of Local Anaesthetic With Fentanyl for Fractured Neck of Femur(Dose Finding Study).", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Minimum Effective Dose of Local Anaesthetic With Fentanyl" ], "start_date": "2013-07", "last_update": "2015-02-04" }, { "nct_id": "NCT01925924", "title": "RMGI v Composite for Orthodontic Bonding", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sheffield Teaching Hospitals NHS Foundation Trust", "conditions": [ "Malocclusion" ], "start_date": "2009-02", "last_update": "2018-01-26" }, { "nct_id": "NCT01931839", "title": "A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation" ], "start_date": "2013-10", "last_update": "2017-05-12" }, { "nct_id": "NCT01936155", "title": "Does NMES Help Relieve Lower Limb Oedema and Improve Joint Mobility and Skin Tissue Oxygenation Levels?", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Oedema" ], "start_date": "2015-08", "last_update": "2015-04-15" }, { "nct_id": "NCT01939717", "title": "A Randomized Controlled Pilot Trial Comparing Irish Set Dancing to Usual Care for People With Parkinson's Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Parkinson's Disease" ], "start_date": "2013-08", "last_update": "2016-06-01" }, { "nct_id": "NCT01942135", "title": "Palbociclib (PD-0332991) Combined With Fulvestrant In Hormone Receptor+ HER2-Negative Metastatic Breast Cancer After Endocrine Failure (PALOMA-3)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Metastatic Breast Cancer" ], "start_date": "2013-09-26", "last_update": "2024-04-04" }, { "nct_id": "NCT01943344", "title": "Safety and Performance Study of Large Hole Vascular Closure Device", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vivasure Medical Limited", "conditions": [ "Percutaneous Closure of Arteriotomy in Common Femoral Artery" ], "start_date": "2013-07", "last_update": "2018-11-02" }, { "nct_id": "NCT01943526", "title": "Ireland Natalizumab (TYSABRI) Observational Program", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2011-11-30", "last_update": "2018-05-04" }, { "nct_id": "NCT01944241", "title": "Cervical Surgery and the Fertility Effect (c-SAFE)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Merrion Fertility Clinic", "conditions": [ "Infertility" ], "start_date": "2012-10", "last_update": "2013-09-17" }, { "nct_id": "NCT01945775", "title": "A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Neoplasms", "BRCA 1 Gene Mutation", "BRCA 2 Gene Mutation" ], "start_date": "2013-10-14", "last_update": "2022-01-20" }, { "nct_id": "NCT01949012", "title": "Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Hypoxemia" ], "start_date": "2013-10", "last_update": "2016-06-03" }, { "nct_id": "NCT01949311", "title": "Open-label Study of Dupilumab in Patients With Atopic Dermatitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Atopic Dermatitis" ], "start_date": "2013-10-10", "last_update": "2023-10-17" }, { "nct_id": "NCT01953926", "title": "Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Puma Biotechnology, Inc.", "conditions": [ "Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations" ], "start_date": "2013-09-30", "last_update": "2024-03-12" }, { "nct_id": "NCT01957176", "title": "A Rollover Study to Provide Continued Treatment With Eltrombopag", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Thrombocytopaenia" ], "start_date": "2013-10-15", "last_update": "2022-12-30" }, { "nct_id": "NCT01957436", "title": "A Phase III Study for Patients With Metastatic Hormone-naïve Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "UNICANCER", "conditions": [ "Metastatic Prostate Cancer" ], "start_date": "2013-11-13", "last_update": "2024-11-12" }, { "nct_id": "NCT01958021", "title": "Study of Efficacy and Safety of LEE011 in Postmenopausal Women With Advanced Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Advanced, Metastatic Breast Cancer" ], "start_date": "2013-12-17", "last_update": "2025-03-07" }, { "nct_id": "NCT01961609", "title": "Secukinumab in Tumor Necrosis Factor (TNF) - Inadequate Response (IR) Psoriasis Participants.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Psoriasis" ], "start_date": "2013-10-09", "last_update": "2019-03-18" }, { "nct_id": "NCT01964430", "title": "Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients With Resected Pancreatic Cancer (the \"Apact\" Study)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Pancreatic Neoplasms", "Digestive System Neoplasms", "Neoplasms by Site", "Neoplasms", "Endocrine Gland Neoplasms", "Pancreatic Diseases", "Digestive System Diseases", "Endocrine System Diseases", "Gemcitabine", "Antimetabolites, Antineoplastic" ], "start_date": "2014-03-28", "last_update": "2023-06-28" }, { "nct_id": "NCT01964443", "title": "Clinical Assessment and Psychosocial Impact of Psoriasis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Pharmaceutica N.V., Belgium", "conditions": [ "Psoriasis" ], "start_date": "2013-09", "last_update": "2015-12-15" }, { "nct_id": "NCT01965314", "title": "A Trial to Determine the Effect of Simulation Based Training on Initial Performance of Ultrasound Guided Axillary Brachial Plexus Blockade in a Clinical Setting", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Anesthesiology Training" ], "start_date": "2010-07", "last_update": "2016-02-02" }, { "nct_id": "NCT01968473", "title": "Comfort and Tolerance of Surface Neuro Muscular Electrical Stimulation in Parkinson's Disease.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Parkinson's Disease" ], "start_date": "2013-09", "last_update": "2013-10-24" }, { "nct_id": "NCT01970891", "title": "Electrical Stimulation for the Relief of Freezing of Gait (FOG) in Parkinson's Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Parkinson's Disease" ], "start_date": "2013-10-01", "last_update": "2020-09-18" }, { "nct_id": "NCT01972282", "title": "Registry on WATCHMAN Outcomes in Real-Life Utilization", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Patients With Atrial Fibrillation at Risk for Thrombus Formation, Thromboembolism, Stroke" ], "start_date": "2013-10-28", "last_update": "2019-05-07" }, { "nct_id": "NCT01973829", "title": "The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mayo Clinic", "conditions": [ "Critical Illness", "Sepsis", "Respiratory Failure", "Shock", "Coma", "Bleeding", "Trauma" ], "start_date": "2013-11", "last_update": "2018-08-20" }, { "nct_id": "NCT01975376", "title": "The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Cardiovascular Disease" ], "start_date": "2013-10-29", "last_update": "2018-07-11" }, { "nct_id": "NCT01975389", "title": "The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Cardiovascular Disease" ], "start_date": "2013-10-29", "last_update": "2019-05-01" }, { "nct_id": "NCT01985334", "title": "Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "COPD" ], "start_date": "2014-02-14", "last_update": "2019-03-19" }, { "nct_id": "NCT01990248", "title": "An Observational Safety Study in Zelboraf (Vemurafenib)-Treated Patients With BRAF-V600 Mutation-Positive Unresectable or Metastatic Melanoma (ZeSS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Malignant Melanoma" ], "start_date": "2013-03-23", "last_update": "2018-06-19" }, { "nct_id": "NCT01990872", "title": "Inter-relationship Between Vitamin D Requirements and Calcium Intake in Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2012-10", "last_update": "2013-11-25" }, { "nct_id": "NCT01991197", "title": "Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients With Diabetes (DIP): A Randomized Clinical Trial.", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Psoriasis", "Type 2 Diabetes Mellitus" ], "start_date": "2014-04", "last_update": "2020-05-14" }, { "nct_id": "NCT01991288", "title": "Analgesic Efficacy of Saphenous Nerve Block in Total Knee Replacement", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Post Operative Pain" ], "start_date": "2012-11", "last_update": "2013-11-25" }, { "nct_id": "NCT01995201", "title": "A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2013-09", "last_update": "2018-01-26" }, { "nct_id": "NCT02001831", "title": "Multi-ingredient Nutrition Supplement in Older Adults", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Physical Disability" ], "start_date": "2014-01", "last_update": "2013-12-05" }, { "nct_id": "NCT02006641", "title": "Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "H. Lundbeck A/S", "conditions": [ "Alzheimer's Disease" ], "start_date": "2014-02", "last_update": "2018-02-20" }, { "nct_id": "NCT02007512", "title": "Efficacy and Safety Study of Enzalutamide in Combination With Exemestane in Patients With Advanced Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Breast Cancer" ], "start_date": "2013-12-16", "last_update": "2025-09-02" }, { "nct_id": "NCT02007551", "title": "Evaluating the RelAte Mealtime Program as an Intervention to Treat Social Isolation and Improve Cooking Behaviour Among Older Adults Living Alone", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Social Isolation", "Meals" ], "start_date": "2013-05", "last_update": "2015-05-27" }, { "nct_id": "NCT02009540", "title": "Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mr HD Flood", "conditions": [ "Overactive Detrusor" ], "start_date": "2013-12", "last_update": "2013-12-12" }, { "nct_id": "NCT02010385", "title": "Investigation of the Effects of Obesity Surgery on Appetitive Behaviour", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Roux-en-Y Bariatric Surgery" ], "start_date": "2013-02", "last_update": "2022-05-23" }, { "nct_id": "NCT02010710", "title": "Use of Decision Support in the Management of Labour", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College, London", "conditions": [ "Fetal Intrauterine Distress First Noted During Labor and or Delivery in Liveborn Infant", "Team Based on Their Existing Guidelines and the Woman Consents to Have EFM and EFM is", "Possible" ], "start_date": "2010-01-06", "last_update": "2018-10-15" }, { "nct_id": "NCT02013167", "title": "Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Amgen", "conditions": [ "Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia" ], "start_date": "2014-01-03", "last_update": "2024-03-05" }, { "nct_id": "NCT02017340", "title": "A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Prof Brian Lawlor", "conditions": [ "Alzheimer's Disease" ], "start_date": "2013-04-24", "last_update": "2017-03-06" }, { "nct_id": "NCT02019147", "title": "BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Hypoxic Ischaemic Encephalopathy (HIE)", "Asphyxia" ], "start_date": "2012-03", "last_update": "2018-07-06" }, { "nct_id": "NCT02021318", "title": "Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe B.V.", "conditions": [ "Anemia in Chronic Kidney Disease in Non-dialysis Patients" ], "start_date": "2014-03-12", "last_update": "2024-11-14" }, { "nct_id": "NCT02036931", "title": "A Multicentre Observational Study to Evaluate Clinical Outcomes of the G7 Acetabular System", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Zimmer Biomet", "conditions": [ "Noninflammatory Degenerative Joint Disease", "Rheumatoid Arthritis" ], "start_date": "2013-03", "last_update": "2025-12-19" }, { "nct_id": "NCT02039388", "title": "Lavage of the Uterine Cavity for the Diagnosis of Serous Tubal Intraepithelial Carcinoma", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medical University of Vienna", "conditions": [ "Ovarian Epithelial Cancer", "Carcinoma in Situ", "Ovarian Cancer" ], "start_date": "2013-11", "last_update": "2022-09-02" }, { "nct_id": "NCT02040714", "title": "Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Texas Scottish Rite Hospital for Children", "conditions": [ "Legg Calve Perthes Disease" ], "start_date": "2012-08", "last_update": "2025-05-06" }, { "nct_id": "NCT02041806", "title": "Assessing Peripheral Nerve Block Scoring Systems for Intra-Operative and Post-Operative Analgesia", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "The Adelaide and Meath Hospital", "conditions": [ "Complication of Anesthesia" ], "start_date": "2013-07", "last_update": "2014-01-22" }, { "nct_id": "NCT02047097", "title": "Dimethyl Fumarate (DMF) Observational Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Multiple Sclerosis" ], "start_date": "2013-11-19", "last_update": "2023-05-24" }, { "nct_id": "NCT02050737", "title": "Plasma Biomarkers C-RAC, ICORG 12-27, V1", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Colorectal Cancer" ], "start_date": "2013-10", "last_update": "2025-07-08" }, { "nct_id": "NCT02050750", "title": "TAILORx Tissue Bank", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2013-12", "last_update": "2025-12-19" }, { "nct_id": "NCT02050997", "title": "Plasma Biomarkers P-DAC, V1", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pancreatic Ductal Adenocarcinoma" ], "start_date": "2014-05-26", "last_update": "2025-07-08" }, { "nct_id": "NCT02051010", "title": "ABC Survey - do we Meet the Needs of Patients With Advanced Breast Cancer?", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Metastatic Breast Cancer" ], "start_date": "2013-05", "last_update": "2015-03-30" }, { "nct_id": "NCT02051348", "title": "Study of Pylopass Versus Placebo in Subjects Who Are Helicobacter Pylori Carriers and With Mild Indigestion", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "HELICOBACTER INFECTION" ], "start_date": "2014-01", "last_update": "2015-01-15" }, { "nct_id": "NCT02054858", "title": "Preconditioning Against Renal Damage Under Contrast Examination", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Acute Kidney Injury" ], "start_date": "2014-01", "last_update": "2014-02-04" }, { "nct_id": "NCT02054871", "title": "RCT to Evaluate the Renal Protective Effects of Remote Ischaemic Preconditioning in Peripheral Angioplasty", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Peripheral Vascular Disease" ], "start_date": "2013-09", "last_update": "2014-02-04" }, { "nct_id": "NCT02057484", "title": "A 5 Year Follow-up of Patients Who Were Previously Enrolled Into an Advagraf Trial Following a Liver or Kidney Transplant", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Liver Transplant", "Kidney Transplant" ], "start_date": "2014-03-03", "last_update": "2024-10-31" }, { "nct_id": "NCT02057601", "title": "Postoperative Analgesia for Fractured Neck of Femur With Periarticular Infiltration of Local Anaesthetic", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Fractured Neck of Femur", "Postoperative Pain" ], "start_date": "2013-01", "last_update": "2014-02-07" }, { "nct_id": "NCT02059291", "title": "Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Hereditary Periodic Fevers" ], "start_date": "2014-06-27", "last_update": "2018-05-17" }, { "nct_id": "NCT02060188", "title": "A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Microsatellite Unstable Colorectal Cancer", "Microsatellite Stable Colorectal Cancer", "Mismatch Repair Proficient Colorectal Cancer", "Mismatch Repair Deficient Colorectal Cancer" ], "start_date": "2014-03-12", "last_update": "2025-11-06" }, { "nct_id": "NCT02066220", "title": "International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Universitätsklinikum Hamburg-Eppendorf", "conditions": [ "Brain Tumors" ], "start_date": "2014-06", "last_update": "2025-12-04" }, { "nct_id": "NCT02066467", "title": "Maximizing CRT Delivery by Using MultipolAr Coronary Sinus Lead FamiLy ACUITY® X4 - RALLY X4 Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Heartfailure" ], "start_date": "2014-02", "last_update": "2019-09-20" }, { "nct_id": "NCT02069509", "title": "Patient Registry of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "European Friedreich's Ataxia Consortium for Translational Studies", "conditions": [ "Friedreich's Ataxia" ], "start_date": "2010-05", "last_update": "2025-10-03" }, { "nct_id": "NCT02073006", "title": "A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "Constipation" ], "start_date": "2014-02", "last_update": "2015-01-15" }, { "nct_id": "NCT02080364", "title": "Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "vTv Therapeutics", "conditions": [ "Alzheimer's Disease" ], "start_date": "2015-04", "last_update": "2021-05-07" }, { "nct_id": "NCT02090413", "title": "Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing-Remitting Multiple Sclerosis" ], "start_date": "2014-05", "last_update": "2016-12-28" }, { "nct_id": "NCT02092818", "title": "EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Hypertension, Pulmonary" ], "start_date": "2014-05-31", "last_update": "2019-06-19" }, { "nct_id": "NCT02097186", "title": "Preconditioning Shields Against Vascular Events in Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mid Western Regional Hospital, Ireland", "conditions": [ "Abdominal Aortic Aneurysm", "Carotid Atherosclerosis", "Critical Lower Limb Ischaemia" ], "start_date": "2014-04", "last_update": "2014-12-12" }, { "nct_id": "NCT02097654", "title": "Clinical Trial of a New Software ENgine for the Assessment & Optimization of Drug and Non-drug Therapy in Older peRsons", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Adverse Drug Reactions" ], "start_date": "2014-07-09", "last_update": "2019-01-22" }, { "nct_id": "NCT02097745", "title": "A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2004-06", "last_update": "2016-11-03" }, { "nct_id": "NCT02099656", "title": "A Study Evaluating the Effects of Lebrikizumab on Airway Eosinophilic Inflammation in Participants With Uncontrolled Asthma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Asthma" ], "start_date": "2014-11-06", "last_update": "2017-09-06" }, { "nct_id": "NCT02104947", "title": "Reversal of Dabigatran Anticoagulant Effect With Idarucizumab", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Hemorrhage" ], "start_date": "2014-05-06", "last_update": "2018-01-05" }, { "nct_id": "NCT02106143", "title": "RejuvenAir™ System Lobectomy Safety and Histology Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "CSA Medical, Inc.", "conditions": [ "Lung Neoplasms", "Airway Obstruction", "Lung Cancer" ], "start_date": "2014-09", "last_update": "2017-05-11" }, { "nct_id": "NCT02106546", "title": "Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Squamous Non-Small Cell Lung Cancer" ], "start_date": "2014-04-10", "last_update": "2020-11-17" }, { "nct_id": "NCT02108860", "title": "Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of South Florida", "conditions": [ "Granulomatosis With Polyangiitis (Wegener's)", "Granulomatosis With Polyangiitis", "Wegener's Granulomatosis", "ANCA-Associated Vasculitis" ], "start_date": "2015-04-25", "last_update": "2024-07-29" }, { "nct_id": "NCT02109666", "title": "Long Term Experience With Abatacept in Routine Clinical Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2008-03", "last_update": "2017-04-19" }, { "nct_id": "NCT02112877", "title": "VIRTUS: An Evaluation of the Vici™ Venous Stent System in Patients With Chronic Iliofemoral Venous Outflow Obstruction", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Chronic Venous Disorder", "Venous Outflow Obstruction", "Symptomatic Venous Outflow Obstruction of Iliofemoral Vein" ], "start_date": "2014-06-26", "last_update": "2021-04-15" }, { "nct_id": "NCT02118896", "title": "Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Heart Transplantation", "Liver Transplantation", "Kidney Transplantation" ], "start_date": "2003-02-24", "last_update": "2024-11-22" }, { "nct_id": "NCT02119663", "title": "A Study of Ruxolitinib in Pancreatic Cancer Patients", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Pancreatic Cancer" ], "start_date": "2014-06", "last_update": "2018-02-13" }, { "nct_id": "NCT02122978", "title": "Comparing Mindfulness Based Cognitive Therapy and Mindfulness Based Self-compassion Therapy in a Psoriasis Sample", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Psoriasis" ], "start_date": "2013-11", "last_update": "2014-04-25" }, { "nct_id": "NCT02123823", "title": "BI 836845 in Estrogen Receptor Positive Metastatic Breast Cancer", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Neoplasms" ], "start_date": "2014-05-15", "last_update": "2025-07-15" }, { "nct_id": "NCT02129699", "title": "Survival imProvement in Lung cancEr iNduced by DenOsUmab theRapy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Lung Cancer Non-small Cell Stage IV" ], "start_date": "2015-01-06", "last_update": "2026-09-08" }, { "nct_id": "NCT02130362", "title": "A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2014-08-28", "last_update": "2025-07-16" }, { "nct_id": "NCT02136459", "title": "Non-neural Vocal Changes After Thyroidectomy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "South Infirmary-Victoria University Hospital", "conditions": [ "Thyroidectomy" ], "start_date": "2012-10", "last_update": "2014-05-13" }, { "nct_id": "NCT02136511", "title": "Expanded Access for Idelalisib in Combination With Rituximab in Chronic Lymphocytic Leukemia", "phases": [], "overall_status": "APPROVED_FOR_MARKETING", "lead_sponsor": "Gilead Sciences", "conditions": [ "Chronic Lymphocytic Leukemia (CLL)" ], "start_date": "", "last_update": "2014-10-28" }, { "nct_id": "NCT02141126", "title": "Lower Limb Resistance Training in Older Inpatients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Muscle Weakness" ], "start_date": "2013-07-01", "last_update": "2021-03-12" }, { "nct_id": "NCT02143791", "title": "Evaluate St Jude Medical Prodigy Neuromodulation for FBSS or Chronic Pain of the Trunk and/or Limbs", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Chronic Pain" ], "start_date": "2014-06", "last_update": "2024-07-08" }, { "nct_id": "NCT02144740", "title": "Effect of NWT-03 on Blood Pressure", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Newtricious R&D BV", "conditions": [ "Blood Pressure", "Albuminuria" ], "start_date": "2013-10", "last_update": "2014-05-23" }, { "nct_id": "NCT02145728", "title": "The Effect of Cognitive Functional Therapy on Patients With Non-specific Chronic Low Back Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Chronic Low Back Pain" ], "start_date": "2014-05", "last_update": "2018-12-12" }, { "nct_id": "NCT02150707", "title": "The Differential Effects of Diabetes Therapy on Inflammation", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Diabetic Nephropathy", "Type 2 Diabetes" ], "start_date": "2014-05", "last_update": "2016-05-18" }, { "nct_id": "NCT02151019", "title": "Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Locally Advanced Rectal Cancer" ], "start_date": "2014-10-17", "last_update": "2026-04-13" }, { "nct_id": "NCT02156804", "title": "A Single-Arm, Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) for Subjects With Histologically Confirmed Stage III (Unresectable) or Stage IV Melanoma Progressing Post Prior Treatment Containing an Anti-CTLA4 Monoclonal Antibody (CheckMate 172)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2014-10-07", "last_update": "2020-09-11" }, { "nct_id": "NCT02158936", "title": "A Study of Eltrombopag or Placebo in Combination With Azacitidine in Subjects With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-risk Myelodysplastic Syndromes (MDS)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Thrombocytopaenia" ], "start_date": "2014-06-10", "last_update": "2017-12-12" }, { "nct_id": "NCT02160171", "title": "ANSeR- The Algorithm for Neonatal Seizure Recognition Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Neonatal Seizures" ], "start_date": "2013-04", "last_update": "2015-08-11" }, { "nct_id": "NCT02160353", "title": "Neo-adjuvant Abiraterone Prostate Study", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "High Risk Localised Prostate Carcinoma" ], "start_date": "2015-07-09", "last_update": "2026-04-13" }, { "nct_id": "NCT02164864", "title": "Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Atrial Fibrillation", "Percutaneous Coronary Intervention" ], "start_date": "2014-07-22", "last_update": "2018-07-31" }, { "nct_id": "NCT02166606", "title": "INGEVITY™ Observational Trial", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Bradycardia" ], "start_date": "2014-04", "last_update": "2021-03-30" }, { "nct_id": "NCT02171975", "title": "Ultrasound - Guided Paramedian Techniques in Spinal Anesthesia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Anaesthesia" ], "start_date": "2014-02", "last_update": "2014-06-24" }, { "nct_id": "NCT02172950", "title": "An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "CSL Behring", "conditions": [ "Hemophilia A", "Severe Hemophilia A" ], "start_date": "2014-10-13", "last_update": "2021-10-27" }, { "nct_id": "NCT02177110", "title": "A Translational Systems Medicine Approach to Provide Predictive Capacity for Therapy Response in Advanced or Metastatic Malignant Melanoma", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Advanced Melanoma", "Metastatic Melanoma" ], "start_date": "2014-09", "last_update": "2020-11-17" }, { "nct_id": "NCT02179879", "title": "Development and Validation of Metrics Lumbar Labor Epidural Catheter Placement", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Labor Pain" ], "start_date": "2013-11", "last_update": "2015-08-28" }, { "nct_id": "NCT02181894", "title": "Identifying the Most Accurate Method for Predicting the Safe Depth of Orally Placed Neonatal Endotracheal Tubes (ETT).", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Colorado, Denver", "conditions": [ "Infant Showing No Response to Resuscitation", "Ventilator Adverse Event", "Apparent Life Threatening Event in Newborn and Infant" ], "start_date": "2014-11", "last_update": "2018-07-26" }, { "nct_id": "NCT02182440", "title": "A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "AM-Pharma", "conditions": [ "Acute Kidney Injury" ], "start_date": "2014-12-18", "last_update": "2020-03-23" }, { "nct_id": "NCT02185079", "title": "The Effect of Metrics Based Performance Based Progression in Provision of Labor Epidural Analgesia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Labor Pain" ], "start_date": "2014-01", "last_update": "2018-07-17" }, { "nct_id": "NCT02188355", "title": "Prospective, Single-arm, Multi Centre Observations Ultimaster Des Registry", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Terumo Europe N.V.", "conditions": [ "Coronary Artery Disease" ], "start_date": "2014-06", "last_update": "2019-10-08" }, { "nct_id": "NCT02189681", "title": "Landmark Guided Midline Versus Pre-procedural Ultrasound Guided Paramedian at L5S1 for Spinal Anaesthesia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Anaesthesia" ], "start_date": "2014-07", "last_update": "2015-08-28" }, { "nct_id": "NCT02190552", "title": "Analysis of Revascularisation in Ischemic Stroke With EmboTrap", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Neuravi Limited", "conditions": [ "Ischemic Stroke" ], "start_date": "2014-11", "last_update": "2019-03-11" }, { "nct_id": "NCT02190604", "title": "Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Cystic Fibrosis" ], "start_date": "2012-07-31", "last_update": "2020-12-30" }, { "nct_id": "NCT02194842", "title": "Phase III Radium 223 mCRPC-PEACE III", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Prostate Cancer" ], "start_date": "2015-10", "last_update": "2025-09-19" }, { "nct_id": "NCT02198651", "title": "A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis", "Musculoskeletal and Connective Tissue Diseases" ], "start_date": "2015-01-05", "last_update": "2019-06-25" }, { "nct_id": "NCT02203266", "title": "Teaching Inhaler Use With the INCA Device in a Community Pharmacy Setting", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Asthma", "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2014-02", "last_update": "2019-07-18" }, { "nct_id": "NCT02208050", "title": "A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Secondary Progressive Multiple Sclerosis", "Primary Progressive Multiple Sclerosis" ], "start_date": "2014-02-21", "last_update": "2021-07-09" }, { "nct_id": "NCT02214134", "title": "SPECTAlung: Screening Patients With Thoracic Tumors for Efficient Clinical Trial Access", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Any Stage of Lung Cancer (Any Histotype)", "Any Stage of Malignant Pleural Mesothelioma", "Any Stage of Any Thymic Malignancy" ], "start_date": "2015-05-22", "last_update": "2025-08-17" }, { "nct_id": "NCT02218632", "title": "Glycosylation in Patients With Galactosaemia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's University Hospital, Ireland", "conditions": [ "Classical Galactosaemia" ], "start_date": "2012-07", "last_update": "2014-08-18" }, { "nct_id": "NCT02219178", "title": "Study of the Efficacy and Safety of RsqVD Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Multiple Myeloma" ], "start_date": "2014-11", "last_update": "2020-07-17" }, { "nct_id": "NCT02219490", "title": "A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Chronic Hepatitis C Virus (HCV) Infection Genotype 1" ], "start_date": "2014-10-30", "last_update": "2023-04-07" }, { "nct_id": "NCT02221362", "title": "A Prospective, Noninterventional, Observational Study of Late-Onset Pompe Disease", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "BioMarin Pharmaceutical", "conditions": [ "Late-onset Pompe Patients Untreated or Treated With rhGAA" ], "start_date": "2014-12", "last_update": "2016-10-31" }, { "nct_id": "NCT02223169", "title": "Human Intervention Study of Egg Protein Derivative on Cardiovascular Risk", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Hypertension" ], "start_date": "2014-04", "last_update": "2017-05-03" }, { "nct_id": "NCT02225704", "title": "Radium-223 in Combination With Enzalutamide", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "2015-06-03", "last_update": "2026-04-13" }, { "nct_id": "NCT02230813", "title": "Predictors of Oral Antibiotic Treatment Failure in Emergency Department Patients With Cellulitis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cellulitis" ], "start_date": "2015-03", "last_update": "2017-01-26" }, { "nct_id": "NCT02230969", "title": "Plegridy Observational Program", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Relapsing Forms of Multiple Sclerosis" ], "start_date": "2014-11-12", "last_update": "2022-09-26" }, { "nct_id": "NCT02231749", "title": "Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Advanced Renal Cell Carcinoma", "Metastatic Renal Cell Carcinoma" ], "start_date": "2014-10-16", "last_update": "2026-05-27" }, { "nct_id": "NCT02232815", "title": "CELTIC Bifurcation Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "European Cardiovascular Research Center", "conditions": [ "Coronary Bifurcations" ], "start_date": "2014-12", "last_update": "2016-09-07" }, { "nct_id": "NCT02233699", "title": "A Study to Assess the Efficacy of XEN-D0501 in Reducing the Cough Frequency in Patients With Chronic Idiopathic Cough", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Xention Ltd", "conditions": [ "Chronic Idiopathic Cough" ], "start_date": "2014-07", "last_update": "2015-07-15" }, { "nct_id": "NCT02234310", "title": "Study to Determine the Safety and Efficacy of rFIXFc in Previously Untreated Males With Severe Hemophilia B", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ, a Sanofi company", "conditions": [ "Hemophilia B" ], "start_date": "2014-11-13", "last_update": "2022-03-25" }, { "nct_id": "NCT02234323", "title": "An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Previously Untreated Males With Severe Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ, a Sanofi company", "conditions": [ "Hemophilia A" ], "start_date": "2015-01-12", "last_update": "2022-04-11" }, { "nct_id": "NCT02234843", "title": "EINSTEIN Junior: Oral Rivaroxaban in Children With Venous Thrombosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Venous Thromboembolism" ], "start_date": "2014-11-13", "last_update": "2020-04-01" }, { "nct_id": "NCT02240680", "title": "Linagliptin as Add on to Basal Insulin in the Elderly", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2014-09-23", "last_update": "2018-07-03" }, { "nct_id": "NCT02241642", "title": "Safety and Performance Study of Large Hole Vascular Closure Device", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vivasure Medical Limited", "conditions": [ "Percutaneous Common Femoral Artery Arteriotomy Closure" ], "start_date": "2013-10", "last_update": "2018-02-01" }, { "nct_id": "NCT02242019", "title": "Study of Erchonia Low Level Laser Light Therapy to Treat Toenail Fungus", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Erchonia Corporation", "conditions": [ "Onychomycosis" ], "start_date": "2013-02", "last_update": "2016-05-17" }, { "nct_id": "NCT02246998", "title": "Renal Effect of Stribild or Other Tenofovir DF-containing Regimens Compared to Ritonavir-boosted Atazanavir Plus Abacavir/Lamivudine in Antiretroviral Treatment-naive HIV-1 Infected Adults", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "HIV-1 Infection" ], "start_date": "2014-12-15", "last_update": "2018-01-03" }, { "nct_id": "NCT02252172", "title": "Study Comparing Daratumumab, Lenalidomide, and Dexamethasone With Lenalidomide and Dexamethasone in Participants With Previously Untreated Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Multiple Myeloma" ], "start_date": "2015-02-16", "last_update": "2025-10-20" }, { "nct_id": "NCT02254278", "title": "Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "NRG Oncology", "conditions": [ "Stage III Oropharyngeal Squamous Cell Carcinoma", "Stage IVA Oropharyngeal Squamous Cell Carcinoma", "Stage IVB Oropharyngeal Squamous Cell Carcinoma", "Stage IVC Oropharyngeal Squamous Cell Carcinoma", "Tongue Carcinoma" ], "start_date": "2014-10", "last_update": "2026-05-22" }, { "nct_id": "NCT02254967", "title": "A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Clostridium Difficile" ], "start_date": "2014-11-06", "last_update": "2024-10-31" }, { "nct_id": "NCT02258464", "title": "Study of Radium-223 Dichloride Versus Placebo and Hormonal Treatment as Background Therapy in Subjects With Bone Predominant HER2 (Human Epidermal Growth Factor Receptor 2) Negative Hormone Receptor Positive Metastatic Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Breast Neoplasms" ], "start_date": "2015-03-02", "last_update": "2020-08-10" }, { "nct_id": "NCT02261467", "title": "A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Allergan", "conditions": [ "Forehead Rhytides", "Glabellar Rhytides" ], "start_date": "2014-10-21", "last_update": "2019-01-08" }, { "nct_id": "NCT02265770", "title": "An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Centre Leon Berard", "conditions": [ "Childhood Ependymoma" ], "start_date": "2015-06-02", "last_update": "2024-04-26" }, { "nct_id": "NCT02265978", "title": "CopeSmart: Using Mobile Technology to Promote Positive Mental Health in Young People", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "General Mental Health and Well-Being" ], "start_date": "2014-10", "last_update": "2015-07-10" }, { "nct_id": "NCT02266927", "title": "A Study to Compare the Bioavailability Intranasal Administration of 200 and 400 µg or 400 µg Alone of OPTINOSE™ FLUTICASONE With 440 µg of Flovent® HFA (Fluticasone Propionate) Inhalation Aerosol (Part 2)", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Optinose US Inc.", "conditions": [ "Mild to Moderate Asthma" ], "start_date": "2014-09", "last_update": "2016-02-03" }, { "nct_id": "NCT02268799", "title": "High Sensitivity Troponin T Levels Following DC Cardioversion for Atrial Fibrillation / Atrial Flutter", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Atrial Fibrillation", "Atrial Flutter" ], "start_date": "2014-10", "last_update": "2015-08-13" }, { "nct_id": "NCT02273232", "title": "Effects of Remote Ischemic Preconditioning on Moderate PVD Patients A Pilot Randomized Control Trial", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Peripheral Arterial Diseases" ], "start_date": "2015-01", "last_update": "2017-09-25" }, { "nct_id": "NCT02276339", "title": "Muscle Activation in Chronic Ankle Instability and the Effect of an Exercise Programme", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Ankle Injuries" ], "start_date": "2014-10", "last_update": "2015-12-03" }, { "nct_id": "NCT02285062", "title": "Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Lymphoma, Large B-Cell, Diffuse" ], "start_date": "2015-02-17", "last_update": "2023-06-22" }, { "nct_id": "NCT02294877", "title": "A Multicenter, Multinational, Observational Morquio A Registry Study (MARS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "BioMarin Pharmaceutical", "conditions": [ "Mucopolysaccharidosis IV Type A", "Morquio A Syndrome", "MPS IVA" ], "start_date": "2014-09", "last_update": "2024-03-05" }, { "nct_id": "NCT02296138", "title": "Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2015-01-13", "last_update": "2018-06-04" }, { "nct_id": "NCT02301442", "title": "Step it Up: An Exercise and Behaviour Change Programme for People With Multiple Sclerosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Multiple Sclerosis" ], "start_date": "2014-09", "last_update": "2016-05-13" }, { "nct_id": "NCT02304484", "title": "Open-label Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Hypercholesterolemia" ], "start_date": "2014-11-24", "last_update": "2019-03-19" }, { "nct_id": "NCT02306291", "title": "Study to Determine Safety, Pharmacokinetics and Efficacy of GMI-1271 in Combination With Chemotherapy in AML", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlycoMimetics Incorporated", "conditions": [ "Leukemia, Myeloid, Acute" ], "start_date": "2015-03", "last_update": "2019-05-17" }, { "nct_id": "NCT02307669", "title": "Inhaler Adherence in Severe Unstable Asthma", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Asthma" ], "start_date": "2015-12", "last_update": "2019-08-16" }, { "nct_id": "NCT02308085", "title": "Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Early Breast Cancer" ], "start_date": "2014-12-04", "last_update": "2026-02-09" }, { "nct_id": "NCT02308527", "title": "Activity Study of Bevacizumab With Temozolomide ± Irinotecan for Neuroblastoma in Children", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Birmingham", "conditions": [ "Neuroblastoma" ], "start_date": "2013-07", "last_update": "2026-05-12" }, { "nct_id": "NCT02310945", "title": "Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Knee Osteoarthritis" ], "start_date": "2014-06", "last_update": "2014-12-08" }, { "nct_id": "NCT02313909", "title": "Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Stroke" ], "start_date": "2014-12-23", "last_update": "2019-01-09" }, { "nct_id": "NCT02314325", "title": "Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Severe Haemophilia A" ], "start_date": "2014-04", "last_update": "2014-12-11" }, { "nct_id": "NCT02320084", "title": "Long Term Safety Study of Orfadin Treatment in HT-1 Patients in Standard Clinical Care", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hereditary Tyrosinemia, Type I" ], "start_date": "2013-09", "last_update": "2024-09-19" }, { "nct_id": "NCT02320773", "title": "A Prospective Non-interventional Study in Overactive Bladder (OAB) Patients Prescribed Betmiga® as Part of Routine Clinical Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Urgency Incontinence", "Urinary Bladder Overactive", "Overactive Bladder", "Urologic Diseases", "Urinary Bladder Diseases" ], "start_date": "2014-11-25", "last_update": "2024-10-31" }, { "nct_id": "NCT02322099", "title": "Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "University College Dublin", "conditions": [ "Bone Demineralization" ], "start_date": "2016-05", "last_update": "2022-05-26" }, { "nct_id": "NCT02328131", "title": "European Registry on the Management of Helicobacter Pylori Infection", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Javier P. Gisbert", "conditions": [ "H. Pylori Infection" ], "start_date": "2013-06", "last_update": "2024-10-02" }, { "nct_id": "NCT02331485", "title": "Randomised Control Study to Asses the Role of Negative Pressure Wound Therapy (NPWT) in the Management of Wound in Surgical Patient", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St James Connolly Memorial Hospital", "conditions": [ "Wound Infection", "Wound Complication" ], "start_date": "2014-08", "last_update": "2015-01-06" }, { "nct_id": "NCT02343198", "title": "The Use of NMES as a Home-based Therapy Following Total Knee Arthroplasty", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Venous Thrombosis" ], "start_date": "2014-08", "last_update": "2015-08-24" }, { "nct_id": "NCT02343406", "title": "Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Glioblastoma" ], "start_date": "2015-02-17", "last_update": "2020-05-22" }, { "nct_id": "NCT02347501", "title": "Dipeptidyl Peptidase-4 Inhibition and Narrow-band Ultraviolet-B Light in Psoriasis (DINUP)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Psoriasis" ], "start_date": "2013-11", "last_update": "2017-04-28" }, { "nct_id": "NCT02347657", "title": "A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2015-01", "last_update": "2018-06-12" }, { "nct_id": "NCT02350920", "title": "Acceptance and Commitment Therapy (ACT) in Inflammatory Bowel Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Inflammatory Bowel Disease" ], "start_date": "2015-06", "last_update": "2018-10-15" }, { "nct_id": "NCT02351063", "title": "HF Assessment With BNP in the Home: Part II", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Alere San Diego", "conditions": [ "Heart Failure" ], "start_date": "2014-04", "last_update": "2024-01-03" }, { "nct_id": "NCT02351596", "title": "Do Core Stability Exercise Classes Help Children With Cerebral Palsy Improve Their Balance", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cerebral Palsy" ], "start_date": "2014-08", "last_update": "2015-02-04" }, { "nct_id": "NCT02355444", "title": "Effects of Blackberry-derived Polyphenols on Cardiovascular Risk in Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Hypertension" ], "start_date": "2015-05", "last_update": "2017-02-27" }, { "nct_id": "NCT02356081", "title": "eSMART Trial to Evaluate ASyMS", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Louise McKean", "conditions": [ "Cancer" ], "start_date": "2015-02", "last_update": "2021-05-26" }, { "nct_id": "NCT02360813", "title": "Cognitive Remediation Therapy Within a Secure Forensic Setting", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Central Mental Hospital", "conditions": [ "Schizophrenia", "Schizoaffective Disorder", "Cognitive Deficits" ], "start_date": "2014-08", "last_update": "2017-07-25" }, { "nct_id": "NCT02362503", "title": "Attachment Inhibitor Comparison in Heavily Treatment Experienced Patients", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ViiV Healthcare", "conditions": [ "HIV Infections" ], "start_date": "2015-02-23", "last_update": "2026-08-21" }, { "nct_id": "NCT02367040", "title": "Copanlisib and Rituximab in Relapsed Indolent B-cell Non-Hodgkin's Lymphoma (iNHL)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Lymphoma,Non-Hodgkin" ], "start_date": "2015-08-03", "last_update": "2025-10-14" }, { "nct_id": "NCT02371694", "title": "What is the Dose Response of Varying Meal Content of Fat on Postprandial Glycaemia in Children With T1DM?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Diabetes Mellitus, Type 1" ], "start_date": "2015-02", "last_update": "2019-08-20" }, { "nct_id": "NCT02374502", "title": "Increasing Physical Activity in Ankylosing Spondylitis: a Randomised Controlled Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Spondylitis, Ankylosing" ], "start_date": "2015-03", "last_update": "2016-03-09" }, { "nct_id": "NCT02375204", "title": "Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alliance for Clinical Trials in Oncology", "conditions": [ "Germ Cell Tumor", "Teratoma", "Choriocarcinoma", "Germinoma", "Mixed Germ Cell Tumor", "Yolk Sac Tumor", "Childhood Teratoma", "Malignant Germ Cell Neoplasm", "Extragonadal Seminoma", "Non-seminomatous Germ Cell Tumor", "Seminoma" ], "start_date": "2015-08-06", "last_update": "2026-06-16" }, { "nct_id": "NCT02381249", "title": "The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Neoplasms", "Stomach Neoplasms", "Weight Loss", "Malnutrition", "Pancreatic Neoplasms", "Duodenal Neoplasms" ], "start_date": "2015-03", "last_update": "2023-11-27" }, { "nct_id": "NCT02381457", "title": "SNP-based Microdeletion and Aneuploidy RegisTry (SMART)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Natera, Inc.", "conditions": [ "22q11 Deletion Syndrome", "DiGeorge Syndrome", "Trisomy 21", "Trisomy 18", "Trisomy 13", "Monosomy X", "Sex Chromosome Abnormalities", "Cri-du-Chat Syndrome", "Angelman Syndrome", "Prader-Willi Syndrome", "1p36 Deletion Syndrome" ], "start_date": "2015-04", "last_update": "2021-01-29" }, { "nct_id": "NCT02382770", "title": "International Register of Open Abdomen", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "A.O. Ospedale Papa Giovanni XXIII", "conditions": [ "Open Abdomen Procedure" ], "start_date": "2015-02", "last_update": "2017-01-27" }, { "nct_id": "NCT02385604", "title": "The Predictive Value of CT-PET in Esophageal Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Neoplasms" ], "start_date": "2014-01", "last_update": "2016-03-10" }, { "nct_id": "NCT02385617", "title": "Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Neoplasms", "Stomach Neoplasms", "Weight Loss", "Malnutrition" ], "start_date": "2014-01", "last_update": "2023-11-27" }, { "nct_id": "NCT02385630", "title": "Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Neoplasms", "Stomach Neoplasms", "Weight Loss", "Malnutrition" ], "start_date": "2015-03", "last_update": "2021-08-18" }, { "nct_id": "NCT02388906", "title": "Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2015-03-16", "last_update": "2025-04-24" }, { "nct_id": "NCT02389933", "title": "Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)", "phases": [], "overall_status": "NO_LONGER_AVAILABLE", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Heart Failure With Reduced Ejection Fraction (HF-rEF)" ], "start_date": "", "last_update": "2021-02-15" }, { "nct_id": "NCT02398656", "title": "A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Calgary", "conditions": [ "Stroke, Acute" ], "start_date": "2015-04-01", "last_update": "2025-01-31" }, { "nct_id": "NCT02400229", "title": "Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Charite University, Berlin, Germany", "conditions": [ "Coronary Artery Disease" ], "start_date": "2015-10-03", "last_update": "2025-02-12" }, { "nct_id": "NCT02404350", "title": "Study to Demonstrate the Efficacy (Including Inhibition of Structural Damage), Safety and Tolerability up to 2 Years of Secukinumab in Active Psoriatic Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Psoriatic Arthritis" ], "start_date": "2015-08-31", "last_update": "2020-04-20" }, { "nct_id": "NCT02404662", "title": "Trial of Supportive Text Messages for Patients With Alcohol Use Disorder and a Co-morbid Depression", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Dual Diagnosis" ], "start_date": "2015-03", "last_update": "2017-10-05" }, { "nct_id": "NCT02405975", "title": "RCT Assessing the Impact of Online Training on Doctors' Prescribing for Older Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Appropriateness of Prescribing in Older Patients" ], "start_date": "2014-08", "last_update": "2015-04-08" }, { "nct_id": "NCT02406131", "title": "Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Peripheral Vascular Diseases" ], "start_date": "2018-04", "last_update": "2017-09-26" }, { "nct_id": "NCT02409368", "title": "An Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) Monotherapy in Subjects With Advanced or Metastatic Squamous Cell (Sq) Non-Small Cell Lung Cancer (NSCLC) Who Have Received at Least One Prior Systemic Regimen for the Treatment of Stage IIIb/IV SqNSCLC", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2015-04-29", "last_update": "2022-11-14" }, { "nct_id": "NCT02412111", "title": "A Phase 3 Study of Tezacaftor (VX-661) in Combination With Ivacaftor (VX-770) in Subjects Aged 12 Years and Older With Cystic Fibrosis (CF), Who Have One F508del-CFTR Mutation and a Second Mutation That Has Been Demonstrated to be Clinically Responsive to Ivacaftor", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2015-06", "last_update": "2019-01-08" }, { "nct_id": "NCT02414932", "title": "Ketamine for Depression Relapse Prevention Following ECT", "phases": [ "EARLY_PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Depression" ], "start_date": "2015-04", "last_update": "2021-05-06" }, { "nct_id": "NCT02415634", "title": "REhabilitation After Critical Illness Assisted Discharge Pack (RECAP)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Maire Gilmartin", "conditions": [ "Critical Illness" ], "start_date": "2014-11", "last_update": "2015-11-17" }, { "nct_id": "NCT02419872", "title": "Study in Patients' With Persistent Asthma and Chronic Obstructive Pulmonary Disease", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Teva Pharmaceuticals Europe", "conditions": [ "Asthma", "Chronic Obstructive Pulmonary Disease" ], "start_date": "2015-05-31", "last_update": "2017-11-07" }, { "nct_id": "NCT02423421", "title": "Faecal Microbiota Transplantation in Irritable Bowel Syndrome", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Irritable Bowel Syndrome" ], "start_date": "2015-03", "last_update": "2015-04-22" }, { "nct_id": "NCT02431780", "title": "A Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Seizures", "Brain Diseases", "Central Nervous System Diseases", "Epilepsy", "Nervous System Diseases", "Neurologic Manifestations" ], "start_date": "2015-02-12", "last_update": "2023-12-11" }, { "nct_id": "NCT02433106", "title": "The Effects of an Exercise Programme on Neuromuscular Outcomes in Gaelic Sport", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dr Ulrik McCarthy Persson", "conditions": [ "Focus of Study is Effects of Neuromuscular Training" ], "start_date": "2012-09", "last_update": "2015-05-04" }, { "nct_id": "NCT02435173", "title": "Study of Efficacy of CDZ173 in Patients With APDS/PASLI", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Common Variable Immunodeficiency (CVID), APDS / PASLI" ], "start_date": "2015-08-24", "last_update": "2022-08-10" }, { "nct_id": "NCT02436655", "title": "Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Clinical Centre of Serbia", "conditions": [ "Aortic Stenosis" ], "start_date": "2015-06", "last_update": "2022-01-12" }, { "nct_id": "NCT02437942", "title": "Anatomical, Radiological and Biomechanical Examination of Athletic Groin Pain Patients and Physical Therapy Intervention", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "Groin Pain" ], "start_date": "2015-04", "last_update": "2024-04-22" }, { "nct_id": "NCT02439749", "title": "SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases" ], "start_date": "2015-06", "last_update": "2025-03-28" }, { "nct_id": "NCT02439775", "title": "SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases" ], "start_date": "2015-07-22", "last_update": "2026-07-30" }, { "nct_id": "NCT02440971", "title": "Adaptive Servo Ventilation (ASV) in Heart Failure", "phases": [], "overall_status": "SUSPENDED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Acute Decompensated Heart Failure", "Sleep Disordered Breathing" ], "start_date": "2013-05", "last_update": "2018-07-26" }, { "nct_id": "NCT02443155", "title": "A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2015-11-10", "last_update": "2021-04-09" }, { "nct_id": "NCT02443428", "title": "Eribulin Use for the Treatment of Advanced Breast Cancer: A Prospective Observational Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Limited", "conditions": [ "Breast Cancer" ], "start_date": "2013-08", "last_update": "2016-04-15" }, { "nct_id": "NCT02446405", "title": "Enzalutamide in First Line Androgen Deprivation Therapy for Metastatic Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Sydney", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2014-03", "last_update": "2025-02-06" }, { "nct_id": "NCT02446444", "title": "Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Sydney", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2014-03", "last_update": "2026-05-06" }, { "nct_id": "NCT02447081", "title": "Amplatzer™Amulet™ Post-Market Study (Amulet™PMS)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Atrial Fibrillation", "Thromboembolism", "Stroke" ], "start_date": "2015-06-01", "last_update": "2019-12-30" }, { "nct_id": "NCT02447172", "title": "Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Innocoll", "conditions": [ "Foot Ulcer, Diabetic", "Infection" ], "start_date": "2015-06", "last_update": "2021-09-29" }, { "nct_id": "NCT02447666", "title": "Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Myelodysplastic Syndrome", "Leukemia, Myelomonocytic, Juvenile" ], "start_date": "2015-09-15", "last_update": "2019-07-11" }, { "nct_id": "NCT02449200", "title": "RCT of Multimodal Physiotherapy for Acute / Sub-acute Cervical Radiculopathy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cervical Radiculopathy" ], "start_date": "2015-05", "last_update": "2019-03-28" }, { "nct_id": "NCT02453139", "title": "Exercise, Prostate Cancer and Circulating Tumour Cells", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Prostate Cancer", "Obesity" ], "start_date": "2014-10", "last_update": "2018-05-02" }, { "nct_id": "NCT02458248", "title": "Sodium Intake in Chronic Kidney Disease (STICK)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Kidney Diseases", "Renal Insufficiency, Chronic", "Renal Insufficiency" ], "start_date": "2016-03", "last_update": "2021-04-28" }, { "nct_id": "NCT02458638", "title": "A Study of Atezolizumab in Advanced Solid Tumors", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Tumors" ], "start_date": "2015-07-16", "last_update": "2021-06-04" }, { "nct_id": "NCT02459405", "title": "Decreasing Leak Rate in Colorectal Surgery Using Near Infra-red (NIR) Imaging", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital, Geneva", "conditions": [ "Anastomotic Leak" ], "start_date": "2013-03", "last_update": "2021-05-04" }, { "nct_id": "NCT02461225", "title": "Study of Low Level Laser Therapy to Treat Diabetic Peripheral Neuropathy Foot Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Erchonia Corporation", "conditions": [ "Diabetic Peripheral Neuropathy" ], "start_date": "2016-03-01", "last_update": "2022-03-15" }, { "nct_id": "NCT02461485", "title": "Effect of a Fermented Milk Product With Probiotics Alone or in Combination With Fibers on Constipation Symptoms", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Danone Global Research & Innovation Center", "conditions": [ "Healthy", "Constipation" ], "start_date": "2015-05", "last_update": "2017-08-22" }, { "nct_id": "NCT02463864", "title": "A Twice-Daily Individual Targeted Exercise Program in Frail Hospitalised Older Medical In-patients (RCT)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Frail Older Adults" ], "start_date": "2015-03", "last_update": "2017-11-17" }, { "nct_id": "NCT02463916", "title": "A Trial to Determine the Effects of Exercise in Inflammatory Bowel Disease and Rheumatoid Arthritis", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Inflammatory Bowel Disease", "Rheumatoid Arthritis" ], "start_date": "2015-03", "last_update": "2015-06-04" }, { "nct_id": "NCT02469246", "title": "Switch Study to Evaluate F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed on Regimens Containing ABC/3TC", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "HIV-1 Infection" ], "start_date": "2015-06-29", "last_update": "2019-10-25" }, { "nct_id": "NCT02469740", "title": "Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Myocardial Ischemia", "Coronary Artery Disease", "Endothelial Dysfunction" ], "start_date": "2015-07", "last_update": "2016-03-11" }, { "nct_id": "NCT02474355", "title": "Real World Treatment Study of AZD9291 for Advanced/Metastatic EGFR T790M Mutation NSCLC", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Lung Cancer" ], "start_date": "2015-09-18", "last_update": "2021-11-11" }, { "nct_id": "NCT02475525", "title": "Oral Nutritional Supplement in Reducing Surgical Site Infections", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Limerick", "conditions": [ "Peripheral Vascular Disease", "Claudication" ], "start_date": "2015-06", "last_update": "2018-05-04" }, { "nct_id": "NCT02477111", "title": "European (EU) Post Approval Study of the INCRAFT® AAA Stent Graft System in Subjects With Abdominal Aortic Aneurysms", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cordis US Corp.", "conditions": [ "Abdominal Aortic Aneurysms" ], "start_date": "2015-03-30", "last_update": "2024-04-09" }, { "nct_id": "NCT02477826", "title": "An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2015-08-05", "last_update": "2025-10-30" }, { "nct_id": "NCT02485691", "title": "Cabazitaxel Versus the Switch to Alternative AR-targeted Agent (Enzalutamide or Abiraterone) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients Previously Treated With Docetaxel and Who Rapidly Failed a Prior AR-targeted Agent", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Prostate Cancer Metastatic" ], "start_date": "2015-11-09", "last_update": "2022-05-27" }, { "nct_id": "NCT02487407", "title": "Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Orion Corporation, Orion Pharma", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2015-07", "last_update": "2017-11-28" }, { "nct_id": "NCT02488915", "title": "Analysis of Revascularization in Ischemic Stroke With EmboTrap", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neuravi Inc.", "conditions": [ "Stroke", "Ischemia" ], "start_date": "2015-11", "last_update": "2018-07-13" }, { "nct_id": "NCT02492815", "title": "PAN-EU Utilization, Effectiveness and Safety of Ipilimumab Administered in EAP Patients With Advanced Melanoma", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2013-10-31", "last_update": "2019-01-30" }, { "nct_id": "NCT02495974", "title": "European Observational Study of Enzalutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Astellas Pharma Europe Ltd.", "conditions": [ "Metastatic Castration Resistant Prostate Cancer" ], "start_date": "2015-09-08", "last_update": "2024-10-21" }, { "nct_id": "NCT02496767", "title": "Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2015-09-03", "last_update": "2020-09-09" }, { "nct_id": "NCT02499484", "title": "Topical Glyceryl Trinitrate (GTN) and Eccentric Exercises in the Treatment of Midportion Achilles Tendinopathy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Tendinopathy", "Achilles Tendon Pain" ], "start_date": "2016-09", "last_update": "2019-06-06" }, { "nct_id": "NCT02499900", "title": "Study to Assess Medication Satisfaction in Patients With Relapsing Remitting Multiple Sclerosis Treated With Copaxone®", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Teva Branded Pharmaceutical Products R&D, Inc.", "conditions": [ "Multiple Sclerosis" ], "start_date": "2015-08-10", "last_update": "2021-12-09" }, { "nct_id": "NCT02500043", "title": "Study of TAS-102 or Placebo Plus BSC in Patients With Metastatic Gastric Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Taiho Oncology, Inc.", "conditions": [ "Refractory Metastatic Gastric Cancer" ], "start_date": "2016-02-24", "last_update": "2024-09-03" }, { "nct_id": "NCT02500342", "title": "Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Insel Gruppe AG, University Hospital Bern", "conditions": [ "Thyroid Dysfunction", "Mental Fatigue", "Fatigue" ], "start_date": "2014-01", "last_update": "2019-03-29" }, { "nct_id": "NCT02500381", "title": "Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Sarepta Therapeutics, Inc.", "conditions": [ "Duchenne Muscular Dystrophy" ], "start_date": "2016-09-28", "last_update": "2025-11-18" }, { "nct_id": "NCT02506153", "title": "Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "Clinical Stage III Cutaneous Melanoma AJCC v8", "Clinical Stage IV Cutaneous Melanoma AJCC v8", "Metastatic Cutaneous Melanoma", "Metastatic Mucosal Melanoma", "Metastatic Non-Cutaneous Melanoma", "Non-Cutaneous Melanoma", "Recurrent Cutaneous Melanoma", "Recurrent Mucosal Melanoma", "Recurrent Non-Cutaneous Melanoma" ], "start_date": "2015-11-10", "last_update": "2026-10-01" }, { "nct_id": "NCT02506439", "title": "Nutritional Requirements for Vitamin D in Pregnant Women", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2014-11-01", "last_update": "2024-11-19" }, { "nct_id": "NCT02508922", "title": "Trial of Vitamin D3 Supplementation in Paediatric Autism", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Autism" ], "start_date": "2015-09", "last_update": "2016-10-25" }, { "nct_id": "NCT02513394", "title": "PALbociclib CoLlaborative Adjuvant Study", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alliance Foundation Trials, LLC.", "conditions": [ "Breast Cancer" ], "start_date": "2015-08", "last_update": "2026-06-15" }, { "nct_id": "NCT02515071", "title": "A 2 Week, Crossover Trial of Dietary Nitrate in Obstructive Sleep Apnoea Syndrome (OSAS).", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Obstructive Sleep Apnoea Syndrome" ], "start_date": "2015-01", "last_update": "2015-10-23" }, { "nct_id": "NCT02520128", "title": "A Study of IMRT in Primary Bone and Soft Tissue Sarcoma", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College, London", "conditions": [ "Soft Tissue Sarcoma, Adult", "Ewing Sarcoma", "Bone Sarcoma", "Chordoma" ], "start_date": "2016-03", "last_update": "2020-12-02" }, { "nct_id": "NCT02520284", "title": "Safety and Efficacy of Andecaliximab (GS-5745) in Adults With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Ulcerative Colitis" ], "start_date": "2015-09", "last_update": "2019-04-10" }, { "nct_id": "NCT02521532", "title": "A 2 Week, Crossover Trial of Dietary Nitrate in Chronic Obstructive Pulmonary Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2015-01", "last_update": "2015-10-23" }, { "nct_id": "NCT02522390", "title": "The Nutrition Researcher Cohort 2014 Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "TNO", "conditions": [ "Nutritional Physiological Phenomena", "Health", "Biological Markers" ], "start_date": "2015-01", "last_update": "2017-04-26" }, { "nct_id": "NCT02525523", "title": "Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantic Pharmaceuticals Ltd", "conditions": [ "Pouchitis" ], "start_date": "2015-12-03", "last_update": "2020-02-25" }, { "nct_id": "NCT02526004", "title": "Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Cystic Fibrosis" ], "start_date": "2013-10-01", "last_update": "2025-04-10" }, { "nct_id": "NCT02526160", "title": "Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Kyowa Kirin, Inc.", "conditions": [ "X-linked Hypophosphatemia" ], "start_date": "2015-10-22", "last_update": "2024-06-18" }, { "nct_id": "NCT02527317", "title": "Dose Dense Chemotherapy With Lipegfilgrastim Support in Early Breast Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Breast Cancer" ], "start_date": "2015-01", "last_update": "2018-02-09" }, { "nct_id": "NCT02535546", "title": "Seasonal Trends in Pneumococcal Carriage in COPD Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2014-07", "last_update": "2017-02-01" }, { "nct_id": "NCT02538666", "title": "An Investigational Immuno-therapy Study of Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Lung Cancer" ], "start_date": "2015-10-13", "last_update": "2023-01-05" }, { "nct_id": "NCT02540993", "title": "Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Chronic Kidney Disease" ], "start_date": "2015-09-17", "last_update": "2023-07-24" }, { "nct_id": "NCT02545049", "title": "Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Diabetic Kidney Disease" ], "start_date": "2015-09-17", "last_update": "2022-04-15" }, { "nct_id": "NCT02549651", "title": "MEDI4736 Alone and in Combination With Tremelimumab or AZD9150 in Adult Subjects With Relapsed/Refractory DLBCL (D4190C00023)", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "MedImmune LLC", "conditions": [ "Diffuse Large B-Cell Lymphoma" ], "start_date": "2016-07-13", "last_update": "2019-02-27" }, { "nct_id": "NCT02552472", "title": "A Study of Inhaler Use in the Community", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Asthma", "Chronic Obstructive Pulmonary Disease", "Airways Disease" ], "start_date": "2012-08", "last_update": "2016-01-12" }, { "nct_id": "NCT02554786", "title": "A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Participants With Asthma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Asthma" ], "start_date": "2015-12-29", "last_update": "2020-03-05" }, { "nct_id": "NCT02555683", "title": "Efficacy and Safety Study of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Asthma" ], "start_date": "2015-12-11", "last_update": "2026-10-07" }, { "nct_id": "NCT02556450", "title": "Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ACS Biomarker", "conditions": [ "Heart Failure" ], "start_date": "2016-01", "last_update": "2022-03-08" }, { "nct_id": "NCT02558231", "title": "The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Actelion", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2016-05-01", "last_update": "2025-03-30" }, { "nct_id": "NCT02562443", "title": "Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Traws Pharma, Inc.", "conditions": [ "Myelodysplastic Syndrome", "MDS", "Refractory Anemia With Excess Blasts", "RAEB" ], "start_date": "2015-12-02", "last_update": "2022-09-26" }, { "nct_id": "NCT02565914", "title": "A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2015-08", "last_update": "2023-09-28" }, { "nct_id": "NCT02568332", "title": "A Study to Assess the Safety of Hep C Vaccine Candidates in HIV Seropositive Individuals", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Oxford", "conditions": [ "Hepatitis C Infection" ], "start_date": "2015-07-21", "last_update": "2018-10-11" }, { "nct_id": "NCT02568722", "title": "Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Unity Health Toronto", "conditions": [ "Acute Kidney Injury" ], "start_date": "2015-10", "last_update": "2024-10-18" }, { "nct_id": "NCT02570048", "title": "1 Tinnitus Alleviation Via Sensory Substitution", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "MuteButton", "conditions": [ "Tinnitus" ], "start_date": "2012-06", "last_update": "2015-10-07" }, { "nct_id": "NCT02570685", "title": "Psychosocial Benefits of Gratitude Journals", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Happiness" ], "start_date": "2015-10", "last_update": "2016-03-02" }, { "nct_id": "NCT02571777", "title": "Study to Compare the Efficacy and Safety of QVM149 With QMF149 in Patients With Asthma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Asthma" ], "start_date": "2015-12-08", "last_update": "2020-07-22" }, { "nct_id": "NCT02573324", "title": "A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Glioblastoma", "Gliosarcoma" ], "start_date": "2015-01-04", "last_update": "2023-05-11" }, { "nct_id": "NCT02576431", "title": "A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Solid Tumors Harboring NTRK Fusion" ], "start_date": "2015-09-30", "last_update": "2026-07-01" }, { "nct_id": "NCT02576574", "title": "Avelumab in First-line NSCLC (JAVELIN Lung 100)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "EMD Serono Research & Development Institute, Inc.", "conditions": [ "First Line Non-Small Cell Lung Cancer" ], "start_date": "2015-10-29", "last_update": "2025-01-31" }, { "nct_id": "NCT02580058", "title": "A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pfizer", "conditions": [ "Ovarian Cancer" ], "start_date": "2015-12-21", "last_update": "2023-07-10" }, { "nct_id": "NCT02580591", "title": "Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 1" ], "start_date": "2015-12-22", "last_update": "2018-11-02" }, { "nct_id": "NCT02583347", "title": "Sleep Disturbance in Patients With End-Stage Renal Disease", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Renal Failure Chronic Requiring Hemodialysis", "Sleep Disorders" ], "start_date": "2015-12", "last_update": "2017-08-28" }, { "nct_id": "NCT02585622", "title": "NEPHSTROM for Diabetic Kidney Disease", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Mario Negri Institute for Pharmacological Research", "conditions": [ "Diabetic Kidney Disease" ], "start_date": "2017-12-11", "last_update": "2024-11-29" }, { "nct_id": "NCT02586259", "title": "Effectiveness of Cortiment® in Patients With Ulcerative Colitis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Ferring Pharmaceuticals", "conditions": [ "Ulcerative Colitis" ], "start_date": "2015-12", "last_update": "2019-11-20" }, { "nct_id": "NCT02597933", "title": "A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Scleroderma, Systemic" ], "start_date": "2015-11-12", "last_update": "2019-12-13" }, { "nct_id": "NCT02599402", "title": "Nivolumab Combined With Ipilimumab Followed by Nivolumab Monotherapy as First-Line Treatment for Patients With Advanced Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2015-12-20", "last_update": "2021-06-15" }, { "nct_id": "NCT02601599", "title": "Medical Student INtervention to Promote Effective Nicotine Dependence and Tobacco HEalthcare", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Smoking" ], "start_date": "2015-11", "last_update": "2017-03-10" }, { "nct_id": "NCT02610777", "title": "An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Millennium Pharmaceuticals, Inc.", "conditions": [ "Myelodysplastic Syndromes", "Leukemia, Myelomonocytic, Chronic", "Leukemia, Myeloid, Acute" ], "start_date": "2016-04-14", "last_update": "2022-09-19" }, { "nct_id": "NCT02611674", "title": "Methodology Study of Novel Outcome Measures to Assess Progression of ALS", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2016-01-06", "last_update": "2019-10-24" }, { "nct_id": "NCT02612428", "title": "Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Vital Therapies, Inc.", "conditions": [ "Acute Alcoholic Hepatitis" ], "start_date": "2016-01", "last_update": "2019-01-25" }, { "nct_id": "NCT02613962", "title": "Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Gustave Roussy, Cancer Campus, Grand Paris", "conditions": [ "Relapsed or Refractory Pediatric Tumor" ], "start_date": "2016-01-13", "last_update": "2026-04-01" }, { "nct_id": "NCT02620280", "title": "Neoadjuvant Therapy in TRIPle Negative Breast Cancer With antiPDL1", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Fondazione Michelangelo", "conditions": [ "Invasive Ductal Breast Carcinoma" ], "start_date": "2016-04", "last_update": "2024-03-06" }, { "nct_id": "NCT02621528", "title": "Lifetech CeraFlex™ Post-Market Surveillance Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Lifetech Scientific (Shenzhen) Co., Ltd.", "conditions": [ "Patent Foramen Ovale", "Atrial Septal Defect", "Patent Ductus Arteriosus" ], "start_date": "2015-10", "last_update": "2020-03-13" }, { "nct_id": "NCT02623387", "title": "Ultrasound Guided Versus Standard Paravertebral Blockade in Breast Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Regional Anaesthesia", "Mastectomy", "Breast-Conserving Surgery" ], "start_date": "2015-06", "last_update": "2015-12-07" }, { "nct_id": "NCT02626455", "title": "Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Lymphoma, Non-Hodgkin" ], "start_date": "2016-01-06", "last_update": "2024-12-11" }, { "nct_id": "NCT02628652", "title": "Study to Evaluate the Tolerability of Prebiotics on the Microbiota", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Kaleido Biosciences", "conditions": [ "Healthy" ], "start_date": "2015-10", "last_update": "2016-02-24" }, { "nct_id": "NCT02629159", "title": "A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2015-12-01", "last_update": "2025-08-05" }, { "nct_id": "NCT02631876", "title": "A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ImmunoGen, Inc.", "conditions": [ "Epithelial Ovarian Cancer", "Primary Peritoneal Carcinoma", "Fallopian Tube Cancer", "Ovarian Cancer" ], "start_date": "2016-03-02", "last_update": "2020-10-14" }, { "nct_id": "NCT02632136", "title": "Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mayo General Hospital, Ireland", "conditions": [ "Laparoscopic TAP Block in TEP Inguinal Hernia Repair." ], "start_date": "2015-11", "last_update": "2015-12-16" }, { "nct_id": "NCT02632409", "title": "An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Various Advanced Cancer" ], "start_date": "2016-03-22", "last_update": "2026-07-30" }, { "nct_id": "NCT02635776", "title": "Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization in Children and Adults (PALISADE)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Aimmune Therapeutics, Inc.", "conditions": [ "Peanut Allergy" ], "start_date": "2015-12-22", "last_update": "2022-03-17" }, { "nct_id": "NCT02636699", "title": "Efficacy and Safety of Viaskin Peanut in Children With Immunoglobulin E (IgE)-Mediated Peanut Allergy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "DBV Technologies", "conditions": [ "Peanut Allergy" ], "start_date": "2015-12", "last_update": "2025-06-18" }, { "nct_id": "NCT02636868", "title": "The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Windtree Therapeutics", "conditions": [ "Respiratory Distress Syndrome" ], "start_date": "2015-12", "last_update": "2021-04-23" }, { "nct_id": "NCT02637440", "title": "The Use Of FFR Guided PCI Versus Complete Revascularization and Treatment Of Infarct Related Artery Only In Patients With STEMI", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Limerick", "conditions": [ "Multivessel Coronary Artery Disease", "STEMI", "FFR Guided PCI" ], "start_date": "2015-12", "last_update": "2015-12-23" }, { "nct_id": "NCT02637687", "title": "A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bayer", "conditions": [ "Solid Tumors Harboring NTRK Fusion" ], "start_date": "2015-12-16", "last_update": "2025-06-22" }, { "nct_id": "NCT02644772", "title": "Preventing Repeat Hospitalisations in Patients With Chronic Obstructive Pulmonary Disease (COPD)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2015-10", "last_update": "2019-07-18" }, { "nct_id": "NCT02648204", "title": "Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2016-01-06", "last_update": "2019-10-15" }, { "nct_id": "NCT02651987", "title": "Efficacy and Safety Study in Pancreatic or Midgut Neuroendocrine Tumours Having Progressed Radiologically While Previously Treated With Lanreotide Autogel® 120 mg", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Ipsen", "conditions": [ "Pancreatic Tumours", "Midgut Neuroendocrine Tumours" ], "start_date": "2015-12-15", "last_update": "2022-10-03" }, { "nct_id": "NCT02654470", "title": "Watchman FLX Left Atrial Appendage Closure Device Post Approval Study ( Europe Only)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Non-valvular Atrial Fibrillation" ], "start_date": "2019-07-16", "last_update": "2021-11-19" }, { "nct_id": "NCT02655016", "title": "A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Tesaro, Inc.", "conditions": [ "Ovarian Neoplasms" ], "start_date": "2016-07-11", "last_update": "2026-03-10" }, { "nct_id": "NCT02655887", "title": "BARD® The VENOVO™ Venous Stent Study for Treatment of Iliofemoral Occlusive Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "C. R. Bard", "conditions": [ "May-Thurner Syndrome", "Peripheral Vascular Disease", "Venous Disease", "Iliofemoral Occlusive Disease" ], "start_date": "2016-06-15", "last_update": "2021-02-04" }, { "nct_id": "NCT02657434", "title": "A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2016-04-30", "last_update": "2023-11-21" }, { "nct_id": "NCT02659761", "title": "Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "University College Dublin", "conditions": [ "Human Immunodeficiency Virus" ], "start_date": "2016-11", "last_update": "2024-05-09" }, { "nct_id": "NCT02661061", "title": "Ketamine for Relapse Prevention in Recurrent Depressive Disorder", "phases": [ "PHASE1" ], "overall_status": "TERMINATED", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Depression", "Relapse", "Recurrent Depressive Disorder", "Major Depressive Disorder" ], "start_date": "2015-12", "last_update": "2020-01-13" }, { "nct_id": "NCT02662985", "title": "Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Psoriatic Arthritis" ], "start_date": "2016-08-22", "last_update": "2021-12-07" }, { "nct_id": "NCT02664584", "title": "The Trinity, Ulster and Department of Agriculture Cohort Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Ulster", "conditions": [ "Cardiovascular Disease", "Osteoporosis", "Alzheimer's Disease", "Hypertension" ], "start_date": "2008-12", "last_update": "2016-01-27" }, { "nct_id": "NCT02669069", "title": "Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neuromod Devices Ltd.", "conditions": [ "Tinnitus" ], "start_date": "2016-06-27", "last_update": "2024-12-20" }, { "nct_id": "NCT02673593", "title": "Safety and Efficacy Study of Orally Administered DS102 in Healthy Subjects", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "DS Biopharma", "conditions": [ "Healthy" ], "start_date": "2015-07", "last_update": "2016-02-04" }, { "nct_id": "NCT02674308", "title": "Entyvio (Vedolizumab) Long Term Safety Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Takeda", "conditions": [ "Ulcerative Colitis and Crohn's Disease" ], "start_date": "2015-03-24", "last_update": "2024-10-31" }, { "nct_id": "NCT02674815", "title": "Preoperative High Intensity Interval Training: The PHIIT Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Colorectal Neoplasms", "Lung Neoplasms" ], "start_date": "2016-02", "last_update": "2017-05-18" }, { "nct_id": "NCT02675426", "title": "A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2015-12-17", "last_update": "2023-04-11" }, { "nct_id": "NCT02676908", "title": "Optimum Duration of Compression Stockings After Endovenous Varicose Vein Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Varicose Veins" ], "start_date": "2016-09", "last_update": "2018-09-07" }, { "nct_id": "NCT02676986", "title": "Short-term Preoperative Treatment With Enzalutamide, Alone or in Combination With Exemestane in Primary Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Queen Mary University of London", "conditions": [ "Primary Breast Cancer ER+ve", "Primary Breast Cancer AR+ve TNBN" ], "start_date": "2015-08-10", "last_update": "2024-07-05" }, { "nct_id": "NCT02678364", "title": "Effect of Vitamin D-biofortified Eggs on Wintertime Serum 25-hydroxyvitamin D in Adults: Randomized Controlled Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2015-01", "last_update": "2016-02-09" }, { "nct_id": "NCT02682368", "title": "Multicentric Point of Care UltraSound by Surgeons Trial", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Biliary Disease", "Gallstone; Cholecystitis, Acute", "Diverticulitis, Colonic", "Abscess Pelvic" ], "start_date": "2015-10-01", "last_update": "2019-07-25" }, { "nct_id": "NCT02684708", "title": "Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Giessen", "conditions": [ "Classical Hodgkin Lymphoma" ], "start_date": "2015-10-01", "last_update": "2026-03-31" }, { "nct_id": "NCT02686086", "title": "A Pilot Comparison Study of Vibrating Mesh Versus Standard Jet Nebuliser for Bronchodilator Delivery in COPD", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2016-02", "last_update": "2019-07-18" }, { "nct_id": "NCT02687711", "title": "Study to Look at How Effective Briviact is as add-on Treatment for Patients With Epilepsy With Partial Onset Seizures", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "UCB Biopharma S.P.R.L.", "conditions": [ "Epilepsy With POS With or Without Secondary Generalization" ], "start_date": "2016-02-01", "last_update": "2021-08-04" }, { "nct_id": "NCT02687724", "title": "Golimumab (GLM) Dose Optimisation to Adequate Levels to Achieve Response in Colitis", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Colitis" ], "start_date": "2016-06", "last_update": "2018-07-19" }, { "nct_id": "NCT02690480", "title": "Fulvestrant (F)+Placebo vs F+Palbociclib First Line for Postmenopausal Hormone Receptor+ Advanced Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Spanish Breast Cancer Research Group", "conditions": [ "Breast Neoplasms" ], "start_date": "2016-02-17", "last_update": "2020-02-05" }, { "nct_id": "NCT02690909", "title": "A Study to Evaluate Safety and Efficacy of the Redy™ Renal Denervation System in the Treatment of Patients With Uncontrolled Hypertension", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Renal Dynamics GmbH", "conditions": [ "Hypertension Resistant to Conventional Therapy" ], "start_date": "2016-04", "last_update": "2016-05-11" }, { "nct_id": "NCT02696902", "title": "Effort to Prevent Nosocomial Pneumonia Caused by Pseudomonas Aeruginosa in Mechanically Ventilated Subjects", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "MedImmune LLC", "conditions": [ "Pseudomonas Aeruginosa" ], "start_date": "2016-03-25", "last_update": "2021-02-04" }, { "nct_id": "NCT02699736", "title": "EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Copenhagen University Hospital, Rigshospitalet", "conditions": [ "HIV", "Hepatitis B", "Hepatitis C", "AIDS", "Coinfection", "Cardiovascular Diseases", "Diabetes Mellitus", "Acidosis, Lactic", "Renal Insufficiency", "Fractures, Bone", "End Stage Liver Disease", "Kidney Failure, Chronic", "Proteinuria" ], "start_date": "1994-01", "last_update": "2024-04-12" }, { "nct_id": "NCT02699879", "title": "Evaluation of Long-Term Safety of Pirfenidone (Esbriet) in Participants With Idiopathic Pulmonary Fibrosis (IPF)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2012-02-16", "last_update": "2017-04-21" }, { "nct_id": "NCT02704104", "title": "Safety and Performance Evaluation of the Topical Hemostatic Device (AC5™) Following Excision of Skin Lesions", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Arch Therapeutics", "conditions": [ "Skin Neoplasms" ], "start_date": "2016-02", "last_update": "2018-08-07" }, { "nct_id": "NCT02704845", "title": "Biopsychosocial Exploration of Pain Profiles in Inflammatory and Chronic Non-specific Axial Low Back Pain", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Back Pain", "Spondylitis, Ankylosing", "Low Back Pain" ], "start_date": "2015-09", "last_update": "2016-10-21" }, { "nct_id": "NCT02705859", "title": "Phase Ib/II Trial of coPANlisib in Combination With Trastuzumab in HER2-positive Breast Cancer. (Panther Study)", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "HER2 Positive Breast Cancer" ], "start_date": "2016-04", "last_update": "2026-04-13" }, { "nct_id": "NCT02706847", "title": "A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2016-03-15", "last_update": "2023-02-08" }, { "nct_id": "NCT02706873", "title": "A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2016-02-23", "last_update": "2023-07-07" }, { "nct_id": "NCT02707562", "title": "Study of GLPG1837 in Subjects With Cystic Fibrosis (G551D Mutation)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lakefront Biotherapeutics NV", "conditions": [ "Cystic Fibrosis" ], "start_date": "2016-02", "last_update": "2016-12-07" }, { "nct_id": "NCT02709109", "title": "A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Parion Sciences", "conditions": [ "Cystic Fibrosis" ], "start_date": "2016-02", "last_update": "2021-07-29" }, { "nct_id": "NCT02714738", "title": "Infraclavicular Block: Decreased Incidence of Tourniquet Pain, Compared to Axillary Brachial Plexus Block?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Tourniquet Pain" ], "start_date": "2016-03", "last_update": "2017-08-22" }, { "nct_id": "NCT02717806", "title": "Technology-enabled Cardiac Rehabilitation Through PATHway. Feasibility, Clinical Effectiveness and Cost-effectiveness", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "KU Leuven", "conditions": [ "Cardiovascular Disease" ], "start_date": "2017-06-01", "last_update": "2019-01-16" }, { "nct_id": "NCT02718417", "title": "Avelumab in Previously Untreated Patients With Epithelial Ovarian Cancer (JAVELIN OVARIAN 100)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Ovarian Cancer" ], "start_date": "2016-05-19", "last_update": "2020-07-14" }, { "nct_id": "NCT02721966", "title": "Study of the Efficacy and Safety of Secukinumab in Participants With Active Psoriatic Arthritis With Axial Skeleton Involvement", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Axial Psoratic Arthritis" ], "start_date": "2016-10-03", "last_update": "2020-10-01" }, { "nct_id": "NCT02724163", "title": "International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Birmingham", "conditions": [ "Acute Myeloid Leukaemia" ], "start_date": "2016-04", "last_update": "2026-06-29" }, { "nct_id": "NCT02725567", "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2016-06-02", "last_update": "2023-09-07" }, { "nct_id": "NCT02735707", "title": "Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "UMC Utrecht", "conditions": [ "Community-acquired Pneumonia, Influenza, COVID-19" ], "start_date": "2016-04-11", "last_update": "2024-07-12" }, { "nct_id": "NCT02738736", "title": "Clarifying Optimal Sodium Intake Project", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Blood Pressure", "Hypertension", "Kidney Disease", "Cardiovascular Disease" ], "start_date": "2016-04", "last_update": "2021-04-28" }, { "nct_id": "NCT02740218", "title": "A Study of Real-World Experience of Psoriasis Patients Treated With Apremilast in Clinical Dermatology Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Psoriasis" ], "start_date": "2016-06-30", "last_update": "2024-03-04" }, { "nct_id": "NCT02741570", "title": "Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Head and Neck Cancer" ], "start_date": "2016-10-05", "last_update": "2023-09-21" }, { "nct_id": "NCT02743494", "title": "An Investigational Immuno-therapy Study of Nivolumab or Placebo in Participants With Resected Esophageal or Gastroesophageal Junction Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Advanced Cancer" ], "start_date": "2016-07-14", "last_update": "2025-11-18" }, { "nct_id": "NCT02752074", "title": "A Phase 3 Study of Pembrolizumab + Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (Keynote-252 / ECHO-301)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Melanoma" ], "start_date": "2016-06-21", "last_update": "2025-08-24" }, { "nct_id": "NCT02755597", "title": "A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Relapsed/Refractory Multiple Myeloma" ], "start_date": "2016-07-11", "last_update": "2023-08-22" }, { "nct_id": "NCT02755649", "title": "A Study to Assess the Efficacy and Safety of Dupilumab in Participants With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically Advisable", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Atopic Dermatitis" ], "start_date": "2016-01-31", "last_update": "2020-08-20" }, { "nct_id": "NCT02756611", "title": "A Study to Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Chronic Lymphocytic Leukemia" ], "start_date": "2016-06-22", "last_update": "2023-04-10" }, { "nct_id": "NCT02758795", "title": "Antiinflammatory Effect of Dietary Protein Intake in Elderly People", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Inflammation" ], "start_date": "2016-02", "last_update": "2017-08-01" }, { "nct_id": "NCT02762877", "title": "Concordance of Key Actionable Genomic Alterations as Assessed in Tumor Tissue and Plasma in Non Small Cell Lung Cancer", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Genomic Health®, Inc.", "conditions": [ "Non Small Cell Lung Carcinoma" ], "start_date": "2016-04", "last_update": "2020-11-17" }, { "nct_id": "NCT02764086", "title": "INTENSE: A Phase I/II Study of INhomogeneous Targeted Dose Escalation in Non-Small CEll Lung Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2016-08-10", "last_update": "2026-04-13" }, { "nct_id": "NCT02771548", "title": "Biomechanical Analysis of Dynamic Tasks and Muscular Strength Following Anterior Cruciate Ligament Reconstruction", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Dr Neil Welch ASCC", "conditions": [ "Rupture of Anterior Cruciate Ligament" ], "start_date": "2014-01", "last_update": "2024-04-22" }, { "nct_id": "NCT02774278", "title": "A Study of Erlotinib (Tarceva) in Participants With Non-Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Squamous Non-Small Cell Lung Cancer" ], "start_date": "2005-07", "last_update": "2016-08-08" }, { "nct_id": "NCT02780453", "title": "Prophylactic Negative Pressure Dressings for Closed Laparotomy Wounds - A Randomised, Controlled, Open Label Trial", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Infection" ], "start_date": "2013-01", "last_update": "2016-11-29" }, { "nct_id": "NCT02786576", "title": "Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2016-07-05", "last_update": "2020-01-09" }, { "nct_id": "NCT02795026", "title": "Trans-perineal Trigger Point Dry Needling for Chronic Pelvic Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Dyspareunia" ], "start_date": "2016-04", "last_update": "2018-09-28" }, { "nct_id": "NCT02804815", "title": "Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College, London", "conditions": [ "Cancer", "Breast Cancer", "Prostate Cancer", "Colorectal Cancer", "Gastro-oesophageal Cancer" ], "start_date": "2015-10", "last_update": "2025-06-10" }, { "nct_id": "NCT02804841", "title": "Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Healthy" ], "start_date": "2015-11", "last_update": "2016-11-22" }, { "nct_id": "NCT02805322", "title": "Comparison of a Novel Non-Invasive, Non-Touch Infrared Thermometer With Routine Thermometry in Routine Clinical Practice", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "ARC Devices", "conditions": [ "Healthy", "Febrile" ], "start_date": "2016-04", "last_update": "2016-06-20" }, { "nct_id": "NCT02808975", "title": "Safety and Efficacy of Adalimumab (Humira) for Hidradenitis Suppurativa (HS) Peri-Surgically", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Hidradenitis Suppurativa (HS)" ], "start_date": "2016-07-18", "last_update": "2020-05-14" }, { "nct_id": "NCT02811822", "title": "A Study to Determine the Efficacy, Safety and Pharmacokinetics of GMI-1271 as Adjunct to Standard of Care for the Treatment of Multiple Myeloma", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "GlycoMimetics Incorporated", "conditions": [ "Multiple Myeloma" ], "start_date": "2016-06", "last_update": "2019-07-10" }, { "nct_id": "NCT02811861", "title": "Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eisai Inc.", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2016-10-13", "last_update": "2026-02-23" }, { "nct_id": "NCT02814019", "title": "A Phase III Double-blind Study With Idebenone in Patients With Duchenne Muscular Dystrophy (DMD) Taking Glucocorticoid Steroids", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Santhera Pharmaceuticals", "conditions": [ "Duchenne Muscular Dystrophy (DMD)" ], "start_date": "2016-09", "last_update": "2021-12-03" }, { "nct_id": "NCT02819635", "title": "A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis (UC)" ], "start_date": "2016-09-26", "last_update": "2022-06-30" }, { "nct_id": "NCT02821117", "title": "FreeStyle Libre Glucose Monitoring System Paediatric Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Abbott Diabetes Care", "conditions": [ "Diabetes Mellitus" ], "start_date": "2016-06-30", "last_update": "2026-09-22" }, { "nct_id": "NCT02823574", "title": "Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Head and Neck Cancer" ], "start_date": "2016-11-08", "last_update": "2023-05-03" }, { "nct_id": "NCT02825862", "title": "Investigating Affective Attitude Question-behaviour Effects on Intention to Become an Organ Donor", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Organ Donation" ], "start_date": "2016-02", "last_update": "2019-03-27" }, { "nct_id": "NCT02832245", "title": "Computerized Registry of Patients With Venous Thromboembolism (RIETE)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Manuel Monreal", "conditions": [ "Venous Thromboembolism" ], "start_date": "2001-03", "last_update": "2026-09-21" }, { "nct_id": "NCT02836392", "title": "CRQ Survey Study: Clinical Research Questionnaire of Oncology Patients - A Nationwide Survey", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Cancer" ], "start_date": "2016-05", "last_update": "2017-08-10" }, { "nct_id": "NCT02839850", "title": "14022 ATTUNE Cementless RP Clinical Performance Evaluation", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DePuy Orthopaedics", "conditions": [ "Osteoarthritis" ], "start_date": "2016-09-01", "last_update": "2026-09-28" }, { "nct_id": "NCT02842086", "title": "Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Pre-Exposure Prophylaxis of HIV-1 Infection" ], "start_date": "2016-09-02", "last_update": "2026-09-08" }, { "nct_id": "NCT02843100", "title": "Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Prof. Arie Levine", "conditions": [ "Crohn's Disease" ], "start_date": "2018-04-10", "last_update": "2022-06-01" }, { "nct_id": "NCT02847637", "title": "A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hemophilia A" ], "start_date": "2016-09-27", "last_update": "2022-11-16" }, { "nct_id": "NCT02848469", "title": "Irish Omega-3 Study", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Psychotic Disorders" ], "start_date": "2013-09", "last_update": "2016-07-28" }, { "nct_id": "NCT02861014", "title": "A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "start_date": "2016-09-09", "last_update": "2022-01-27" }, { "nct_id": "NCT02862132", "title": "Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Shaare Zedek Medical Center", "conditions": [ "Crohn's Disease", "Ulcerative Colitis", "Inflammatory Bowel Disease" ], "start_date": "2017-01", "last_update": "2022-10-25" }, { "nct_id": "NCT02868177", "title": "Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Valbiotis", "conditions": [ "Prediabetes", "Type 2 Diabetes", "Hypertriglyceridemia", "Obesity", "Disease", "Insulin Resistance" ], "start_date": "2016-10", "last_update": "2020-10-05" }, { "nct_id": "NCT02881073", "title": "Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Irish Centre for Fetal and Neonatal Translational Research", "conditions": [ "Pre-eclampsia", "Pregnancy, High Risk", "Pregnancy Complications" ], "start_date": "2017-06-29", "last_update": "2019-08-07" }, { "nct_id": "NCT02882815", "title": "Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Lifetech Scientific (Shenzhen) Co., Ltd.", "conditions": [ "Patent Foramen Ovale" ], "start_date": "2014-09", "last_update": "2018-08-09" }, { "nct_id": "NCT02883049", "title": "Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "National Cancer Institute (NCI)", "conditions": [ "B Acute Lymphoblastic Leukemia", "B Acute Lymphoblastic Leukemia, BCR-ABL1-Like", "Central Nervous System Leukemia", "Testicular Leukemia" ], "start_date": "2012-02-29", "last_update": "2026-06-02" }, { "nct_id": "NCT02885415", "title": "Prevalence of Myocardial Injury in Gastrointestinal Surgery Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Myocardial Injury" ], "start_date": "2016-08", "last_update": "2017-09-26" }, { "nct_id": "NCT02885948", "title": "The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Respiratory Depression" ], "start_date": "2016-04", "last_update": "2017-12-19" }, { "nct_id": "NCT02886728", "title": "Filgotinib Alone and in Combination With Methotrexate (MTX) in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Are Naive to MTX Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2016-08-08", "last_update": "2021-06-01" }, { "nct_id": "NCT02886754", "title": "Proficiency-Based Progression Training for Clinical Communication", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Clinical Communication", "ISBAR", "Simulation", "Proficiency-Based Progression", "Non Technical Skills", "Performance", "Deteriorating Patient" ], "start_date": "2016-09-14", "last_update": "2017-07-25" }, { "nct_id": "NCT02887300", "title": "Mantra Meditation to Reduce Emotional Exhaustion in Emergency Department Staff", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Psychological Stress" ], "start_date": "2017-01-31", "last_update": "2017-02-14" }, { "nct_id": "NCT02889796", "title": "Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2016-08-30", "last_update": "2021-06-09" }, { "nct_id": "NCT02889874", "title": "EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Breast Cancer Trials, Australia and New Zealand", "conditions": [ "Early Stage Breast Carcinoma" ], "start_date": "2017-08-21", "last_update": "2025-09-18" }, { "nct_id": "NCT02893228", "title": "Does Saline Injection Around Phrenic Nerve Reduce Incidence of Diaphragmatic Paresis Following Interscalene Block?", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Phrenic Nerve Palsy" ], "start_date": "2016-10", "last_update": "2021-07-20" }, { "nct_id": "NCT02895958", "title": "The Dublin Zepatier Study", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Hepatitis C" ], "start_date": "2018-03-15", "last_update": "2019-12-10" }, { "nct_id": "NCT02897934", "title": "CWI and Discharge After Breast Cancer Surgery", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Breast Cancer", "Pain" ], "start_date": "2016-08", "last_update": "2021-02-02" }, { "nct_id": "NCT02898610", "title": "Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Ischemic Attack, Transient", "Stroke" ], "start_date": "2016-12-12", "last_update": "2025-03-13" }, { "nct_id": "NCT02900183", "title": "Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels", "phases": [ "PHASE2" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Arrowhead Pharmaceuticals", "conditions": [ "Alpha-1 Antitrypsin Deficiency" ], "start_date": "2016-10", "last_update": "2025-12-18" }, { "nct_id": "NCT02900378", "title": "randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Chronic Heart Failure With Reduced Ejection Fraction" ], "start_date": "2016-12-20", "last_update": "2020-09-02" }, { "nct_id": "NCT02901171", "title": "The Contribution of a Smartphone Application to Acceptance and Commitment Therapy Group Treatment for Smoking Cessation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Smoking" ], "start_date": "2016-09", "last_update": "2018-07-30" }, { "nct_id": "NCT02913053", "title": "The Effects of an Extensive Exercise Program on the Progression of Mild Cognitive Impairment", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Radboud University Medical Center", "conditions": [ "Mild Cognitive Impairment" ], "start_date": "2015-06", "last_update": "2019-11-14" }, { "nct_id": "NCT02913287", "title": "Seaweed-Derived Mineral-Rich Nutraceuticals in Cognition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Cognition" ], "start_date": "2015-10-15", "last_update": "2024-06-27" }, { "nct_id": "NCT02914522", "title": "Study to Evaluate the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Ulcerative Colitis" ], "start_date": "2016-11-14", "last_update": "2021-04-21" }, { "nct_id": "NCT02914535", "title": "Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2017-02-23", "last_update": "2026-09-17" }, { "nct_id": "NCT02914561", "title": "Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Lakefront Biotherapeutics NV", "conditions": [ "Crohn's Disease" ], "start_date": "2016-10-31", "last_update": "2023-12-18" }, { "nct_id": "NCT02914600", "title": "Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Lakefront Biotherapeutics NV", "conditions": [ "Crohn's Disease" ], "start_date": "2017-03-17", "last_update": "2024-07-10" }, { "nct_id": "NCT02916134", "title": "Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Appendicitis" ], "start_date": "2016-09-12", "last_update": "2020-07-13" }, { "nct_id": "NCT02921230", "title": "Trial Comparing ELUVIA Versus Bare Metal Stent in Treatment of Superficial Femoral and/or Proximal Popliteal Artery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Arterial Occlusive Diseases", "Atherosclerosis", "Vascular Diseases", "Arteriosclerosis" ], "start_date": "2016-10-25", "last_update": "2025-02-24" }, { "nct_id": "NCT02922088", "title": "EU Multicenter Registry to Assess Outcomes in CABG Patients: Treatment of Vascular Conduits With DuraGraft [VASC]", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Somahlution LLC", "conditions": [ "Cardiovascular Diseases", "Coronary Artery Disease" ], "start_date": "2016-12-09", "last_update": "2021-03-18" }, { "nct_id": "NCT02922686", "title": "Penicillin for the Emergency Department Outpatient Treatment of CELLulitis", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cellulitis", "Wound Infection", "Abscess" ], "start_date": "2016-12", "last_update": "2016-10-04" }, { "nct_id": "NCT02927769", "title": "A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Hodgkin Disease" ], "start_date": "2017-03-28", "last_update": "2025-02-10" }, { "nct_id": "NCT02928406", "title": "A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Urinary Tract Cancer" ], "start_date": "2016-11-30", "last_update": "2024-04-04" }, { "nct_id": "NCT02928796", "title": "Attentional Capacity and Clinician Performance", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Change in Sustained Attention" ], "start_date": "2016-09", "last_update": "2016-10-10" }, { "nct_id": "NCT02929160", "title": "Percutaneous Nephrostomy Versus Stent In Sepsis Trial", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Ureteric Calculus", "Sepsis", "Hydronephrosis" ], "start_date": "2017-01-01", "last_update": "2022-09-27" }, { "nct_id": "NCT02930018", "title": "Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "NoNO Inc.", "conditions": [ "Stroke, Acute" ], "start_date": "2017-03-01", "last_update": "2022-10-10" }, { "nct_id": "NCT02931669", "title": "Meaning, Value and Purpose of Augmentative and Alternative Communication (AAC)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Meaning, Value and Purpose of AAC" ], "start_date": "2016-10", "last_update": "2017-10-27" }, { "nct_id": "NCT02936427", "title": "Effects and Dose Response of Dexamethasone on Intercostal Blocks With Bupivicaine in Post Thoracic Surgery Patients", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Pain" ], "start_date": "2016-07", "last_update": "2017-05-16" }, { "nct_id": "NCT02936635", "title": "A Study for Patients Who Completed VITALITY-ALS (CY 4031)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "start_date": "2016-10-17", "last_update": "2021-06-15" }, { "nct_id": "NCT02937597", "title": "E-learning Proficiency Based Progression Training Programme for Clinical Communication on ISBAR Performance (eISBAR)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Communication" ], "start_date": "2016-10", "last_update": "2018-05-02" }, { "nct_id": "NCT02944019", "title": "Edoxaban Treatment in Routine Clinical Practice for Patients With Non Valvular Atrial Fibrillation", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "Atrial Fibrillation" ], "start_date": "2015-08", "last_update": "2022-06-01" }, { "nct_id": "NCT02950051", "title": "Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "German CLL Study Group", "conditions": [ "Chronic Lymphocytic Leukemia" ], "start_date": "2016-12-13", "last_update": "2024-12-30" }, { "nct_id": "NCT02952534", "title": "A Study of Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "pharmaand GmbH", "conditions": [ "Metastatic Castration Resistant Prostate Cancer" ], "start_date": "2017-02-15", "last_update": "2023-06-09" }, { "nct_id": "NCT02952586", "title": "Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Squamous Cell Carcinoma of the Head and Neck" ], "start_date": "2016-11-28", "last_update": "2021-09-22" }, { "nct_id": "NCT02955810", "title": "Cyclophosphamide-Bortezomib-Dexamethasone (CyBorD) With Daratumumab (DARA)", "phases": [ "PHASE1" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Multiple Myeloma" ], "start_date": "2016-11", "last_update": "2018-03-29" }, { "nct_id": "NCT02966067", "title": "A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Dental Pain", "Anesthesia, Local" ], "start_date": "2017-09-01", "last_update": "2018-01-25" }, { "nct_id": "NCT02967211", "title": "A \"Real World\" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to \"Standard of Care\" Basal Insulin in Patients Already Using Basal Insulin", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2015-12-21", "last_update": "2022-04-25" }, { "nct_id": "NCT02967224", "title": "A \"Real World\" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to \"Standard of Care\" Basal Insulins in Insulin Naïve Patients Initiating Insulin", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Sanofi", "conditions": [ "Diabetes Mellitus, Type 2" ], "start_date": "2015-11-05", "last_update": "2022-04-25" }, { "nct_id": "NCT02970604", "title": "PPARGC1β and CNTN4 Genotype Aspirin Study", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2016-05", "last_update": "2016-11-22" }, { "nct_id": "NCT02975934", "title": "A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "pharmaand GmbH", "conditions": [ "Metastatic Castration Resistant Prostate Cancer" ], "start_date": "2017-06-13", "last_update": "2025-07-25" }, { "nct_id": "NCT02976623", "title": "Metric-based Feedback Training for the Acquisition of Sonographic Skills", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Simulation Training" ], "start_date": "2016-06", "last_update": "2017-05-09" }, { "nct_id": "NCT02979119", "title": "The European Paediatric Network for Haemophilia Management ( PedNet Registry)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "PedNet Haemophilia Research Foundation", "conditions": [ "Factor VIII Deficiency", "Factor IX Deficiency" ], "start_date": "2014-06", "last_update": "2025-09-16" }, { "nct_id": "NCT02980276", "title": "RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Gestational Diabetes" ], "start_date": "2017-06-06", "last_update": "2025-03-17" }, { "nct_id": "NCT02986425", "title": "OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Insel Gruppe AG, University Hospital Bern", "conditions": [ "3 or More Chronic Conditions for 6 Months or Longer", "5 or More Regular Drugs" ], "start_date": "2016-12", "last_update": "2020-08-25" }, { "nct_id": "NCT02991469", "title": "A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Sanofi", "conditions": [ "Juvenile Idiopathic Arthritis" ], "start_date": "2018-08-09", "last_update": "2026-09-23" }, { "nct_id": "NCT02993107", "title": "PALISADE Follow-on Study (ARC004)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Aimmune Therapeutics, Inc.", "conditions": [ "Peanut Allergy" ], "start_date": "2016-12-29", "last_update": "2022-03-17" }, { "nct_id": "NCT02994927", "title": "A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "ANCA-Associated Vasculitis" ], "start_date": "2017-03-15", "last_update": "2025-03-24" }, { "nct_id": "NCT02998177", "title": "Characterization of Rebound Pain Following Peripheral Nerve Block and Its Association With Gut Microbiome Diversity", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cork University Hospital", "conditions": [ "Pain, Postoperative", "Gastrointestinal Microbiome" ], "start_date": "2016-11", "last_update": "2017-08-22" }, { "nct_id": "NCT02998710", "title": "Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Travere Therapeutics, Inc.", "conditions": [ "Homocystinuria Due to CBS Deficiency" ], "start_date": "2017-01", "last_update": "2026-09-09" }, { "nct_id": "NCT03005782", "title": "Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Malignancies" ], "start_date": "2016-11-07", "last_update": "2024-05-01" }, { "nct_id": "NCT03006068", "title": "A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis (UC)" ], "start_date": "2017-01-31", "last_update": "2026-01-12" }, { "nct_id": "NCT03009929", "title": "Validation Study of ClassIntra®", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital, Basel, Switzerland", "conditions": [ "Patient Safety", "Intraoperative Complications", "Postoperative Complications", "Risk Management" ], "start_date": "2017-02-15", "last_update": "2019-10-17" }, { "nct_id": "NCT03013517", "title": "Follow-up of the PEPITES Study to Evaluate Long-term Efficacy and Safety of Viaskin Peanut in Children", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DBV Technologies", "conditions": [ "Peanut Allergy" ], "start_date": "2017-01-23", "last_update": "2020-12-02" }, { "nct_id": "NCT03013595", "title": "The MILESTONE Study: Improving Transition From Child to Adult Mental Health Care", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Warwick", "conditions": [ "Mental Health Impairment", "Mental Health Disorder" ], "start_date": "2015-10", "last_update": "2017-11-17" }, { "nct_id": "NCT03017326", "title": "Paediatric Hepatic International Tumour Trial", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Birmingham", "conditions": [ "Hepatoblastoma", "Carcinoma, Hepatocellular" ], "start_date": "2017-08-24", "last_update": "2026-05-13" }, { "nct_id": "NCT03019367", "title": "Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sharp HealthCare", "conditions": [ "Intraventricular Haemorrhage Neonatal", "Death; Neonatal" ], "start_date": "2017-06-06", "last_update": "2022-11-23" }, { "nct_id": "NCT03021707", "title": "Early Feasibility Study of UV-Femtosecond Laser Assisted Lenticular Extraction", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Alcon Research", "conditions": [ "Refractive Error - Myopia Severe", "Refractive Error - Myopia Simple" ], "start_date": "2017-03-07", "last_update": "2022-04-07" }, { "nct_id": "NCT03024697", "title": "Single-shot Pectoral Plane(PECs) Block Versus Continuous Local Anaesthetic Infusion Analgesia or Both PECS Block and Local Anaesthetic Infusion After Breast Surgery: A Prospective Randomised, Double-blind Trial", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Breast Diseases", "Anesthesia", "Block" ], "start_date": "2017-01", "last_update": "2017-09-11" }, { "nct_id": "NCT03024996", "title": "A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2017-01-03", "last_update": "2023-08-03" }, { "nct_id": "NCT03025308", "title": "Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2017-02-28", "last_update": "2026-07-27" }, { "nct_id": "NCT03027583", "title": "The Effect of Probiotic Intervention on Intestinal Permeability", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Chr Hansen", "conditions": [ "Intestinal Permeability" ], "start_date": "2017-03-01", "last_update": "2018-05-03" }, { "nct_id": "NCT03028844", "title": "The Effect of a Musical Intervention on Stress Response to Venepuncture", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Pain", "Stress, Physiological" ], "start_date": "2016-04", "last_update": "2017-01-23" }, { "nct_id": "NCT03033511", "title": "A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "AbbVie", "conditions": [ "Small Cell Lung Cancer" ], "start_date": "2017-02-07", "last_update": "2021-07-29" }, { "nct_id": "NCT03036436", "title": "The IMPETUS Cancer Trial. A Technology Delivered Physical Activity Intervention in Cancer", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer, Breast", "Cancer, Colorectal", "Malignancy" ], "start_date": "2017-01", "last_update": "2018-07-24" }, { "nct_id": "NCT03036488", "title": "Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Triple Negative Breast Neoplasms" ], "start_date": "2017-03-07", "last_update": "2025-10-29" }, { "nct_id": "NCT03036800", "title": "Saxenda in Obesity Services (STRIVE Study)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Leicester", "conditions": [ "Obesity", "Weight Loss", "Diabetes Mellitus" ], "start_date": "2017-11-28", "last_update": "2024-08-13" }, { "nct_id": "NCT03038438", "title": "ABRE Clinical Study of the Abre Venous Self-expanding Stent System", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Endovascular", "conditions": [ "Iliofemoral Venous Obstruction" ], "start_date": "2017-12-13", "last_update": "2022-11-08" }, { "nct_id": "NCT03038646", "title": "A Pharmacokinetic Study of Modified Release (MR) Formulations of MIN-101 in Healthy Subjects", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Minerva Neurosciences", "conditions": [ "Healthy Subjects" ], "start_date": "2016-11-30", "last_update": "2017-08-31" }, { "nct_id": "NCT03045523", "title": "A Study to Evaluate GLPG2222 in Ivacaftor-treated Subjects With Cystic Fibrosis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Lakefront Biotherapeutics NV", "conditions": [ "Cystic Fibrosis" ], "start_date": "2017-01", "last_update": "2017-11-21" }, { "nct_id": "NCT03048565", "title": "A Trial of an Online Mindfulness Based Programme for Informal Caregivers of People With Chronic Illnesses", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Chronic Illness" ], "start_date": "2017-09-13", "last_update": "2018-05-04" }, { "nct_id": "NCT03050528", "title": "The Effectiveness of Exercise Combined With Acceptance and Commitment Therapy for Chronic Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Chronic Pain" ], "start_date": "2017-02-06", "last_update": "2020-11-12" }, { "nct_id": "NCT03061370", "title": "Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Cancer", "Gastric Cancer", "Sarcopenia", "Sarcopenic Obesity", "Obesity", "Visceral Obesity", "Quality of Life", "Surgery", "Complication of Treatment", "Chemotherapeutic Toxicity", "Physical Activity", "Oncology" ], "start_date": "2010-01-01", "last_update": "2020-03-26" }, { "nct_id": "NCT03062046", "title": "Evaluation of Ablation Index and VISITAG™ (ABI-173)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Biosense Webster, Inc.", "conditions": [ "Paroxysmal Atrial Fibrillation" ], "start_date": "2017-01-27", "last_update": "2025-06-25" }, { "nct_id": "NCT03066323", "title": "Effect of Tea Extract on Post Prandial Blood Glucose", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Unilever R&D", "conditions": [ "Healthy" ], "start_date": "2017-01", "last_update": "2017-07-28" }, { "nct_id": "NCT03066778", "title": "A Study of Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Small Cell Lung Cancer (SCLC)" ], "start_date": "2017-05-02", "last_update": "2022-10-03" }, { "nct_id": "NCT03067220", "title": "Can A Virtual Clinic Review Replace A Surgical Clinic Visit After Discharge?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Outpatients General Surgery Virtual Clinic" ], "start_date": "2016-05-01", "last_update": "2017-06-09" }, { "nct_id": "NCT03068780", "title": "Phase III Efficacy and Safety Study of Oleogel-S10 in Epidermolysis Bullosa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amryt Research Limited", "conditions": [ "Epidermolysis Bullosa" ], "start_date": "2017-03-29", "last_update": "2023-07-20" }, { "nct_id": "NCT03069352", "title": "A Study of Venetoclax in Combination With Low Dose Cytarabine Versus Low Dose Cytarabine Alone in Treatment Naive Patients With Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Acute Myeloid Leukemia (AML)" ], "start_date": "2017-05-23", "last_update": "2025-09-30" }, { "nct_id": "NCT03072056", "title": "A Pharmacokinetic Study of MIN-101 and Its Metabolites in Healthy Subjects to Compare MIN-101 in Poor and Extensive Metabolizers", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Minerva Neurosciences", "conditions": [ "Healthy Subjects" ], "start_date": "2017-01-09", "last_update": "2017-08-31" }, { "nct_id": "NCT03072238", "title": "Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednisone/Prednisolone in Adult Male Patients With Metastatic Castrate-Resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Metastatic Prostate Cancer" ], "start_date": "2017-06-30", "last_update": "2025-06-06" }, { "nct_id": "NCT03072719", "title": "The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Dentine Hypersensitivity" ], "start_date": "2012-03-01", "last_update": "2018-03-06" }, { "nct_id": "NCT03078907", "title": "Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Actelion", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2017-11-08", "last_update": "2025-03-30" }, { "nct_id": "NCT03083600", "title": "Effect of Protein Hydrolysates on HbA1c Levels in Pre-diabetics", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "PreDiabetes" ], "start_date": "2017-05-22", "last_update": "2018-01-11" }, { "nct_id": "NCT03086343", "title": "A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis (RA)" ], "start_date": "2017-05-09", "last_update": "2024-07-18" }, { "nct_id": "NCT03089281", "title": "Strategic Management to Optimize Response To Cardiac Resynchronization Therapy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Heart Failure" ], "start_date": "2017-08-01", "last_update": "2022-04-05" }, { "nct_id": "NCT03089944", "title": "A Study of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults With Chronic Hepatitis C Virus (HCV) Genotype 1-6 Infection and Compensated Cirrhosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Hepatitis C Virus (HCV)" ], "start_date": "2017-04-28", "last_update": "2020-07-13" }, { "nct_id": "NCT03098992", "title": "The Efficacy and Safety of Fotona Smooth® Device for the Treatment of Stress Urinary Incontinence", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Stress Urinary Incontinence" ], "start_date": "2017-06-01", "last_update": "2019-06-12" }, { "nct_id": "NCT03099187", "title": "A Study of Pirfenidone in Patients With Unclassifiable Progressive Fibrosing Interstitial Lung Disease", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Lung Diseases, Interstitial" ], "start_date": "2017-05-15", "last_update": "2021-01-13" }, { "nct_id": "NCT03102463", "title": "The Role of Milk Derived Peptides on Glycaemic Control", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Insulin Resistance" ], "start_date": "2015-10", "last_update": "2017-08-14" }, { "nct_id": "NCT03103542", "title": "Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia A" ], "start_date": "2017-08-29", "last_update": "2024-09-19" }, { "nct_id": "NCT03104322", "title": "Patient-reported Monitoring of Symptoms and Spirometry Via the patientMpower Platform in Idiopathic Pulmonary Fibrosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "patientMpower Ltd.", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2017-06-15", "last_update": "2019-04-02" }, { "nct_id": "NCT03104400", "title": "A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Psoriatic Arthritis" ], "start_date": "2017-04-27", "last_update": "2025-09-22" }, { "nct_id": "NCT03104413", "title": "A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2017-12-18", "last_update": "2022-06-14" }, { "nct_id": "NCT03105037", "title": "The Effect of Supraglottic Airway Insertion on the Accuracy of Cricothyroid Membrane Identification in Females", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Airway Obstruction" ], "start_date": "2017-01-31", "last_update": "2018-09-25" }, { "nct_id": "NCT03105102", "title": "A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2018-04-09", "last_update": "2026-08-14" }, { "nct_id": "NCT03105128", "title": "A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2017-05-10", "last_update": "2022-07-06" }, { "nct_id": "NCT03106324", "title": "A Safety Study of Lenalidomide in Previously Untreated Adult Multiple Myeloma Patients Who Are Not Eligible for Transplant", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2017-03-31", "last_update": "2026-05-28" }, { "nct_id": "NCT03106584", "title": "The Marigot Osteoarthritis Nutritional Intervention (MOANi) Trial", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Knee Osteoarthritis" ], "start_date": "2017-05-01", "last_update": "2017-04-10" }, { "nct_id": "NCT03108092", "title": "Health Economic Evaluation Alongside the OPERAM Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Insel Gruppe AG, University Hospital Bern", "conditions": [ "3 or More Chronic Conditions for 6 Months or Longer", "5 or More Regular Drugs" ], "start_date": "2016-12", "last_update": "2020-08-27" }, { "nct_id": "NCT03111329", "title": "Does Routine Assessment of Gastric Residuals in Preterm Neonates Influence Time Taken to Reach Full Enteral Feeding?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute for the Care of Mother and Child, Prague, Czech Republic", "conditions": [ "Gastric Residuals Assessment", "Prematurity", "Sepsis Newborn", "Necrotizing Enterocolitis of Newborn" ], "start_date": "2017-10-06", "last_update": "2024-05-10" }, { "nct_id": "NCT03112928", "title": "Phantom Motor Execution Via MPR, VR/AR, and SG, as a Treatment of PLP", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Integrum", "conditions": [ "Phantom Limb Pain" ], "start_date": "2017-05-08", "last_update": "2023-06-22" }, { "nct_id": "NCT03113305", "title": "Changes in Ingestive Behaviour Following Gastric Bypass", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Ulster", "conditions": [ "Morbid Obesity" ], "start_date": "2016-09-01", "last_update": "2023-06-29" }, { "nct_id": "NCT03114033", "title": "Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Out-Of-Hospital Cardiac Arrest" ], "start_date": "2018-02-15", "last_update": "2022-04-20" }, { "nct_id": "NCT03116750", "title": "Post-Market Clinical Follow-up Study with ASPIREX®S to Assess the Safety and Effectiveness in the Treatment of DVT", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Straub Medical AG", "conditions": [ "Deep Vein Thrombosis", "Bypass Complication", "Dialysis Shunt", "Stent Occlusion" ], "start_date": "2017-04-03", "last_update": "2024-12-03" }, { "nct_id": "NCT03122808", "title": "Uterine Activity in Moderate-Severe Neonatal Encephalopathy: A Case Control Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Neonatal Encephalopathy" ], "start_date": "2016-09-01", "last_update": "2023-05-22" }, { "nct_id": "NCT03133377", "title": "Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Critically Ill, Mechanically Ventilated" ], "start_date": "2018-02-28", "last_update": "2023-12-18" }, { "nct_id": "NCT03133546", "title": "Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Non Small Cell Lung Cancer Metastatic" ], "start_date": "2017-05-31", "last_update": "2026-08-26" }, { "nct_id": "NCT03136484", "title": "Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "start_date": "2017-03-15", "last_update": "2020-01-21" }, { "nct_id": "NCT03136861", "title": "SKIPPAIN - Speed of Onset of SecuKinumab-Induced Relief From Pain in Patients With AxIal SpoNdyloarthritis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Spondyloarthritis" ], "start_date": "2017-06-30", "last_update": "2021-09-05" }, { "nct_id": "NCT03140306", "title": "CT Using MBIR in Crohn's Disease: Prospective Clinical Evaluation of Diagnostic Efficacy, Safety and Patient Outcome.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Radiology", "Inflammatory Bowel Diseases" ], "start_date": "2017-10-24", "last_update": "2019-09-25" }, { "nct_id": "NCT03140995", "title": "Sleep and Exercise in Rheumatoid Arthritis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Rheumatoid Arthritis", "Inflammatory Arthritis" ], "start_date": "2017-10-02", "last_update": "2019-07-08" }, { "nct_id": "NCT03142334", "title": "Safety and Efficacy Study of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (MK-3475-564/KEYNOTE-564)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2017-06-09", "last_update": "2026-03-10" }, { "nct_id": "NCT03145142", "title": "PREMOD2 With Near Infrared Spectroscopy Sub-study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Sharp HealthCare", "conditions": [ "Hypoxia, Brain", "Premature Birth" ], "start_date": "2017-06-06", "last_update": "2021-12-13" }, { "nct_id": "NCT03145584", "title": "Continuous Versus Single-Shot Adductor Canal Block in Total Knee Arthroplasty", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Pain, Postoperative" ], "start_date": "2015-07", "last_update": "2017-05-09" }, { "nct_id": "NCT03146923", "title": "Decreasing Intakes & Absorption of Phosphorus in Haemodialysis Patients Through Food Choices", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Renal Dialysis", "Hyperphosphatemia", "Dietary Modification" ], "start_date": "2017-03-06", "last_update": "2020-01-18" }, { "nct_id": "NCT03148457", "title": "Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Insel Gruppe AG, University Hospital Bern", "conditions": [ "Ischaemic Stroke" ], "start_date": "2017-11-06", "last_update": "2023-07-18" }, { "nct_id": "NCT03150017", "title": "An Internet-Delivered Pain Management Programme for Spinal Cord Injury Pain", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Dearbhla Burke", "conditions": [ "Chronic Pain, Widespread", "Spinal Cord Injuries" ], "start_date": "2017-03-08", "last_update": "2017-05-11" }, { "nct_id": "NCT03151629", "title": "International Registry for Men With Advanced Prostate Cancer (IRONMAN)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Prostate Cancer Clinical Trials Consortium", "conditions": [ "Prostate Cancer" ], "start_date": "2017-07-21", "last_update": "2026-05-22" }, { "nct_id": "NCT03152552", "title": "A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Diabetes Mellitus and Heart Failure" ], "start_date": "2017-07-25", "last_update": "2019-08-28" }, { "nct_id": "NCT03152734", "title": "Periinterventional Outcome Study in the Elderly", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Mark Coburn", "conditions": [ "Mortality", "Complication, Postoperative" ], "start_date": "2017-10-01", "last_update": "2019-11-20" }, { "nct_id": "NCT03153280", "title": "Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer", "phases": [ "PHASE1" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Colorectal Neoplasms", "Stomach Neoplasm", "Esophageal Neoplasms" ], "start_date": "2022-01-13", "last_update": "2025-07-08" }, { "nct_id": "NCT03153449", "title": "ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DePuy Orthopaedics", "conditions": [ "Primary Knee Arthroplasty" ], "start_date": "2017-09-19", "last_update": "2026-09-25" }, { "nct_id": "NCT03153475", "title": "ATTUNE Revision System in the Revision Total Knee Arthroplasty Population", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DePuy Orthopaedics", "conditions": [ "Revision Total Knee Arthroplasty" ], "start_date": "2017-05-30", "last_update": "2026-09-28" }, { "nct_id": "NCT03155243", "title": "Impact of Humira® Therapy on Ocular Inflammation, Selected Health Care Resource Utilization and Patient Reported Outcomes in Patients With Active Non-infectious Intermediate, Posterior and Panuveitis in Routine Clinical Practice", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Uveitis" ], "start_date": "2017-06-20", "last_update": "2021-02-11" }, { "nct_id": "NCT03160066", "title": "The Effects of Lactobacillus Rhamnosus (JB-1) on Stress and Cognition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2015-07", "last_update": "2017-05-30" }, { "nct_id": "NCT03160898", "title": "A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2017-07-24", "last_update": "2020-09-11" }, { "nct_id": "NCT03162003", "title": "Irish Programme for Stratified Prostate Cancer Therapy", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Cancer" ], "start_date": "2015-02", "last_update": "2025-07-08" }, { "nct_id": "NCT03166722", "title": "Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medical University of Graz", "conditions": [ "Preterm Infant", "Brain Injuries", "Birth Hypoxia" ], "start_date": "2017-09-20", "last_update": "2022-02-11" }, { "nct_id": "NCT03166735", "title": "Different Doses of BI 1467335 Compared to Placebo in Patients With Clinical Evidence of NASH", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Non-alcoholic Fatty Liver Disease" ], "start_date": "2017-06-06", "last_update": "2020-06-11" }, { "nct_id": "NCT03167320", "title": "Low Von Willebrand in Ireland Cohort Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Von Willebrand Factor, Deficiency" ], "start_date": "2014-10", "last_update": "2019-03-28" }, { "nct_id": "NCT03171311", "title": "The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Aarhus University Hospital Skejby", "conditions": [ "Ischaemic Heart Disease", "Ischemic Heart Disease" ], "start_date": "2017-07-05", "last_update": "2026-05-18" }, { "nct_id": "NCT03183921", "title": "Study on ICU Patients With Nosocomial Lower Respiratory Tract Infections", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS", "conditions": [ "Pneumonia" ], "start_date": "2016-09-01", "last_update": "2017-06-12" }, { "nct_id": "NCT03187769", "title": "Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disorder", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alkermes, Inc.", "conditions": [ "Schizophrenia", "Schizophreniform Disorders", "Bipolar I Disorder" ], "start_date": "2017-06-08", "last_update": "2023-01-19" }, { "nct_id": "NCT03191786", "title": "A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2017-09-11", "last_update": "2024-10-23" }, { "nct_id": "NCT03192969", "title": "A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)", "phases": [ "PHASE3" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Giant Cell Arteritis" ], "start_date": "2017-07-15", "last_update": "2017-07-12" }, { "nct_id": "NCT03193476", "title": "Registry for Patients With X-Linked Hypophosphatemia", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Kyowa Kirin Pharmaceutical Development Ltd", "conditions": [ "X-Linked Hypophosphatemia" ], "start_date": "2017-09-12", "last_update": "2026-07-09" }, { "nct_id": "NCT03201003", "title": "ARTEMIS Peanut Allergy In Children", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Aimmune Therapeutics, Inc.", "conditions": [ "Peanut Allergy" ], "start_date": "2017-06-12", "last_update": "2021-08-03" }, { "nct_id": "NCT03201757", "title": "Study to Evaluate the Long-term Safety, Tolerability, and Durability of Treatment Effect of ALKS 3831", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Alkermes, Inc.", "conditions": [ "Schizophrenia", "Schizophreniform Disorder", "Bipolar I Disorder" ], "start_date": "2017-06-15", "last_update": "2024-09-26" }, { "nct_id": "NCT03211247", "title": "Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Young Children 1-3 Years of Age", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "DBV Technologies", "conditions": [ "Peanut Allergy" ], "start_date": "2017-07-31", "last_update": "2024-12-16" }, { "nct_id": "NCT03215056", "title": "Methoxyflurane Analgesia for Paediatric Injuries", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Medical Developments International Limited", "conditions": [ "Pain, Acute" ], "start_date": "2017-08-14", "last_update": "2024-09-19" }, { "nct_id": "NCT03215511", "title": "A Study to Test the Safety of the Investigational Drug Selitrectinib in Children and Adults That May Treat Cancer", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Solid Tumors Harboring NTRK Fusion" ], "start_date": "2017-07-03", "last_update": "2024-10-30" }, { "nct_id": "NCT03215706", "title": "A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2017-08-24", "last_update": "2025-12-17" }, { "nct_id": "NCT03220425", "title": "Evaluation of the Efficacy and Safety of Insulin Detemir Compared With That of NPH Insulin in Subjects With Type 1 Diabetes.", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes Mellitus, Type 1" ], "start_date": "2001-02-01", "last_update": "2017-07-18" }, { "nct_id": "NCT03224351", "title": "A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2017-08-08", "last_update": "2021-04-22" }, { "nct_id": "NCT03226964", "title": "Assessment of High Flow Nasal Cannula Oxygenation in EBUS Bronchoscopy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Lung Cancer", "Lymphadenopathy" ], "start_date": "2016-10-01", "last_update": "2018-05-02" }, { "nct_id": "NCT03228589", "title": "The Effect of a Probiotic Strain on Aspirin-induced GI Damage.", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Chr Hansen", "conditions": [ "Side Effects of Acetylsalicylic Acid Use" ], "start_date": "2017-07-15", "last_update": "2018-05-03" }, { "nct_id": "NCT03230318", "title": "Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Basilea Pharmaceutica", "conditions": [ "Intrahepatic Cholangiocarcinoma", "Combined Hepatocellular and Cholangiocarcinoma" ], "start_date": "2017-09-28", "last_update": "2023-12-19" }, { "nct_id": "NCT03240523", "title": "A Study to Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Bayer", "conditions": [ "Uterine Fibroids" ], "start_date": "2017-07-31", "last_update": "2024-10-18" }, { "nct_id": "NCT03253263", "title": "A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "OHB Neonatology Ltd.", "conditions": [ "Bronchopulmonary Dysplasia", "Chronic Lung Disease of Prematurity", "Intraventricular Hemorrhage", "Retinopathy of Prematurity (ROP)" ], "start_date": "2019-05-09", "last_update": "2026-08-03" }, { "nct_id": "NCT03256162", "title": "Ketamine as an Adjunctive Therapy for Major Depression", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Major Depressive Episode", "Unipolar Depression", "Bipolar Depression" ], "start_date": "2017-09-07", "last_update": "2020-01-18" }, { "nct_id": "NCT03259308", "title": "Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Shire", "conditions": [ "Ulcerative Colitis" ], "start_date": "2017-12-05", "last_update": "2021-04-26" }, { "nct_id": "NCT03260894", "title": "Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Renal Cell Carcinoma (RCC)" ], "start_date": "2017-12-07", "last_update": "2026-05-22" }, { "nct_id": "NCT03261037", "title": "A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic Period", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Idiopathic Pulmonary Fibrosis", "Interstitial Lung Disease" ], "start_date": "2017-12-25", "last_update": "2021-03-26" }, { "nct_id": "NCT03266783", "title": "Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Ottawa Hospital Research Institute", "conditions": [ "Venous Thromboembolism" ], "start_date": "2017-12-13", "last_update": "2026-06-24" }, { "nct_id": "NCT03271645", "title": "Internet-delivered Interventions for Stress, Anxiety and Depression in the Workplace", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Silver Cloud Health", "conditions": [ "Depression", "Anxiety", "Stress" ], "start_date": "2018-09-11", "last_update": "2018-09-11" }, { "nct_id": "NCT03277196", "title": "A Study to Evaluate the Safety of Long-term Ivacaftor Treatment in Participants With Cystic Fibrosis Who Are Less Than 24 Months of Age at Treatment Initiation and Have an Approved Ivacaftor-Responsive Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2017-08-16", "last_update": "2024-10-23" }, { "nct_id": "NCT03282487", "title": "Optimising Steroid Replacement in Patients With Adrenal Insufficiency", "phases": [ "PHASE4" ], "overall_status": "UNKNOWN", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Adrenal Insufficiency" ], "start_date": "2017-09-05", "last_update": "2017-09-14" }, { "nct_id": "NCT03283085", "title": "A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Crohn's Disease", "Ulcerative Colitis" ], "start_date": "2018-02-27", "last_update": "2024-06-21" }, { "nct_id": "NCT03286855", "title": "Effectiveness of Vibrating Mesh Versus Small Volume Nebuliser in Chronic Obstructive Pulmonary Disease (COPD)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Chronic Obstructive Pulmonary Disease", "COPD", "Copd Exacerbation Acute", "COPD Exacerbation" ], "start_date": "2017-10-18", "last_update": "2019-07-18" }, { "nct_id": "NCT03287414", "title": "Study of Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of VAY736 in Patients With Idiopathic Pulmonary Fibrosis", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2017-12-20", "last_update": "2024-06-18" }, { "nct_id": "NCT03290781", "title": "An Efficacy and Safety Study of Ontamalimab as Maintenance Therapy in Participants With Moderate to Severe Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Shire", "conditions": [ "Ulcerative Colitis" ], "start_date": "2018-04-04", "last_update": "2022-01-14" }, { "nct_id": "NCT03292484", "title": "Longer-term Study of AR101 in Subjects Who Participated in a Prior AR101 Study (ARC008)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Aimmune Therapeutics, Inc.", "conditions": [ "Peanut Allergy" ], "start_date": "2017-11-02", "last_update": "2024-12-19" }, { "nct_id": "NCT03296189", "title": "Local Anaesthetic and Steroid in the Ureter", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Pain, Postoperative", "Ureter Stone" ], "start_date": "2018-11-01", "last_update": "2018-01-17" }, { "nct_id": "NCT03297151", "title": "Protein Supplementation and Recovery of Muscle Function", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Resistance Training", "Muscle Damage" ], "start_date": "2017-07-01", "last_update": "2025-01-31" }, { "nct_id": "NCT03301467", "title": "Controlled Trial Evaluating Avacopan in C3 Glomerulopathy", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "C3 Glomerulopathy (C3G)" ], "start_date": "2017-09-29", "last_update": "2025-03-13" }, { "nct_id": "NCT03302234", "title": "Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2017-12-14", "last_update": "2023-09-26" }, { "nct_id": "NCT03306238", "title": "LAParoscopic Entry Technique in REnal Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Kidney Diseases" ], "start_date": "2017-11-01", "last_update": "2017-12-21" }, { "nct_id": "NCT03306394", "title": "A Study of Trifluridine/Tipiracil (Also Known as S 95005 or TAS-102) in Patients With a Pretreated Colorectal Cancer That Has Spread (Metastatic).", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Institut de Recherches Internationales Servier", "conditions": [ "Metastatic Colorectal Cancer" ], "start_date": "2016-10-18", "last_update": "2024-07-25" }, { "nct_id": "NCT03314311", "title": "Rehabilitative Strategies Following Oesophageal Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Esophageal Cancer" ], "start_date": "2014-10", "last_update": "2017-10-19" }, { "nct_id": "NCT03316716", "title": "Active Warming Versus Non Active Warming During Caesarean Section for Preventing Neonatal Hypothermia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Aliona Vilinsky-Redmond", "conditions": [ "Neonatal Hypothermia" ], "start_date": "2018-01-24", "last_update": "2018-06-15" }, { "nct_id": "NCT03322540", "title": "Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Lung Cancer" ], "start_date": "2017-12-15", "last_update": "2025-08-22" }, { "nct_id": "NCT03322566", "title": "A Study of Pembrolizumab Plus Epacadostat With Platinum-based Chemotherapy Versus Pembrolizumab Plus Platinum-based Chemotherapy Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-715-06/ECHO-306-06)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Lung Cancer" ], "start_date": "2018-01-09", "last_update": "2022-01-24" }, { "nct_id": "NCT03325283", "title": "The PROTEMBO SF Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Protembis GmbH", "conditions": [ "Aortic Stenosis" ], "start_date": "2017-08-09", "last_update": "2018-10-31" }, { "nct_id": "NCT03325439", "title": "A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "UCB Biopharma SRL", "conditions": [ "Electroencephalographic Neonatal Seizures" ], "start_date": "2019-05-07", "last_update": "2024-04-08" }, { "nct_id": "NCT03329846", "title": "An Investigational Immuno-therapy Study of BMS-986205 Combined With Nivolumab, Compared to Nivolumab by Itself, in Patients With Advanced Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma", "Skin Cancer" ], "start_date": "2017-11-30", "last_update": "2021-07-09" }, { "nct_id": "NCT03330847", "title": "To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Metastatic Triple Negative Breast Cancer" ], "start_date": "2018-03-07", "last_update": "2026-07-02" }, { "nct_id": "NCT03337971", "title": "Nutritional Supplement and Bone Health in Post-Menopausal Women", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Bone and Bones", "Osteoporosis Risk", "Osteoporosis, Postmenopausal" ], "start_date": "2017-10-03", "last_update": "2025-01-31" }, { "nct_id": "NCT03339401", "title": "The AdAPT Trial; Adenovirus After Allogeneic Pediatric Transplantation", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Jazz Pharmaceuticals", "conditions": [ "Adenovirus" ], "start_date": "2017-12-22", "last_update": "2021-01-25" }, { "nct_id": "NCT03344653", "title": "A Randomized Controlled Trial With Resolute Onyx in One Month Dual Antiplatelet Therapy (DAPT) for High-Bleeding Risk Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Coronary Artery Disease" ], "start_date": "2017-11-02", "last_update": "2020-12-02" }, { "nct_id": "NCT03345823", "title": "A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2018-03-21", "last_update": "2026-04-09" }, { "nct_id": "NCT03345836", "title": "A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2017-11-29", "last_update": "2022-08-15" }, { "nct_id": "NCT03345849", "title": "A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2017-12-07", "last_update": "2022-11-23" }, { "nct_id": "NCT03350620", "title": "CHAMP: Study of NVK-002 in Children With Myopia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vyluma, Inc.", "conditions": [ "Myopia" ], "start_date": "2017-11-20", "last_update": "2024-11-27" }, { "nct_id": "NCT03361865", "title": "Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "UC (Urothelial Cancer)" ], "start_date": "2017-12-04", "last_update": "2025-08-22" }, { "nct_id": "NCT03362879", "title": "COmedication Study Assessing Mono- and cOmbination Therapy With Levodopa-carbidopa inteStinal Gel", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Parkinson's Disease (PD)" ], "start_date": "2017-12-14", "last_update": "2020-01-06" }, { "nct_id": "NCT03363581", "title": "Food Preference Following Bariatric Surgery", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Imperial College London", "conditions": [ "Obesity" ], "start_date": "2017-12-15", "last_update": "2023-08-08" }, { "nct_id": "NCT03367702", "title": "Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "NRG Oncology", "conditions": [ "Stage II Prostate Adenocarcinoma AJCC v7" ], "start_date": "2018-02-01", "last_update": "2026-01-15" }, { "nct_id": "NCT03369444", "title": "A Factor IX Gene Therapy Study (FIX-GT)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "University College, London", "conditions": [ "Hemophilia B" ], "start_date": "2017-12-05", "last_update": "2022-12-02" }, { "nct_id": "NCT03370120", "title": "Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "UCB Biopharma SRL", "conditions": [ "Drug-Resistant Epilepsy", "Focal-Onset Seizures" ], "start_date": "2018-08-27", "last_update": "2021-12-29" }, { "nct_id": "NCT03374488", "title": "Pembrolizumab + Epacadostat vs Pembrolizumab + Placebo in Recurrent or Progressive Metastatic Urothelial Carcinoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Corporation", "conditions": [ "UC (Urothelial Cancer)" ], "start_date": "2017-12-22", "last_update": "2025-08-22" }, { "nct_id": "NCT03374748", "title": "Examination of Meal Patterns in National Adult Nutrition Survey (NANS), Ireland", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Food Consumption Database Analysis" ], "start_date": "2008-10", "last_update": "2017-12-19" }, { "nct_id": "NCT03375710", "title": "SIRONA Trial Heart Failure NYHA Class III", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Endotronix, Inc.", "conditions": [ "Heart Failure NYHA Class III" ], "start_date": "2017-12-01", "last_update": "2025-09-02" }, { "nct_id": "NCT03377660", "title": "Resection of the Esophagus and Subsequent Weight Loss", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Imperial College London", "conditions": [ "Esophageal Cancer", "Weight Gain", "Eating Behavior", "Food Reward" ], "start_date": "2018-01-01", "last_update": "2024-03-27" }, { "nct_id": "NCT03377699", "title": "Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Diabetes", "Diabetes Mellitus, Type 1" ], "start_date": "2017-11-22", "last_update": "2023-01-20" }, { "nct_id": "NCT03379922", "title": "Strategies to Maximise Patient Comfort During ESWL", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cliodhna Browne", "conditions": [ "Nephrolithiasis" ], "start_date": "2017-03-27", "last_update": "2019-04-17" }, { "nct_id": "NCT03381027", "title": "BABY SMART (Study of Massage Therapy, Sleep And neurodevelopMenT)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Sleep", "Neurodevelopmental Disorders" ], "start_date": "2017-06-05", "last_update": "2020-10-28" }, { "nct_id": "NCT03396887", "title": "The Effectiveness of a Smartphone Application in the Treatment of Alcohol Use Disorder", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Alcohol Use Disorder" ], "start_date": "2017-05-01", "last_update": "2018-01-11" }, { "nct_id": "NCT03403491", "title": "Study of Self-monitoring of Weight & Blood Pressure (Via patientMpower Platform) in Hemodialysis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "patientMpower Ltd.", "conditions": [ "Renal Dialysis" ], "start_date": "2018-11-07", "last_update": "2020-06-16" }, { "nct_id": "NCT03408509", "title": "Cognitive Training to Promote Brain Health: Implementation and Engagement", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Universidade Federal do Rio de Janeiro", "conditions": [ "Aging", "Mild Cognitive Impairment" ], "start_date": "2018-01-12", "last_update": "2018-01-26" }, { "nct_id": "NCT03409614", "title": "Combinations of Cemiplimab (Anti-PD-1 Antibody) and Platinum-based Doublet Chemotherapy in Patients With Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2018-03-06", "last_update": "2026-05-18" }, { "nct_id": "NCT03410693", "title": "Study of Rogaratinib (BAY1163877) vs Chemotherapy in Patients With FGFR (Fibroblast Growth Factor Receptor)-Positive Locally Advanced or Metastatic Urothelial Carcinoma", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Carcinoma, Transitional Cell" ], "start_date": "2018-05-31", "last_update": "2022-09-28" }, { "nct_id": "NCT03416595", "title": "A Study on Efficacy of Feeding N1115 Probiotic Supplement to Young Children", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Junlebao Dairy Group Co., Ltd.", "conditions": [ "Intestinal Growth of Young Children" ], "start_date": "2017-09-18", "last_update": "2018-07-24" }, { "nct_id": "NCT03423602", "title": "Safety and Performance Study of Large Hole Vascular Closure Device FIV", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vivasure Medical Limited", "conditions": [ "Percutaneous CFA Arteriotomy Closure" ], "start_date": "2017-10-12", "last_update": "2023-02-01" }, { "nct_id": "NCT03425539", "title": "Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Idorsia Pharmaceuticals Ltd.", "conditions": [ "Fabry Disease" ], "start_date": "2018-06-21", "last_update": "2024-08-09" }, { "nct_id": "NCT03425643", "title": "Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2018-04-24", "last_update": "2026-07-29" }, { "nct_id": "NCT03429491", "title": "Novel Nutrition Solutions for Sarcopenia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Sarcopenia" ], "start_date": "2017-06-01", "last_update": "2019-04-18" }, { "nct_id": "NCT03440372", "title": "Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Celgene", "conditions": [ "Crohn Disease" ], "start_date": "2018-02-27", "last_update": "2025-11-04" }, { "nct_id": "NCT03445000", "title": "ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancer", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Non-small Cell Lung Cancer", "Non-small Cell Lung Cancer Metastatic", "Non-small Cell Lung Cancer Recurrent" ], "start_date": "2018-11-06", "last_update": "2026-07-21" }, { "nct_id": "NCT03447249", "title": "A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-03-07", "last_update": "2020-03-13" }, { "nct_id": "NCT03447262", "title": "A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-07-13", "last_update": "2022-01-25" }, { "nct_id": "NCT03449875", "title": "Global Post-market Registry for the Treovance Stent-graft.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bolton Medical", "conditions": [ "Abdominal Aortic Aneurysm" ], "start_date": "2014-02-05", "last_update": "2020-06-26" }, { "nct_id": "NCT03450395", "title": "The Effect of Oats Containing 1.4g Beta Glucan on Fecal Bacterial Population(s) and Plasma Cholesterol in Healthy Adults With Elevated Cholesterol Levels", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "PepsiCo Global R&D", "conditions": [ "Microbiome", "Plasma Cholesterol", "Prebiotic" ], "start_date": "2018-01-28", "last_update": "2019-12-05" }, { "nct_id": "NCT03455335", "title": "Autologous Stem Cells for the Treatment of No Option Critical Limb Ischemia", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Critical Limb Ischemia" ], "start_date": "2015-03-23", "last_update": "2021-03-04" }, { "nct_id": "NCT03457285", "title": "Investigating the Use of Salaso to Improve Physiotherapy Management of Ankylosing Spondylitis (AS).", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Ankylosing Spondylitis" ], "start_date": "2018-10-17", "last_update": "2018-11-07" }, { "nct_id": "NCT03458468", "title": "Tranexamic Acid for the Latarjet Procedure.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "Anterior Shoulder Instability" ], "start_date": "2018-03-01", "last_update": "2019-07-30" }, { "nct_id": "NCT03460717", "title": "Thermal Micro-cautery for Painful Knee Osteoarthritis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The National Children's Hospital, Tallaght", "conditions": [ "Chronic Pain Syndrome" ], "start_date": "2016-11-01", "last_update": "2019-11-07" }, { "nct_id": "NCT03460990", "title": "A Study of VX-659 Combination Therapy in CF Subjects Homozygous for F508del (F/F)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-05-01", "last_update": "2019-10-17" }, { "nct_id": "NCT03461341", "title": "European iNvestigation of SUrveillance After Resection for Esophageal Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Cancer", "Metastatic Cancer", "Recurrent Esophageal Cancer", "Chemoradiation", "Chemotherapy", "Radiation", "Surgery" ], "start_date": "2009-06-01", "last_update": "2020-03-26" }, { "nct_id": "NCT03462524", "title": "Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Cancer", "Radiation Pneumonitis", "Pulmonary Fibrosis", "Respiratory Failure", "Pneumonia", "Surgery", "Chemotherapy Effect", "Radiation Fibrosis", "Radiation Toxicity", "Adenocarcinoma", "Squamous Cell Carcinoma" ], "start_date": "2010-01-01", "last_update": "2018-03-12" }, { "nct_id": "NCT03464097", "title": "A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Celgene", "conditions": [ "Crohn Disease" ], "start_date": "2018-06-27", "last_update": "2025-10-09" }, { "nct_id": "NCT03466047", "title": "The Effect of Macronutrients on Satiety and Gut Hormone Responses", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Imperial College London", "conditions": [ "Eating Behavior" ], "start_date": "2018-03-15", "last_update": "2020-10-20" }, { "nct_id": "NCT03467607", "title": "A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Low Tidal Volume Ventilation" ], "start_date": "2016-10-20", "last_update": "2018-03-16" }, { "nct_id": "NCT03467958", "title": "An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Celgene", "conditions": [ "Crohn Disease" ], "start_date": "2018-08-24", "last_update": "2025-09-17" }, { "nct_id": "NCT03468504", "title": "Mirror Therapy and Treadmill Training for Patients With Chronic Stroke", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stroke" ], "start_date": "2014-04-01", "last_update": "2018-05-14" }, { "nct_id": "NCT03469674", "title": "PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Leiden University Medical Center", "conditions": [ "Endometrial Cancer Stage I", "Endometrial Cancer Stage II" ], "start_date": "2016-06-10", "last_update": "2023-10-11" }, { "nct_id": "NCT03475992", "title": "Pilot Clinical Study on a Low-power Electromagnetic Wave Breast Imaging Device for Cancer Screening Purposes.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "MVG Industries SAS", "conditions": [ "Breast Cancer", "Breast Cyst" ], "start_date": "2018-10-10", "last_update": "2021-06-07" }, { "nct_id": "NCT03476005", "title": "Proficiency Based Training to Investigate WBIT", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Patrick Henn", "conditions": [ "Transfusion Related Complication", "Wrong Blood in Tube" ], "start_date": "2017-07-05", "last_update": "2018-07-05" }, { "nct_id": "NCT03476980", "title": "Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Sharp HealthCare", "conditions": [ "Neurodevelopmental Abnormality" ], "start_date": "2019-07-06", "last_update": "2022-11-25" }, { "nct_id": "NCT03481738", "title": "Pyruvate Kinase Deficiency Global Longitudinal Registry", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Agios Pharmaceuticals, Inc.", "conditions": [ "Pyruvate Kinase Deficiency" ], "start_date": "2018-04-23", "last_update": "2026-09-28" }, { "nct_id": "NCT03483480", "title": "Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "The National Children's Hospital, Tallaght", "conditions": [ "Pilonidal Disease", "Pilonidal Sinus" ], "start_date": "2018-05-21", "last_update": "2019-04-05" }, { "nct_id": "NCT03486873", "title": "Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Solid Tumors", "Hematologic Malignancies" ], "start_date": "2018-08-21", "last_update": "2026-10-07" }, { "nct_id": "NCT03489135", "title": "The Venous Thrombus Extraction (VETEX) Clinical Study: A Preliminary Investigation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vetex Medical Ltd.", "conditions": [ "Deep Vein Thrombosis Leg" ], "start_date": "2018-11-13", "last_update": "2021-05-21" }, { "nct_id": "NCT03497650", "title": "Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stroke" ], "start_date": "2014-10-22", "last_update": "2018-04-13" }, { "nct_id": "NCT03498521", "title": "A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Cancer of Unknown Primary Site" ], "start_date": "2018-07-10", "last_update": "2025-11-19" }, { "nct_id": "NCT03498716", "title": "A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Triple Negative Breast Cancer" ], "start_date": "2018-08-02", "last_update": "2024-08-21" }, { "nct_id": "NCT03500705", "title": "Upper Limb Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stroke" ], "start_date": "2014-10-22", "last_update": "2018-04-18" }, { "nct_id": "NCT03501108", "title": "Discontinuation of Long-term Medications in Older People Entering Nursing Home Care", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Polypharmacy", "Frail Elderly Syndrome", "Inappropriate Prescribing", "Drug-Related Side Effects and Adverse Reactions" ], "start_date": "2018-03-27", "last_update": "2018-04-18" }, { "nct_id": "NCT03505021", "title": "Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Orion Corporation, Orion Pharma", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2018-06-21", "last_update": "2022-05-11" }, { "nct_id": "NCT03516981", "title": "A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Advanced Non-Small Cell Lung Cancer" ], "start_date": "2018-10-01", "last_update": "2026-06-08" }, { "nct_id": "NCT03517449", "title": "Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775])", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Inc.", "conditions": [ "Endometrial Neoplasms" ], "start_date": "2018-06-11", "last_update": "2026-03-19" }, { "nct_id": "NCT03518086", "title": "An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Ulcerative Colitis" ], "start_date": "2018-06-18", "last_update": "2025-05-31" }, { "nct_id": "NCT03519945", "title": "A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Ulcerative Colitis" ], "start_date": "2018-07-18", "last_update": "2026-04-20" }, { "nct_id": "NCT03522246", "title": "A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "pharmaand GmbH", "conditions": [ "Epithelial Ovarian Cancer", "Primary Peritoneal", "Fallopian Tube Cancer", "Newly Diagnosed", "FIGO Stage III-IV", "Partial Response", "Complete Response" ], "start_date": "2018-05-14", "last_update": "2025-06-24" }, { "nct_id": "NCT03523858", "title": "A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Progressive Multiple Sclerosis (PMS)" ], "start_date": "2018-05-28", "last_update": "2026-07-23" }, { "nct_id": "NCT03524092", "title": "A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Ulcerative Colitis" ], "start_date": "2018-10-19", "last_update": "2026-05-13" }, { "nct_id": "NCT03524677", "title": "Mutation of K-RAS, CDKN2A, SMAD4 and TP53 in Pancreatic Cancer: Role of Liquid Biopsy in Preoperative Diagnosis", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Roma La Sapienza", "conditions": [ "Pancreatic Cancer" ], "start_date": "2019-01-23", "last_update": "2019-01-25" }, { "nct_id": "NCT03530306", "title": "Treatment Evaluation of Neuromodulation for Tinnitus - Stage A2", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neuromod Devices Ltd.", "conditions": [ "Tinnitus" ], "start_date": "2018-03-20", "last_update": "2024-12-20" }, { "nct_id": "NCT03537651", "title": "A Study to Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-04-25", "last_update": "2024-04-19" }, { "nct_id": "NCT03539536", "title": "Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2018-10-10", "last_update": "2025-11-05" }, { "nct_id": "NCT03544372", "title": "Reliability of Self-reported Concussion History in Current Rugby Union Players", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Concussion, Mild" ], "start_date": "2017-03-15", "last_update": "2018-06-07" }, { "nct_id": "NCT03548363", "title": "Effect of Gingest on Symptoms of Dyspepsia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "Dyspepsia", "Epigastric Fullness", "Bloating", "Epigastric Pain" ], "start_date": "2018-03-13", "last_update": "2019-01-10" }, { "nct_id": "NCT03549871", "title": "A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prophylaxis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Genzyme, a Sanofi Company", "conditions": [ "Hemophilia" ], "start_date": "2018-07-25", "last_update": "2023-02-06" }, { "nct_id": "NCT03551860", "title": "Quadratus Lumborum Block Versus Fascia Iliaca Nerve Block for Patients Undergoing Total Hip Replacement", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "The Adelaide and Meath Hospital, incorporating The National Children's Hospital", "conditions": [ "Hip Replacement" ], "start_date": "2018-04-10", "last_update": "2018-06-11" }, { "nct_id": "NCT03558152", "title": "A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of UTTR1147A Compared With Placebo and With Vedolizumab in Participants With Moderate to Severe Ulcerative Colitis (UC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Genentech, Inc.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2018-10-26", "last_update": "2023-04-14" }, { "nct_id": "NCT03559062", "title": "A Study to Evaluate Efficacy and Safety of TEZ/IVA in Subjects Aged 6 Through 11 Years With Cystic Fibrosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-05-17", "last_update": "2020-02-11" }, { "nct_id": "NCT03559699", "title": "A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Agios Pharmaceuticals, Inc.", "conditions": [ "Pyruvate Kinase Deficiency", "Anemia, Hemolytic" ], "start_date": "2018-06-26", "last_update": "2022-01-04" }, { "nct_id": "NCT03559933", "title": "PEPNS System Feasibility Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Stimdia Medical Inc.", "conditions": [ "Ventilator Induced Diaphragmatic Dysfunction (VIDD)" ], "start_date": "2018-07-10", "last_update": "2021-09-16" }, { "nct_id": "NCT03562546", "title": "The Effect of Structured Exercise on Chronic Venous Insufficiency", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Shannon Hernon", "conditions": [ "Chronic Venous Insufficiency" ], "start_date": "2018-08-01", "last_update": "2018-06-19" }, { "nct_id": "NCT03566823", "title": "Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Shire", "conditions": [ "Crohn's Disease" ], "start_date": "2018-07-17", "last_update": "2021-05-11" }, { "nct_id": "NCT03568318", "title": "A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Atopic Dermatitis" ], "start_date": "2018-08-09", "last_update": "2025-12-23" }, { "nct_id": "NCT03568929", "title": "Safety Profile of Idelalisib in Patients With Refractory Follicular Lymphoma", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Follicular Non-Hodgkin's Lymphoma Refractory" ], "start_date": "2018-05-25", "last_update": "2021-11-19" }, { "nct_id": "NCT03569891", "title": "HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "CSL Behring", "conditions": [ "Hemophilia B" ], "start_date": "2018-06-27", "last_update": "2026-03-27" }, { "nct_id": "NCT03570424", "title": "Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Muscle, Skeletal", "High-Intensity Interval Training", "Exercise" ], "start_date": "2018-01-31", "last_update": "2020-01-13" }, { "nct_id": "NCT03574597", "title": "Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Overweight", "Obesity" ], "start_date": "2018-10-24", "last_update": "2024-08-30" }, { "nct_id": "NCT03574909", "title": "IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Pre-Gestational Diabetes" ], "start_date": "2018-09-01", "last_update": "2026-03-27" }, { "nct_id": "NCT03576911", "title": "A Randomised Controlled Trial of Coenzyme Q10 in Patients With Schizophrenia and Schizoaffective Disorder", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Schizophrenia", "Schizoaffective Disorder" ], "start_date": "2016-11", "last_update": "2019-06-20" }, { "nct_id": "NCT03577561", "title": "Proficiency Based Training to Investigate Blood Sampling Errors Including WBIT", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Patrick Henn", "conditions": [ "Blood Transfusion Complication", "Wrong Blood in Tube", "Pre Analytical Blood Sample Errors" ], "start_date": "2018-07-04", "last_update": "2019-07-09" }, { "nct_id": "NCT03579641", "title": "Precision Event Monitoring for Patients With Heart Failure Using HeartLogic", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Heart Failure", "Defibrillators, Implantable", "Monitoring, Physiologic", "Cardiac Resynchronization Therapy", "Cardiovascular Disease", "Heart Disease" ], "start_date": "2018-06-01", "last_update": "2022-10-25" }, { "nct_id": "NCT03582098", "title": "Clinical Outcomes and Routine Management of Adults With Chronic Lymphocytic Leukaemia Treated With Idelalisib and Rituximab in the United Kingdom (UK) and Ireland", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Chronic Lymphocytic Leukaemia" ], "start_date": "2018-09-12", "last_update": "2019-04-12" }, { "nct_id": "NCT03587987", "title": "Comparison of Two Different Resuscitation Devices", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Manual Ventilation" ], "start_date": "2018-07-03", "last_update": "2023-02-28" }, { "nct_id": "NCT03592342", "title": "Intra-oral Treatment of OLP With Rivelin®-CLO Patches", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Dermtreat", "conditions": [ "Oral Lichen Planus" ], "start_date": "2018-06-28", "last_update": "2020-07-14" }, { "nct_id": "NCT03599245", "title": "This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Multiple Sclerosis" ], "start_date": "2018-07-12", "last_update": "2026-09-25" }, { "nct_id": "NCT03599622", "title": "An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Granulomatous Colitis", "Crohn's Disease", "Crohn's Enteritis", "Granulomatous Enteritis" ], "start_date": "2018-07-16", "last_update": "2024-07-03" }, { "nct_id": "NCT03603769", "title": "In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2018-09-03", "last_update": "2019-12-19" }, { "nct_id": "NCT03607422", "title": "A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Atopic Dermatitis" ], "start_date": "2018-07-27", "last_update": "2026-06-02" }, { "nct_id": "NCT03610308", "title": "ESTES Snapshot Audit 2018", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "European Society for Trauma and Emergency Surgery", "conditions": [ "Cholangitis; Gallstone", "Pancreatitis Gallstone", "Cholecystitis; Gangrenous" ], "start_date": "2018-10-01", "last_update": "2019-07-05" }, { "nct_id": "NCT03614260", "title": "The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ReCor Medical, Inc.", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases" ], "start_date": "2018-12-14", "last_update": "2026-09-24" }, { "nct_id": "NCT03615326", "title": "Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Gastric Neoplasms", "Gastroesophageal Junction Adenocarcinoma" ], "start_date": "2018-10-05", "last_update": "2026-08-26" }, { "nct_id": "NCT03616470", "title": "Study to Determine the Efficacy of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "GlycoMimetics Incorporated", "conditions": [ "Acute Myeloid Leukemia" ], "start_date": "2018-10-15", "last_update": "2024-07-29" }, { "nct_id": "NCT03623061", "title": "F-Point Validation Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Low Fibrinogen" ], "start_date": "2018-05-14", "last_update": "2018-08-09" }, { "nct_id": "NCT03624634", "title": "Assessment of the Effects of Concussion on Adolescent Rugby Union Players", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "Concussion, Mild", "Concussion, Intermediate", "Concussion, Severe" ], "start_date": "2016-08-01", "last_update": "2024-04-22" }, { "nct_id": "NCT03626012", "title": "A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2018-09-10", "last_update": "2022-01-14" }, { "nct_id": "NCT03627091", "title": "Efficacy and Safety Study of Ontamalimab as Maintenance Treatment in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 307)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Shire", "conditions": [ "Crohn's Disease" ], "start_date": "2019-02-06", "last_update": "2022-03-31" }, { "nct_id": "NCT03635983", "title": "A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2018-09-21", "last_update": "2025-04-01" }, { "nct_id": "NCT03640689", "title": "DEep VEin Lesion OPtimisation (DEVELOP) Trial", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Venous Leg Ulcer" ], "start_date": "2019-07-15", "last_update": "2021-03-03" }, { "nct_id": "NCT03642132", "title": "Avelumab and Talazoparib in Untreated Advanced Ovarian Cancer (JAVELIN OVARIAN PARP 100)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Pfizer", "conditions": [ "Ovarian Cancer" ], "start_date": "2018-07-19", "last_update": "2023-04-06" }, { "nct_id": "NCT03644160", "title": "A Physiotherapist Led Intervention to Promote Physical Activity in Rheumatoid Arthritis - a Pilot Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2019-10-01", "last_update": "2022-06-13" }, { "nct_id": "NCT03647215", "title": "CALLS: CML and Ph+ALL Low Level Mutation Prevalence Survey", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Incyte Biosciences UK", "conditions": [ "Chronic Phase Chronic Myelogenous Leukemia", "Accelerated Phase Chronic Myelogenous Leukemia", "Blastic Phase Chronic Myelogenous Leukemia", "Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia" ], "start_date": "2017-12-18", "last_update": "2021-08-16" }, { "nct_id": "NCT03650413", "title": "An Extension Study to Evaluate the Long-Term Safety and Tolerability of UTTR1147A in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Genentech, Inc.", "conditions": [ "Ulcerative Colitis", "Crohn's Disease" ], "start_date": "2019-01-14", "last_update": "2023-09-29" }, { "nct_id": "NCT03653026", "title": "A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis (UC)" ], "start_date": "2018-12-06", "last_update": "2022-03-02" }, { "nct_id": "NCT03653507", "title": "A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Astellas Pharma Global Development, Inc.", "conditions": [ "Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer", "Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer", "Metastatic Gastric Adenocarcinoma or Cancer", "Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma" ], "start_date": "2018-11-28", "last_update": "2026-09-28" }, { "nct_id": "NCT03656536", "title": "A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Unresectable Cholangiocarcinoma", "Metastatic Cholangiocarcinoma" ], "start_date": "2019-06-03", "last_update": "2026-08-11" }, { "nct_id": "NCT03657043", "title": "A Study of Weekly Tisotumab Vedotin for Patients With Platinum-Resistant Ovarian Cancer With Safety Run-in (innovaTV 208)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Seagen Inc.", "conditions": [ "Ovarian Cancer", "Fallopian Tube Cancer", "Peritoneal Cancer" ], "start_date": "2019-03-20", "last_update": "2023-05-06" }, { "nct_id": "NCT03666780", "title": "Lifetech LAmbre™ Left Atrial Appendage (LAA) Closure System Post-Market Clinical Follow-up Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Lifetech Scientific (Shenzhen) Co., Ltd.", "conditions": [ "Atrial Fibrillation" ], "start_date": "2018-11-16", "last_update": "2025-07-04" }, { "nct_id": "NCT03668964", "title": "Effect of Nutrition Ingredients on Microbiota Modulation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "dsm-firmenich Switzerland AG", "conditions": [ "Healthy Volunteers" ], "start_date": "2018-08-20", "last_update": "2020-03-30" }, { "nct_id": "NCT03671096", "title": "Safety and Efficacy of the Transform™ Corneal Allograft for Hyperopia Correction", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Allotex, Inc.", "conditions": [ "Hyperopia" ], "start_date": "2018-10", "last_update": "2020-03-11" }, { "nct_id": "NCT03671135", "title": "Safety and Efficacy of an Intrastromal Transform™ Corneal Allograft (TCA) for Presbyopia Correction", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Allotex, Inc.", "conditions": [ "Presbyopia" ], "start_date": "2018-08-09", "last_update": "2024-02-23" }, { "nct_id": "NCT03671395", "title": "The DCU Running Injury Surveillance Centre Study: A Prospective Investigation of Factors Relating to Running Injuries", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin City University", "conditions": [ "Musculoskeletal Injury" ], "start_date": "2018-02-01", "last_update": "2020-07-22" }, { "nct_id": "NCT03672058", "title": "Steps Ahead: Optimising Physical Activity and Health in Adults With Cystic Fibrosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-10-01", "last_update": "2025-01-30" }, { "nct_id": "NCT03674606", "title": "Trial of Early Screening Test for Pre-eclampsia and Growth Restriction", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Pre-Eclampsia", "Placenta Diseases", "Eclampsia Preeclampsia", "Fetal Growth Retardation", "Foetal Growth Restriction" ], "start_date": "2014-02-01", "last_update": "2018-09-17" }, { "nct_id": "NCT03675438", "title": "Safety and Efficacy of a Sub-epitheilal Transform™ Corneal Allograft (TCA) for Presbyopia Correction", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Allotex, Inc.", "conditions": [ "Presbyopia", "Refractive Errors" ], "start_date": "2018-10", "last_update": "2020-03-11" }, { "nct_id": "NCT03675737", "title": "Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Stomach Neoplasms" ], "start_date": "2018-11-08", "last_update": "2026-02-27" }, { "nct_id": "NCT03676933", "title": "Efficacy and Steroid Sparing Potential Study of DGLA Cream in Early Childhood Patients With Moderate to Severe Atopic Dermatitis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "DS Biopharma", "conditions": [ "Atopic Dermatitis" ], "start_date": "2015-10", "last_update": "2019-02-08" }, { "nct_id": "NCT03682211", "title": "Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Pain", "Sickle Cell Disease" ], "start_date": "2012-12-12", "last_update": "2018-09-24" }, { "nct_id": "NCT03685838", "title": "Compression Stockings Therapy Following Mechano-Chemical Ablation (Clarivein®)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Singapore General Hospital", "conditions": [ "Varicose Veins", "Chronic Venous Insufficiency" ], "start_date": "2019-02-13", "last_update": "2020-10-30" }, { "nct_id": "NCT03688841", "title": "Negative Pressure Vs. Compression in Venous Ulcers", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Western Vascular Institute, Ireland", "conditions": [ "Varicose Ulcer" ], "start_date": "2016-01-19", "last_update": "2021-08-04" }, { "nct_id": "NCT03691779", "title": "Evaluation of VX 445/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2018-10-02", "last_update": "2021-10-22" }, { "nct_id": "NCT03692715", "title": "Antibiotic Prophylaxis Before Shock Wave Lithotripsy", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Clinical Urology and Epidemiology Working Group", "conditions": [ "Ureteral Stones", "Ureteral Calculi", "Nephrolithiasis" ], "start_date": "2018-09-27", "last_update": "2025-03-28" }, { "nct_id": "NCT03692806", "title": "Efficacy of STABLOR® on Visceral Fat Mass Reduction in Patients With Metabolic Syndrome", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "LNC THERAPEUTICS", "conditions": [ "Metabolic Syndrome" ], "start_date": "2018-09-11", "last_update": "2020-12-17" }, { "nct_id": "NCT03694509", "title": "Gastric Emptying After Tea With Milk in Pregnancy.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Gastric Emptying" ], "start_date": "2018-10-30", "last_update": "2019-08-16" }, { "nct_id": "NCT03695588", "title": "Quadratus Lumborum Block (QLB) for Pain Relief After Caesarean Section", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Quadratus Lumborum Block" ], "start_date": "2018-10-30", "last_update": "2019-07-23" }, { "nct_id": "NCT03696160", "title": "The Late Presenter Treatment Optimisation Study", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "NEAT ID Foundation", "conditions": [ "HIV/AIDS" ], "start_date": "2019-03-05", "last_update": "2025-12-17" }, { "nct_id": "NCT03698201", "title": "Blood Biomarker Signature in Glioma", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Glioma of Brain" ], "start_date": "2009-07", "last_update": "2025-07-08" }, { "nct_id": "NCT03698630", "title": "Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Asthma", "Acute Asthma" ], "start_date": "2011-07-06", "last_update": "2018-10-09" }, { "nct_id": "NCT03699111", "title": "Identification of New Patient Stratification Tools in MSS RAS mt mCRC", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Advanced Colorectal Cancer" ], "start_date": "2018-09-19", "last_update": "2026-04-13" }, { "nct_id": "NCT03701113", "title": "Milk Protein and Bone Health in Postmenopausal Women", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Bone and Bones", "Osteoporosis Risk", "Osteoporosis, Postmenopausal" ], "start_date": "2018-10-22", "last_update": "2025-01-29" }, { "nct_id": "NCT03701334", "title": "A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Early Breast Cancer" ], "start_date": "2018-12-07", "last_update": "2026-10-09" }, { "nct_id": "NCT03703024", "title": "An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "Osteoarthritis, Knee" ], "start_date": "2017-06-01", "last_update": "2019-01-10" }, { "nct_id": "NCT03703882", "title": "Phase III Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Catabasis Pharmaceuticals", "conditions": [ "Muscular Dystrophy, Duchenne" ], "start_date": "2018-10-02", "last_update": "2022-06-21" }, { "nct_id": "NCT03711552", "title": "Validation of an Obstetric QoR Score and to Establish Its MCID.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Quality of Recovery", "Caesarean Section" ], "start_date": "2018-10-31", "last_update": "2019-08-16" }, { "nct_id": "NCT03713593", "title": "Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Hepatocellular" ], "start_date": "2018-12-31", "last_update": "2026-02-05" }, { "nct_id": "NCT03721107", "title": "A Trial for New Treatment of Adult Participants With Irritable Bowel Syndrome", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "4D pharma plc", "conditions": [ "Irritable Bowel Syndrome" ], "start_date": "2018-10-11", "last_update": "2022-01-11" }, { "nct_id": "NCT03721705", "title": "Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of the Alzheimer's Type", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Renew Research, LLC", "conditions": [ "Alzheimer Disease", "Cognitive Dysfunction", "Mild Cognitive Impairment", "Mild Dementia", "Cognitive Decline", "Dementia, Alzheimer Type" ], "start_date": "2018-11-12", "last_update": "2022-05-11" }, { "nct_id": "NCT03725059", "title": "Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Breast Cancer" ], "start_date": "2018-12-27", "last_update": "2025-07-11" }, { "nct_id": "NCT03731195", "title": "GentleTouch (Study to Evaluate Somatosensory Evoked Potential (SSEP) Responses to Affective Touch and How it Develops in Healthy Term Babies)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Pleasant Touch", "Cortical Response" ], "start_date": "2018-05-09", "last_update": "2023-12-11" }, { "nct_id": "NCT03734627", "title": "Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophageal Cancer", "Nutrition Disorders", "Appetite Disorders", "Dumping Syndrome", "Delayed Gastric Emptying", "Surgery" ], "start_date": "2016-07-01", "last_update": "2021-08-16" }, { "nct_id": "NCT03735537", "title": "Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Edinburgh", "conditions": [ "Osteogenesis Imperfecta" ], "start_date": "2016-11-01", "last_update": "2026-06-11" }, { "nct_id": "NCT03738397", "title": "A Study to Compare Safety and Efficacy of Upadacitinib to Dupilumab in Adult Participants With Moderate to Severe Atopic Dermatitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Atopic Dermatitis" ], "start_date": "2019-02-21", "last_update": "2024-03-15" }, { "nct_id": "NCT03739515", "title": "Impact of an Allied Health Team in the Emergency Department on Older Adults' Care", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Limerick", "conditions": [ "ED-based Allied Health Services" ], "start_date": "2018-12-03", "last_update": "2019-09-06" }, { "nct_id": "NCT03739840", "title": "A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "UCB Biopharma SRL", "conditions": [ "Drug-Resistant Epilepsy", "Focal-Onset Seizures" ], "start_date": "2019-03-06", "last_update": "2022-12-21" }, { "nct_id": "NCT03742895", "title": "Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Advanced Solid Neoplasms" ], "start_date": "2018-12-12", "last_update": "2026-08-14" }, { "nct_id": "NCT03744598", "title": "Self-monitoring of Spirometry & Symptoms Via patientMpower App in Idiopathic Pulmonary Fibrosis", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "patientMpower Ltd.", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2018-11-28", "last_update": "2022-07-28" }, { "nct_id": "NCT03745222", "title": "A Study of Tislelizumab (BGB-A317) Plus Chemoradiotherapy Followed by Tislelizumab Monotherapy in Newly Diagnosed, Stage III Subjects With Locally Advanced, Unresectable Non-small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Celgene", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2019-05-22", "last_update": "2020-07-15" }, { "nct_id": "NCT03754790", "title": "Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitory Antibodies to Factor VIII or IX", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Genzyme, a Sanofi Company", "conditions": [ "Hemophilia" ], "start_date": "2019-01-09", "last_update": "2026-09-30" }, { "nct_id": "NCT03755791", "title": "Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Exelixis", "conditions": [ "Hepatocellular Carcinoma" ], "start_date": "2018-06-10", "last_update": "2025-12-11" }, { "nct_id": "NCT03765918", "title": "Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Head and Neck Neoplasms" ], "start_date": "2018-12-17", "last_update": "2026-07-31" }, { "nct_id": "NCT03768193", "title": "Deep Serratus Anterior Plane Block vs Surgically-placed Paravertebral Block for VATS Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Thoracic Diseases", "Thoracic Surgery", "Rib Fractures", "Pain, Postoperative", "Pain, Procedural", "Anaesthesia, Regional" ], "start_date": "2017-10-04", "last_update": "2018-12-07" }, { "nct_id": "NCT03772028", "title": "Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "The Netherlands Cancer Institute", "conditions": [ "Ovarian Cancer" ], "start_date": "2020-01-01", "last_update": "2026-04-08" }, { "nct_id": "NCT03775200", "title": "The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "COMPASS Pathways", "conditions": [ "Treatment Resistant Depression" ], "start_date": "2019-03-01", "last_update": "2023-04-24" }, { "nct_id": "NCT03775291", "title": "Validation of Software for Assessment of Sleep Apnea From Data Acquired by a Wearable Smartwatch", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Fitbit LLC", "conditions": [ "Sleep Apnea" ], "start_date": "2018-11-09", "last_update": "2022-08-22" }, { "nct_id": "NCT03778931", "title": "Phase 3 Trial of Elacestrant Versus Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Stemline Therapeutics, Inc.", "conditions": [ "Breast Cancer" ], "start_date": "2019-05-10", "last_update": "2025-09-15" }, { "nct_id": "NCT03786081", "title": "Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other Cancer Agents in Subjects With Cervical Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Seagen, a wholly owned subsidiary of Pfizer", "conditions": [ "Cervical Cancer" ], "start_date": "2019-02-27", "last_update": "2026-07-22" }, { "nct_id": "NCT03786107", "title": "HER-Seq: A Blood-based Screening Study to Identify Patients With HER2 Mutations for Enrollment Into Clinical Research Studies of Neratinib", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Puma Biotechnology, Inc.", "conditions": [ "Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer", "Metastatic Cervical Cancer" ], "start_date": "2019-03-14", "last_update": "2021-05-19" }, { "nct_id": "NCT03800251", "title": "Rate of Gastric Emptying in Term Parturients Undergoing Elective Cesarean Section", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Gastric Emptying", "Pregnancy" ], "start_date": "2018-06-06", "last_update": "2019-01-11" }, { "nct_id": "NCT03800524", "title": "Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Humanitas Mirasole SpA", "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "start_date": "2019-02-22", "last_update": "2023-07-10" }, { "nct_id": "NCT03807518", "title": "Pre- and Post-Operative Exercise Program in Upper Gastrointestinal Cancers", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Exercise Intervention" ], "start_date": "2019-03-01", "last_update": "2021-03-09" }, { "nct_id": "NCT03811535", "title": "A Research Study in Children With a Low Level of Hormone to Grow. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day (REAL4)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Growth Hormone Deficiency in Children" ], "start_date": "2019-05-20", "last_update": "2026-05-22" }, { "nct_id": "NCT03812887", "title": "Photopatch Test Study (POST Study)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Photoallergy" ], "start_date": "2018-09-01", "last_update": "2019-01-23" }, { "nct_id": "NCT03816163", "title": "A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Astellas Pharma Global Development, Inc.", "conditions": [ "Pancreatic Cancer", "Metastatic Pancreatic Cancer", "Metastatic Pancreatic Adenocarcinoma" ], "start_date": "2019-03-15", "last_update": "2026-07-14" }, { "nct_id": "NCT03818503", "title": "E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Cancer" ], "start_date": "2019-06-24", "last_update": "2025-03-21" }, { "nct_id": "NCT03818607", "title": "A Study Evaluating the Efficacy and Safety of ABP 959 Compared With Eculizumab in Adult Participants With PNH", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Paroxysmal Nocturnal Hemoglobinuria" ], "start_date": "2019-01-22", "last_update": "2023-05-23" }, { "nct_id": "NCT03825835", "title": "30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Alberta", "conditions": [ "Premature Infant", "Respiratory Distress Syndrome in Premature Infant", "Neurodevelopmental Outcome" ], "start_date": "2022-06-27", "last_update": "2026-10-05" }, { "nct_id": "NCT03827018", "title": "KPL-301 for Subjects With Giant Cell Arteritis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Kiniksa Pharmaceuticals, Ltd.", "conditions": [ "Giant Cell Arteritis" ], "start_date": "2018-09-20", "last_update": "2023-10-23" }, { "nct_id": "NCT03827187", "title": "Awareness Detection and Communication in Disorders of Consciousness", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Ulster", "conditions": [ "Disorder of Consciousness", "Paralysis", "Motor Neuron Disease", "Stroke", "Physical Disability" ], "start_date": "2022-02-08", "last_update": "2024-12-13" }, { "nct_id": "NCT03832946", "title": "A Study to Test the Efficacy and Safety of Inhaled GB0139 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Galecto Biotech AB", "conditions": [ "Idiopathic Pulmonary Fibrosis (IPF)" ], "start_date": "2019-02-19", "last_update": "2024-05-22" }, { "nct_id": "NCT03833167", "title": "Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Squamous Cell" ], "start_date": "2019-04-01", "last_update": "2026-09-28" }, { "nct_id": "NCT03834493", "title": "Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2019-07-28", "last_update": "2026-09-28" }, { "nct_id": "NCT03834506", "title": "Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2019-05-02", "last_update": "2025-07-18" }, { "nct_id": "NCT03834519", "title": "Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostatic Neoplasms" ], "start_date": "2019-05-02", "last_update": "2025-05-18" }, { "nct_id": "NCT03839771", "title": "A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Stichting Hemato-Oncologie voor Volwassenen Nederland", "conditions": [ "Acute Myeloid Leukemia", "Myelodysplastic Syndrome With Excess Blasts-2" ], "start_date": "2019-03-01", "last_update": "2026-09-22" }, { "nct_id": "NCT03843346", "title": "The Impact of the Gene Recurrence Score on Chemotherapy Prescribing in ER Positive, Lymph Node Positive Early Stage Breast Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2017-03-16", "last_update": "2026-04-13" }, { "nct_id": "NCT03843866", "title": "Sutures Versus Glue in Laparoscopic Port Site Closure.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Cosmetic Outcome", "Infection", "Cost" ], "start_date": "2019-02-11", "last_update": "2019-02-20" }, { "nct_id": "NCT03844048", "title": "An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Chronic Lymphocytic Leukemia", "Acute Myeloid Leukemia", "Multiple Myeloma", "Non-Hodgkin's Lymphoma", "Acute Lymphoblastic Leukemia", "Cancer" ], "start_date": "2019-09-06", "last_update": "2026-05-13" }, { "nct_id": "NCT03844932", "title": "A Study Evaluating the Efficacy and Safety of ST-0529 in Subjects With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Sublimity Therapeutics Holdco Limited", "conditions": [ "Colitis, Ulcerative" ], "start_date": "2019-01-24", "last_update": "2021-05-07" }, { "nct_id": "NCT03847831", "title": "Feasibility Study of the Pilot Post-primary Active School Flag (PPASF) Program", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Physical Activity", "Health Behavior", "Health Knowledge, Attitudes, Practice", "Educational Problems" ], "start_date": "2018-09-01", "last_update": "2024-05-16" }, { "nct_id": "NCT03850782", "title": "Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Open-Angle Glaucoma", "Ocular Hypertension" ], "start_date": "2019-02-28", "last_update": "2025-08-19" }, { "nct_id": "NCT03852706", "title": "EEG-based Neurofeedback for Auditory Verbal Hallucinations (HALFEED)", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Schizophrenia" ], "start_date": "2019-03-01", "last_update": "2022-04-05" }, { "nct_id": "NCT03853798", "title": "Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Agios Pharmaceuticals, Inc.", "conditions": [ "Pyruvate Kinase Deficiency" ], "start_date": "2019-03-21", "last_update": "2025-11-18" }, { "nct_id": "NCT03855098", "title": "Biomarkers of Food Intake Using a Cross-over Feeding Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Diet Habit" ], "start_date": "2019-09-01", "last_update": "2021-05-05" }, { "nct_id": "NCT03856047", "title": "Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity.", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Overweight", "Obesity" ], "start_date": "2019-03-01", "last_update": "2024-07-05" }, { "nct_id": "NCT03857503", "title": "Radiographic Imaging Validation and EvALuation for Angio iFR (ReVEAL iFR)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Volcano Corporation", "conditions": [ "Cardiac Ischemia", "Coronary Artery Disease", "Coronary Stenosis" ], "start_date": "2019-08-01", "last_update": "2021-04-01" }, { "nct_id": "NCT03859895", "title": "Zoledronate In the Prevention of Paget's Disease: Long Term Extension", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "University of Edinburgh", "conditions": [ "Paget Disease" ], "start_date": "2019-04-05", "last_update": "2026-02-17" }, { "nct_id": "NCT03860389", "title": "The Effects of Exercise in Anxiety in Children With ASD", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "South East Technological University", "conditions": [ "Autism Spectrum Disorder", "Anxiety", "Behavior" ], "start_date": "2019-01-07", "last_update": "2019-03-01" }, { "nct_id": "NCT03860883", "title": "Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Melanoma and Skin Cancer Trials Limited", "conditions": [ "Cutaneous Melanoma, Stage II" ], "start_date": "2019-12-17", "last_update": "2024-11-27" }, { "nct_id": "NCT03860935", "title": "Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Eidos Therapeutics, a BridgeBio company", "conditions": [ "Amyloidosis", "Amyloid Cardiomyopathy", "Transthyretin Amyloidosis", "Cardiomyopathies", "Heart Diseases" ], "start_date": "2019-03-19", "last_update": "2024-06-27" }, { "nct_id": "NCT03862612", "title": "Efficacy of SAP Block Versus ESP Block in VATS Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Regional Anesthesia Morbidity" ], "start_date": "2019-06-05", "last_update": "2020-05-04" }, { "nct_id": "NCT03862911", "title": "Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "British Columbia Cancer Agency", "conditions": [ "Metastatic Tumors" ], "start_date": "2019-11-01", "last_update": "2026-04-29" }, { "nct_id": "NCT03866265", "title": "Anti-Inflammatory and Anti-Coagulant Effects of Salmon Polar Lipids", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Platelet Thrombus" ], "start_date": "2019-04-01", "last_update": "2019-12-19" }, { "nct_id": "NCT03867084", "title": "Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Hepatocellular Carcinoma" ], "start_date": "2019-05-28", "last_update": "2026-04-24" }, { "nct_id": "NCT03869762", "title": "Denosumab in Combination With Enzalutamide in Progressive Metastatic Castrate-resistant Prostate Cancer and Bone Metastases.", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Castration-resistant Prostate Cancer", "Metastatic Cancer", "Bone Metastases" ], "start_date": "2019-01-09", "last_update": "2026-04-13" }, { "nct_id": "NCT03869892", "title": "Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Institut de Recherches Internationales Servier", "conditions": [ "Metastatic Colorectal Cancer" ], "start_date": "2019-03-21", "last_update": "2025-12-22" }, { "nct_id": "NCT03871023", "title": "Prophylactic Negative Wound Therapy in Laparotomy Wounds.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay" ], "start_date": "2019-11-06", "last_update": "2019-09-18" }, { "nct_id": "NCT03871998", "title": "Short-term Topical Application to Prevent Atopic Dermatitis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Eczema Atopic Dermatitis", "Eczema", "Eczema, Infantile", "Food Allergy" ], "start_date": "2019-04-16", "last_update": "2022-06-22" }, { "nct_id": "NCT03875534", "title": "A Multi-center, Longitudinal, Observational Study of Children With Achondroplasia", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Ascendis Pharma A/S", "conditions": [ "Achondroplasia" ], "start_date": "2019-06-19", "last_update": "2024-03-19" }, { "nct_id": "NCT03878446", "title": "A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Short Stature Children Born Small for Gestational Age (SGA)" ], "start_date": "2019-07-04", "last_update": "2026-10-06" }, { "nct_id": "NCT03884101", "title": "Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Endometrial Neoplasms" ], "start_date": "2019-04-11", "last_update": "2026-02-02" }, { "nct_id": "NCT03892395", "title": "An Intervention Study to Investigate the Effect of B-vitamin Supplementation for 2-years on Bone Health", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Bone Health" ], "start_date": "2017-05-05", "last_update": "2023-12-08" }, { "nct_id": "NCT03894267", "title": "An Evaluation of the Impact of a Wound Dressing on Pressure Ulcer Incidence.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Wounds" ], "start_date": "2019-03-12", "last_update": "2019-03-28" }, { "nct_id": "NCT03899155", "title": "Pan Tumor Rollover Study", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Cancer" ], "start_date": "2019-08-09", "last_update": "2026-09-23" }, { "nct_id": "NCT03901755", "title": "An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia B" ], "start_date": "2019-09-12", "last_update": "2025-09-29" }, { "nct_id": "NCT03901898", "title": "Feasibility of an Intervention to Increase Diabetic Retinopathy Screening Attendance", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Diabetes", "Retinopathy" ], "start_date": "2019-07-16", "last_update": "2021-05-11" }, { "nct_id": "NCT03906032", "title": "Comparison of Sliding Hip Screw to Intra Medullary Nailing in the Treatment of Intertrochanteric Hip Fracture", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital Waterford", "conditions": [ "Hip Fractures", "Gait, Unsteady", "Function" ], "start_date": "2019-04-02", "last_update": "2025-07-03" }, { "nct_id": "NCT03909386", "title": "Non-interventional Study on Patients With Atrial Fibrillation and Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Heart Care Foundation", "conditions": [ "Atrial Fibrillation", "Cancer" ], "start_date": "2019-06-26", "last_update": "2023-01-12" }, { "nct_id": "NCT03911713", "title": "A Phase 2 Study to Evaluate Efficacy and Safety of VX-561 in Subjects Aged 18 Years and Older With Cystic Fibrosis", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2019-04-17", "last_update": "2022-01-25" }, { "nct_id": "NCT03911986", "title": "Risk-Based Screening for the Evaluation of Atrial Fibrillation Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Atrial Fibrillation and Flutter" ], "start_date": "2018-03-21", "last_update": "2024-02-28" }, { "nct_id": "NCT03913832", "title": "TReAtmeNt of Small Coronary Vessels: MagicTouch Sirolimus Coated Balloon", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Concept Medicals BV", "conditions": [ "Coronary Artery Disease", "DCB" ], "start_date": "2020-08-28", "last_update": "2022-10-05" }, { "nct_id": "NCT03920072", "title": "Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Kyowa Kirin Pharmaceutical Development Ltd", "conditions": [ "X-linked Hypophosphatemia" ], "start_date": "2019-03-07", "last_update": "2022-05-20" }, { "nct_id": "NCT03924856", "title": "Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Bladder Cancer" ], "start_date": "2019-06-13", "last_update": "2026-10-08" }, { "nct_id": "NCT03924895", "title": "Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Urinary Bladder Cancer, Muscle-invasive" ], "start_date": "2019-07-24", "last_update": "2026-06-30" }, { "nct_id": "NCT03927144", "title": "Study of Sustained Benefit of AMG334 in Adult Episodic Migraine Patients", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Episodic Migraine" ], "start_date": "2019-05-15", "last_update": "2023-11-18" }, { "nct_id": "NCT03929354", "title": "Lifestyle Modification Programme for Patients With Asymptomatic Carotid Artery Stenosis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Western Vascular Institute, Ireland", "conditions": [ "Carotid Stenosis" ], "start_date": "2018-06-01", "last_update": "2021-08-04" }, { "nct_id": "NCT03935750", "title": "STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Pittsburgh", "conditions": [ "Anterior Cruciate Ligament Injury", "Anterior Cruciate Ligament Reconstruction", "Joint Instability" ], "start_date": "2020-07-28", "last_update": "2026-06-17" }, { "nct_id": "NCT03935763", "title": "Management of Metastatic Colorectal Cancer: A Clinical and Patient Perspective", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Servier Affaires Médicales", "conditions": [ "Metastatic Colorectal Cancer" ], "start_date": "2019-03-08", "last_update": "2024-04-22" }, { "nct_id": "NCT03935776", "title": "Lifestyle Modification Programme for Patients With Peripheral Arterial Disease", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Western Vascular Institute, Ireland", "conditions": [ "Peripheral Arterial Occlusive Disease" ], "start_date": "2018-06-01", "last_update": "2021-08-04" }, { "nct_id": "NCT03937609", "title": "TITRATE (inducTIon for acuTe ulceRATivE Colitis)", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "conditions": [ "Colitis, Ulcerative" ], "start_date": "2019-09-04", "last_update": "2025-02-06" }, { "nct_id": "NCT03939767", "title": "Assessment of Proactive Treatments in Patients With Wet Age-related Macular Degeneration (wAMD) Which Have Never Undergone Treatment of This Particular Disease", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Bayer", "conditions": [ "Wet Age-related Macular Degeneration" ], "start_date": "2019-05-12", "last_update": "2024-09-20" }, { "nct_id": "NCT03948178", "title": "Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Orion Corporation, Orion Pharma", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2019-06-26", "last_update": "2023-03-09" }, { "nct_id": "NCT03951103", "title": "rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia A", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia A With Inhibitor" ], "start_date": "2018-11-07", "last_update": "2024-09-19" }, { "nct_id": "NCT03952039", "title": "An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Celgene", "conditions": [ "Primary Myelofibrosis", "Post-Polycythemia Vera", "Myelofibrosis" ], "start_date": "2019-09-09", "last_update": "2025-08-28" }, { "nct_id": "NCT03958019", "title": "Rehabilitation Strategies Following Oesophagogastric and Hepatopancreaticobiliary Cancer", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Oesophageal Cancer", "Gastric Cancer", "Liver Cancer", "Pancreatic Cancer" ], "start_date": "2022-01-25", "last_update": "2022-04-13" }, { "nct_id": "NCT03965806", "title": "Awareness About Anaesthesiology AND Role of Anaesthetist", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Our Lady of Lourdes Hospital, Drogheda", "conditions": [ "SURVEY" ], "start_date": "2019-05-15", "last_update": "2019-05-29" }, { "nct_id": "NCT03969004", "title": "Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Cutaneous Squamous Cell Carcinoma" ], "start_date": "2019-06-04", "last_update": "2026-03-27" }, { "nct_id": "NCT03970564", "title": "Neck Ultrasound by Respiratory Physicians in Patients With Lung Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Lung Cancer Metastatic", "Nodes, Lung" ], "start_date": "2016-10-21", "last_update": "2019-05-31" }, { "nct_id": "NCT03978325", "title": "Preoperative Exercise for Patients Undergoing Complex Cancer Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Postoperative Complications", "Physical Activity", "Surgery--Complications" ], "start_date": "2021-07-01", "last_update": "2022-04-13" }, { "nct_id": "NCT03979118", "title": "Exercise Prescription in Patients With Bone Metastases", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Advanced Cancer", "Bone Metastases" ], "start_date": "2019-10-15", "last_update": "2022-05-18" }, { "nct_id": "NCT03980314", "title": "A Study to Compare Nivolumab Drug Product Process D to Nivolumab Drug Product Process C in Participants With Stage IIIa/b/c/d or Stage IV Melanoma After Complete Resection", "phases": [ "PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Melanoma" ], "start_date": "2019-06-24", "last_update": "2023-12-15" }, { "nct_id": "NCT03982394", "title": "Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Chronic Plaque Psoriasis" ], "start_date": "2019-07-01", "last_update": "2025-11-17" }, { "nct_id": "NCT03988660", "title": "The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Appendicitis" ], "start_date": "2015-06-10", "last_update": "2019-06-17" }, { "nct_id": "NCT03992430", "title": "A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Sarepta Therapeutics, Inc.", "conditions": [ "Muscular Dystrophy, Duchenne" ], "start_date": "2020-07-13", "last_update": "2026-02-27" }, { "nct_id": "NCT03997643", "title": "Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's", "conditions": [ "Head and Neck Cancer" ], "start_date": "2019-09-06", "last_update": "2026-10-05" }, { "nct_id": "NCT04002297", "title": "A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "BeOne Medicines", "conditions": [ "Mantle Cell Lymphoma; Non-Hodgkin Lymphoma" ], "start_date": "2019-08-20", "last_update": "2026-09-30" }, { "nct_id": "NCT04003597", "title": "'Low-salt' Bread as a Means of Reducing Dietary Salt and Lowering Blood Pressure", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Elevated Blood Pressure" ], "start_date": "2008-01-03", "last_update": "2019-07-01" }, { "nct_id": "NCT04003610", "title": "Pemigatinib + Pembrolizumab vs Pemigatinib Alone vs Standard of Care for Urothelial Carcinoma (FIGHT-205)", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Incyte Corporation", "conditions": [ "Metastatic Urothelial Carcinoma", "Unresectable Urothelial Carcinoma" ], "start_date": "2020-05-14", "last_update": "2025-11-04" }, { "nct_id": "NCT04003636", "title": "Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Biliary Tract Carcinoma" ], "start_date": "2019-09-24", "last_update": "2026-03-24" }, { "nct_id": "NCT04004013", "title": "Evaluate the Effect of Lifenol in Improving Bone Status in Postmenopausal Osteopenic Women", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Givaudan France Naturals", "conditions": [ "Osteopenia, Generalized" ], "start_date": "2019-08-01", "last_update": "2021-01-06" }, { "nct_id": "NCT04008030", "title": "A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Metastatic Colorectal Cancer" ], "start_date": "2019-08-05", "last_update": "2026-08-20" }, { "nct_id": "NCT04009330", "title": "Clinical Evaluation of a Point of Care (POC) Assay to Identify Phenotypes in the Acute Respiratory Distress Syndrome", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Queen's University, Belfast", "conditions": [ "Acute Respiratory Distress Syndrome (ARDS)" ], "start_date": "2019-11-22", "last_update": "2026-10-08" }, { "nct_id": "NCT04009720", "title": "RESPOND EDGE Post Market Study", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Aortic Valve Stenosis" ], "start_date": "2019-10-11", "last_update": "2021-07-15" }, { "nct_id": "NCT04012944", "title": "SIRONA 2 Trial Heart Failure NYHA Class III", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Endotronix, Inc.", "conditions": [ "Heart Failure NYHA Class III" ], "start_date": "2019-06-26", "last_update": "2026-07-27" }, { "nct_id": "NCT04013945", "title": "Study to Investigate the Effect of Superba Boost on the Skin.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Aker BioMarine Human Ingredients AS", "conditions": [ "Physiology, Skin" ], "start_date": "2019-03-13", "last_update": "2023-02-01" }, { "nct_id": "NCT04016649", "title": "The Mechanical Characterisation of Human Saphenous and Popliteal Vein", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Peripheral Vascular Diseases" ], "start_date": "2019-01-21", "last_update": "2025-04-17" }, { "nct_id": "NCT04025879", "title": "A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2019-11-05", "last_update": "2026-08-26" }, { "nct_id": "NCT04026412", "title": "A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-Small Cell Lung Cancer (NSCLC)" ], "start_date": "2019-10-08", "last_update": "2025-07-24" }, { "nct_id": "NCT04026659", "title": "The Feasibility of Implementing an Exercise Programme for Deconditioned Cancer Survivors", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer" ], "start_date": "2019-09-25", "last_update": "2020-11-30" }, { "nct_id": "NCT04027309", "title": "A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Stichting Hemato-Oncologie voor Volwassenen Nederland", "conditions": [ "Acute Myeloid Leukemia", "Myelodysplastic Syndrome With Excess Blasts-2" ], "start_date": "2019-12-20", "last_update": "2024-12-17" }, { "nct_id": "NCT04033445", "title": "A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Ulcerative Colitis" ], "start_date": "2019-09-26", "last_update": "2026-09-28" }, { "nct_id": "NCT04034498", "title": "A Multicenter, International, Follow-up Study to Monitor the Efficacy and Safety of the Occlutech® PmVSD Occluder in Patients With Perimembranous Ventricular Septal Defects", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Occlutech International AB", "conditions": [ "Perimembranous Ventricular Septal Defect" ], "start_date": "2019-07-07", "last_update": "2026-01-16" }, { "nct_id": "NCT04036734", "title": "Longitudinal or Transverse Orientation of Ultrasound Probe in Minimally Invasive Venous Surgery.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Varicose Veins", "Endovenous Procedures", "Venous Access" ], "start_date": "2019-07-24", "last_update": "2020-03-26" }, { "nct_id": "NCT04042051", "title": "Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer", "phases": [ "PHASE1" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "HER2-positive Breast Cancer", "Metastatic Breast Cancer", "Locally Advanced Breast Cancer", "Unresectable Breast Cancer" ], "start_date": "2019-11-12", "last_update": "2025-07-22" }, { "nct_id": "NCT04042181", "title": "The Effects of Supplementation of a Probiotic, B. Longum, on BMI and Anthropometric Outcomes in Overweight/Obese Adults.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Obesity" ], "start_date": "2018-07-09", "last_update": "2019-08-01" }, { "nct_id": "NCT04043494", "title": "International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "University Hospital Muenster", "conditions": [ "Lymphoblastic Lymphoma, Childhood" ], "start_date": "2019-08-23", "last_update": "2026-05-06" }, { "nct_id": "NCT04043806", "title": "A Study Evaluating the Long-term Safety of VX-445 Combination Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2019-08-09", "last_update": "2023-07-06" }, { "nct_id": "NCT04047537", "title": "Placebo-Controlled Clinical Nutrition Study of the Metabolic Effects of Food Product WBF-0011 in Type 2 Diabetes", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "Pendulum Therapeutics", "conditions": [ "Type 2 Diabetes Mellitus" ], "start_date": "2019-08-06", "last_update": "2022-05-06" }, { "nct_id": "NCT04047615", "title": "The Effects of Exercise on Behavior and Fitness in Children With ASD", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "South East Technological University", "conditions": [ "Autism Spectrum Disorder", "Behavior" ], "start_date": "2019-09-01", "last_update": "2019-08-09" }, { "nct_id": "NCT04051697", "title": "The SEA CHANGE Study: A Self Management Intervention for Head and Neck Cancer Survivors", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin City University", "conditions": [ "Head and Neck Cancer" ], "start_date": "2018-09-10", "last_update": "2019-08-09" }, { "nct_id": "NCT04053764", "title": "Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Sickle Cell Disease (SCD)" ], "start_date": "2019-12-10", "last_update": "2024-10-09" }, { "nct_id": "NCT04055909", "title": "Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Inotrem", "conditions": [ "Shock, Septic" ], "start_date": "2019-11-13", "last_update": "2023-04-11" }, { "nct_id": "NCT04058353", "title": "A Phase 3 Study of VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2019-08-28", "last_update": "2021-07-02" }, { "nct_id": "NCT04058366", "title": "Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2019-12-05", "last_update": "2024-01-16" }, { "nct_id": "NCT04079192", "title": "Biolimus A9™ (BA9™) Drug Coated Balloon (DCB) Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Biosensors Europe SA", "conditions": [ "Coronary Artery Disease", "In-Stent Restenosis" ], "start_date": "2020-08-07", "last_update": "2022-08-10" }, { "nct_id": "NCT04082858", "title": "Ketamine Interleaved With Electroconvulsive Therapy for Depression", "phases": [ "PHASE1" ], "overall_status": "TERMINATED", "lead_sponsor": "St Patrick's Hospital, Ireland", "conditions": [ "Depression" ], "start_date": "2020-01-06", "last_update": "2021-09-09" }, { "nct_id": "NCT04085523", "title": "A Dose Escalation Trial Evaluating Safety, Efficacy, and Pharmacokinetics of TransCon CNP Administered Once Weekly in Prepubertal Children With Achondroplasia", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Ascendis Pharma A/S", "conditions": [ "Achondroplasia" ], "start_date": "2020-06-24", "last_update": "2026-07-02" }, { "nct_id": "NCT04089059", "title": "PROACTIVE-HF IDE Trial Heart Failure NYHA Class III", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Endotronix, Inc.", "conditions": [ "Heart Failure NYHA Class III" ], "start_date": "2020-01-10", "last_update": "2026-07-24" }, { "nct_id": "NCT04089514", "title": "A Real-world Study of Imraldi® Use", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Biogen", "conditions": [ "Arthritis, Rheumatoid (RA)", "Axial Spondyloarthritis (axSpA)", "Arthritis, Psoriatic (PsA)", "Crohn's Disease (CD)", "Colitis, Ulcerative (UC)" ], "start_date": "2019-06-30", "last_update": "2023-04-18" }, { "nct_id": "NCT04091048", "title": "Optimize PRO Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Cardiovascular", "conditions": [ "Symptomatic Aortic Stenosis" ], "start_date": "2019-09-16", "last_update": "2026-01-13" }, { "nct_id": "NCT04095364", "title": "Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "NRG Oncology", "conditions": [ "Low Grade Fallopian Tube Serous Adenocarcinoma", "Ovarian Low Grade Serous Adenocarcinoma", "Primary Peritoneal Low Grade Serous Adenocarcinoma", "Stage II Fallopian Tube Cancer AJCC v8", "Stage II Ovarian Cancer AJCC v8", "Stage II Primary Peritoneal Cancer AJCC v8", "Stage III Fallopian Tube Cancer AJCC v8", "Stage III Ovarian Cancer AJCC v8", "Stage III Primary Peritoneal Cancer AJCC v8", "Stage IV Fallopian Tube Cancer AJCC v8", "Stage IV Ovarian Cancer AJCC v8", "Stage IV Primary Peritoneal Cancer AJCC v8" ], "start_date": "2019-09-20", "last_update": "2026-03-24" }, { "nct_id": "NCT04102189", "title": "A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Overweight", "Obesity" ], "start_date": "2019-10-07", "last_update": "2025-12-11" }, { "nct_id": "NCT04108572", "title": "The Choosing Healthy Eating for Infant Health (CHErIsH) Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Pediatric Obesity" ], "start_date": "2019-04-11", "last_update": "2021-10-05" }, { "nct_id": "NCT04109066", "title": "Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Breast Cancer" ], "start_date": "2019-11-18", "last_update": "2025-01-08" }, { "nct_id": "NCT04109079", "title": "Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University Hospitals of Derby and Burton NHS Foundation Trust", "conditions": [ "Breast Cancer", "Sentinel Lymph Node", "Neoplasm, Breast" ], "start_date": "2021-02-26", "last_update": "2026-03-30" }, { "nct_id": "NCT04110717", "title": "Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control as a Means of Reducing Excess Body Weight", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neurovalens Ltd.", "conditions": [ "Overweight", "Obesity", "Overweight and Obesity", "Overweight or Obesity", "Metabolic Syndrome" ], "start_date": "2020-10-09", "last_update": "2023-04-03" }, { "nct_id": "NCT04111237", "title": "Rescuer Fatigue Using Two Thumb Versus Two Finger Method During Simulated Neonatal Cardiopulomnary Resuscitation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Cardiac Output, High" ], "start_date": "2018-06-28", "last_update": "2020-06-24" }, { "nct_id": "NCT04116047", "title": "CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Birmingham", "conditions": [ "Oropharyngeal Cancer" ], "start_date": "2015-07", "last_update": "2026-05-07" }, { "nct_id": "NCT04116944", "title": "The Resistance Exercise Training for Worry Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Analogue Generalized Anxiety Disorder" ], "start_date": "2018-01-18", "last_update": "2019-10-07" }, { "nct_id": "NCT04120207", "title": "An Eight-week RCT of Home-based Pilates for Symptoms of Anxiety, Depression, and Fatigue Among People With MS", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Multiple Sclerosis" ], "start_date": "2019-01-01", "last_update": "2019-10-09" }, { "nct_id": "NCT04122794", "title": "The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells Harvested From Umbilical Cords", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Vascular Diseases" ], "start_date": "2019-11-20", "last_update": "2024-04-12" }, { "nct_id": "NCT04125810", "title": "A Study to Assess the Safety and Efficacy of Probiotic to Modulate Psychological Stress", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Danisco", "conditions": [ "Stress, Psychological", "Healthy" ], "start_date": "2019-09-02", "last_update": "2020-03-25" }, { "nct_id": "NCT04127409", "title": "Impacts of Omega-3-PUFA Enriched Chicken-meat and Eggs in Healthy Humans", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Alice Stanton", "conditions": [ "Healthy Diet" ], "start_date": "2015-02-01", "last_update": "2023-11-14" }, { "nct_id": "NCT04128696", "title": "Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Head and Neck" ], "start_date": "2019-11-21", "last_update": "2024-07-10" }, { "nct_id": "NCT04133909", "title": "Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2019-10-30", "last_update": "2026-08-21" }, { "nct_id": "NCT04134819", "title": "Missing Microbes in Infants Born by Cesarean Section", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "C Section" ], "start_date": "2019-07-01", "last_update": "2024-01-09" }, { "nct_id": "NCT04134871", "title": "Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMI", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Ulster", "conditions": [ "Mental Illness", "Schizophrenia", "Bipolar Disorder", "Major Depression", "Psychosis" ], "start_date": "2019-08-22", "last_update": "2023-05-11" }, { "nct_id": "NCT04136353", "title": "Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Sydney", "conditions": [ "Prostate Cancer" ], "start_date": "2020-03-31", "last_update": "2026-05-06" }, { "nct_id": "NCT04142437", "title": "Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Bayer", "conditions": [ "Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion" ], "start_date": "2020-04-03", "last_update": "2026-10-02" }, { "nct_id": "NCT04149951", "title": "Effect of VeSTAL Device in Type 2 Diabetes Mellitus", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neurovalens Ltd.", "conditions": [ "Type 2 Diabetes", "Metabolic Syndrome" ], "start_date": "2020-06-03", "last_update": "2024-01-16" }, { "nct_id": "NCT04151524", "title": "Classification of Adenocarcinoma of the Esophagogastric Junction", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Oesophagus Cancer", "Barrett Esophagus", "Siewert Type I Adenocarcinoma of Esophagogastric Junction", "Siewert Type II Adenocarcinoma of Esophagogastric Junction", "Siewert Type III Adenocarcinoma of Esophagogastric Junction" ], "start_date": "2019-10-23", "last_update": "2019-11-05" }, { "nct_id": "NCT04152044", "title": "Obesity and Liver Function in Oesophageal Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Obesity", "Liver Function" ], "start_date": "2019-11-01", "last_update": "2019-11-05" }, { "nct_id": "NCT04153149", "title": "HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alnylam Pharmaceuticals", "conditions": [ "Transthyretin Amyloidosis (ATTR) With Cardiomyopathy" ], "start_date": "2019-11-26", "last_update": "2026-01-12" }, { "nct_id": "NCT04153760", "title": "Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity", "phases": [ "EARLY_PHASE1" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Calgary", "conditions": [ "Venous Thromboembolism", "Postpartum Period", "Aspirin" ], "start_date": "2020-10-07", "last_update": "2023-09-13" }, { "nct_id": "NCT04154189", "title": "A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Eisai Inc.", "conditions": [ "Osteosarcoma" ], "start_date": "2020-03-23", "last_update": "2024-07-22" }, { "nct_id": "NCT04156074", "title": "Innovative Food Structures to Enhance Nutrient Bioavailability", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Vitamin D Deficiency", "Aging Well" ], "start_date": "2019-11-04", "last_update": "2023-03-06" }, { "nct_id": "NCT04159948", "title": "Preoperative Carbohydrate Drink Prior to Elective Caesarean Section", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Fasting", "Cesarean Delivery Affecting Fetus", "Glucose, Low Blood" ], "start_date": "2020-01-20", "last_update": "2021-08-02" }, { "nct_id": "NCT04160130", "title": "RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Optimapharm", "conditions": [ "Aortic Valve Stenosis", "Heart Valve Diseases" ], "start_date": "2019-11-29", "last_update": "2023-06-01" }, { "nct_id": "NCT04160481", "title": "A Pilot Study to Investigate the Effect of Water-soluble Tomato Extract on TMAO", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "dsm-firmenich Switzerland AG", "conditions": [ "Cardiovascular Risk Factor" ], "start_date": "2019-11-12", "last_update": "2020-03-26" }, { "nct_id": "NCT04161105", "title": "Treatment Time-frame Guideline for Dry Needling in the Lower Limb", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "South East Technological University", "conditions": [ "Trigger Points" ], "start_date": "2019-09-16", "last_update": "2020-02-17" }, { "nct_id": "NCT04165109", "title": "Trial-Ready Cohort-Down Syndrome (TRC-DS)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Southern California", "conditions": [ "Down Syndrome", "Alzheimer Disease", "Dementia" ], "start_date": "2021-06-07", "last_update": "2026-05-18" }, { "nct_id": "NCT04167345", "title": "Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Alpha 1-Antitrypsin Deficiency" ], "start_date": "2020-01-13", "last_update": "2022-02-02" }, { "nct_id": "NCT04167475", "title": "Effect of B. Longum 1714™ on Sleep Quality", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "PrecisionBiotics Group Ltd.", "conditions": [ "Subjective Sleep Quality", "Objective Sleep Quality" ], "start_date": "2020-01-06", "last_update": "2020-06-30" }, { "nct_id": "NCT04174157", "title": "Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Spinal Muscular Atrophy (SMA)" ], "start_date": "2018-09-25", "last_update": "2025-01-31" }, { "nct_id": "NCT04174755", "title": "Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Obesity", "HIV-1-infection" ], "start_date": "2022-06-22", "last_update": "2026-04-29" }, { "nct_id": "NCT04175015", "title": "The SMARTY Trial: Evaluating the Effects of Colour of Candy on Perceptions of Taste", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Education" ], "start_date": "2019-11-24", "last_update": "2024-10-15" }, { "nct_id": "NCT04175600", "title": "A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Actelion", "conditions": [ "Hypertension, Pulmonary" ], "start_date": "2020-01-16", "last_update": "2026-09-25" }, { "nct_id": "NCT04179487", "title": "The OPTICA Study - The Optimised Computed Tomography Pulmonary Angiography (CTPA) in Pregnancy, Quality and Safety Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Pulmonary Embolism", "Pregnancy Related", "Venous Thromboembolism" ], "start_date": "2018-05-29", "last_update": "2019-12-02" }, { "nct_id": "NCT04181879", "title": "Appropriate Polypharmacy in Older People in Primary Care", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Queen's University, Belfast", "conditions": [ "Polypharmacy" ], "start_date": "2019-09-01", "last_update": "2021-12-02" }, { "nct_id": "NCT04182204", "title": "A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Diffuse Large B-Cell Lymphoma" ], "start_date": "2020-02-07", "last_update": "2025-12-22" }, { "nct_id": "NCT04183790", "title": "Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA TC Combination Therapy in Participants With Cystic Fibrosis Who Are 6 Years of Age and Older", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2020-02-17", "last_update": "2025-05-18" }, { "nct_id": "NCT04185818", "title": "Citizen Science: The People's Trial: A Randomised Controlled Trial", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Sleep" ], "start_date": "2019-12-04", "last_update": "2020-01-31" }, { "nct_id": "NCT04186494", "title": "Effect of Liraglutide vs CPAP on Cardiometabolic Outcomes in Obstructive Sleep Apnea", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Sleep Apnea, Obstructive" ], "start_date": "2019-12-02", "last_update": "2023-12-18" }, { "nct_id": "NCT04191096", "title": "Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Metastatic Hormone-Sensitive Prostate Cancer" ], "start_date": "2020-02-12", "last_update": "2026-09-28" }, { "nct_id": "NCT04191135", "title": "Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction With First-Line Chemotherapy Plus Pembrolizumab in Triple Negative Breast Cancer (TNBC) (MK-7339-009/KEYLYNK-009)", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Triple Negative Breast Neoplasms" ], "start_date": "2019-12-19", "last_update": "2026-09-14" }, { "nct_id": "NCT04191486", "title": "Efficacy and Safety of T-817MA in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "FUJIFILM Toyama Chemical Co., Ltd.", "conditions": [ "Mild Cognitive Impairment" ], "start_date": "2019-12-24", "last_update": "2023-10-23" }, { "nct_id": "NCT04191694", "title": "Chewing Gum to Prevent Nausea and Vomiting After Caesarean Section Under Spinal Anaesthesia", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "PONV" ], "start_date": "2019-10-28", "last_update": "2020-01-23" }, { "nct_id": "NCT04195698", "title": "Open-Label Extension Study of Upadacitinib in Adult Participants With Moderate to Severe Atopic Dermatitis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Atopic Dermatitis" ], "start_date": "2020-01-15", "last_update": "2025-01-09" }, { "nct_id": "NCT04196192", "title": "Febrile Infants - Diagnostic Assessment and Outcome", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Belfast Health and Social Care Trust", "conditions": [ "Meningitis, Bacterial", "Bacterial Infections", "Urinary Tract Infections" ], "start_date": "2020-03-01", "last_update": "2021-05-11" }, { "nct_id": "NCT04203576", "title": "First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF)", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Foundry Innovation & Research 1, Limited (FIRE1)", "conditions": [ "Heart Failure" ], "start_date": "2019-11-22", "last_update": "2026-09-03" }, { "nct_id": "NCT04204252", "title": "Phase III, Efficacy and Safety of \"Kamada-AAT for Inhalation\"", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Kamada, Ltd.", "conditions": [ "Alpha 1-Antitrypsin Deficiency" ], "start_date": "2019-11-25", "last_update": "2026-08-12" }, { "nct_id": "NCT04210804", "title": "A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Bipolar Depression" ], "start_date": "2014-04-01", "last_update": "2019-12-26" }, { "nct_id": "NCT04211961", "title": "Scopolamine in Bipolar Depression", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Dr. Brian Hallahan", "conditions": [ "Bipolar Disorder Depression" ], "start_date": "2021-03-23", "last_update": "2025-04-29" }, { "nct_id": "NCT04220242", "title": "Future of Colorectal Cancer Surgery", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Colorectal Cancer", "Surgery" ], "start_date": "2019-12-30", "last_update": "2020-01-07" }, { "nct_id": "NCT04221945", "title": "Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Uterine Cervical Neoplasms" ], "start_date": "2020-05-12", "last_update": "2026-02-20" }, { "nct_id": "NCT04222972", "title": "A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "RET-fusion Non Small Cell Lung Cancer", "Lung Neoplasm", "Carcinoma, Non-Small-Cell Lung", "Respiratory Tract Neoplasms", "Thoracic Neoplasms", "Neoplasms by Site", "Neoplasms", "Lung Diseases", "Respiratory Tract Disease", "Carcinoma, Bronchogenic", "Bronchial Diseases", "Head and Neck Neoplasms", "Adenocarcinoma", "Carcinoma", "Neoplasms by Histologic Type", "Neoplasms, Germ Cell and Embryonal", "Neoplasms, Nerve Tissue" ], "start_date": "2020-07-24", "last_update": "2026-03-05" }, { "nct_id": "NCT04231604", "title": "Evaluation of a School-based Programme Aimed at Promoting Well-being in Adolescents", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Adolescent Well-Being", "Resilience, Psychological" ], "start_date": "2020-01-17", "last_update": "2021-09-28" }, { "nct_id": "NCT04236609", "title": "Randomized Comparison of Abluminus DES+ Sirolimus-Eluting Stents Versus Everolimus-Eluting Stents in Coronary Artery Disease Patients With Diabetes Mellitus Global", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Concept Medical Inc.", "conditions": [ "Diabetes", "Coronary Artery Disease", "Acute Coronary Syndrome" ], "start_date": "2020-06-15", "last_update": "2023-03-27" }, { "nct_id": "NCT04242498", "title": "A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Biopharma SRL", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2020-03-02", "last_update": "2026-09-25" }, { "nct_id": "NCT04243018", "title": "Feasibility Trial of an Acceptance and Commitment Therapy Intervention for Individuals Experiencing Homelessness", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Shame", "Stigma, Social", "Well-Being" ], "start_date": "2019-05-15", "last_update": "2020-04-02" }, { "nct_id": "NCT04244968", "title": "Satisfaction, QoL,Health Status & Clinic Outcomes for Patients Attending MSK Triage Clinics in Rheumatology", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Health Service Executive, Ireland", "conditions": [ "Musculoskeletal Pain", "Rheumatologic Disorder" ], "start_date": "2023-06-22", "last_update": "2024-10-04" }, { "nct_id": "NCT04245020", "title": "A Study Comparing Three Methods of Outpatient Follow up After Surgical Admission; Text Message, Phone Call and In-person Appointment", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Outpatients", "Virtual Clinic", "Text Messaging", "General Surgery" ], "start_date": "2019-09-16", "last_update": "2021-04-26" }, { "nct_id": "NCT04246177", "title": "Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Hepatocellular" ], "start_date": "2020-05-22", "last_update": "2026-09-03" }, { "nct_id": "NCT04248465", "title": "An Efficacy and Safety Study of Ravulizumab in ALS Participants", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis", "ALS" ], "start_date": "2020-03-30", "last_update": "2023-01-10" }, { "nct_id": "NCT04249492", "title": "PMCF Study on EDOF (Isopure) vs Monofocal (Micropure) IOL", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Beaver-Visitec International, Inc.", "conditions": [ "Cataract", "Lens Opacities" ], "start_date": "2020-02-11", "last_update": "2025-11-21" }, { "nct_id": "NCT04249661", "title": "Differential Effects of Bacteria Colonising Venous Leg Ulcers on Pain and Healing Rates", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Venous Leg Ulcer" ], "start_date": "2020-01-09", "last_update": "2023-12-15" }, { "nct_id": "NCT04260126", "title": "Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "PDS Biotechnology Corp.", "conditions": [ "Metastatic Head and Neck Cancer", "Recurrent Head and Neck Cancer", "HPV Positive Oropharyngeal Squamous Cell Carcinoma", "Neoplasms, Head and Neck" ], "start_date": "2021-03-29", "last_update": "2025-10-01" }, { "nct_id": "NCT04260269", "title": "Feasibility of Switching Fluoropyrimidine Due to Cardiotoxicity Study", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Helsinki University Central Hospital", "conditions": [ "Solid Tumor" ], "start_date": "2018-06-01", "last_update": "2024-12-12" }, { "nct_id": "NCT04260997", "title": "Effect of a Probiotic, Lactobacillus Gasseri BNR17, on Body Composition and Weight Management in Overweight Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "UAS Labs LLC", "conditions": [ "Weight Management" ], "start_date": "2020-07-01", "last_update": "2021-09-29" }, { "nct_id": "NCT04262466", "title": "Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Immunocore Ltd", "conditions": [ "Select Advanced Solid Tumors" ], "start_date": "2020-02-25", "last_update": "2026-03-06" }, { "nct_id": "NCT04262505", "title": "A MEDiterranean Diet in Rheumatoid Arthritis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Rheumatoid Arthritis" ], "start_date": "2020-02-06", "last_update": "2022-05-17" }, { "nct_id": "NCT04266951", "title": "Singstrong: Singing for Better Lung Health", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Respiratory Disease", "COPD" ], "start_date": "2019-04-01", "last_update": "2025-01-31" }, { "nct_id": "NCT04270409", "title": "Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Sanofi", "conditions": [ "Plasma Cell Myeloma" ], "start_date": "2020-06-16", "last_update": "2025-12-12" }, { "nct_id": "NCT04271280", "title": "Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company", "conditions": [ "Dyslipidemia", "Cardiovascular Diseases", "Hypercholesterolemia", "Atherosclerotic Cardiovascular Disease" ], "start_date": "2020-03-17", "last_update": "2024-02-20" }, { "nct_id": "NCT04271774", "title": "Genome Environment Microbiome and Metabolome in Autism Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Massachusetts General Hospital", "conditions": [ "Autism Spectrum Disorder" ], "start_date": "2019-07-01", "last_update": "2026-04-15" }, { "nct_id": "NCT04272554", "title": "AAV Gene Therapy Screening/Observational Protocol (ECLIPSE)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Spur Therapeutics", "conditions": [ "Hemophilia B", "Blood Coagulation Disorders, Inherited", "Blood Coagulation Disorder", "Haematologic Disease" ], "start_date": "2020-02-14", "last_update": "2022-11-04" }, { "nct_id": "NCT04273685", "title": "Cognitive Remediation and Social Recovery in Early Psychosis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Psychosis" ], "start_date": "2019-10-01", "last_update": "2022-03-28" }, { "nct_id": "NCT04279275", "title": "Knowledge About Anaesthesiology and Anaesthesiologists", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Our Lady of Lourdes Hospital, Drogheda", "conditions": [ "Knowledge", "Anaesthesiology" ], "start_date": "2017-12-01", "last_update": "2020-02-21" }, { "nct_id": "NCT04285723", "title": "Retrospective Chart Review Study of Patients With PIK3CA-Related Overgrowth Spectrum Who Have Received Alpelisib", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "PIK3CA-Related Overgrowth Spectrum (PROS)" ], "start_date": "2020-06-09", "last_update": "2023-02-09" }, { "nct_id": "NCT04286932", "title": "National Children's Food Survey II", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Dietary Habits", "Life Style", "Body Weight" ], "start_date": "2017-04-01", "last_update": "2020-11-05" }, { "nct_id": "NCT04290299", "title": "Endometrial Cancer Conservative Treatment (E.C.Co). A Multicentre Archive", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "National Cancer Institute, Naples", "conditions": [ "Endometrial Cancer" ], "start_date": "2015-09-15", "last_update": "2021-10-13" }, { "nct_id": "NCT04290637", "title": "The Galway Sea Swimmers Study", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Cardiovascular Diseases", "Hypertension" ], "start_date": "2020-10", "last_update": "2020-06-30" }, { "nct_id": "NCT04292041", "title": "Fasting Mimicking Diet in Prostate Cancer and Metabolic Syndrome", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Galway Clinic", "conditions": [ "Prostate Cancer", "Metabolic Syndrome", "Intermittent Fasting" ], "start_date": "2019-01-15", "last_update": "2020-03-02" }, { "nct_id": "NCT04293614", "title": "Invasive Arterio-Venous Fistula Blood Pressure Monitoring & Fluid Dynamics Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Arterio-venous Fistula" ], "start_date": "2019-08-14", "last_update": "2023-03-24" }, { "nct_id": "NCT04294927", "title": "TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University Medical Center Nijmegen", "conditions": [ "BRCA1 Gene Mutation", "BRCA2 Gene Mutation", "RAD51C Gene Mutation", "RAD51D Gene Mutation", "BRIP1 Gene Mutation", "Ovarian Cancer" ], "start_date": "2020-03-01", "last_update": "2026-04-06" }, { "nct_id": "NCT04296045", "title": "A Study to Investigate the Effect of MCE on Glucose and Insulin Responses in Healthy Males", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cambridge Glycoscience", "conditions": [ "Dysglycemia" ], "start_date": "2020-07-02", "last_update": "2022-10-19" }, { "nct_id": "NCT04296890", "title": "A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ImmunoGen, Inc.", "conditions": [ "Epithelial Ovarian Cancer", "Peritoneal Cancer", "Fallopian Tube Cancer" ], "start_date": "2020-07-23", "last_update": "2024-08-07" }, { "nct_id": "NCT04297111", "title": "Probiotic-Muscle Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Old Age; Debility", "Muscle Weakness", "Protein Deregulation", "Protein Deposition" ], "start_date": "2019-11-25", "last_update": "2022-11-03" }, { "nct_id": "NCT04298164", "title": "Evaluating the Effectiveness of an Acceptance and Commitment Therapy-based Group Intervention for Parents of Children With a Diagnosis of Autism Spectrum Disorder", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Autism Spectrum Disorder" ], "start_date": "2019-11-25", "last_update": "2021-05-03" }, { "nct_id": "NCT04300465", "title": "MySlainte: Testing the Effect of Involving Partners in a CVD Prevention Community Lifestyle Program", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Rheumatoid Arthritis", "Chronic Kidney Diseases", "Cardiovascular Risk Factor", "Partner, Domestic" ], "start_date": "2020-03-10", "last_update": "2020-09-09" }, { "nct_id": "NCT04301167", "title": "Loneliness and Health: The Moderating Role of Befriending Services", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Loneliness" ], "start_date": "2018-09-01", "last_update": "2020-03-10" }, { "nct_id": "NCT04307576", "title": "A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Mats Heyman", "conditions": [ "Leukemia, Acute Lymphoblastic" ], "start_date": "2020-07-13", "last_update": "2026-08-12" }, { "nct_id": "NCT04310436", "title": "Modifying Unconscious Tongue Movements in Adults With Developmental Stammer.", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stammering" ], "start_date": "2020-03-10", "last_update": "2024-10-26" }, { "nct_id": "NCT04312737", "title": "Evaluation of in Vitro Devices on Self-collected Vaginal Swab and Urine Sample for Testing of Human Papilloma Virus", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hiantis Srl", "conditions": [ "Cervical Intraepithelial Neoplasia Grade 2/3", "Neoplasm Cervix", "Carcinoma in Situ", "Carcinoma Cervix Uterine", "Neoplasms", "Neoplasms by Histologic Type" ], "start_date": "2020-07-16", "last_update": "2023-01-06" }, { "nct_id": "NCT04316117", "title": "Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ECOG-ACRIN Cancer Research Group", "conditions": [ "Anatomic Stage IV Breast Cancer AJCC v8", "Hormone Receptor Positive Breast Carcinoma", "Metastatic Breast Carcinoma", "Prognostic Stage IV Breast Cancer AJCC v8" ], "start_date": "2020-09-15", "last_update": "2026-09-14" }, { "nct_id": "NCT04319627", "title": "Statins for Venous Event Reduction in Patients With Venous Thromboembolism", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Ottawa Hospital Research Institute", "conditions": [ "Venous Thromboembolism", "Blood Clot", "Post Thrombotic Syndrome" ], "start_date": "2021-02-10", "last_update": "2026-01-15" }, { "nct_id": "NCT04323761", "title": "Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)", "phases": [], "overall_status": "APPROVED_FOR_MARKETING", "lead_sponsor": "Gilead Sciences", "conditions": [ "SARS-CoV2 Infection" ], "start_date": "", "last_update": "2020-11-13" }, { "nct_id": "NCT04326062", "title": "Supporting Prescribing in Irish Primary Care: General Practice Pharmacist Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Polypharmacy", "Multimorbidity" ], "start_date": "2017-06-14", "last_update": "2020-03-30" }, { "nct_id": "NCT04330300", "title": "Coronavirus (COVID-19) ACEi/ARB Investigation", "phases": [ "PHASE4" ], "overall_status": "SUSPENDED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Hypertension", "COVID-19" ], "start_date": "2020-04-30", "last_update": "2020-06-30" }, { "nct_id": "NCT04347941", "title": "Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "ARDS, Human", "Mechanical Ventilation Complication", "COVID19" ], "start_date": "2020-07-11", "last_update": "2021-12-02" }, { "nct_id": "NCT04353713", "title": "Gel for Early Hypoglycaemia Prevention in Preterm Infants", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Hypoglycemia in Newborn Infants" ], "start_date": "2020-11-05", "last_update": "2021-09-30" }, { "nct_id": "NCT04365491", "title": "European Society for Trauma and Emergency Surgery (ESTES) Cohort Study Snapshot Audit 2020 - Acute Appendicitis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Gary Alan Bass, MD PhD", "conditions": [ "Appendicitis" ], "start_date": "2020-09-01", "last_update": "2023-03-01" }, { "nct_id": "NCT04370951", "title": "Efficacy of the Erector Spinae Plane Block in Posterior Thoraco- Lumbar Spinal Decompression Surgery", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Spinal Surgery" ], "start_date": "2020-05-01", "last_update": "2020-05-13" }, { "nct_id": "NCT04375904", "title": "'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "NSCLC/Oligometastatic Cancer (Single Lung Lesion)" ], "start_date": "2020-12-22", "last_update": "2025-05-02" }, { "nct_id": "NCT04384874", "title": "A Novel Multi-factorial Criteria-based Rehabilitation Program for Chronic Mid-portion Achilles Tendinopathy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "Achilles Tendinopathy" ], "start_date": "2020-01-29", "last_update": "2024-04-22" }, { "nct_id": "NCT04390672", "title": "Multivessel TALENT", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Coronary Artery Disease", "Myocardial Ischemia", "Coronary Disease", "Heart Diseases", "Cardiovascular Diseases", "Arterial Occlusive Diseases", "Vascular Diseases" ], "start_date": "2020-09-22", "last_update": "2026-02-27" }, { "nct_id": "NCT04395378", "title": "Use of Dexcom G6 in Commercial Pilots With Insulin Treated Diabetes", "phases": [], "overall_status": "SUSPENDED", "lead_sponsor": "University of Surrey", "conditions": [ "Type 1 Diabetes" ], "start_date": "2019-12-05", "last_update": "2021-04-29" }, { "nct_id": "NCT04402645", "title": "Novel Echocardiographic Methods for Early Identification of Neonates at Risk for Chronic Pulmonary Hypertension", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Mount Sinai Hospital, Canada", "conditions": [ "Pulmonary Hypertension", "Infant, Premature" ], "start_date": "2017-08-31", "last_update": "2024-06-14" }, { "nct_id": "NCT04411199", "title": "D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "PolyPid Ltd.", "conditions": [ "Surgical Site Infection", "Colon Surgery", "Abdominal Surgery", "Post-Op Infection" ], "start_date": "2020-12-15", "last_update": "2026-07-13" }, { "nct_id": "NCT04411472", "title": "(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "AM-Pharma", "conditions": [ "Acute Kidney Injury Due to Sepsis" ], "start_date": "2020-11-02", "last_update": "2024-06-03" }, { "nct_id": "NCT04419558", "title": "Zephyrus II: Efficacy and Safety Study of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Kyntra Bio", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2020-09-30", "last_update": "2024-08-12" }, { "nct_id": "NCT04419779", "title": "Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "Fractyl Health Inc.", "conditions": [ "Type 2 Diabetes" ], "start_date": "2021-03-08", "last_update": "2025-11-13" }, { "nct_id": "NCT04419792", "title": "'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy'", "phases": [], "overall_status": "SUSPENDED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Narcolepsy", "Narcolepsy 1", "Narcolepsy Type 1", "Narcolepsy With Cataplexy", "Narcolepsy Without Cataplexy", "Narcolepsy and Hypersomnia", "Hypersomnolence" ], "start_date": "2019-10-15", "last_update": "2020-06-05" }, { "nct_id": "NCT04421820", "title": "BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Bold Therapeutics, Inc.", "conditions": [ "Colorectal Cancer", "Pancreatic Cancer", "Gastric Cancers", "Cholangiocarcinoma" ], "start_date": "2020-08-28", "last_update": "2026-05-18" }, { "nct_id": "NCT04422327", "title": "The Impact of a Combination of Bifidobacterium Longum 35624® and 1714™ Strains in Adults With Irritable Bowel Syndrome", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "PrecisionBiotics Group Ltd.", "conditions": [ "IBS - Irritable Bowel Syndrome", "Depression, Anxiety" ], "start_date": "2017-09-20", "last_update": "2020-06-09" }, { "nct_id": "NCT04428333", "title": "Study of GSK3359609 With Pembrolizumab and 5-fluorouracil (5-FU)-Platinum Chemotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Head and Neck" ], "start_date": "2020-08-12", "last_update": "2024-10-09" }, { "nct_id": "NCT04432025", "title": "Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Imperial College London", "conditions": [ "Obesity", "Type 2 Diabetes" ], "start_date": "2021-04-01", "last_update": "2022-08-08" }, { "nct_id": "NCT04432584", "title": "A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Paroxysmal Nocturnal Hemoglobinuria" ], "start_date": "2020-09-30", "last_update": "2026-07-28" }, { "nct_id": "NCT04435639", "title": "Using an Adjustable Compression Garment for Secondary Upper Limb Lymphoedema", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Lymphedema of Upper Arm" ], "start_date": "2025-10-30", "last_update": "2024-10-26" }, { "nct_id": "NCT04437303", "title": "Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "St. Antonius Hospital", "conditions": [ "Aortic Valve Disease", "Aortic Valve Stenosis", "Stroke", "Bleeding", "Vascular Complications", "Myocardial Infarction", "Thrombosis Embolism" ], "start_date": "2020-11-25", "last_update": "2024-05-31" }, { "nct_id": "NCT04449354", "title": "HidraWear Study for Hidradenitis Suppurativa Wounds", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "HidraMed Solutions Ltd", "conditions": [ "Hidradenitis Suppurativa", "Hidradenitis" ], "start_date": "2019-10-30", "last_update": "2024-10-21" }, { "nct_id": "NCT04457336", "title": "A Ph2b to Evaluate Clinical Efficacy and Safety of Tildacerfont in Adult CAH", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Spruce Biosciences", "conditions": [ "Congenital Adrenal Hyperplasia" ], "start_date": "2020-08-26", "last_update": "2025-07-08" }, { "nct_id": "NCT04459117", "title": "Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Institut National de la Santé Et de la Recherche Médicale, France", "conditions": [ "Patency of the Ductus Arteriosus", "Acetaminophen", "Extreme Prematurity" ], "start_date": "2020-10-29", "last_update": "2026-03-16" }, { "nct_id": "NCT04460352", "title": "Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Karolinska University Hospital", "conditions": [ "Esophageal Squamous Cell Carcinoma" ], "start_date": "2020-11-27", "last_update": "2025-03-06" }, { "nct_id": "NCT04460365", "title": "European Nutrition in Glaucoma Management Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Centre for Eye Research Ireland", "conditions": [ "Glaucoma, Open-Angle" ], "start_date": "2017-10-01", "last_update": "2021-08-06" }, { "nct_id": "NCT04463511", "title": "Placing Preterm Infants in Polyethylene Bags Immediately After Birth", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Newborn", "Infant", "Hypothermia", "Premature" ], "start_date": "2020-07-13", "last_update": "2022-05-18" }, { "nct_id": "NCT04464564", "title": "Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "conditions": [ "Agitation in Patients With Dementia of the Alzheimer's Type" ], "start_date": "2020-09-11", "last_update": "2025-05-30" }, { "nct_id": "NCT04468373", "title": "Study of WA-NG (NG-IMT) Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "VisionCare, Inc.", "conditions": [ "Age Related Macular Degeneration" ], "start_date": "2015-05", "last_update": "2020-07-13" }, { "nct_id": "NCT04471103", "title": "Comparison of Multi-Round and Real-Time Delphi Survey Methods", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Consensus Development" ], "start_date": "2021-08-13", "last_update": "2021-09-02" }, { "nct_id": "NCT04474197", "title": "Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Alpha1-Antitrypsin Deficiency" ], "start_date": "2020-07-24", "last_update": "2022-05-26" }, { "nct_id": "NCT04475939", "title": "Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Lung Cancer, Non-Small Cell" ], "start_date": "2020-10-26", "last_update": "2026-06-18" }, { "nct_id": "NCT04484168", "title": "Axial Ablation Versus Terminal Interruption of the Reflux Source", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Venous Ulcer" ], "start_date": "2020-07-21", "last_update": "2022-05-18" }, { "nct_id": "NCT04485494", "title": "Blood-based Biomarkers for the Prognosis of Sports Related Concussion", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Traumatic Brain Injury", "Sports Injury", "Concussion, Mild" ], "start_date": "2018-07-01", "last_update": "2023-06-02" }, { "nct_id": "NCT04489771", "title": "A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2020-09-13", "last_update": "2026-09-24" }, { "nct_id": "NCT04489810", "title": "Digestion of Gluten in the Presence of Enzymes", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Archer-Daniels-Midland Company", "conditions": [ "Main Focus: Gluten and Starch Digestibility" ], "start_date": "2020-10-19", "last_update": "2025-04-10" }, { "nct_id": "NCT04489836", "title": "GlutDigest - Pilot Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Deerland Enzymes", "conditions": [ "Main Focus: Gluten and Starch Digestibility" ], "start_date": "2020-08-31", "last_update": "2020-10-23" }, { "nct_id": "NCT04491279", "title": "Neuropilates Compared to General Exercise Classes in Chronic Stroke", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dr. John Bartlett", "conditions": [ "Stroke" ], "start_date": "2020-10-30", "last_update": "2024-10-24" }, { "nct_id": "NCT04497597", "title": "A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Rheumatoid Arthritis (RA)" ], "start_date": "2020-10-16", "last_update": "2025-04-13" }, { "nct_id": "NCT04500353", "title": "Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Infant, Premature, Diseases", "Continuous Positive Airway Pressure", "Positive-Pressure Respiration", "Resuscitation", "Respiratory Distress Syndrome, Newborn" ], "start_date": "2020-10-11", "last_update": "2023-12-05" }, { "nct_id": "NCT04508413", "title": "A Clinical Study to Assess the Effects of KB295 in Patients With Ulcerative Colitis (UC) on Gut Microbiota Structure and Function", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Kaleido Biosciences", "conditions": [ "Ulcerative Colitis" ], "start_date": "2020-08-12", "last_update": "2022-01-24" }, { "nct_id": "NCT04511312", "title": "Management and Outcomes of Perioperative Care Among European Diabetic Patients", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "European Society of Anaesthesiology", "conditions": [ "Diabetes Mellitus", "Postoperative Complications" ], "start_date": "2021-05-01", "last_update": "2024-04-17" }, { "nct_id": "NCT04511923", "title": "Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Covid19", "ARDS, Human", "Lung Injury, Acute", "Ventilation Perfusion Mismatch" ], "start_date": "2020-12-23", "last_update": "2024-07-24" }, { "nct_id": "NCT04519957", "title": "Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "COMPASS Pathways", "conditions": [ "Treatment Resistant Depression" ], "start_date": "2020-07-20", "last_update": "2022-09-22" }, { "nct_id": "NCT04525092", "title": "Online Hemodiafiltration vs Conventional Hemodialysis in Acute Kidney Injury", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Centre hospitalier de l'Université de Montréal (CHUM)", "conditions": [ "Acute Kidney Injury" ], "start_date": "2021-01-01", "last_update": "2025-02-18" }, { "nct_id": "NCT04527991", "title": "Study of Sacituzumab Govitecan Versus Physician's Choice of Treatment in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Gilead Sciences", "conditions": [ "Locally Advanced or Metastatic Unresectable Urothelial Cancer" ], "start_date": "2021-01-13", "last_update": "2026-06-02" }, { "nct_id": "NCT04528784", "title": "Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Bladder Dysfunction", "Neurogenic Bladder Dysfunction", "Urinary Incontinence", "Urinary Bladder, Overactive", "Urinary Incontinence, Urge", "Nocturia", "Urinary Frequency More Than Once at Night", "Lower Urinary Tract Symptoms", "Multiple Sclerosis", "Urinary Bladder, Neurogenic" ], "start_date": "2020-10-14", "last_update": "2021-04-28" }, { "nct_id": "NCT04529122", "title": "A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Solid Tumours" ], "start_date": "2020-08-27", "last_update": "2026-05-27" }, { "nct_id": "NCT04529473", "title": "Efficacy and Safety of 12-weeks Supplementation of Eubacterium Hallii on Insulin Sensitivity and Glycaemic Control", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "Pre Diabetes", "Impaired Glucose Tolerance", "Insulin Sensitivity", "Insulin Resistance", "Glucose Metabolism Disorders", "Metabolic Syndrome" ], "start_date": "2021-02-03", "last_update": "2022-11-15" }, { "nct_id": "NCT04538079", "title": "Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "University College Cork", "conditions": [ "Hypotension and Shock", "Hypoperfusion", "Hemodynamic Instability", "Intraventricular Hemorrhage", "Cardiac Function", "Circulatory Transition" ], "start_date": "2019-11-09", "last_update": "2023-01-27" }, { "nct_id": "NCT04540497", "title": "A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Amgen", "conditions": [ "IgG4 Related Disease" ], "start_date": "2020-12-04", "last_update": "2025-12-11" }, { "nct_id": "NCT04542070", "title": "A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY® (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "ViiV Healthcare", "conditions": [ "HIV Infections" ], "start_date": "2020-11-09", "last_update": "2024-06-04" }, { "nct_id": "NCT04544293", "title": "Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Savara Inc.", "conditions": [ "Autoimmune Pulmonary Alveolar Proteinosis" ], "start_date": "2021-05-19", "last_update": "2026-08-26" }, { "nct_id": "NCT04569942", "title": "Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Shock, Septic" ], "start_date": "2021-10-26", "last_update": "2026-03-17" }, { "nct_id": "NCT04579666", "title": "MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Apellis Pharmaceuticals, Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis", "Motor Neuron Disease" ], "start_date": "2020-09-30", "last_update": "2025-04-24" }, { "nct_id": "NCT04581070", "title": "The COVID-IYON Study - Study Examining Data Pertaining to Clinical Outcomes and Organisational Responses to the 2020 SARS-CoV-2 Pandemic\"", "phases": [], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Cancer", "COVID-19" ], "start_date": "2020-04-29", "last_update": "2020-10-30" }, { "nct_id": "NCT04586231", "title": "A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2021-02-25", "last_update": "2026-05-05" }, { "nct_id": "NCT04587635", "title": "Evaluation of Changes in Bowel Movement Frequency Following the Consumption of PHGG in Adults with Constipation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Société des Produits Nestlé (SPN)", "conditions": [ "Constipation - Functional" ], "start_date": "2020-09-16", "last_update": "2024-10-21" }, { "nct_id": "NCT04588311", "title": "ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Australian and New Zealand Intensive Care Research Centre", "conditions": [ "Trauma", "Traumatic Injury", "Traumatic Brain Injury", "Wounds and Injuries", "Penetrating Injury", "Blunt Injury", "Major Trauma", "Multiple Trauma" ], "start_date": "2020-11-09", "last_update": "2025-07-16" }, { "nct_id": "NCT04594369", "title": "A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Insmed Incorporated", "conditions": [ "Non-Cystic Fibrosis Bronchiectasis" ], "start_date": "2020-12-01", "last_update": "2025-12-16" }, { "nct_id": "NCT04595565", "title": "Sacituzumab Govitecan in Primary HER2-negative Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "GBG Forschungs GmbH", "conditions": [ "HER2-negative Breast Cancer", "Triple Negative Breast Cancer" ], "start_date": "2020-10-28", "last_update": "2026-04-22" }, { "nct_id": "NCT04595968", "title": "Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control As a Means of Improving Glycemic Control in Adults with Type 2 Diabetes Mellitus", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neurovalens Ltd.", "conditions": [ "Type 2 Diabetes" ], "start_date": "2021-05-21", "last_update": "2024-09-19" }, { "nct_id": "NCT04602468", "title": "Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)", "phases": [ "PHASE4" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cystic Fibrosis", "Cystic Fibrosis Liver Disease", "Cystic Fibrosis in Children", "Adherence, Medication", "Cystic Fibrosis Gastrointestinal Disease" ], "start_date": "2020-09-03", "last_update": "2026-09-09" }, { "nct_id": "NCT04603339", "title": "ReStOre@Home: Feasibility Study of a 12-week Multidisciplinary Telehealth Rehabilitation Programme for Survivors of Upper Gastrointestinal (UGI) Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Oesophageal Cancer", "Gastric Cancer" ], "start_date": "2021-05-01", "last_update": "2022-04-13" }, { "nct_id": "NCT04608318", "title": "Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "German CLL Study Group", "conditions": [ "Chronic Lymphoid Leukemia" ], "start_date": "2021-03-01", "last_update": "2026-04-30" }, { "nct_id": "NCT04608591", "title": "A Prospective Study to Assess the Risk Factors That Contribute to Thrombosis in Patients With Lower Limb Injuries.", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Limerick", "conditions": [ "Thromboses, Venous", "Lower Limb Injury" ], "start_date": "2018-12-01", "last_update": "2020-10-29" }, { "nct_id": "NCT04613596", "title": "Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Mirati Therapeutics Inc.", "conditions": [ "Advanced Non-Small Cell Lung Cancer", "Metastatic Non-Small Cell Lung Cancer" ], "start_date": "2020-12-02", "last_update": "2026-09-16" }, { "nct_id": "NCT04617067", "title": "Paricalcitol Trial: Phase II, Open Label Clinical Trial of Paricalcitol in Combination With Gemcitabine/ Nab-Paclitaxel Therapy in Advanced Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Advanced Pancreatic Cancer" ], "start_date": "2020-10-16", "last_update": "2024-03-06" }, { "nct_id": "NCT04622319", "title": "A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "HER2-Positive Primary Breast Cancer", "Residual Invasive Breast Cancer" ], "start_date": "2020-12-04", "last_update": "2026-05-15" }, { "nct_id": "NCT04623242", "title": "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Washington University School of Medicine", "conditions": [ "Alzheimers Disease", "Dementia", "Alzheimers Disease, Familial" ], "start_date": "2012-12", "last_update": "2022-09-22" }, { "nct_id": "NCT04623281", "title": "Haemodialysis Outcomes & Patient Empowerment Study 02", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "End Stage Renal Disease", "Dialysis; Complications", "Volume Overload" ], "start_date": "2021-01-21", "last_update": "2021-09-05" }, { "nct_id": "NCT04623775", "title": "A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-small Cell Lung Cancer", "Recurrent Non-small Cell Lung Cancer", "Metastatic Non-small Cell Lung Cancer" ], "start_date": "2021-02-17", "last_update": "2026-06-18" }, { "nct_id": "NCT04625907", "title": "FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Birmingham", "conditions": [ "Rhabdomyosarcoma" ], "start_date": "2020-09-17", "last_update": "2024-05-23" }, { "nct_id": "NCT04626349", "title": "International Study to Evaluate Two Programs of Support for Patients With Advanced Cancer and Their Families", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Vrije Universiteit Brussel", "conditions": [ "Advanced Cancer" ], "start_date": "2021-02-24", "last_update": "2024-06-12" }, { "nct_id": "NCT04628754", "title": "A Randomized Control Trial of an Intervention to Reverse Frailty and Enhance Resilience Through Exercise and Education", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Frailty", "Sarcopenia" ], "start_date": "2020-12-01", "last_update": "2021-12-17" }, { "nct_id": "NCT04629690", "title": "SOLAR- Frailty Screening and Multidisciplinary Assessment of Older Adults in the Emergency Department", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty" ], "start_date": "2020-11-09", "last_update": "2023-06-13" }, { "nct_id": "NCT04630756", "title": "AZD4573 in Novel Combinations With Anti-cancer Agents in Patients With Advanced Blood Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Advanced Haematological Malignancies" ], "start_date": "2021-02-17", "last_update": "2025-04-09" }, { "nct_id": "NCT04644575", "title": "Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bioverativ, a Sanofi company", "conditions": [ "Hemophilia A" ], "start_date": "2021-02-23", "last_update": "2026-07-28" }, { "nct_id": "NCT04644978", "title": "European Study on the Attitude of Psychiatrists Towards Their Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Semmelweis University", "conditions": [ "Mental Illness", "Stigmatization" ], "start_date": "2020-07-29", "last_update": "2022-10-27" }, { "nct_id": "NCT04647292", "title": "European Blood Pressure Intensive Control After Stroke", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Ischemic Stroke", "Transient Ischemic Attack" ], "start_date": "2024-05-02", "last_update": "2024-07-11" }, { "nct_id": "NCT04654975", "title": "Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Universitaire Ziekenhuizen KU Leuven", "conditions": [ "Esophageal Neoplasms", "Esophagectomy", "Brain Metastases" ], "start_date": "2020-06-02", "last_update": "2024-07-03" }, { "nct_id": "NCT04660344", "title": "A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Muscle-invasive Bladder Cancer" ], "start_date": "2021-05-03", "last_update": "2026-09-28" }, { "nct_id": "NCT04662710", "title": "Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Advanced/Metastatic Gastroesophageal Adenocarcinoma" ], "start_date": "2020-12-30", "last_update": "2026-04-28" }, { "nct_id": "NCT04662775", "title": "Formative Evaluation of The HERizon Project", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Liverpool John Moores University", "conditions": [ "Physical Activity" ], "start_date": "2020-04-15", "last_update": "2020-12-16" }, { "nct_id": "NCT04662944", "title": "A Non-interventional Study to Assess the Influence of Automated Optical Coherence Tomography Image Enrichment With Segmentation Information on Disease Activity Assessment in Patients Treated With Licensed Anti- VEGF Injections", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Neovascular Age-Related Macular Degeneration" ], "start_date": "2021-02-23", "last_update": "2024-06-18" }, { "nct_id": "NCT04663750", "title": "Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "King's College Hospital NHS Trust", "conditions": [ "Eye Diseases", "Macular Degeneration, Wet", "Sub-Macular Hemorrhage" ], "start_date": "2021-04-16", "last_update": "2026-09-11" }, { "nct_id": "NCT04666038", "title": "Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Loxo Oncology, Inc.", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2021-03-09", "last_update": "2026-04-24" }, { "nct_id": "NCT04667663", "title": "CPD-DARA in Patients With Relapsed/Refractory Multiple Myeloma.", "phases": [ "PHASE1" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Multiple Myeloma" ], "start_date": "2021-12-08", "last_update": "2026-04-13" }, { "nct_id": "NCT04671602", "title": "Learning to Evaluate Blood Pressure at Home (LEANBH)", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Hypertension in Pregnancy" ], "start_date": "2020-08-19", "last_update": "2020-12-17" }, { "nct_id": "NCT04674449", "title": "iCorMicA - Stratified Medicine in Angina", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "NHS Greater Glasgow and Clyde", "conditions": [ "Microvascular Angina", "Angina, Stable", "Ischemia With No Obstructive Coronary Arteries (INOCA)", "Coronary Microvascular Dysfunction (CMD)", "Ischaemic Heart Disease", "Non-Obstructive Coronary Atherosclerosis", "Coronary Artery Disease", "Vasospastic Angina", "Coronary; Ischemic", "Angina Attacks" ], "start_date": "2020-12-30", "last_update": "2026-04-09" }, { "nct_id": "NCT04677036", "title": "Self-Reported Surgeon Health Behaviours: A Multicentre, Observational Exploration With the Association of Surgeons in Training Into the Modifiable Factors That Impact Surgical Performance", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Health Behavior" ], "start_date": "2020-05-01", "last_update": "2020-12-21" }, { "nct_id": "NCT04680052", "title": "A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Follicular Lymphoma", "Marginal Zone Lymphoma" ], "start_date": "2021-04-15", "last_update": "2026-09-04" }, { "nct_id": "NCT04680299", "title": "European Geriatric Emergency Departments Registry Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Gazi University", "conditions": [ "Geriatric Patients", "Emergencies", "Length of Stay", "Early Warning Score", "Hospital Mortality" ], "start_date": "2020-10-15", "last_update": "2020-12-22" }, { "nct_id": "NCT04685135", "title": "Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Mirati Therapeutics Inc.", "conditions": [ "Metastatic Non Small Cell Lung Cancer", "Advanced Non Small Cell Lung Cancer" ], "start_date": "2021-02-23", "last_update": "2026-08-11" }, { "nct_id": "NCT04685616", "title": "Brentuximab Vedotin in Early Stage Hodgkin Lymphoma", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "University College, London", "conditions": [ "Hodgkin Lymphoma" ], "start_date": "2022-04-14", "last_update": "2026-07-08" }, { "nct_id": "NCT04687072", "title": "A Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "argenx", "conditions": [ "Primary Immune Thrombocytopenia" ], "start_date": "2020-12-16", "last_update": "2024-10-31" }, { "nct_id": "NCT04687111", "title": "Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Mark Ledwidge", "conditions": [ "Atrial Remodeling", "Myocardial Dysfunction", "Left Ventricular Remodeling", "Left Ventricular Diastolic Dysfunction", "Hypertension", "Cardiovascular Morbidity", "Fibrosis Myocardial", "Inflammatory Myopathy", "Atrial Arrhythmia" ], "start_date": "2015-12-16", "last_update": "2021-05-11" }, { "nct_id": "NCT04695873", "title": "A 3 Day In-use Assessment of the Scholl Corn Foam Cushions on Pain Levels Associated With Heloma Durum.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Reckitt Benckiser Healthcare (UK) Limited", "conditions": [ "Heloma Durum" ], "start_date": "2021-06-16", "last_update": "2021-12-27" }, { "nct_id": "NCT04698577", "title": "Evaluation of a School-Based Attention Training Programme for Improving Concentration", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Attention Concentration Difficulty" ], "start_date": "2018-11-26", "last_update": "2021-01-07" }, { "nct_id": "NCT04699253", "title": "Usability and Feasibility of a Personalized, Web-based Education and Self-management Approach for Patients With Chronic Heart Failure Across Four European Sites", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Maastricht University Medical Center", "conditions": [ "Chronic Heart Failure" ], "start_date": "2021-07-01", "last_update": "2024-04-17" }, { "nct_id": "NCT04704219", "title": "Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61)", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2021-02-23", "last_update": "2025-12-03" }, { "nct_id": "NCT04704934", "title": "Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "Gastric Cancer, Adenocarcinoma", "Gastroesophageal Junction Adenocarcinoma" ], "start_date": "2021-05-21", "last_update": "2026-05-27" }, { "nct_id": "NCT04709835", "title": "Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "COVID-19" ], "start_date": "2021-02-03", "last_update": "2022-10-26" }, { "nct_id": "NCT04715308", "title": "Patient Experiences Following Urinary Diversion as Part of Surgery for Advanced and Recurrent Rectal Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Patient Satisfaction", "Quality of Life", "Patient Participation" ], "start_date": "2020-12-01", "last_update": "2021-02-10" }, { "nct_id": "NCT04717414", "title": "An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Celgene", "conditions": [ "Myeloproliferative Disorders", "Myelofibrosis", "Primary Myelofibrosis", "Post-Polycythemia Vera Myelofibrosis", "Anemia" ], "start_date": "2021-02-25", "last_update": "2026-07-16" }, { "nct_id": "NCT04718389", "title": "A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Asthma" ], "start_date": "2021-01-26", "last_update": "2026-05-18" }, { "nct_id": "NCT04719832", "title": "Placebo-controlled Efficacy and Safety Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Asthma" ], "start_date": "2021-03-17", "last_update": "2024-12-17" }, { "nct_id": "NCT04721002", "title": "Study to Evaluate t(11;14) Status and BCL2 Expression in Adult Participants With Multiple Myeloma (MM)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Multiple Myeloma (MM)" ], "start_date": "2021-07-07", "last_update": "2023-10-18" }, { "nct_id": "NCT04723836", "title": "Optimal Nutrition for Prevention of Hypertension in Pregnancy", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Ulster", "conditions": [ "Blood Pressure", "Pregnancy" ], "start_date": "2017-03-01", "last_update": "2025-10-07" }, { "nct_id": "NCT04728893", "title": "Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Hematologic Malignancies", "Waldenstroms Macroglobulinaemia", "Non-Hodgkins Lymphoma", "Chronic Lymphocytic Leukaemia" ], "start_date": "2021-04-05", "last_update": "2026-10-05" }, { "nct_id": "NCT04729712", "title": "Efficacy of Ultrasound Guided ESP Vs Video-assisted PVB Catheter Placement in Minimally Invasive Thoracic Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Regional Anesthesia Morbidity", "Pain, Postoperative", "Pain, Chronic" ], "start_date": "2021-05-12", "last_update": "2022-05-20" }, { "nct_id": "NCT04736706", "title": "A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2021-04-14", "last_update": "2026-10-02" }, { "nct_id": "NCT04739761", "title": "A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Breast Cancer" ], "start_date": "2021-06-22", "last_update": "2026-08-11" }, { "nct_id": "NCT04739865", "title": "The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "COMPASS Pathways", "conditions": [ "Treatment Resistant Depression" ], "start_date": "2020-08-10", "last_update": "2023-11-09" }, { "nct_id": "NCT04744194", "title": "The Effect of 6 Week Hamstring Exercise Programs on Hamstring Muscle Strength", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dublin City University", "conditions": [ "Hamstring Injury" ], "start_date": "2022-02-13", "last_update": "2023-02-10" }, { "nct_id": "NCT04750161", "title": "The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Psoriasis Vulgaris", "Atopic Dermatitis", "Ichthyosis Vulgaris" ], "start_date": "2021-03-02", "last_update": "2021-03-05" }, { "nct_id": "NCT04750798", "title": "An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Biosense Webster, Inc.", "conditions": [ "Arrhythmias, Cardiac" ], "start_date": "2021-02-22", "last_update": "2026-09-25" }, { "nct_id": "NCT04753242", "title": "Psychosocial Care During the COVID-19 Pandemic in Acute Hospitals", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital, Basel, Switzerland", "conditions": [ "Covid-19", "COVID-19 Related Psychosocial Burden" ], "start_date": "2020-12-08", "last_update": "2021-10-28" }, { "nct_id": "NCT04753294", "title": "Confirm Safety and Performance of Avance Solo and Avance Solo Adapt NPWT Systems", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Molnlycke Health Care AB", "conditions": [ "Venous Leg Ulcer", "Pressure Ulcer", "Diabetic Foot Ulcer", "Chronic Ulcer" ], "start_date": "2021-06-14", "last_update": "2023-09-08" }, { "nct_id": "NCT04759131", "title": "Safety, Efficacy and PK of BIVV001 in Pediatric Patients With Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Bioverativ, a Sanofi company", "conditions": [ "Hemophilia A" ], "start_date": "2021-02-19", "last_update": "2025-09-11" }, { "nct_id": "NCT04761484", "title": "Umbilical or Peripheral Catheter Insertion for Preterm Infants on Admission to the NICU", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Hypothermia, Newborn", "Preterm Birth Complication", "Neonatal Hypothermia" ], "start_date": "2021-03-01", "last_update": "2021-04-28" }, { "nct_id": "NCT04762108", "title": "Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College, London", "conditions": [ "Sjogren's Syndrome Childhood-onset" ], "start_date": "2020-01-11", "last_update": "2021-04-19" }, { "nct_id": "NCT04764448", "title": "A Study of Belcesiran in Patients With AATLD", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Dicerna Pharmaceuticals, Inc., a Novo Nordisk company", "conditions": [ "Alpha 1-Antitrypsin Deficiency" ], "start_date": "2021-02-12", "last_update": "2026-04-07" }, { "nct_id": "NCT04766229", "title": "The Menopause After Cancer Study", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Menopause", "Cancer", "Insomnia" ], "start_date": "2021-06-21", "last_update": "2023-01-06" }, { "nct_id": "NCT04766372", "title": "A Multi-component Physical Activity Intervention for Adolescent Girls", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Liverpool John Moores University", "conditions": [ "Exercise" ], "start_date": "2020-11-30", "last_update": "2021-02-23" }, { "nct_id": "NCT04767867", "title": "Pre-oxygenation With Facemask Oxygen vs High-flow Nasal Oxygen vs High-flow Nasal Oxygen Plus Mouthpiece Oxygen", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Apnea", "Respiration; Arrest", "Anesthesia" ], "start_date": "2020-08-01", "last_update": "2021-02-23" }, { "nct_id": "NCT04768972", "title": "FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Ionis Pharmaceuticals, Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2021-06-14", "last_update": "2026-07-21" }, { "nct_id": "NCT04777396", "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Early Alzheimer's Disease" ], "start_date": "2021-05-18", "last_update": "2026-07-07" }, { "nct_id": "NCT04777409", "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Early Alzheimer´s Disease" ], "start_date": "2021-05-18", "last_update": "2026-06-26" }, { "nct_id": "NCT04778072", "title": "A Clinical Study on Adherence and Efficacy of Different Doses of Active Iron in Treatment Resistant Subjects", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Solvotrin Innovations Ltd", "conditions": [ "Premenopause", "Iron-deficiency", "Iron Adverse Reaction", "Iron Deficiency Anemia", "Heavy Menstrual Bleeding" ], "start_date": "2018-10-08", "last_update": "2021-03-26" }, { "nct_id": "NCT04780295", "title": "Coronavirus Disease (COvid-)19 REgistry on THROMBOSIS Complications", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Johannes Gutenberg University Mainz", "conditions": [ "Covid19" ], "start_date": "2020-04-15", "last_update": "2023-01-25" }, { "nct_id": "NCT04783298", "title": "Can Methods From Computational Psychology be Used to Phenotype Individuals Most Likely to be Non-adherent to Fitness Goals?", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin City University", "conditions": [ "Lifestyle, Sedentary" ], "start_date": "2021-01-01", "last_update": "2021-03-05" }, { "nct_id": "NCT04783584", "title": "Agreement Between Video and In-person Airway Assessment Performed by Anaesthetists in Patients Scheduled for Elective Same-day Gynaecological Procedures", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Michael Ma", "conditions": [ "Difficult Intubation", "Difficult Airway Intubation" ], "start_date": "2020-12-01", "last_update": "2021-03-05" }, { "nct_id": "NCT04790370", "title": "Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism", "phases": [ "PHASE4" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Pulmonary Embolism" ], "start_date": "2021-08-02", "last_update": "2026-07-01" }, { "nct_id": "NCT04793919", "title": "Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Associazione Italiana Ematologia Oncologia Pediatrica", "conditions": [ "Acute Promyelocytic Leukemia" ], "start_date": "2019-10-09", "last_update": "2024-04-15" }, { "nct_id": "NCT04793958", "title": "Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Mirati Therapeutics Inc.", "conditions": [ "Advanced Colorectal Cancer", "Metastatic Colorectal Cancer" ], "start_date": "2021-06-24", "last_update": "2026-09-28" }, { "nct_id": "NCT04796545", "title": "Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "VisionCare, Inc.", "conditions": [ "AMD", "Age-Related Macular Degeneration" ], "start_date": "2022-09-13", "last_update": "2026-09-29" }, { "nct_id": "NCT04809129", "title": "Testing the Gravitostat in Humans: the Impact of a Weighted Vest in Patients Post Bariatric Surgery on Fat-free Mass Retention and Weight Loss", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "University College Dublin", "conditions": [ "Obesity" ], "start_date": "2021-04-08", "last_update": "2022-10-13" }, { "nct_id": "NCT04810065", "title": "SingStrong: Strong Lungs Through Song - Long COVID-19 Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Long Covid" ], "start_date": "2021-03-29", "last_update": "2021-09-28" }, { "nct_id": "NCT04810078", "title": "A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Clear Cell Renal Cell Carcinoma" ], "start_date": "2021-05-21", "last_update": "2026-09-22" }, { "nct_id": "NCT04811885", "title": "The Effects of Covid-19 Pandemic on the Cardiovascular Heath of Children With Autism Spectrum Disorder", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "South East Technological University", "conditions": [ "Autism Spectrum Disorder", "Cardiovascular Health" ], "start_date": "2019-10-14", "last_update": "2021-03-24" }, { "nct_id": "NCT04812925", "title": "A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "argenx", "conditions": [ "Primary Immune Thrombocytopenia" ], "start_date": "2021-11-17", "last_update": "2026-09-23" }, { "nct_id": "NCT04813731", "title": "COVID-19 And Lingering Symptoms In Primary Care Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Katarina Hedin", "conditions": [ "Covid19", "Symptoms and Signs" ], "start_date": "2020-12-12", "last_update": "2025-09-04" }, { "nct_id": "NCT04816331", "title": "Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Neonatal Encephalopathy" ], "start_date": "2020-08-04", "last_update": "2021-03-25" }, { "nct_id": "NCT04822181", "title": "Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Non-alcoholic Steatohepatitis" ], "start_date": "2021-04-01", "last_update": "2026-09-04" }, { "nct_id": "NCT04823182", "title": "Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Cardiovascular Research Institute Dublin", "conditions": [ "SARS-CoV Infection", "Covid19", "Cardiomyopathies" ], "start_date": "2021-02-16", "last_update": "2021-09-24" }, { "nct_id": "NCT04823663", "title": "BoStOn SCientific Rhythm MAnagemenT REgiStry", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Cardiac Disease" ], "start_date": "2021-03-31", "last_update": "2026-09-25" }, { "nct_id": "NCT04823871", "title": "Early Detection of High Grade Ovarian Cancer Using Uterine Lavage EHUD Study and Duplex Sequencing", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Paul Speiser, Prof.MD,", "conditions": [ "Ovarian Epithelial Cancer", "Carcinoma in Situ", "Ovarian Cancer" ], "start_date": "2018-11-01", "last_update": "2022-09-02" }, { "nct_id": "NCT04824092", "title": "Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Diffuse Large B-cell Lymphoma" ], "start_date": "2021-05-11", "last_update": "2026-04-01" }, { "nct_id": "NCT04829929", "title": "Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eclipse Medical Ltd.", "conditions": [ "Non-Valvular Atrial Fibrillation" ], "start_date": "2020-11-17", "last_update": "2025-12-03" }, { "nct_id": "NCT04832412", "title": "Effect of BrainPhyt, a Microalgae Based Ingredient on Cognitive Function in Healthy Older Subjects", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Microphyt", "conditions": [ "Healthy Aging", "Dietary Supplement", "Fucoxanthin", "Cognitive Impairment", "Neuroprotection", "Mood", "Stress", "Sleep" ], "start_date": "2022-09-01", "last_update": "2024-12-17" }, { "nct_id": "NCT04851990", "title": "Assessment of the Safety & Tolerability of Long-term Use of Patented Transdermal Patches in Healthy Adults.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Horopito Limited", "conditions": [ "Vitamin D" ], "start_date": "2021-04-19", "last_update": "2021-08-05" }, { "nct_id": "NCT04858776", "title": "Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Mercator MedSystems, Inc.", "conditions": [ "Iliofemoral; Thrombosis" ], "start_date": "2022-08-08", "last_update": "2026-06-25" }, { "nct_id": "NCT04860050", "title": "Turmeric for Memory Impairment and Cognition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Givaudan France Naturals", "conditions": [ "Cognitive Change", "Mood", "Stress" ], "start_date": "2021-04-19", "last_update": "2024-01-18" }, { "nct_id": "NCT04862468", "title": "Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Mercator MedSystems, Inc.", "conditions": [ "Thrombosis, Deep Vein", "Iliofemoral; Thrombosis" ], "start_date": "2021-10-29", "last_update": "2026-09-25" }, { "nct_id": "NCT04872530", "title": "Bioavailability of Plant Protein Amino Acids", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men" ], "start_date": "2020-01-08", "last_update": "2023-11-30" }, { "nct_id": "NCT04881136", "title": "Frailty and Falls Implantable System for Prediction and Prevention", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Fall Patients", "Frailty" ], "start_date": "2021-03-23", "last_update": "2021-06-28" }, { "nct_id": "NCT04891133", "title": "EU SolidAct: An Adaptive Pandemic and Emerging Infection Platform Trial", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Oslo University Hospital", "conditions": [ "COVID-19", "Emerging Infectious Disease" ], "start_date": "2021-06-03", "last_update": "2023-02-06" }, { "nct_id": "NCT04895358", "title": "Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Breast Neoplasms" ], "start_date": "2021-06-18", "last_update": "2026-07-22" }, { "nct_id": "NCT04895696", "title": "A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Beeline Medicines Corporation", "conditions": [ "Systemic Lupus Erythematosus" ], "start_date": "2021-10-11", "last_update": "2026-08-17" }, { "nct_id": "NCT04899622", "title": "Mindfulness Online and Virtual Exercise (MOVE) Compared With Self-Management for Chronic Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Orla Deegan", "conditions": [ "Chronic Pain" ], "start_date": "2021-04-01", "last_update": "2022-10-05" }, { "nct_id": "NCT04901195", "title": "A Study to Test the Long-term Treatment of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "UCB Biopharma SRL", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2021-05-27", "last_update": "2026-10-06" }, { "nct_id": "NCT04905069", "title": "Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Prostate Cancer" ], "start_date": "2021-12-21", "last_update": "2026-09-14" }, { "nct_id": "NCT04905290", "title": "Conduction System Pacing Optimized Therapy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Medtronic Cardiac Rhythm and Heart Failure", "conditions": [ "Heart Failure" ], "start_date": "2021-11-27", "last_update": "2025-04-15" }, { "nct_id": "NCT04908202", "title": "A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Psoriatic Arthritis" ], "start_date": "2021-07-13", "last_update": "2026-09-24" }, { "nct_id": "NCT04910685", "title": "(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Blueprint Medicines Corporation", "conditions": [ "Indolent Systemic Mastocytosis", "Smoldering Systemic Mastocytosis" ], "start_date": "2021-11-30", "last_update": "2026-10-07" }, { "nct_id": "NCT04912648", "title": "FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Hyperandrogenism", "Metabolic Disease", "Sex Hormones Adverse Reaction" ], "start_date": "2021-04-01", "last_update": "2024-05-02" }, { "nct_id": "NCT04915755", "title": "Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Breast" ], "start_date": "2021-06-28", "last_update": "2025-07-16" }, { "nct_id": "NCT04916613", "title": "ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "UNICANCER", "conditions": [ "Prostate Cancer Metastatic" ], "start_date": "2022-04-19", "last_update": "2026-04-28" }, { "nct_id": "NCT04918251", "title": "EEG and TMS-based Biomarkers of ALS, MS and FTD", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Amyotrophic Lateral Sclerosis", "Frontotemporal Dementia", "Multiple Sclerosis" ], "start_date": "2012-09", "last_update": "2021-06-08" }, { "nct_id": "NCT04921059", "title": "An Investigation of Heart Rate Recovery Responses to Repeated Active Stand Protocols", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Caitríona Quinn", "conditions": [ "Heart Rate Response", "Orthostasis" ], "start_date": "2021-11-17", "last_update": "2025-02-10" }, { "nct_id": "NCT04923191", "title": "The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Coronary Artery Disease" ], "start_date": "2021-11-12", "last_update": "2023-10-30" }, { "nct_id": "NCT04923893", "title": "A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Multiple Myeloma" ], "start_date": "2021-08-19", "last_update": "2026-09-25" }, { "nct_id": "NCT04924010", "title": "Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Breast Cancer", "Chronic Pain", "Chronic Postsurgical Pain", "Quality of Life" ], "start_date": "2021-05-31", "last_update": "2023-03-14" }, { "nct_id": "NCT04925440", "title": "The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "PrecisionBiotics Group Ltd.", "conditions": [ "Low Mood", "Depressive Symptoms" ], "start_date": "2021-09-13", "last_update": "2022-11-10" }, { "nct_id": "NCT04931082", "title": "Probiotic Intervention for Stress and Cognition", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Probi AB", "conditions": [ "Stress", "Cognition" ], "start_date": "2021-07-07", "last_update": "2023-11-18" }, { "nct_id": "NCT04931771", "title": "Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "ECRI bv", "conditions": [ "Coronary Artery Disease" ], "start_date": "2021-11-09", "last_update": "2026-06-23" }, { "nct_id": "NCT04931862", "title": "Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Wave Life Sciences USA, Inc.", "conditions": [ "ALS", "FTD" ], "start_date": "2021-06-28", "last_update": "2023-10-23" }, { "nct_id": "NCT04932317", "title": "Oral Symptom Assessment Scale (OSAS): Validity and Reliability", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Neoplasms" ], "start_date": "2021-08-05", "last_update": "2023-03-31" }, { "nct_id": "NCT04935034", "title": "Absorption Kinetics and Efficacy of Vitamin D Enriched Supplements in Older Adults.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2018-07-01", "last_update": "2024-09-19" }, { "nct_id": "NCT04938128", "title": "Effect of CPAP vs Control on Nocturnal Dipping in Normotensive Patients With Obstructive Sleep Apnea", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Sleep Apnea, Obstructive" ], "start_date": "2021-04-12", "last_update": "2023-12-21" }, { "nct_id": "NCT04939649", "title": "Ketamine As an Adjunctive Therapy for Major Depression (2)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Major Depressive Episode", "Unipolar Depression", "Bipolar Depression" ], "start_date": "2021-09-13", "last_update": "2025-02-13" }, { "nct_id": "NCT04944784", "title": "A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2021-08-16", "last_update": "2024-12-05" }, { "nct_id": "NCT04946981", "title": "Recovery and Muscle Function After Supplementation With Turmeric", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Givaudan France Naturals", "conditions": [ "Muscle Soreness", "Pain", "Muscle Damage" ], "start_date": "2021-07-12", "last_update": "2022-12-12" }, { "nct_id": "NCT04948762", "title": "A Contemporary Review of Surgical Approaches in Pelvic Exenterative Surgery", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Pelvic Exenteration", "Advanced Pelvic Malignancy", "Locally Advanced Rectal Cancer" ], "start_date": "2021-08-01", "last_update": "2021-10-20" }, { "nct_id": "NCT04950075", "title": "Study of INBRX-109 in Conventional Chondrosarcoma", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Inhibrx Biosciences, Inc", "conditions": [ "Conventional Chondrosarcoma" ], "start_date": "2021-09-23", "last_update": "2026-07-14" }, { "nct_id": "NCT04951674", "title": "Dietary Fiber, Microbiota and Cognitive Function in Healthy Adults", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2021-07", "last_update": "2021-07-07" }, { "nct_id": "NCT04957641", "title": "A Study of the Burden of Illness and Treatment Patterns in Teenagers and Adults With Hereditary Angioedema", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Takeda", "conditions": [ "Hereditary Angioedema" ], "start_date": "2022-04-21", "last_update": "2023-06-26" }, { "nct_id": "NCT04959565", "title": "Evaluation of a Practice-oriented Recovery Program for Female Endurance Athletes With Relative Energy Deficiency", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Monica Klungland Torstveit", "conditions": [ "Relative Energy Deficiency in Sport" ], "start_date": "2020-10-08", "last_update": "2023-12-15" }, { "nct_id": "NCT04961996", "title": "A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Early Breast Cancer" ], "start_date": "2021-08-27", "last_update": "2026-06-17" }, { "nct_id": "NCT04965493", "title": "A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Loxo Oncology, Inc.", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2021-09-20", "last_update": "2026-01-29" }, { "nct_id": "NCT04966234", "title": "A New Posaconazole Dosing Regimen for Paediatric Patients With Cystic Fibrosis and Aspergillus Infection", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Bambino Gesù Hospital and Research Institute", "conditions": [ "Cystic Fibrosis", "Aspergillosis" ], "start_date": "2021-04-22", "last_update": "2021-07-19" }, { "nct_id": "NCT04972721", "title": "SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Overweight", "Obesity" ], "start_date": "2023-09-01", "last_update": "2026-02-11" }, { "nct_id": "NCT04973137", "title": "A Study to Evaluate the Efficacy and Safety of Birtamimab in Mayo Stage IV Patients With AL Amyloidosis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Prothena Biosciences Ltd.", "conditions": [ "Light Chain (AL) Amyloidosis" ], "start_date": "2021-08-30", "last_update": "2025-12-16" }, { "nct_id": "NCT04974931", "title": "Application of PREVENA in Reducing Surgical Site Complications Following Reversal of Ileostomy or Colostomy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Stoma Site Infection", "Ileostomy - Stoma", "Colostomy Stoma" ], "start_date": "2021-11-01", "last_update": "2021-09-21" }, { "nct_id": "NCT04975997", "title": "Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2022-06-23", "last_update": "2026-04-03" }, { "nct_id": "NCT04976972", "title": "A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Smith & Nephew Orthopaedics AG", "conditions": [ "Arthritis", "Osteoarthritis", "Knee", "Joint Diseases", "Musculoskeletal Diseases", "Rheumatic Diseases" ], "start_date": "2021-09-30", "last_update": "2022-07-11" }, { "nct_id": "NCT04977986", "title": "Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Harmony Biosciences Management, Inc.", "conditions": [ "Fragile X Syndrome", "Fragile X Syndrome (FXS)" ], "start_date": "2021-09-13", "last_update": "2026-09-01" }, { "nct_id": "NCT04979442", "title": "Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Rain Oncology Inc", "conditions": [ "Dedifferentiated Liposarcoma" ], "start_date": "2021-07-14", "last_update": "2025-01-14" }, { "nct_id": "NCT04980833", "title": "Study Assessing Long-term Safety and Efficacy of Alpelisib in Patients With PIK3CA-Related Overgrowth Spectrum (PROS) Who Previously Participated in Study CBYL719F12002 (EPIK-P1)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "PIK3CA-related Overgrowth Spectrum (PROS)" ], "start_date": "2022-01-27", "last_update": "2026-04-02" }, { "nct_id": "NCT04983602", "title": "Physiotherapy Led Community Intervention for Older Adults Discharged From the Emergency Department", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Old Age; Debility", "Health Services for the Aged" ], "start_date": "2021-09-13", "last_update": "2022-07-27" }, { "nct_id": "NCT04988386", "title": "Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eidos Therapeutics, a BridgeBio company", "conditions": [ "Amyloid Cardiomyopathy, Transthyretin-Related" ], "start_date": "2021-10-27", "last_update": "2025-10-14" }, { "nct_id": "NCT04990089", "title": "VIVO European Observational Registry", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Catheter Precision. Inc.", "conditions": [ "Ventricular Arrythmia", "Ventricular Tachycardia", "Premature Ventricular Contraction" ], "start_date": "2021-10-21", "last_update": "2025-01-31" }, { "nct_id": "NCT04992078", "title": "A Comparison of Patients Receiving a Unicompartmental Knee Replacement With Robotic Assistance or With Conventional Instrumentation", "phases": [ "NA" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Smith & Nephew Orthopaedics AG", "conditions": [ "Arthritis", "Osteoarthritis", "Knee", "Joint Diseases", "Musculoskeletal Diseases", "Rheumatic Diseases" ], "start_date": "2022-01-01", "last_update": "2022-06-29" }, { "nct_id": "NCT04994652", "title": "Video- Or Direct Laryngoscopy for Endotracheal Intubation in Newborns", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Intubation, Intratracheal", "Infant, Newborn", "Laryngoscopes" ], "start_date": "2021-09-04", "last_update": "2023-11-21" }, { "nct_id": "NCT05002725", "title": "PENG Versus Femoral Nerve Block in Neck of Femur Fracture", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Neck of Femur Fracture" ], "start_date": "2021-01-28", "last_update": "2021-08-12" }, { "nct_id": "NCT05012345", "title": "Distal Radial Fractures in Adult Patients: 4 Weeks Versus 6 Weeks of Cast Immobilisation Following Closed Reduction.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Hospital", "conditions": [ "Distal Radius Fracture" ], "start_date": "2021-08-20", "last_update": "2021-08-19" }, { "nct_id": "NCT05014581", "title": "Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Turin, Italy", "conditions": [ "Critical Illness", "Respiratory Failure" ], "start_date": "2024-08-01", "last_update": "2025-03-28" }, { "nct_id": "NCT05020808", "title": "The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Metabolism", "Exercise", "Dietary Supplements" ], "start_date": "2021-09-14", "last_update": "2022-06-22" }, { "nct_id": "NCT05021536", "title": "Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Amylyx Pharmaceuticals Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2021-10-28", "last_update": "2024-08-14" }, { "nct_id": "NCT05027724", "title": "Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Covid19", "Post Viral Fatigue" ], "start_date": "2021-05-17", "last_update": "2022-05-20" }, { "nct_id": "NCT05031754", "title": "Assessing SleeP IN Infants With Atopic Dermatitis by Longitudinal Evaluation", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Atopic Dermatitis", "Sleep Disturbance" ], "start_date": "2020-12-03", "last_update": "2022-05-27" }, { "nct_id": "NCT05033080", "title": "A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2021-09-14", "last_update": "2024-10-03" }, { "nct_id": "NCT05035173", "title": "The LYSA (Linking You to Support and Advice) Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Survivorship", "Breast Cancer", "Cervical Cancer", "Endometrial Cancer" ], "start_date": "2021-03-13", "last_update": "2026-03-04" }, { "nct_id": "NCT05038735", "title": "Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Breast Cancer" ], "start_date": "2021-12-17", "last_update": "2026-09-29" }, { "nct_id": "NCT05039645", "title": "Use of Remote Thermovisual Monitoring in Patients With a Previous Diabetic Foot Ulcer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Bluedrop Medical Limited", "conditions": [ "Diabetic Foot Ulcer" ], "start_date": "2022-03-31", "last_update": "2024-01-03" }, { "nct_id": "NCT05041257", "title": "Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "AbbVie", "conditions": [ "Ovarian Cancer", "Peritoneal Cancer", "Fallopian Tube Cancer" ], "start_date": "2021-10-19", "last_update": "2026-01-09" }, { "nct_id": "NCT05043103", "title": "Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Britannia Pharmaceuticals Ltd.", "conditions": [ "Advanced Parkinson Disease" ], "start_date": "2021-07-06", "last_update": "2026-10-06" }, { "nct_id": "NCT05047185", "title": "Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Pharvaris Netherlands B.V.", "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor Deficiency", "C1 Inhibitor Deficiency" ], "start_date": "2022-04-19", "last_update": "2026-08-17" }, { "nct_id": "NCT05050162", "title": "Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "SUSPENDED", "lead_sponsor": "NRG Oncology", "conditions": [ "Advanced Head and Neck Squamous Cell Carcinoma", "Advanced Hypopharyngeal Squamous Cell Carcinoma", "Advanced Laryngeal Squamous Cell Carcinoma", "Advanced Oropharyngeal Squamous Cell Carcinoma", "Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8", "Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8", "Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8", "Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8", "Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8", "Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8" ], "start_date": "2022-02-01", "last_update": "2026-06-25" }, { "nct_id": "NCT05051202", "title": "A Study Assessing the Tolerable Upper Intake Level and Safety of Sugars From Fiber", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Cambridge Glycoscience", "conditions": [ "Gastrointestinal Tolerance" ], "start_date": "2021-06-21", "last_update": "2022-10-19" }, { "nct_id": "NCT05052801", "title": "Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amgen", "conditions": [ "Gastric Cancer", "Gastroesophageal Junction Adenocarcinoma" ], "start_date": "2022-03-07", "last_update": "2026-05-27" }, { "nct_id": "NCT05053139", "title": "A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Haemophilia A", "Haemophilia A With Inhibitors" ], "start_date": "2021-12-02", "last_update": "2025-12-08" }, { "nct_id": "NCT05061381", "title": "Effectiveness of a School Wellbeing Programme for Internalising Problems in Irish Primary School Children", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Anxiety", "Low Mood" ], "start_date": "2021-10-11", "last_update": "2022-11-04" }, { "nct_id": "NCT05061550", "title": "Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2022-04-14", "last_update": "2026-09-23" }, { "nct_id": "NCT05061810", "title": "The Effect of a Smartphone Application Self-management Programme on Clinical Health Outcomes in Patients With Chronic Obstructive Pulmonary Disease.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2021-09-13", "last_update": "2023-05-12" }, { "nct_id": "NCT05064358", "title": "Study to Investigate Alternative Dosing Regimens of Belantamab Mafodotin in Participants With Relapsed or Refractory Multiple Myeloma", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Multiple Myeloma" ], "start_date": "2022-03-03", "last_update": "2026-05-05" }, { "nct_id": "NCT05064878", "title": "A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Zogenix, Inc.", "conditions": [ "CDKL5 Deficiency Disorder", "Generalized Tonic Clonic Seizure", "Epileptic Spasm", "Refractory Seizures" ], "start_date": "2022-03-08", "last_update": "2026-04-29" }, { "nct_id": "NCT05066867", "title": "LMWH Compliance in Pregnancy", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Cork University Maternity Hospital", "conditions": [ "Venous Thromboembolism", "Antenatal Deep Vein Thrombosis" ], "start_date": "2021-01-01", "last_update": "2021-10-04" }, { "nct_id": "NCT05074069", "title": "A Review of Functional and Surgical Outcomes of Gynaecological Reconstruction in the Context of Pelvic Exenteration", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Pelvic Cancer" ], "start_date": "2021-07-01", "last_update": "2023-03-31" }, { "nct_id": "NCT05074082", "title": "Perineal Flap Reconstruction Following Surgery for Advanced Pelvic Malignancy", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Pelvic Cancer", "Rectal Cancer", "Flap Disorder", "Flap Ischemia", "Flap Necrosis", "Perioperative Complication" ], "start_date": "2021-07-31", "last_update": "2023-03-31" }, { "nct_id": "NCT05074732", "title": "Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Health Service Executive, Ireland", "conditions": [ "Schizophrenia", "Forensic Psychiatry", "Outcome Measure", "Violence", "Personality Disorders", "Recovery", "Obesity", "Type II Diabetes", "Cardiovascular Diseases", "Frailty", "Psychosis", "Treatment-resistant Schizophrenia" ], "start_date": "2019-12-01", "last_update": "2021-10-12" }, { "nct_id": "NCT05074914", "title": "Unintentional Weight Loss After Oesophagectomy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Oesophageal Cancer" ], "start_date": "2021-06-30", "last_update": "2022-04-13" }, { "nct_id": "NCT05076149", "title": "A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2021-10-27", "last_update": "2024-06-13" }, { "nct_id": "NCT05076305", "title": "PelvEx 4: Advanced Pelvic Malignancy and the Role of the Multi-disciplinary Team Meeting", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Multidisciplinary Communication", "Locally Advanced Rectal Cancer", "Recurrent Rectal Cancer", "Multidisciplinary Team Meeting (MDT)", "Treatment Decisions" ], "start_date": "2021-10-15", "last_update": "2021-10-13" }, { "nct_id": "NCT05086692", "title": "A Beta-only IL-2 ImmunoTherapY Study", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Medicenna Therapeutics, Inc.", "conditions": [ "Advanced Solid Tumor", "Unresectable Solid Tumor", "Clear Cell Renal Cell Carcinoma", "Triple Negative Breast Cancer", "Non-Small Cell Lung Cancer Squamous", "Non-Small Cell Lung Cancer Non-squamous", "Colorectal Cancer (MSI-H)", "Gastric Cancer", "Cervical Cancer", "Basal Cell Carcinoma", "Bladder Cancer", "Merkel Cell Carcinoma", "Squamous Cell Carcinoma of Head and Neck", "Cutaneous Squamous Cell Carcinoma", "Pleural Mesothelioma", "Esophageal Cancer", "Endometrial Carcinoma", "Solid Tumor", "Solid Tumor, Adult", "MSI-H Solid Malignant Tumor", "Cancer With A High Tumor Mutational Burden", "Epithelial Ovarian Carcinoma", "Primary Peritoneal Cancer", "Gastroesophageal Junction (GEJ) Cancer", "Acral Melanoma", "Mucosal Melanoma", "Cutaneous Melanoma", "DMMR Solid Malignant Tumor", "Fallopian Tube Cancer", "Ovarian Cancer", "MSI-H Cancer", "DMMR Cancer", "Pancreas Adenocarcinoma (MSI-H)", "Skin Cancer", "Viral Cancer", "Cervical Cancers", "Endometrial Cancer" ], "start_date": "2021-08-27", "last_update": "2025-07-09" }, { "nct_id": "NCT05089084", "title": "Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Arrowhead Pharmaceuticals", "conditions": [ "Familial Chylomicronemia" ], "start_date": "2021-12-14", "last_update": "2026-06-05" }, { "nct_id": "NCT05093933", "title": "A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Chronic Heart Failure With Reduced Ejection Fraction" ], "start_date": "2021-11-02", "last_update": "2025-12-19" }, { "nct_id": "NCT05095025", "title": "PENG: an Estimation of ED50 in Neck of Femur Fracture", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Hip Fractures", "Pain, Acute" ], "start_date": "2021-09-14", "last_update": "2021-10-27" }, { "nct_id": "NCT05097287", "title": "Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma", "phases": [ "PHASE4" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Sanofi", "conditions": [ "Asthma" ], "start_date": "2021-12-16", "last_update": "2026-04-16" }, { "nct_id": "NCT05098132", "title": "Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Synthekine", "conditions": [ "Advanced Solid Tumor", "Non Small Cell Lung Cancer", "Untreated Advanced NSCLC", "1st Line NSCLC" ], "start_date": "2022-01-25", "last_update": "2026-07-21" }, { "nct_id": "NCT05100862", "title": "A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "BeOne Medicines", "conditions": [ "Relapsed/Refractory Follicular Lymphoma", "Marginal Zone Lymphoma" ], "start_date": "2022-03-10", "last_update": "2026-09-28" }, { "nct_id": "NCT05109026", "title": "Connect-5 Needs Assessment Survey to Identify Healthy Lifestyle Requirements of a Rural Irish Community", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Healthy Lifestyle" ], "start_date": "2022-09-05", "last_update": "2023-10-16" }, { "nct_id": "NCT05114018", "title": "Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "A-Mansia Biotech S.A.", "conditions": [ "Metabolic Syndrome", "Pre-diabetes", "Overweight and Obesity" ], "start_date": "2020-06-24", "last_update": "2025-06-08" }, { "nct_id": "NCT05114031", "title": "FB101 Intervention in Women Screened to Have Vaginal Dysbiosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Freya Biosciences ApS", "conditions": [ "Vaginal Flora Imbalance" ], "start_date": "2021-10-20", "last_update": "2023-05-03" }, { "nct_id": "NCT05116189", "title": "Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Ovarian Cancer", "Carcinoma, Ovarian Epithelial", "Fallopian Tube Neoplasms" ], "start_date": "2021-12-13", "last_update": "2026-03-09" }, { "nct_id": "NCT05117866", "title": "Acetyl Salicylic Elimination Trial JAPAN: The ASET JAPAN Pilot Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Meditrix Corp", "conditions": [ "Chronic Coronary Syndrome", "Non ST Segment Elevation Acute Coronary Syndrome" ], "start_date": "2020-09-15", "last_update": "2024-08-22" }, { "nct_id": "NCT05121857", "title": "What is the Effect of Vision on Movement Control in Anterior Cruciate Ligament Reconstructed Patients 7 Months Post-surgery?", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "ACL" ], "start_date": "2021-12", "last_update": "2021-12-15" }, { "nct_id": "NCT05123131", "title": "Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Multiple Myeloma" ], "start_date": "2022-04-01", "last_update": "2025-07-08" }, { "nct_id": "NCT05124093", "title": "The Effect of High-flow Nasal Oxygen Flow Rate on Gas Exchange During Apnoea", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Apnea", "Respiration; Arrest", "Anesthesia" ], "start_date": "2021-11-22", "last_update": "2022-07-11" }, { "nct_id": "NCT05126199", "title": "Time-restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Ruairí Floyd", "conditions": [ "PCOS", "Hyperinsulinemia", "Insulin Resistance" ], "start_date": "2021-05-05", "last_update": "2022-09-19" }, { "nct_id": "NCT05129670", "title": "Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Reckitt Benckiser Healthcare (UK) Limited", "conditions": [ "Esophagitis", "Gastro Oesophageal Reflux Disease" ], "start_date": "2022-06-01", "last_update": "2023-06-08" }, { "nct_id": "NCT05130697", "title": "A Multicenter Survey Study Into Patient Experience With Mobile Apps", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Malignant Pleural Effusion" ], "start_date": "2021-07-01", "last_update": "2021-11-23" }, { "nct_id": "NCT05133063", "title": "The Impact of a Gratitude Intervention on Stress Reactivity", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Maynooth", "conditions": [ "Positive Emotions", "Blood Pressure", "Stress, Psychological" ], "start_date": "2021-10-20", "last_update": "2022-04-29" }, { "nct_id": "NCT05138445", "title": "Effectiveness of Fatigue and Activity Management in Work (FAME-W) for Individuals With Inflammatory Arthritis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Inflammatory Arthritis" ], "start_date": "2021-01-28", "last_update": "2021-12-01" }, { "nct_id": "NCT05141812", "title": "What is the Influence of Visual-motor Reliance on Planned and Unplanned Change of Direction Biomechanics 7 Months Post Anterior Cruciate Ligament Reconstruction?", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Sports Surgery Clinic, Santry, Dublin", "conditions": [ "ACL" ], "start_date": "2021-12", "last_update": "2021-12-02" }, { "nct_id": "NCT05146466", "title": "Enhancing Men's Awareness of Testicular Diseases (E-MAT): A Feasibility Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Testicular Diseases" ], "start_date": "2022-03-15", "last_update": "2022-11-30" }, { "nct_id": "NCT05147220", "title": "Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Relapsing Multiple Sclerosis" ], "start_date": "2021-12-16", "last_update": "2026-08-18" }, { "nct_id": "NCT05149755", "title": "Evolut™ EXPAND TAVR II Pivotal Trial", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Medtronic Cardiovascular", "conditions": [ "Moderate Aortic Valve Stenosis" ], "start_date": "2022-04-27", "last_update": "2026-09-30" }, { "nct_id": "NCT05149833", "title": "European Study of Opioid Induced Constipation", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Opioid-Induced Constipation" ], "start_date": "2021-09-16", "last_update": "2025-04-03" }, { "nct_id": "NCT05152147", "title": "A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Jazz Pharmaceuticals", "conditions": [ "Gastric Neoplasms", "Gastroesophageal Adenocarcinoma", "Esophageal Adenocarcinoma" ], "start_date": "2021-12-02", "last_update": "2026-09-24" }, { "nct_id": "NCT05156424", "title": "A Comparison of Aerobic and Resistance Exercise to Counteract Treatment Side Effects in Men With Prostate Cancer", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "Kira Murphy", "conditions": [ "Exercise", "Prostate Cancer" ], "start_date": "2021-09-09", "last_update": "2021-12-14" }, { "nct_id": "NCT05157815", "title": "Study to Investigate the Effect of Dietary Fibre Supplementation on Long-term Glucose Control in Prediabetic Subjects", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Tate & Lyle", "conditions": [ "Dietary Habits" ], "start_date": "2021-10-04", "last_update": "2021-12-15" }, { "nct_id": "NCT05159375", "title": "Effects of Protein Hydrolysate Supplementation Influencing Strength Recovery and Expression of Muscle Damage Markers Post-exercise", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Nuritas Ltd", "conditions": [ "Muscle Injury" ], "start_date": "2021-08-06", "last_update": "2023-11-21" }, { "nct_id": "NCT05159921", "title": "Can the SurgInfoBot Improve the Consent Process for Endoscopy? A Randomised Controlled Trial", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Tallaght University Hospital", "conditions": [ "Gastro-Intestinal Disorder" ], "start_date": "2021-11-29", "last_update": "2021-12-16" }, { "nct_id": "NCT05165589", "title": "Validation of Active-Insights Device to Measure Crying Time", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "BioGaia AB", "conditions": [ "Infant Behavior" ], "start_date": "2021-10-15", "last_update": "2021-12-21" }, { "nct_id": "NCT05169645", "title": "STOP CSUA: phySical acTivity, mOod and sleeP in Chronic Spontaneous Urticaria and Angioedema", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Chronic Spontaneous Urticaria" ], "start_date": "2022-02-01", "last_update": "2021-12-27" }, { "nct_id": "NCT05170100", "title": "Evaluating a Digital Intervention for Overactive Bladder", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Overactive Bladder" ], "start_date": "2021-09-01", "last_update": "2021-12-27" }, { "nct_id": "NCT05171049", "title": "A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Anthos Therapeutics, Inc.", "conditions": [ "Venous Thromboembolism", "Deep Venous Thrombosis", "Pulmonary Embolism" ], "start_date": "2022-05-05", "last_update": "2026-02-23" }, { "nct_id": "NCT05171075", "title": "A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Anthos Therapeutics, Inc.", "conditions": [ "Venous Thromboembolism", "Deep Venous Thrombosis", "Pulmonary Embolism" ], "start_date": "2022-09-27", "last_update": "2026-04-17" }, { "nct_id": "NCT05173168", "title": "A Pilot Study to Assess the Safety Profile of resB®", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "ResBiotic Nutrition, Inc.", "conditions": [ "Healthy", "Asthma" ], "start_date": "2021-11-23", "last_update": "2022-04-29" }, { "nct_id": "NCT05173987", "title": "Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Endometrial Neoplasms" ], "start_date": "2022-02-03", "last_update": "2026-05-05" }, { "nct_id": "NCT05174754", "title": "Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Inflammatory Bowel Diseases" ], "start_date": "2022-08-30", "last_update": "2022-11-01" }, { "nct_id": "NCT05178810", "title": "Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Ferrer Internacional S.A.", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2021-10-18", "last_update": "2025-03-18" }, { "nct_id": "NCT05181371", "title": "ESP Block in VATS: Programmed Intermittent Bolus Versus Continuous Infusion on Quality of Recovery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Pain, Acute", "Surgery" ], "start_date": "2022-06-02", "last_update": "2023-09-21" }, { "nct_id": "NCT05186740", "title": "ProVee Urethral Expander System IDE Study (ProVIDE)", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ProVerum Medical", "conditions": [ "BPH With Symptomatic Lower Urinary Tract Symptoms" ], "start_date": "2022-06-09", "last_update": "2026-07-28" }, { "nct_id": "NCT05186753", "title": "(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cogent Biosciences, Inc.", "conditions": [ "SSM", "Mastocytosis, Indolent", "Mastocytosis, Systemic", "Mastocytosis", "ISM", "BMM", "Smoldering Systemic Mastocytosis", "Bone Marrow Mastocytosis" ], "start_date": "2022-06-27", "last_update": "2026-05-22" }, { "nct_id": "NCT05193994", "title": "Triumeq in Amyotrophic Lateral Sclerosis", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Macquarie University, Australia", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2022-02-24", "last_update": "2025-07-11" }, { "nct_id": "NCT05198674", "title": "SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases", "Chronic Kidney Diseases", "Diabetes Mellitus" ], "start_date": "2021-10-20", "last_update": "2026-09-14" }, { "nct_id": "NCT05203536", "title": "Respiratory Mechanics Assessment During Assisted Mechanical Ventilation", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Milano Bicocca", "conditions": [ "Acute Hypoxemic Respiratory Failure" ], "start_date": "2021-09-01", "last_update": "2025-05-30" }, { "nct_id": "NCT05205785", "title": "Human Milk Oligosaccharides (HMOs) for Irritable Bowel Syndrome (IBS)", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "dsm-firmenich Switzerland AG", "conditions": [ "Irritable Bowel Syndrome", "IBS - Irritable Bowel Syndrome" ], "start_date": "2023-03-22", "last_update": "2024-08-07" }, { "nct_id": "NCT05224141", "title": "Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Small Cell Lung Carcinoma" ], "start_date": "2022-03-24", "last_update": "2025-07-08" }, { "nct_id": "NCT05227365", "title": "Treatment Evaluation of Neuromodulation for Tinnitus - Stage A3", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Neuromod Devices Ltd.", "conditions": [ "Tinnitus" ], "start_date": "2022-03-21", "last_update": "2022-12-27" }, { "nct_id": "NCT05232916", "title": "Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Greenwich LifeSciences, Inc.", "conditions": [ "Breast Cancer" ], "start_date": "2022-12-16", "last_update": "2026-08-06" }, { "nct_id": "NCT05239416", "title": "Fat Grafting in Reducing Recurrence in Patients With Healed Venous Ulcers A Prospective Randomised Clinical Pilot Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Varicose Ulcer" ], "start_date": "2022-02", "last_update": "2022-02-14" }, { "nct_id": "NCT05239728", "title": "A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Renal Cell" ], "start_date": "2022-03-15", "last_update": "2026-05-15" }, { "nct_id": "NCT05241678", "title": "Evaluation of the 24/7 EEG™ SubQ System in Subjects With Uncontrolled Genetic Generalised Epilepsy Syndrome", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Epilepsy, Generalized" ], "start_date": "2022-02-15", "last_update": "2024-03-07" }, { "nct_id": "NCT05241704", "title": "Endovenous Ablation Combined With Fat Grafting for Venous Ulcers", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Varicose Ulcer" ], "start_date": "2022-02", "last_update": "2022-02-16" }, { "nct_id": "NCT05243797", "title": "Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "European Myeloma Network B.V.", "conditions": [ "Multiple Myeloma" ], "start_date": "2022-09-08", "last_update": "2026-10-07" }, { "nct_id": "NCT05252182", "title": "Comprehensive Geriatric Assessment in the Emergency Department", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty" ], "start_date": "2022-02-01", "last_update": "2023-06-22" }, { "nct_id": "NCT05253547", "title": "Dietary Intervention Study on Food Based Dietary Guidelines for Sustainable and Healthy Lifestyles", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Dietary Habits", "Healthy Diet", "Healthy Nutrition", "Personalized Nutrition" ], "start_date": "2022-03-21", "last_update": "2023-10-04" }, { "nct_id": "NCT05253651", "title": "A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Seagen, a wholly owned subsidiary of Pfizer", "conditions": [ "Colorectal Neoplasms" ], "start_date": "2022-10-24", "last_update": "2026-07-22" }, { "nct_id": "NCT05259293", "title": "Characteristics of Pneumothorax Associated With Transthoracic Percutaneous Lung Biopsy in Standard of Care", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Centre Hospitalier Universitaire de Besancon", "conditions": [ "Pneumothorax Iatrogenic Postprocedural" ], "start_date": "2021-12-09", "last_update": "2024-09-19" }, { "nct_id": "NCT05259891", "title": "eegCap Application in Paediatrics wiTh redUced GCS in REsus", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Status Epilepticus", "Altered Level of Consciousness", "Non-epileptic Seizures", "Epilepsy", "Encephalopathy" ], "start_date": "2021-07-05", "last_update": "2023-05-16" }, { "nct_id": "NCT05259930", "title": "Impact of Dietary Assessment and Intervention on Outcomes in Liver Cirrhosis Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Sarcopenia", "Cirrhosis, Liver" ], "start_date": "2022-03-02", "last_update": "2023-12-13" }, { "nct_id": "NCT05261412", "title": "Varicose Vein Education and Informed coNsent (VVEIN) Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Varicose Veins" ], "start_date": "2022-04-04", "last_update": "2024-04-23" }, { "nct_id": "NCT05263557", "title": "Dissecting the IMpact of 11-OXygenated and Classic Androgens on Skeletal Muscle Insulin Sensitivity (DIMOXIS)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Polycystic Ovary Syndrome", "Insulin Resistance", "Androgen; Hypersecretion", "Endocrine System Diseases" ], "start_date": "2022-08-19", "last_update": "2023-07-25" }, { "nct_id": "NCT05269394", "title": "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Washington University School of Medicine", "conditions": [ "Alzheimers Disease", "Dementia", "Alzheimers Disease, Familial" ], "start_date": "2021-12-22", "last_update": "2026-07-27" }, { "nct_id": "NCT05289804", "title": "Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Mild Cognitive Impairment", "Memory Impairment", "Memory Disorders in Old Age" ], "start_date": "2022-09-01", "last_update": "2026-01-26" }, { "nct_id": "NCT05290883", "title": "Antithrombotic Activities of a Novel Yoghurt Drink: a Postprandial Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2021-05-14", "last_update": "2022-11-07" }, { "nct_id": "NCT05293951", "title": "Mirror Aided Cross Education in Post Stroke Upper Limb Rehabilitation.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stroke" ], "start_date": "2022-11-01", "last_update": "2023-10-02" }, { "nct_id": "NCT05295134", "title": "Effect of Candida Rugosa Lipase on Serum Triglyceride Lowering", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "BIO-CAT, Inc.", "conditions": [ "Hypertriglyceridemia" ], "start_date": "2014-03-13", "last_update": "2022-03-24" }, { "nct_id": "NCT05305820", "title": "Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritoneal Malignancy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin City University", "conditions": [ "Peritoneal Malignancy", "Ovarian Cancer", "Rectum Cancer", "Appendix Cancer", "Colon Cancer" ], "start_date": "2022-09-01", "last_update": "2024-03-21" }, { "nct_id": "NCT05306756", "title": "Fetal Scalp Stimulation Versus Fetal Blood Sampling in Labour", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Intrapartum Fetal Distress" ], "start_date": "2022-05-10", "last_update": "2024-02-20" }, { "nct_id": "NCT05318911", "title": "Antithrombotic Activities of a Novel Yogurt Drink", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Cardiovascular Diseases" ], "start_date": "2022-05-01", "last_update": "2022-11-07" }, { "nct_id": "NCT05321069", "title": "A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2022-10-06", "last_update": "2025-10-20" }, { "nct_id": "NCT05321082", "title": "A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Lung Diseases, Interstitial" ], "start_date": "2022-11-16", "last_update": "2026-01-09" }, { "nct_id": "NCT05322473", "title": "Evaluation of Sonelokimab for the Treatment of Patients With Active Moderate to Severe Hidradenitis Suppurativa", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "MoonLake Immunotherapeutics AG", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2022-04-25", "last_update": "2026-09-09" }, { "nct_id": "NCT05324241", "title": "Laxative Properties of Microencapsulated Lipid (Constipation Study)", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Constipation" ], "start_date": "2022-04-15", "last_update": "2022-05-31" }, { "nct_id": "NCT05327686", "title": "Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "NRG Oncology", "conditions": [ "Metastatic Renal Cell Carcinoma", "Stage III Renal Cell Cancer AJCC v8", "Stage IV Renal Cell Cancer AJCC v8", "Unresectable Renal Cell Carcinoma" ], "start_date": "2023-02-01", "last_update": "2026-09-18" }, { "nct_id": "NCT05327894", "title": "Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Princess Maxima Center for Pediatric Oncology", "conditions": [ "Acute Lymphoblastic Leukemia", "Mixed Phenotype Acute Leukemia" ], "start_date": "2022-12-15", "last_update": "2026-07-10" }, { "nct_id": "NCT05329350", "title": "Follow-up Study to Monitor the Efficacy and Safety of the Occlutech® mVSD Cases", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Occlutech International AB", "conditions": [ "Muscular Ventricular Septal Defect" ], "start_date": "2022-03-03", "last_update": "2026-07-30" }, { "nct_id": "NCT05330325", "title": "A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "SGA, Turner Syndrome, Noonan Syndrome, ISS" ], "start_date": "2022-08-10", "last_update": "2026-06-12" }, { "nct_id": "NCT05340582", "title": "Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Mount Sinai Hospital, Canada", "conditions": [ "Patent Ductus Arteriosus After Premature Birth" ], "start_date": "2022-12-12", "last_update": "2026-09-15" }, { "nct_id": "NCT05347238", "title": "Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Mount Sinai Hospital, Canada", "conditions": [ "Late-Onset Neonatal Sepsis", "Extreme Prematurity", "Neonatal Hypotension" ], "start_date": "2023-02-06", "last_update": "2025-07-08" }, { "nct_id": "NCT05352672", "title": "Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Melanoma" ], "start_date": "2022-07-14", "last_update": "2026-04-22" }, { "nct_id": "NCT05354440", "title": "Post Marketing Clinical Follow Up of the BioProtect Balloon Implant System", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "BioProtect", "conditions": [ "Prostate Cancer" ], "start_date": "2022-01-01", "last_update": "2025-09-19" }, { "nct_id": "NCT05357274", "title": "A System to Classify Treatable Traits in Primary Care", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Respiratory Disease", "Asthma", "Copd" ], "start_date": "2022-05-16", "last_update": "2022-05-02" }, { "nct_id": "NCT05357339", "title": "Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Rachael Cusack", "conditions": [ "Sepsis, Severe", "Sepsis", "Septic Shock" ], "start_date": "2021-09-01", "last_update": "2024-10-26" }, { "nct_id": "NCT05360446", "title": "Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Coronary Artery Disease" ], "start_date": "2022-07-08", "last_update": "2026-10-05" }, { "nct_id": "NCT05367648", "title": "Effects of Protein Hydrolysate Supplement on Systemic Muscle Function Markers Following Resistance Type Exercise in Male Subjects", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Nuritas Ltd", "conditions": [ "Muscle Injury" ], "start_date": "2020-09-24", "last_update": "2022-05-10" }, { "nct_id": "NCT05376020", "title": "Osseodensification and Dental Implant Stability", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Osseointegration", "Osseodensification" ], "start_date": "2022-05-13", "last_update": "2022-05-17" }, { "nct_id": "NCT05377047", "title": "Stereotactic Ablative Radiotherapy for OligoMetastatic Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Vastra Gotaland Region", "conditions": [ "Breast Cancer Stage IV", "Oligometastatic Disease" ], "start_date": "2022-09-19", "last_update": "2026-09-21" }, { "nct_id": "NCT05378152", "title": "Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Postmenopausal Bleeding", "Endometrial Cancer", "Endometrial Hyperplasia" ], "start_date": "2022-09-24", "last_update": "2024-04-23" }, { "nct_id": "NCT05384314", "title": "A Retrospective Study to Evaluate the Predictability of Abnormal Arterial Blood Gas Measurements Through Novel Observations of Continuous Trends in Electronically Measured Respiratory Rate in a Mixed Cohort of Respiratory Compromised Patients", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Respiratory Failure", "COPD", "Pneumonia", "Community-acquired Pneumonia", "COVID-19", "Pulmonary Disease" ], "start_date": "2021-07-12", "last_update": "2022-05-20" }, { "nct_id": "NCT05387096", "title": "OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Multimorbidity", "Polypharmacy" ], "start_date": "2023-01-17", "last_update": "2024-07-10" }, { "nct_id": "NCT05390125", "title": "Effectiveness of a Proficiency-based Progression Communication Training Programme", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Dorothy Breen", "conditions": [ "Adverse Events" ], "start_date": "2020-09-30", "last_update": "2022-05-25" }, { "nct_id": "NCT05394519", "title": "A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Overweight", "Obesity", "Type 2 Diabetes Mellitus" ], "start_date": "2023-02-01", "last_update": "2026-01-28" }, { "nct_id": "NCT05406596", "title": "LiquID Guide Catheter Extension Safety Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Seigla Medical, Inc.", "conditions": [ "Coronary Artery Disease" ], "start_date": "2022-10-13", "last_update": "2024-05-23" }, { "nct_id": "NCT05407324", "title": "Dazucorilant in Patients With Amyotrophic Lateral Sclerosis", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Corcept Therapeutics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2022-11-15", "last_update": "2026-09-24" }, { "nct_id": "NCT05408754", "title": "Pulsed Field Ablation and Pulsed Field CRyoAbLation in PErsistent AtriaL FibrilLation", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Adagio Medical", "conditions": [ "Atrial Fibrillation" ], "start_date": "2022-10-20", "last_update": "2026-04-13" }, { "nct_id": "NCT05409976", "title": "The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "W.L.Gore & Associates", "conditions": [ "Venous Thromboses", "Venous Disease", "Venous Leg Ulcer", "Venous Stasis", "Venous Ulcer", "Venous Stenosis", "Venous Occlusion", "Vein Thrombosis", "Vein Occlusion", "Vein Disease" ], "start_date": "2022-10-25", "last_update": "2026-08-27" }, { "nct_id": "NCT05414539", "title": "OptiCogs: A Multicomponent Intervention to Rehabilitate Cognitive Impairment in People Post-stroke", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Stroke, Cardiovascular", "Cognitive Impairment" ], "start_date": "2022-05-09", "last_update": "2022-11-02" }, { "nct_id": "NCT05420142", "title": "Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Aging", "Undernutrition", "Appetite Loss", "Age-Related Sarcopenia" ], "start_date": "2022-03-14", "last_update": "2022-09-26" }, { "nct_id": "NCT05429268", "title": "Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Large B-Cell Lymphoma", "Diffuse Large B-Cell Lymphoma" ], "start_date": "2022-12-23", "last_update": "2026-05-05" }, { "nct_id": "NCT05442775", "title": "A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Cytokinetics", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2022-08-04", "last_update": "2024-08-13" }, { "nct_id": "NCT05444257", "title": "A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Cystic Fibrosis" ], "start_date": "2022-11-08", "last_update": "2026-10-09" }, { "nct_id": "NCT05445778", "title": "Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ovarian Cancer", "Peritoneal Cancer", "Fallopian Tube Cancer" ], "start_date": "2023-03-15", "last_update": "2026-06-02" }, { "nct_id": "NCT05450692", "title": "A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Advanced or Metastatic Non-Small Cell Lung Cancer" ], "start_date": "2022-09-15", "last_update": "2026-07-13" }, { "nct_id": "NCT05458297", "title": "A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Chronic Lymphocytic Leukemia", "Mantle Cell Lymphoma", "Follicular Lymphoma", "Richter Transformation Lymphoma" ], "start_date": "2022-07-21", "last_update": "2026-08-21" }, { "nct_id": "NCT05458401", "title": "EUropean Real-world Experience Of Previously Treated Advanced/Metastatic HER2-positive Breast Cancer Patients Accessing Trastuzumab Deruxtecan", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "HER2-positive Breast Cancer" ], "start_date": "2022-11-11", "last_update": "2024-03-15" }, { "nct_id": "NCT05458882", "title": "Impact of an Educational Tool on Quality of Life and Anxiety in Parents of Children With Nut Allergy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Health Ireland", "conditions": [ "Child Allergy", "Food Allergy" ], "start_date": "2021-05-25", "last_update": "2024-01-05" }, { "nct_id": "NCT05460884", "title": "Effects of Seaweed Extract on Postprandial Response to White Bread", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Glycemic Control", "Diabetes Mellitus Risk", "Glucose Intolerance", "Postprandial Hyperglycemia", "Healthy Subjects" ], "start_date": "2020-09-12", "last_update": "2023-02-21" }, { "nct_id": "NCT05461560", "title": "Effects of Seaweed Extract on Blood Glucose Response to Sucrose", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Glucose Intolerance", "Diabetes Mellitus, Type 2", "Healthy Diet", "Postprandial Hyperglycemia" ], "start_date": "2021-12-05", "last_update": "2022-07-19" }, { "nct_id": "NCT05462067", "title": "Combined EDOF / Trifocal", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Carl Zeiss Meditec AG", "conditions": [ "Cataract" ], "start_date": "2019-03-14", "last_update": "2022-07-18" }, { "nct_id": "NCT05463835", "title": "RubusElite Efficacy Testing of a Novel High Protein, Berry Polyphenol Enriched Dairy Beverage", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Muscle Damage", "Muscle Soreness", "Exercise Performance", "Gut Microbiome", "Stress", "Anxiety" ], "start_date": "2022-08-01", "last_update": "2023-07-11" }, { "nct_id": "NCT05481736", "title": "Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "COMPASS Pathways", "conditions": [ "Anorexia Nervosa" ], "start_date": "2022-10-12", "last_update": "2024-12-04" }, { "nct_id": "NCT05492344", "title": "Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "conditions": [ "ARDS, Human", "Lung Ultrasound", "Mechanical Ventilation" ], "start_date": "2022-08-09", "last_update": "2026-05-27" }, { "nct_id": "NCT05494606", "title": "An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis" ], "start_date": "2022-08-15", "last_update": "2025-02-28" }, { "nct_id": "NCT05495360", "title": "Effect of Omega 3 Enriched Oral Nutritional Supplement on Nutritional Status of CRC and NSCLC Patients", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Nutricia Research", "conditions": [ "Malnutrition", "Oncology" ], "start_date": "2023-01-17", "last_update": "2025-02-19" }, { "nct_id": "NCT05501873", "title": "Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Atrial Fibrillation" ], "start_date": "2023-03-24", "last_update": "2026-08-19" }, { "nct_id": "NCT05507216", "title": "ABTECT-2 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -2", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Abivax S.A.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2023-01-25", "last_update": "2026-09-10" }, { "nct_id": "NCT05512234", "title": "Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying Time in Infants With Colic", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "BioGaia AB", "conditions": [ "Colic, Infantile" ], "start_date": "2022-07-13", "last_update": "2025-09-22" }, { "nct_id": "NCT05512364", "title": "Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "ER-positive Breast Cancer", "HER2-negative Breast Cancer", "Stage IIB Breast Cancer", "Stage III Breast Cancer" ], "start_date": "2023-12-15", "last_update": "2026-10-07" }, { "nct_id": "NCT05514054", "title": "A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Breast Neoplasms" ], "start_date": "2022-10-04", "last_update": "2026-04-02" }, { "nct_id": "NCT05514756", "title": "VINCI-AD: An Investigation of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Tallaght University Hospital", "conditions": [ "Mild Cognitive Impairment", "Neurocardiogenic Syncope", "Memory Impairment", "Inflammatory Response", "Alzheimer Disease" ], "start_date": "2022-06-01", "last_update": "2024-06-14" }, { "nct_id": "NCT05516563", "title": "LEAP-Ireland Feasibility Trial of Exercise and Education for Gluteal Tendinopathy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Gluteal Tendinopathy", "Trochanteric Bursitis", "Greater Trochanteric Pain Syndrome" ], "start_date": "2023-03-27", "last_update": "2026-01-20" }, { "nct_id": "NCT05518110", "title": "PaTcH Study: A Phase 2 Study of Trametinib and Hydroxychloroquine in Patients With Metastatic Refractory Pancreatic Cancer", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pancreatic Cancer" ], "start_date": "2023-05-31", "last_update": "2026-04-13" }, { "nct_id": "NCT05518591", "title": "COMpassion FOcused Therapy and Breathing Pattern REtraining After Cancer Recurrence", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Psychological Distress", "Cancer Recurrence" ], "start_date": "2022-03-25", "last_update": "2022-08-26" }, { "nct_id": "NCT05519085", "title": "A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Celgene", "conditions": [ "Relapsed or Refractory Multiple Myeloma" ], "start_date": "2022-09-20", "last_update": "2026-09-30" }, { "nct_id": "NCT05523167", "title": "A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "argenx", "conditions": [ "Active Idiopathic Inflammatory Myopathy", "Myositis", "Dermatomyositis", "Polymyositis", "Immune-Mediated Necrotizing Myopathy", "Antisynthetase Syndrome" ], "start_date": "2022-10-12", "last_update": "2026-09-21" }, { "nct_id": "NCT05524883", "title": "Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Dyne Therapeutics", "conditions": [ "Duchenne Muscular Dystrophy (DMD)" ], "start_date": "2022-08-12", "last_update": "2026-08-11" }, { "nct_id": "NCT05527184", "title": "First in Human Study of IMGN151 in Recurrent Gynaecological Cancers", "phases": [ "PHASE1" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Endometrial Cancer", "High Grade Serous Adenocarcinoma of Ovary", "Primary Peritoneal Carcinoma", "Fallopian Tube Cancer", "Cervical Cancer" ], "start_date": "2023-01-11", "last_update": "2026-02-20" }, { "nct_id": "NCT05527223", "title": "Integrated Care with GP Participation for Older Persons in the Ambulatory Care Hub: a Prospective Cohort Study.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty", "Comprehensive Geriatric Assessment" ], "start_date": "2022-02-02", "last_update": "2025-02-10" }, { "nct_id": "NCT05529693", "title": "Efficacy of a Probiotic Strain on Level of Markers of Inflammation in an Elderly Population", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Chr Hansen", "conditions": [ "Inflammation" ], "start_date": "2022-09-29", "last_update": "2023-12-04" }, { "nct_id": "NCT05530330", "title": "Markers of Platelet Activation foR Identification of Late Onset Sepsis in Preterm Infants", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Late-Onset Neonatal Sepsis", "Necrotising Enterocolitis", "Culture Negative Neonatal Sepsis" ], "start_date": "2022-09-02", "last_update": "2025-07-03" }, { "nct_id": "NCT05533502", "title": "Combination Plant-Based Protein and Marine-Based Multi-Mineral Supplement and Bone Remodeling in Young Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Bone Resorption", "Bone and Bones" ], "start_date": "2022-09-01", "last_update": "2023-12-19" }, { "nct_id": "NCT05535946", "title": "ABTECT - Maintenance", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Abivax S.A.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2023-01-16", "last_update": "2026-07-07" }, { "nct_id": "NCT05542485", "title": "PLAsma Genomic Testing in Patients With Advanced Non-Small Cell Lung Cancer: The PLAN Study", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2023-08-06", "last_update": "2023-12-15" }, { "nct_id": "NCT05548855", "title": "Natural History of Danon Disease", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Rocket Pharmaceuticals Inc.", "conditions": [ "Danon Disease" ], "start_date": "2022-09-26", "last_update": "2023-11-21" }, { "nct_id": "NCT05561868", "title": "COVID-19 Antibody Responses in Cystic Fibrosis", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Health Ireland", "conditions": [ "Cystic Fibrosis", "COVID-19" ], "start_date": "2022-08-22", "last_update": "2024-01-17" }, { "nct_id": "NCT05562739", "title": "Pilot Study to Assess the Effect of a Postbiotic Blend on Moderate Self-reported Anxiety", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Archer-Daniels-Midland Company", "conditions": [ "Anxiety" ], "start_date": "2024-01-04", "last_update": "2025-01-22" }, { "nct_id": "NCT05562752", "title": "Pilot Study to Assess the Effect of a Probiotic Blend on Moderate Self-reported Anxiety.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Archer-Daniels-Midland Company", "conditions": [ "Anxiety" ], "start_date": "2022-12-20", "last_update": "2025-01-22" }, { "nct_id": "NCT05564754", "title": "Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Region Skane", "conditions": [ "Cardiac Arrest With Successful Resuscitation", "Hypoxia, Brain" ], "start_date": "2023-08-17", "last_update": "2026-06-02" }, { "nct_id": "NCT05566795", "title": "DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Day One Biopharmaceuticals, Inc.", "conditions": [ "Low-grade Glioma", "Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma", "Pediatric Low-grade Glioma" ], "start_date": "2023-02-27", "last_update": "2026-05-14" }, { "nct_id": "NCT05576649", "title": "Dynamic Difficulty Adjustment in a P300 Speller Task for Attention Training", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Maynooth", "conditions": [ "Attention" ], "start_date": "2022-10-03", "last_update": "2023-03-22" }, { "nct_id": "NCT05577065", "title": "A Study to Assess the Effect of a Probiotic on Upper Respiratory Tract Infections in Healthy Children", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Archer-Daniels-Midland Company", "conditions": [ "Upper Respiratory Tract Infections", "Upper Resp Tract Infection" ], "start_date": "2023-01-30", "last_update": "2025-04-09" }, { "nct_id": "NCT05581966", "title": "Wound Assessment Using Spectral Imaging EU/UK", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "SpectralMD", "conditions": [ "Diabetes", "Diabetic Foot", "Diabetic Foot Ulcer" ], "start_date": "2023-03-15", "last_update": "2024-11-08" }, { "nct_id": "NCT05582993", "title": "A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Von Willebrand Disease (VWD)" ], "start_date": "2024-11-06", "last_update": "2026-09-09" }, { "nct_id": "NCT05587296", "title": "A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bayer", "conditions": [ "Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer", "Hot Flashes" ], "start_date": "2022-10-14", "last_update": "2026-07-09" }, { "nct_id": "NCT05598320", "title": "A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Children With Achondroplasia", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Ascendis Pharma Growth Disorders A/S", "conditions": [ "Achondroplasia" ], "start_date": "2023-03-03", "last_update": "2026-07-14" }, { "nct_id": "NCT05598619", "title": "Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "dsm-firmenich Switzerland AG", "conditions": [ "Quality of Life" ], "start_date": "2022-07-01", "last_update": "2024-08-22" }, { "nct_id": "NCT05606770", "title": "The Adaptive Physical Activity Study for Stroke", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Limerick", "conditions": [ "Stroke" ], "start_date": "2023-09-01", "last_update": "2024-05-29" }, { "nct_id": "NCT05608291", "title": "A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Melanoma" ], "start_date": "2023-01-16", "last_update": "2026-07-06" }, { "nct_id": "NCT05608707", "title": "APPETITE: Plant Protein and Exercise Solutions for the Prevention of Undernutrition in Older Adults.", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Appetite Loss", "Physical Inactivity", "Undernutrition", "Anorexia of Aging", "Aging", "Ageing Well" ], "start_date": "2022-09-22", "last_update": "2024-12-09" }, { "nct_id": "NCT05609396", "title": "Interventions to Improve Bowel Cancer Screening Uptake in Ireland: a 2x2 Factorial Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dublin City University", "conditions": [ "Colorectal Cancer" ], "start_date": "2022-05-03", "last_update": "2022-11-14" }, { "nct_id": "NCT05610241", "title": "Preliminary Investigation of a Smart Compression Therapy Prototype", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "DeRoyal Industries, Inc.", "conditions": [ "Venous Leg Ulcer", "Venous Insufficiency of Leg" ], "start_date": "2023-03-04", "last_update": "2023-09-07" }, { "nct_id": "NCT05611931", "title": "Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Karyopharm Therapeutics Inc", "conditions": [ "Endometrial Cancer" ], "start_date": "2023-04-18", "last_update": "2026-09-30" }, { "nct_id": "NCT05613023", "title": "A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Institute of Cancer Research, United Kingdom", "conditions": [ "Prostate Cancer" ], "start_date": "2022-09-09", "last_update": "2024-09-19" }, { "nct_id": "NCT05614063", "title": "A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Xenon Pharmaceuticals Inc.", "conditions": [ "Focal Onset Seizures" ], "start_date": "2022-11-18", "last_update": "2026-05-14" }, { "nct_id": "NCT05615272", "title": "Treatment of Alveolar Osteitis: Traditional or Regenerative?", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Alveolar Osteitis", "Dry Socket", "Pain", "Healing", "Tooth Extraction" ], "start_date": "2022-10-01", "last_update": "2022-11-14" }, { "nct_id": "NCT05615285", "title": "Personalised Exercise Rehabilitation for Cancer Survivorship", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer" ], "start_date": "2022-12-12", "last_update": "2023-12-04" }, { "nct_id": "NCT05617534", "title": "Impact of Exercise Training on Single Ventricle Function in Paediatric Fontan Patients", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Children's Health Ireland", "conditions": [ "Univentricular Heart" ], "start_date": "2023-01-10", "last_update": "2022-12-21" }, { "nct_id": "NCT05617677", "title": "A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Systemic Lupus Erythematosus" ], "start_date": "2023-01-12", "last_update": "2025-12-03" }, { "nct_id": "NCT05619783", "title": "Extension Study Evaluating The Safety And Tolerability of AMX0035", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Amylyx Pharmaceuticals Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2022-12-29", "last_update": "2025-01-13" }, { "nct_id": "NCT05633459", "title": "A Study Evaluating the Safety and Tolerability of QRL-201 in ALS", "phases": [ "PHASE1" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "QurAlis Corporation", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2022-12-16", "last_update": "2026-05-15" }, { "nct_id": "NCT05633654", "title": "Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Gilead Sciences", "conditions": [ "Triple Negative Breast Cancer" ], "start_date": "2022-12-12", "last_update": "2026-09-09" }, { "nct_id": "NCT05636176", "title": "A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Heart Failure" ], "start_date": "2023-05-08", "last_update": "2026-10-01" }, { "nct_id": "NCT05638477", "title": "Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Conor Fearon", "conditions": [ "Parkinson's Disease and Parkinsonism", "Progressive Supranuclear Palsy", "Multiple System Atrophy", "Corticobasal Degeneration" ], "start_date": "2022-12-01", "last_update": "2023-03-15" }, { "nct_id": "NCT05642988", "title": "Application of Wearable Technology in High-risk Surgical Patients in the Perioperative Period", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Adult ALL", "Surgery", "Anesthesia", "Postoperative Complications" ], "start_date": "2023-03-01", "last_update": "2023-12-22" }, { "nct_id": "NCT05643495", "title": "A Study to Evaluate Efficacy and Safety of VX-864 in Participants With the PiZZ Genotype", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Alpha-1 Antitrypsin Deficiency" ], "start_date": "2023-02-23", "last_update": "2025-09-08" }, { "nct_id": "NCT05647356", "title": "The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Polycystic Ovary Syndrome", "Androgen Excess", "Metabolic Disease" ], "start_date": "2023-01-01", "last_update": "2022-12-12" }, { "nct_id": "NCT05648955", "title": "Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment", "phases": [ "EARLY_PHASE1" ], "overall_status": "UNKNOWN", "lead_sponsor": "Nutricia Research", "conditions": [ "Colorectal Cancer (CRC)", "Non-small Cell Lung Cancer (NSCLC)" ], "start_date": "2023-03-31", "last_update": "2023-07-28" }, { "nct_id": "NCT05650957", "title": "PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "conditions": [ "Acute Respiratory Distress Syndrome", "COVID-19", "Pneumonia", "Mechanical Ventilation Complication" ], "start_date": "2022-08-01", "last_update": "2024-07-03" }, { "nct_id": "NCT05658497", "title": "Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Biogen", "conditions": [ "Multiple Sclerosis" ], "start_date": "2023-10-27", "last_update": "2026-08-11" }, { "nct_id": "NCT05658640", "title": "HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Princess Maxima Center for Pediatric Oncology", "conditions": [ "Acute Lymphoblastic Leukemia, in Relapse", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory" ], "start_date": "2023-11-14", "last_update": "2025-09-16" }, { "nct_id": "NCT05663008", "title": "Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "ALS (Amyotrophic Lateral Sclerosis)", "Postpoliomyelitis Syndrome", "Spinal Muscular Atrophy" ], "start_date": "2015-10-01", "last_update": "2022-12-23" }, { "nct_id": "NCT05665595", "title": "A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Melanoma" ], "start_date": "2023-01-19", "last_update": "2026-09-10" }, { "nct_id": "NCT05668377", "title": "Automated Diagnostic Performance of Smartwatch ECG for Arrhythmia Detection Using the PulseAI Neural Network.", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "PulseAI Ltd", "conditions": [ "Arrhythmias, Cardiac" ], "start_date": "2023-01-01", "last_update": "2022-12-29" }, { "nct_id": "NCT05669755", "title": "REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Cardiovascular Disease" ], "start_date": "2023-03-01", "last_update": "2026-08-31" }, { "nct_id": "NCT05669950", "title": "A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "H. Lundbeck A/S", "conditions": [ "Congenital Adrenal Hyperplasia" ], "start_date": "2022-12-19", "last_update": "2026-03-09" }, { "nct_id": "NCT05673187", "title": "Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "NSCLC Stage IV", "KRAS P.G12C" ], "start_date": "2023-06-12", "last_update": "2026-09-03" }, { "nct_id": "NCT05677971", "title": "Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Alpha1-Antitrypsin Deficiency" ], "start_date": "2023-03-06", "last_update": "2026-05-13" }, { "nct_id": "NCT05679401", "title": "A Study With Imlifidase in Anti-GBM Disease", "phases": [ "PHASE3" ], "overall_status": "TERMINATED", "lead_sponsor": "Hansa Biopharma AB", "conditions": [ "Anti-Glomerular Basement Membrane Disease", "Anti-Glomerular Basement Membrane Antibody Disease", "Goodpasture Syndrome", "Good Pasture Syndrome" ], "start_date": "2022-12-22", "last_update": "2026-03-04" }, { "nct_id": "NCT05685238", "title": "A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Haemophilia A", "Haemophilia A With Inhibitors" ], "start_date": "2023-02-13", "last_update": "2026-09-09" }, { "nct_id": "NCT05686252", "title": "RCT: The Effect of Held Position During Kangaroo Care on Physiological Parameters of Premature Infants", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Extreme Prematurity", "Extremely Low Birth Weight", "Very Low Birth Weight Infant", "Premature Birth" ], "start_date": "2022-05-16", "last_update": "2023-01-19" }, { "nct_id": "NCT05688956", "title": "Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Sarcopenia" ], "start_date": "2023-02-01", "last_update": "2026-03-17" }, { "nct_id": "NCT05690724", "title": "Exploratory Trial in Healthy Adults With Mild Cognitive Impairment,16-week Intervention With Mitocholine™", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Mitocholine Ltd", "conditions": [ "Mild Cognitive Impairment" ], "start_date": "2023-01-09", "last_update": "2026-08-18" }, { "nct_id": "NCT05698316", "title": "A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Association for Innovation and Biomedical Research on Light and Image", "conditions": [ "Age Related Macular Degeneration", "Intermediate AMD", "Atrophy", "Prediction" ], "start_date": "2023-05-04", "last_update": "2026-05-08" }, { "nct_id": "NCT05700305", "title": "Physical Rehabilitation Intervention With Protein Supplementation for People With Problematic Substance Use and Homelessness", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Social Isolation", "Chronic Disease", "Physical Disability", "Addiction" ], "start_date": "2022-10-10", "last_update": "2023-05-12" }, { "nct_id": "NCT05705973", "title": "Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Terumo Europe N.V.", "conditions": [ "Cardiovascular Disease", "Coronary Artery Occlusion", "Ischemic Heart Disease" ], "start_date": "2023-04-25", "last_update": "2026-07-10" }, { "nct_id": "NCT05710666", "title": "Neoadjuvant Trastuzumab Deruxtecan (T-DXd) With Response-directed Definitive Therapy in Early Stage HER2-positive Breast Cancer (SHAMROCK Study)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "HER2-positive Breast Cancer" ], "start_date": "2023-10-26", "last_update": "2024-08-05" }, { "nct_id": "NCT05711303", "title": "Study to Investigate the Effect of Superba Boost on the Skin", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Atlantia Food Clinical Trials", "conditions": [ "Trans-epidermal Water Loss" ], "start_date": "2019-03-13", "last_update": "2023-02-08" }, { "nct_id": "NCT05711940", "title": "Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "COMPASS Pathways", "conditions": [ "Treatment Resistant Depression" ], "start_date": "2023-02-14", "last_update": "2026-08-10" }, { "nct_id": "NCT05714085", "title": "Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Heart Failure", "Left Ventricular Systolic Dysfunction" ], "start_date": "2023-05-31", "last_update": "2026-08-28" }, { "nct_id": "NCT05714410", "title": "Evaluation of Changes in Bowel Movement Frequency Following the Consumption of PHGG Compared to Placebo", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Société des Produits Nestlé (SPN)", "conditions": [ "Constipation - Functional" ], "start_date": "2023-01-25", "last_update": "2024-09-19" }, { "nct_id": "NCT05718817", "title": "An Open-label Study of XEN1101 in Epilepsy", "phases": [ "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Xenon Pharmaceuticals Inc.", "conditions": [ "Focal Epilepsy", "Tonic-Clonic Seizures" ], "start_date": "2023-04-25", "last_update": "2026-10-08" }, { "nct_id": "NCT05722938", "title": "Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Biotest", "conditions": [ "Community-acquired Pneumonia" ], "start_date": "2023-09-09", "last_update": "2026-09-14" }, { "nct_id": "NCT05724602", "title": "Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma", "phases": [ "PHASE2" ], "overall_status": "TERMINATED", "lead_sponsor": "European Organisation for Research and Treatment of Cancer - EORTC", "conditions": [ "Locally Advanced Head and Neck Squamous Cell Carcinoma" ], "start_date": "2023-11-15", "last_update": "2026-08-20" }, { "nct_id": "NCT05731362", "title": "An ESD Model of Care for Older Adults Admitted to Hospital: a Protocol for a Descriptive Cohort Study", "phases": [], "overall_status": "WITHDRAWN", "lead_sponsor": "University of Limerick", "conditions": [ "Aging", "Hospitalization", "Function" ], "start_date": "2023-01", "last_update": "2023-11-13" }, { "nct_id": "NCT05733247", "title": "The Effect of 6 Week Adductor Exercise Programs on Adductor Muscle Function and Performance", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin City University", "conditions": [ "Adductor Strain" ], "start_date": "2023-02-15", "last_update": "2023-02-17" }, { "nct_id": "NCT05733273", "title": "The Effect of 6 Week Hamstring Exercise Programs on Hamstring Muscle Function Performance in Female Athletes", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dublin City University", "conditions": [ "Hamstring Injury" ], "start_date": "2023-02-15", "last_update": "2025-05-22" }, { "nct_id": "NCT05735288", "title": "Haemodialysis Outcomes & Patient Empowerment Study 03", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Volume Overload", "Dialysis" ], "start_date": "2023-02-14", "last_update": "2023-05-19" }, { "nct_id": "NCT05739422", "title": "Online Neuropilates Classes in Chronic Stroke Patients: A Pilot Randomised Feasibility Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Institute of Technology, Sligo", "conditions": [ "Stroke" ], "start_date": "2022-11-16", "last_update": "2023-09-29" }, { "nct_id": "NCT05740566", "title": "Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Amgen", "conditions": [ "Small Cell Lung Cancer (SCLC)" ], "start_date": "2023-05-31", "last_update": "2026-01-05" }, { "nct_id": "NCT05741476", "title": "Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Children 4-7 Years of Age", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DBV Technologies", "conditions": [ "Allergy, Peanut" ], "start_date": "2023-02-21", "last_update": "2026-01-22" }, { "nct_id": "NCT05741710", "title": "A Study to Assess the Use of Methylone in the Treatment of PTSD", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Transcend Therapeutics", "conditions": [ "Post Traumatic Stress Disorder" ], "start_date": "2023-03-01", "last_update": "2026-04-15" }, { "nct_id": "NCT05745714", "title": "HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Princess Maxima Center for Pediatric Oncology", "conditions": [ "Acute Lymphoblastic Leukemia, in Relapse", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory" ], "start_date": "2025-10-01", "last_update": "2025-09-16" }, { "nct_id": "NCT05749731", "title": "Pan-European Study on Geriatric Rehabilitation After COVID-19 Disease", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Leiden University Medical Center", "conditions": [ "COVID-19" ], "start_date": "2020-10-01", "last_update": "2023-03-01" }, { "nct_id": "NCT05751044", "title": "HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Princess Maxima Center for Pediatric Oncology", "conditions": [ "Acute Lymphoblastic Leukemia", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent", "Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory", "Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory" ], "start_date": "2025-10-01", "last_update": "2025-09-16" }, { "nct_id": "NCT05753852", "title": "Open Label Extension of TUDCA-ALS Study", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Humanitas Mirasole SpA", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2021-10-25", "last_update": "2023-03-03" }, { "nct_id": "NCT05757427", "title": "Pilot Clinical Evaluation of a Microwave Imaging System for Breast Cancer Detection", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "MVG Industries SAS", "conditions": [ "Breast Cancer" ], "start_date": "2023-03-09", "last_update": "2025-11-26" }, { "nct_id": "NCT05759299", "title": "International obServational sTudy on AiRway manaGement in operAting Room and Non-operaTing Room anaEsthesia", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Turin, Italy", "conditions": [ "Airway Complication of Anesthesia" ], "start_date": "2024-01-15", "last_update": "2025-01-20" }, { "nct_id": "NCT05767034", "title": "Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Polymyalgia Rheumatica" ], "start_date": "2023-03-22", "last_update": "2026-06-22" }, { "nct_id": "NCT05768139", "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Breast Cancer", "Solid Tumors, Adult" ], "start_date": "2023-04-17", "last_update": "2026-07-07" }, { "nct_id": "NCT05773183", "title": "Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Hypogonadism, Male", "Testosterone Deficiency", "Prostate Cancer", "Androgen Deficiency", "Metabolic Disease", "Metabolic Syndrome", "Metabolic Disturbance", "Obesity", "Cardiovascular Diseases", "NAFLD", "Diabetes" ], "start_date": "2023-03-12", "last_update": "2023-03-17" }, { "nct_id": "NCT05783427", "title": "An Evaluation of a Liberal Hydration Regimen Before Elective Caesarean Section Using Beside Gastric Ultrasound", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Coombe Women and Infants University Hospital", "conditions": [ "Aspiration; Gastric Contents, Anesthesia" ], "start_date": "2023-03-13", "last_update": "2023-08-03" }, { "nct_id": "NCT05784428", "title": "Single vs. Multiple Fraction Trial of Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastases/Progression", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Robert Olson", "conditions": [ "Oligometastatic Disease", "Oligoprogression", "Toxicity Due to Radiotherapy", "Quality of Life" ], "start_date": "2025-04-16", "last_update": "2026-09-24" }, { "nct_id": "NCT05793554", "title": "CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Rectum Neoplasm", "Rectum Polyp", "Rectal Cancer" ], "start_date": "2023-03-31", "last_update": "2025-01-17" }, { "nct_id": "NCT05800860", "title": "A Trial of GH001 in Patients With Treatment-resistant Depression", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "GH Research Ireland Limited", "conditions": [ "Treatment-resistant Depression" ], "start_date": "2023-05-24", "last_update": "2025-05-31" }, { "nct_id": "NCT05801549", "title": "Arterio-Venous Fistula Audit. Successful Utilisation Rates of Arterio-Venous Fistulae for Haemodialysis at University Hospital Limerick", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Arterio-venous Fistula" ], "start_date": "2022-09-13", "last_update": "2023-04-06" }, { "nct_id": "NCT05802706", "title": "The Biomechanical Study of Diseased Human Carotid, Femoral and Abdominal Aortic Tissue", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Vascular Diseases" ], "start_date": "2016-01-01", "last_update": "2025-04-17" }, { "nct_id": "NCT05803577", "title": "Microbiome Establishment in Preterm Infants", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Prematurity", "Microbial Colonization" ], "start_date": "2021-04-07", "last_update": "2023-04-07" }, { "nct_id": "NCT05803811", "title": "Effect of Colon Delivered Vitamin B2 on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "dsm-firmenich Switzerland AG", "conditions": [ "Quality of Life" ], "start_date": "2022-12-12", "last_update": "2025-01-17" }, { "nct_id": "NCT05804565", "title": "MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Diabetic Foot", "Gangrene; Limb", "Wound Infection", "Wound Healing Delayed", "Wound Complication", "Critical Limb-Threatening Ischaemia", "Amputation" ], "start_date": "2023-01-01", "last_update": "2023-04-07" }, { "nct_id": "NCT05815745", "title": "\"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment\" (PROTECT-HF)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Imperial College London", "conditions": [ "Bradycardia", "Pacing", "Right Ventricular Pacing", "His Bundle Pacing", "Left Bundle Branch Area Pacing" ], "start_date": "2023-06-05", "last_update": "2026-07-22" }, { "nct_id": "NCT05816460", "title": "The Sleepio After Cancer Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Insomnia", "Cancer" ], "start_date": "2023-05-22", "last_update": "2023-05-23" }, { "nct_id": "NCT05817812", "title": "A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia A, Severe" ], "start_date": "2023-07-31", "last_update": "2026-07-02" }, { "nct_id": "NCT05817942", "title": "Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2023-06-12", "last_update": "2025-12-24" }, { "nct_id": "NCT05822583", "title": "Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Minnesota", "conditions": [ "COVID-19" ], "start_date": "2023-07-06", "last_update": "2026-08-31" }, { "nct_id": "NCT05839704", "title": "A Comparison of Two Regional Techniques for Bariatric Sleeve Gastrectomy", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Bariatric Surgery Candidate", "Weight Loss", "Surgery" ], "start_date": "2023-03-02", "last_update": "2023-05-03" }, { "nct_id": "NCT05840978", "title": "Effect of Probiotics on Stress in Young Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Chr Hansen", "conditions": [ "Stress" ], "start_date": "2023-04-05", "last_update": "2023-12-15" }, { "nct_id": "NCT05850078", "title": "FB101 Intervention in Women Screened to Have Vaginal Dysbiosis (Dyscover-3)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Freya Biosciences ApS", "conditions": [ "Vaginal Flora Imbalance" ], "start_date": "2023-05-18", "last_update": "2025-12-10" }, { "nct_id": "NCT05850429", "title": "BioDulse: The Effect of an Irish Seaweed Protein Extract on Glucose Control in Healthy Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Healthy" ], "start_date": "2023-05-09", "last_update": "2024-04-09" }, { "nct_id": "NCT05851638", "title": "The NIOMI Study: Non-Invasive Lung Oxygen Monitoring of Term Infants", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Lung Diseases" ], "start_date": "2021-11-01", "last_update": "2023-05-10" }, { "nct_id": "NCT05853432", "title": "A Descriptive Study of Baseline Characteristics, Clinical Outcomes, and Treatment Patterns of HR+/HER2- Advanced or Metastatic Breast Cancer Patients Treated With Alpelisib Plus Fulvestrant Who Have Received Fulvestrant in Any Prior Line of Therapy", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "HR+/HER2- Advanced or Metastatic Breast Cancer" ], "start_date": "2022-03-16", "last_update": "2023-05-10" }, { "nct_id": "NCT05856266", "title": "An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog Alfa", "phases": [ "PHASE4" ], "overall_status": "TERMINATED", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia A", "Hemophilia B" ], "start_date": "2023-08-24", "last_update": "2025-01-16" }, { "nct_id": "NCT05866757", "title": "Discontinuation Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Multiple Myeloma", "Cancer", "Hematologic Cancer" ], "start_date": "2023-08-28", "last_update": "2026-03-04" }, { "nct_id": "NCT05871060", "title": "Effect of a Novel Protein Supplement on Appetite in Older Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Aging", "Appetite Loss" ], "start_date": "2023-04-25", "last_update": "2023-11-27" }, { "nct_id": "NCT05871996", "title": "Palliative Care and Oncology Survey on Terminology", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Cancer" ], "start_date": "2023-10-03", "last_update": "2025-06-27" }, { "nct_id": "NCT05876754", "title": "An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Servier Affaires Médicales", "conditions": [ "Cholangiocarcinoma" ], "start_date": "2023-05-03", "last_update": "2026-07-31" }, { "nct_id": "NCT05883748", "title": "HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Disc Medicine, Inc", "conditions": [ "Erythropoietic Protoporphyria" ], "start_date": "2023-08-31", "last_update": "2026-10-09" }, { "nct_id": "NCT05889182", "title": "A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2023-06-21", "last_update": "2026-08-20" }, { "nct_id": "NCT05895799", "title": "Whole-task Hybrid Simulation Improves Medical Student Competence in Cardiology Clerkship", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Valvular Heart Disease" ], "start_date": "2021-01-01", "last_update": "2023-06-09" }, { "nct_id": "NCT05896566", "title": "A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Breast Cancer" ], "start_date": "2024-01-23", "last_update": "2026-02-24" }, { "nct_id": "NCT05897424", "title": "Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Sanofi", "conditions": [ "Alpha 1-Antitrypsin Deficiency", "Emphysema" ], "start_date": "2024-06-20", "last_update": "2026-04-13" }, { "nct_id": "NCT05899335", "title": "Feasibility Study of a Mobile Health App for Symptom Monitoring in People With Chronic Pancreatitis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Chronic Pancreatitis" ], "start_date": "2023-11", "last_update": "2023-08-18" }, { "nct_id": "NCT05899608", "title": "Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Summit Therapeutics", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2023-10-26", "last_update": "2026-10-08" }, { "nct_id": "NCT05906043", "title": "A Multidisciplinary Approach to Assessing and Treating Fatigue in Inflammatory Bowel Disease", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Inflammatory Bowel Diseases", "Fatigue" ], "start_date": "2023-06-20", "last_update": "2023-06-22" }, { "nct_id": "NCT05907837", "title": "Early Detection & Intervention of Cerebral Palsy in Ireland", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Cerebral Palsy", "Neurodevelopmental Disorders" ], "start_date": "2023-07-01", "last_update": "2023-10-02" }, { "nct_id": "NCT05911295", "title": "Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Seagen, a wholly owned subsidiary of Pfizer", "conditions": [ "Urothelial Carcinoma" ], "start_date": "2023-09-22", "last_update": "2026-07-22" }, { "nct_id": "NCT05912517", "title": "A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Hemolytic Disease of the Fetus and Newborn" ], "start_date": "2023-12-20", "last_update": "2026-09-25" }, { "nct_id": "NCT05915988", "title": "U011 - Wireless Ultra Long-Term EEG Recordings in Epilepsy", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "UNEEG Medical A/S", "conditions": [ "Epilepsy" ], "start_date": "2023-12-04", "last_update": "2025-11-28" }, { "nct_id": "NCT05921279", "title": "Understanding CARdiac Events in Breast Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Breast Cancer", "Cardiotoxicity", "Cardiomyopathies", "Chemotherapeutic Toxicity", "Heart Failure", "Oncology" ], "start_date": "2023-01-14", "last_update": "2023-07-25" }, { "nct_id": "NCT05924633", "title": "A Study of a Dietary Supplement in Breastfeeding Mothers (WellFed)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Dietary Habits", "Dietary Supplements", "Maternal Health", "Breastfeeding", "Infant Health" ], "start_date": "2023-06-06", "last_update": "2024-09-19" }, { "nct_id": "NCT05927038", "title": "Coffee Consumption, the Gut Microbiome, and the Microbiota-Gut-Brain Axis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2021-09-21", "last_update": "2023-07-03" }, { "nct_id": "NCT05927103", "title": "Differences Between Coffee and Non-coffee Drinkers in the Gut Microbiome and Microbiota-Gut-Brain Axis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2021-09-21", "last_update": "2023-07-03" }, { "nct_id": "NCT05929807", "title": "A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Ascendis Pharma Growth Disorders A/S", "conditions": [ "Achondroplasia" ], "start_date": "2023-06-21", "last_update": "2026-08-17" }, { "nct_id": "NCT05930275", "title": "Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2024-02-19", "last_update": "2025-07-17" }, { "nct_id": "NCT05931536", "title": "The Relationship Between Diet, Cognition, Stress, and the Gut Microbiota", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2022-07-14", "last_update": "2024-09-24" }, { "nct_id": "NCT05931562", "title": "The Impact of Diet on the Gut-Microbiota-Brain Axis", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2022-07-14", "last_update": "2024-07-16" }, { "nct_id": "NCT05931835", "title": "Feasibility Study on the VERAFEYE System", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "LUMA Vision Ltd.", "conditions": [ "Atrial Septal Defect", "Atrial Fibrillation", "Atrial Arrhythmia", "Left Atrial Appendage Closure" ], "start_date": "2025-01-09", "last_update": "2026-02-10" }, { "nct_id": "NCT05934487", "title": "PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Endotronix, Inc.", "conditions": [ "Heart Failure NYHA Class II", "Heart Failure NYHA Class III", "Heart Failure" ], "start_date": "2023-11-29", "last_update": "2026-06-29" }, { "nct_id": "NCT05934526", "title": "Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "GB002, Inc.", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2023-12-28", "last_update": "2026-05-19" }, { "nct_id": "NCT05942586", "title": "The Symbiont-Restore Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Obesity" ], "start_date": "2023-05-22", "last_update": "2025-02-10" }, { "nct_id": "NCT05942924", "title": "The NEU-STIM Trial", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Leiden University Medical Center", "conditions": [ "Infant, Premature, Diseases", "Birth, Preterm" ], "start_date": "2024-03-11", "last_update": "2025-03-10" }, { "nct_id": "NCT05946993", "title": "Linking In With Advice and Supports for Men Impacted by Metastatic Cancer", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Survivorship", "Prostate Cancer", "Kidney Cancer", "Urothelial Tract/Bladder Cancer, Nos", "Testicular Cancer", "Penile Cancer" ], "start_date": "2023-05-08", "last_update": "2026-10-01" }, { "nct_id": "NCT05947903", "title": "Validation of the European Oncology Quality of Life Toolkit", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Fondazione IRCCS Istituto Nazionale dei Tumori, Milano", "conditions": [ "Cancer", "Survivorship", "Palliative Care" ], "start_date": "2024-08-31", "last_update": "2024-08-20" }, { "nct_id": "NCT05950945", "title": "Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "Breast Cancer" ], "start_date": "2023-12-30", "last_update": "2026-06-12" }, { "nct_id": "NCT05952557", "title": "An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Breast Cancer, Early Breast Cancer" ], "start_date": "2023-10-05", "last_update": "2026-08-10" }, { "nct_id": "NCT05961943", "title": "RESPONSE-2-PAD to Reduce Sedentary Time in Peripheral Arterial Disease Patients", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National Institute for Prevention and Cardiovascular Health, Ireland", "conditions": [ "Peripheral Arterial Disease", "Sedentary Behavior", "Sedentary Time", "Peripheral Arterial Occlusive Disease" ], "start_date": "2023-09-29", "last_update": "2024-04-09" }, { "nct_id": "NCT05962398", "title": "Long-term Follow-up Study of Male Adults With Hemophilia B Previously Treated With Etranacogene Dezaparvovec (CSL222)", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "CSL Behring", "conditions": [ "Hemophilia B" ], "start_date": "2023-08-30", "last_update": "2025-07-18" }, { "nct_id": "NCT05968378", "title": "Diet, Immunometabolism and Non-alcoholic Fatty Liver Disease", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Non-Alcoholic Fatty Liver Disease", "Liver Fat", "Obesity", "Inflammation" ], "start_date": "2023-06-01", "last_update": "2023-08-01" }, { "nct_id": "NCT05970172", "title": "A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Astellas Pharma Global Development, Inc.", "conditions": [ "Chronic Kidney Disease", "Renal Anemia" ], "start_date": "2024-01-16", "last_update": "2026-09-22" }, { "nct_id": "NCT05973175", "title": "REFUEL PCOS Study 1", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Polycystic Ovary Syndrome" ], "start_date": "2023-08-01", "last_update": "2024-04-17" }, { "nct_id": "NCT05977816", "title": "PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Wound Surgical", "Wound Infection", "Cosmesis" ], "start_date": "2023-07-14", "last_update": "2026-07-21" }, { "nct_id": "NCT05979311", "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ViiV Healthcare", "conditions": [ "HIV", "HIV Infections" ], "start_date": "2024-02-21", "last_update": "2026-07-02" }, { "nct_id": "NCT05979441", "title": "A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy", "phases": [ "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "argenx", "conditions": [ "Myositis", "Active Idiopathic Inflammatory Myopathy", "Dermatomyositis", "Polymyositis", "Immune-Mediated Necrotizing Myopathy", "Antisynthetase Syndrome" ], "start_date": "2023-09-12", "last_update": "2026-09-21" }, { "nct_id": "NCT05986253", "title": "BioDulse II: The Effect of an Irish Seaweed Protein Extract on Glucose Control in Adults With Type 2 Diabetes", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Type 2 Diabetes" ], "start_date": "2023-08-07", "last_update": "2024-04-09" }, { "nct_id": "NCT06001177", "title": "A Study of Efficacy, Safety, and Tolerability of KAN-101 in People With Celiac Disease", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Kanyos Bio, Inc., a wholly-owned subsidiary of Anokion SA", "conditions": [ "Celiac Disease", "Coeliac Disease" ], "start_date": "2023-12-13", "last_update": "2025-12-18" }, { "nct_id": "NCT06003426", "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2023-09-14", "last_update": "2026-03-24" }, { "nct_id": "NCT06007001", "title": "Telerehabilitation and Tele-psychological Support in Cancer Patients eCAN JA", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Sciensano", "conditions": [ "Cancer" ], "start_date": "2023-09-25", "last_update": "2024-04-19" }, { "nct_id": "NCT06014398", "title": "Improving Survivorship and Health-related Quality of Life in Patients With Primary Brain Tumours", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Hypopituitarism", "Radiotherapy-Induced Hypopituitarism", "Brain Tumor" ], "start_date": "2023-09-01", "last_update": "2023-08-28" }, { "nct_id": "NCT06016946", "title": "Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Friedreich's Ataxia Research Alliance", "conditions": [ "Friedreich Ataxia" ], "start_date": "2023-06-28", "last_update": "2026-09-01" }, { "nct_id": "NCT06017219", "title": "Bioavailability of Spermidine in Healthy Males", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Chrysea Labs Lda", "conditions": [ "Healthy Subjects" ], "start_date": "2023-05-05", "last_update": "2024-08-30" }, { "nct_id": "NCT06023654", "title": "Identifying Circadian Rest-Activity Rhythm Disorders in Patients With Advanced Cancer", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer", "Circadian Rhythm Disorders", "Sleep Disturbance", "Activity, Motor", "Accelerometry" ], "start_date": "2023-05-15", "last_update": "2025-04-03" }, { "nct_id": "NCT06024824", "title": "Dose-Painted Intensity Modulated Radiotherapy Pancreas (DP-IMRT Pancreas)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pancreatic Adenocarcinoma" ], "start_date": "2024-01-30", "last_update": "2025-07-20" }, { "nct_id": "NCT06025253", "title": "PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Wound Surgical", "Wound Infection", "Cosmesis" ], "start_date": "2024-03-01", "last_update": "2026-07-21" }, { "nct_id": "NCT06025578", "title": "A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Progressive Pulmonary Fibrosis" ], "start_date": "2023-10-25", "last_update": "2026-04-23" }, { "nct_id": "NCT06026345", "title": "Affera Global Registry", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Medtronic Cardiac Ablation Solutions", "conditions": [ "Atrial Fibrillation" ], "start_date": "2023-12-22", "last_update": "2026-10-09" }, { "nct_id": "NCT06030349", "title": "Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Children's Health Ireland", "conditions": [ "Obstructive Sleep Apnea", "Down Syndrome", "Quality of Life", "Behavior", "Adherence, Treatment" ], "start_date": "2022-11-28", "last_update": "2024-02-12" }, { "nct_id": "NCT06032182", "title": "PSYCHE Cognitive Remediation & Social Recovery Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Early Psychosis" ], "start_date": "2023-03-01", "last_update": "2024-03-22" }, { "nct_id": "NCT06040086", "title": "Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "start_date": "2023-09-22", "last_update": "2026-07-24" }, { "nct_id": "NCT06062277", "title": "COlchicine iN Circulating Inflammatory Markers After StrokE (CONCISE)", "phases": [ "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Ischemic Stroke", "Atherosclerosis" ], "start_date": "2023-10", "last_update": "2023-10-02" }, { "nct_id": "NCT06072781", "title": "A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Verastem, Inc.", "conditions": [ "Low Grade Serous Ovarian Cancer" ], "start_date": "2024-03-18", "last_update": "2026-10-07" }, { "nct_id": "NCT06073132", "title": "An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "TWi Biotechnology, Inc.", "conditions": [ "Generalized Epidermolysis Bullosa Simplex" ], "start_date": "2024-04-04", "last_update": "2026-07-09" }, { "nct_id": "NCT06076993", "title": "Cluster Randomised Control Trial of the BodyKind Body Image Programme", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Body Image" ], "start_date": "2023-06-01", "last_update": "2023-10-11" }, { "nct_id": "NCT06077760", "title": "A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2023-12-06", "last_update": "2026-09-18" }, { "nct_id": "NCT06077864", "title": "A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Obesity" ], "start_date": "2023-11-20", "last_update": "2026-09-30" }, { "nct_id": "NCT06078813", "title": "Spine SABR - Dose-escalated Stereotactic Ablative Body Radiotherapy (SABR) for Solid Tumour Spine Metastases", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Solid Tumor Spine Metastases" ], "start_date": "2023-11-21", "last_update": "2025-04-30" }, { "nct_id": "NCT06079398", "title": "A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Ascendis Pharma A/S", "conditions": [ "Achondroplasia" ], "start_date": "2024-01-23", "last_update": "2026-04-08" }, { "nct_id": "NCT06089993", "title": "Impact of Acute Resistance Exercise on Taste Perception and Appetite Response to Plant Protein in Resistance Trained Adults", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Appetite", "Taste, Altered", "Exercise" ], "start_date": "2022-08-08", "last_update": "2023-10-19" }, { "nct_id": "NCT06090344", "title": "Designing Multimedia Patient Education for Adolescent Idiopathic Scoliosis", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Adolescent Idiopathic Scoliosis", "Patient Engagement" ], "start_date": "2024-01-30", "last_update": "2024-12-05" }, { "nct_id": "NCT06091865", "title": "A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Diffuse Large B-cell Lymphoma (DLBCL)" ], "start_date": "2023-12-13", "last_update": "2026-10-07" }, { "nct_id": "NCT06093178", "title": "Assessing the Feasibility of a Coach-led Digital Platform", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Population", "Life Style, Healthy" ], "start_date": "2024-05-01", "last_update": "2023-10-25" }, { "nct_id": "NCT06093672", "title": "Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Italfarmaco", "conditions": [ "Polycythemia Vera" ], "start_date": "2024-03-26", "last_update": "2026-03-25" }, { "nct_id": "NCT06095648", "title": "Study Comparing Platelet Transfusion Volumes in Premature Babies", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Thrombocytopenia", "Transfusion" ], "start_date": "2023-10-28", "last_update": "2023-10-23" }, { "nct_id": "NCT06097572", "title": "Improved Diagnostics in Food Allergy Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Imperial College London", "conditions": [ "Food Allergy" ], "start_date": "2023-10-18", "last_update": "2024-03-28" }, { "nct_id": "NCT06100289", "title": "A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Ulcerative Colitis", "Crohn's Disease" ], "start_date": "2025-01-22", "last_update": "2026-08-03" }, { "nct_id": "NCT06108869", "title": "Improving Health and Wellbeing for People Diagnosed With Chronic Spontaneous Urticaria (CSU)", "phases": [ "NA" ], "overall_status": "SUSPENDED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Chronic Spontaneous Urticaria" ], "start_date": "2022-06-01", "last_update": "2023-10-31" }, { "nct_id": "NCT06115629", "title": "Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial", "phases": [ "PHASE3" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Esophageal Cancer", "Gastric Cancer" ], "start_date": "2023-11", "last_update": "2023-11-03" }, { "nct_id": "NCT06127680", "title": "Brief Health Promotion Intervention for Older People in Mental Health", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Mental Health Issue", "Frailty" ], "start_date": "2023-03-01", "last_update": "2023-11-13" }, { "nct_id": "NCT06132958", "title": "Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Endometrial Cancer" ], "start_date": "2023-12-06", "last_update": "2026-08-28" }, { "nct_id": "NCT06135766", "title": "Evaluating the Effectiveness of a School-based Intervention to Improve the Wellbeing of Children Aged 10 to 13 Years.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Well-Being, Psychological", "Child, Only" ], "start_date": "2023-08-31", "last_update": "2024-01-18" }, { "nct_id": "NCT06135779", "title": "Evaluation of the Effectiveness of a School-based Intervention to Improve the Wellbeing of Children Aged 8-11 Years.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Well-Being, Psychological", "Child, Only" ], "start_date": "2023-08-31", "last_update": "2024-01-18" }, { "nct_id": "NCT06136624", "title": "Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostate Cancer Metastatic" ], "start_date": "2023-12-31", "last_update": "2026-10-06" }, { "nct_id": "NCT06136650", "title": "A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Metastatic Castration-resistant Prostate Cancer (mCRPC)", "Prostatic Neoplasms" ], "start_date": "2023-12-18", "last_update": "2026-10-06" }, { "nct_id": "NCT06140524", "title": "A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Monoclonal Gammopathy of Undetermined Significance (MGUS)", "Smoldering Multiple Myeloma (SMM)" ], "start_date": "2024-09-16", "last_update": "2026-07-08" }, { "nct_id": "NCT06141733", "title": "2 Year Follow up of COSGOD III", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Medical University of Graz", "conditions": [ "Neurodevelopmental Disability", "Death" ], "start_date": "2024-01-01", "last_update": "2025-03-13" }, { "nct_id": "NCT06147479", "title": "Cognitive Stimulation in Daily Activities for People Living With Early to Middle Stage Dementia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Dementia", "Dementia, Mild", "Dementia Moderate" ], "start_date": "2023-11-03", "last_update": "2024-08-06" }, { "nct_id": "NCT06149546", "title": "Exploring the Impact of a Multi-modal Nutritional Intervention in Patients Undergoing Chemotherapy for Pancreatic Cancer (FEED Trial)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Pancreatic Cancer" ], "start_date": "2024-05-01", "last_update": "2025-07-08" }, { "nct_id": "NCT06157736", "title": "Microbiome in the Acute Stage of New Onset Paediatric Type 1 Diabetes", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Type 1 Diabetes" ], "start_date": "2023-10-06", "last_update": "2024-05-30" }, { "nct_id": "NCT06164912", "title": "Investigating the Use of a Brain-computer Interface Based on TMS Neurofeedback for Upper Limb Stroke Rehabilitation", "phases": [ "PHASE1" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Transcranial Magnetic Stimulation", "Stroke", "Stroke Rehabilitation", "Upper Extremity Paresis" ], "start_date": "2023-06-01", "last_update": "2023-12-11" }, { "nct_id": "NCT06175234", "title": "Feasibility Study on the FARAVIEW Technology", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Atrial Fibrillation", "Paroxysmal Atrial Fibrillation", "Persistent Atrial Fibrillation" ], "start_date": "2024-04-03", "last_update": "2025-09-17" }, { "nct_id": "NCT06183931", "title": "Study of ALXN2220 Versus Placebo in Adults With ATTR-CM", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Transthyretin Amyloid Cardiomyopathy" ], "start_date": "2024-01-11", "last_update": "2026-08-10" }, { "nct_id": "NCT06188663", "title": "SalT Supplementation in Older Adults With Orthostatic Intolerance Disorders", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Galway", "conditions": [ "Orthostatic Hypotension" ], "start_date": "2024-07-09", "last_update": "2026-06-22" }, { "nct_id": "NCT06192628", "title": "Behavioural Change Techniques for Physical Activity and Exercise Adherence Among People With Parkinson's", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Parkinson Disease" ], "start_date": "2023-09-10", "last_update": "2024-01-05" }, { "nct_id": "NCT06200519", "title": "Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Diastolic Dysfunction", "Neonatal Encephalopathy", "Small for Gestational Age at Delivery", "Transient Tachypnea of the Newborn", "Trisomy 21", "Gestational Diabetes" ], "start_date": "2024-02-12", "last_update": "2026-03-04" }, { "nct_id": "NCT06204471", "title": "Acceptability of Hip Protector Airbags in Older People", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Falls Risk" ], "start_date": "2024-01-02", "last_update": "2024-01-12" }, { "nct_id": "NCT06205238", "title": "The Impact of Domiciliary Versus 'Hub' Based Comprehensive Geriatric Assessment on Clinical and Process Outcomes Among Older Adults Attending Community Specialist Teams: a Randomised Controlled Trial.", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty", "Comprehensive Geriatric Assessment", "Older Adults", "Domiciliary Care" ], "start_date": "2024-01-15", "last_update": "2025-08-20" }, { "nct_id": "NCT06211036", "title": "Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Amgen", "conditions": [ "Extensive-Stage Small-Cell Lung Cancer", "Small-Cell Lung Cancer" ], "start_date": "2024-06-05", "last_update": "2025-12-17" }, { "nct_id": "NCT06212050", "title": "Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Aortic Stenosis", "Transcatheter Aortic Valve Implantation", "Bicuspid Aortic Valve", "Transcatheter Aortic Valve Replacement" ], "start_date": "2023-09-15", "last_update": "2024-06-21" }, { "nct_id": "NCT06221540", "title": "The Impact of an Evidence-based Myth-busting Information Intervention on Maternal Food Allergy Related Quality of Life, Anxiety and Self-efficacy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Children's Health Ireland", "conditions": [ "Child Allergy", "Food Allergy" ], "start_date": "2021-05-21", "last_update": "2024-01-24" }, { "nct_id": "NCT06227910", "title": "A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Crohn's Disease" ], "start_date": "2025-01-02", "last_update": "2026-05-27" }, { "nct_id": "NCT06232707", "title": "A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)", "phases": [ "PHASE3" ], "overall_status": "WITHDRAWN", "lead_sponsor": "Celgene", "conditions": [ "Multiple Myeloma" ], "start_date": "2024-05-03", "last_update": "2024-05-31" }, { "nct_id": "NCT06236802", "title": "ProVIDE II Bridging Study", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "ProVerum Medical", "conditions": [ "BPH With Symptomatic Lower Urinary Tract Symptoms" ], "start_date": "2024-03-06", "last_update": "2026-07-09" }, { "nct_id": "NCT06237426", "title": "An Evaluation of the Long-term Efficacy and Safety of Methylone for the Treatment of PTSD", "phases": [ "PHASE2" ], "overall_status": "COMPLETED", "lead_sponsor": "Transcend Therapeutics", "conditions": [ "Post Traumatic Stress Disorder" ], "start_date": "2024-03-06", "last_update": "2025-11-25" }, { "nct_id": "NCT06237452", "title": "VE303 for Prevention of Recurrent Clostridioides Difficile Infection", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Vedanta Biosciences, Inc.", "conditions": [ "Clostridium Difficile", "Clostridium Difficile Infections", "Clostridium Difficile Infection Recurrence", "Clostridioides Difficile Infection", "Clostridioides Difficile Infection Recurrence", "CDI", "C. Diff Infection", "Recurrent Clostridium Difficile Infection", "C.Difficile Diarrhea", "Diarrhea Infectious" ], "start_date": "2024-05-20", "last_update": "2026-09-29" }, { "nct_id": "NCT06237803", "title": "European Myeloma Network (EMN) Sample Project", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "European Myeloma Network B.V.", "conditions": [ "Multiple Myeloma", "Smoldering Multiple Myeloma", "Plasma Cell Leukemia", "Extramedullary Myeloma", "MGUS" ], "start_date": "2022-12-21", "last_update": "2025-12-03" }, { "nct_id": "NCT06238583", "title": "Expanded Access to Provide Copanlisib for Patients With Cancer Who Are Experiencing a Positive Response, as Determined by Their Doctors", "phases": [], "overall_status": "NO_LONGER_AVAILABLE", "lead_sponsor": "Bayer", "conditions": [ "Cancer" ], "start_date": "", "last_update": "2024-02-02" }, { "nct_id": "NCT06238622", "title": "A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Idiopathic Pulmonary Fibrosis", "Progressive Pulmonary Fibrosis" ], "start_date": "2024-05-06", "last_update": "2026-09-30" }, { "nct_id": "NCT06247085", "title": "Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Travere Therapeutics, Inc.", "conditions": [ "Homocystinuria" ], "start_date": "2023-12-28", "last_update": "2026-10-08" }, { "nct_id": "NCT06253221", "title": "A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Cardiomyopathy, Hypertrophic" ], "start_date": "2024-04-17", "last_update": "2025-12-19" }, { "nct_id": "NCT06253871", "title": "A Phase 1/1b Study of IAM1363 in HER2 Cancers", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Iambic Therapeutics, Inc", "conditions": [ "HER2 Mutation-Related Tumors", "HER2", "HER2-positive Breast Cancer", "HER2 + Breast Cancer", "Brain Metastases From Solid Tumors", "Brain Metastases From HER2 and Breast Cancer", "CNS Metastases", "HER2-Positive Solid Tumors", "NSCLC (Non-small Cell Lung Cancer)", "HER2-positive Bladder Cancer", "HER2-positive Colorectal Cancer", "HER2 + Gastric Cancer", "HER2-positive Gastroesophageal Cancer" ], "start_date": "2024-03-25", "last_update": "2026-09-09" }, { "nct_id": "NCT06256653", "title": "Assess the Effect of a Whole Fruit Powder on Gut Microbiome Function on Overweight & Obese Adults", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Obesity", "Overweight and Obesity" ], "start_date": "2024-01-29", "last_update": "2024-07-16" }, { "nct_id": "NCT06257875", "title": "A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis" ], "start_date": "2024-03-23", "last_update": "2025-10-07" }, { "nct_id": "NCT06260995", "title": "The Role of Intermediaries in Connecting Individuals to Local Physical Activity - Study Protocol", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Physical Inactivity" ], "start_date": "2023-09-01", "last_update": "2026-05-12" }, { "nct_id": "NCT06263946", "title": "Essilor® Stellest® Lenses Multicentre European Study (SLOMES)", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Essilor International", "conditions": [ "Myopia" ], "start_date": "2024-03-22", "last_update": "2026-08-21" }, { "nct_id": "NCT06264895", "title": "Protocol for a Low Threshold Exercise Intervention for Women Experiencing Homelessness and Addiction.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Social Exclusion", "Chronic Disease", "Physical Disability", "Addiction" ], "start_date": "2024-02-26", "last_update": "2024-05-10" }, { "nct_id": "NCT06274541", "title": "Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Serous Ovarian Tumor", "Endometrioid Carcinoma Ovary", "Fallopian Tube Cancer", "Primary Peritoneal Carcinoma" ], "start_date": "2019-03-22", "last_update": "2026-04-13" }, { "nct_id": "NCT06274801", "title": "Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Gossamer Bio USA, Inc.", "conditions": [ "Pulmonary Arterial Hypertension" ], "start_date": "2024-09-03", "last_update": "2026-07-29" }, { "nct_id": "NCT06274905", "title": "Topical Anaesthesia in Cutaneous Head and Neck Surgery", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital Waterford", "conditions": [ "Pain, Acute", "Head and Neck Cancer", "Cutaneous Tumor" ], "start_date": "2023-02-20", "last_update": "2024-02-23" }, { "nct_id": "NCT06275204", "title": "H. Pylori Screen-and-treat Study in a Population of Young Adults", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Latvia", "conditions": [ "Gastric Cancer", "H Pylori Infection", "H Pylori Eradication", "H-pylori" ], "start_date": "2024-03-04", "last_update": "2024-03-05" }, { "nct_id": "NCT06280885", "title": "A Flexible Individualized ExeRcise Programme for Cancer Patients During ChEmotherapy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer" ], "start_date": "2025-01-01", "last_update": "2026-04-30" }, { "nct_id": "NCT06284317", "title": "A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Non Small Cell Lung Cancer" ], "start_date": "2025-01-15", "last_update": "2026-05-14" }, { "nct_id": "NCT06285318", "title": "A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Janssen-Cilag Ltd.", "conditions": [ "Relapsed/Refractory Multiple Myeloma (RRMM)" ], "start_date": "2023-12-18", "last_update": "2026-08-28" }, { "nct_id": "NCT06286982", "title": "The Oral Symptom Assessment Scale in Older Patients With Frailty", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Frailty", "Older Adults" ], "start_date": "2023-06-06", "last_update": "2025-08-11" }, { "nct_id": "NCT06287294", "title": "An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Taste, Altered", "Xerostomia", "Neoplasms" ], "start_date": "2023-08-30", "last_update": "2024-09-19" }, { "nct_id": "NCT06297005", "title": "The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Vaping", "Pregnancy Related", "Pediatric Respiratory Diseases" ], "start_date": "2023-10-09", "last_update": "2024-04-12" }, { "nct_id": "NCT06299618", "title": "Environmental Influence on Mental Illness Via Modifications of Genomes and Metabolomes in Adolescents With Autism", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Autism", "Autism Spectrum Disorder" ], "start_date": "2024-09", "last_update": "2024-08-14" }, { "nct_id": "NCT06302348", "title": "A Study of Sepiapterin in Participants With Phenylketonuria (PKU)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "PTC Therapeutics", "conditions": [ "Phenylketonuria" ], "start_date": "2024-03-04", "last_update": "2026-08-28" }, { "nct_id": "NCT06304480", "title": "Effect of The Substitution of Animal Protein by Soya-Based Fermented Product on Human Gut Microbiome", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Gut Microbiome" ], "start_date": "2024-06-17", "last_update": "2024-09-24" }, { "nct_id": "NCT06310252", "title": "Safety and Efficacy of an Intrastromal Transform Corneal Allograft (TCA) for Presbyopia Correction - Long Term Follow-up", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Allotex, Inc.", "conditions": [ "Presbyopia" ], "start_date": "2024-02-13", "last_update": "2024-12-19" }, { "nct_id": "NCT06311682", "title": "A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "LEO Pharma", "conditions": [ "Atopic Dermatitis" ], "start_date": "2024-06-10", "last_update": "2026-07-07" }, { "nct_id": "NCT06312176", "title": "A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Breast Neoplasms" ], "start_date": "2024-04-14", "last_update": "2026-10-06" }, { "nct_id": "NCT06319820", "title": "A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Janssen Research & Development, LLC", "conditions": [ "Non-Muscle Invasive Bladder Neoplasms" ], "start_date": "2024-04-18", "last_update": "2026-09-25" }, { "nct_id": "NCT06320444", "title": "Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Motor Neuron Disease, Amyotrophic Lateral Sclerosis", "Motor Neuron Disease Progressive Spinal Muscle Atrophy", "Primary Lateral Sclerosis", "Multiple Sclerosis", "Postpoliomyelitis Syndrome" ], "start_date": "2023-06-15", "last_update": "2024-03-20" }, { "nct_id": "NCT06327139", "title": "Optimising Patient Experience in Head and Neck Radiotherapy", "phases": [ "PHASE3" ], "overall_status": "UNKNOWN", "lead_sponsor": "Irish Research Radiation Oncology Group", "conditions": [ "Head and Neck Cancer" ], "start_date": "2024-01-02", "last_update": "2024-03-25" }, { "nct_id": "NCT06327191", "title": "EMERGE Mothers and Kids", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Gestational Diabetes" ], "start_date": "2024-07-09", "last_update": "2026-06-15" }, { "nct_id": "NCT06329479", "title": "A Feasibility Trial for Circadian Rest-activity Rhythm Disorders in Cancer (RALI)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Circadian Rhythm Disorders", "Cancer" ], "start_date": "2023-06-01", "last_update": "2025-04-03" }, { "nct_id": "NCT06330064", "title": "A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "Recurrent or Metastatic Solid Tumors" ], "start_date": "2024-04-10", "last_update": "2026-08-05" }, { "nct_id": "NCT06339333", "title": "Evaluation of ACT Now GAIN Later", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Psychological Flexibility", "Child Behavior", "Relationship, Parent Child", "Well-Being, Psychological", "Self-efficacy" ], "start_date": "2024-05-12", "last_update": "2024-05-16" }, { "nct_id": "NCT06343779", "title": "Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Pharvaris Netherlands B.V.", "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor [C1-INH] Deficiency", "C1 Esterase Inhibitor Deficiency", "C1 Esterase Inhibitor, Deficiency of", "C1 Inhibitor Deficiency", "Hereditary Angioedema - Type 3", "Hereditary Angioedema Type III" ], "start_date": "2024-02-26", "last_update": "2025-11-21" }, { "nct_id": "NCT06346444", "title": "Biomarkers in Rett Syndrome", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "IRCCS Fondazione Stella Maris", "conditions": [ "Rett Syndrome" ], "start_date": "2020-08-03", "last_update": "2024-04-04" }, { "nct_id": "NCT06353386", "title": "Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostatic Neoplasms, Castration-Resistant" ], "start_date": "2024-05-20", "last_update": "2026-10-06" }, { "nct_id": "NCT06365853", "title": "A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Recurrent Ovarian Cancer", "Folate Receptor-Alpha Positive" ], "start_date": "2024-07-29", "last_update": "2026-08-21" }, { "nct_id": "NCT06367803", "title": "Cost Analysis of Vascular Surgical Techniques", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Critical Limb Ischemia" ], "start_date": "2023-06-01", "last_update": "2025-05-04" }, { "nct_id": "NCT06374875", "title": "Fibrosis Lessens After Metabolic Surgery", "phases": [ "PHASE4" ], "overall_status": "RECRUITING", "lead_sponsor": "The Cleveland Clinic", "conditions": [ "Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)", "Non-Alcoholic Fatty Liver Disease", "Metabolic Dysfunction-Associated Steatohepatitis (MASH)", "Liver Fibrosis", "Obesity" ], "start_date": "2024-07-11", "last_update": "2026-07-31" }, { "nct_id": "NCT06383949", "title": "Real World Data Collection on the Synergy Disc", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Synergy Spine Solutions", "conditions": [ "Cervical Degenerative Disc Disease" ], "start_date": "2024-08-06", "last_update": "2026-01-09" }, { "nct_id": "NCT06388499", "title": "A Physiotherapy-led Disease-agnostic Telerehabilitation Programme for People With Chronic Health Conditions", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Chronic Conditions, Multiple" ], "start_date": "2024-04-16", "last_update": "2024-12-12" }, { "nct_id": "NCT06389474", "title": "Efficacy of INM004 in Children With STEC-HUS", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Inmunova S.A.", "conditions": [ "Hemolytic-Uremic Syndrome" ], "start_date": "2024-10-05", "last_update": "2026-01-15" }, { "nct_id": "NCT06389877", "title": "A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Beam Therapeutics Inc.", "conditions": [ "Alpha 1-Antitrypsin Deficiency" ], "start_date": "2024-06-19", "last_update": "2026-10-05" }, { "nct_id": "NCT06393374", "title": "Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Triple-Negative Breast Cancer" ], "start_date": "2024-06-24", "last_update": "2026-10-06" }, { "nct_id": "NCT06398496", "title": "The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Depressive Disorder, Major" ], "start_date": "2024-02-14", "last_update": "2024-11-08" }, { "nct_id": "NCT06399614", "title": "Occupational Therapy-led Services for Adults Presenting Acutely With a Hand Condition", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Hand Injuries" ], "start_date": "2024-01-11", "last_update": "2025-10-01" }, { "nct_id": "NCT06405087", "title": "A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Ulcerative Colitis", "Crohn's Disease" ], "start_date": "2025-10-27", "last_update": "2026-10-09" }, { "nct_id": "NCT06410053", "title": "The All Ireland Infectious Diseases Cohort Project", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Infectious Disease" ], "start_date": "2011-03", "last_update": "2024-05-10" }, { "nct_id": "NCT06411379", "title": "Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "MoonLake Immunotherapeutics AG", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2024-05-14", "last_update": "2026-06-08" }, { "nct_id": "NCT06411847", "title": "The Effectiveness of Virtual Appointments on Compliance With Twin Block Wear", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Compliance, Patient" ], "start_date": "2023-11-21", "last_update": "2024-05-16" }, { "nct_id": "NCT06413810", "title": "The Effects of a Food Ingredient on Self-reported Stress", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Unilever R&D", "conditions": [ "Stress" ], "start_date": "2024-07-15", "last_update": "2025-01-13" }, { "nct_id": "NCT06416254", "title": "The Fibre Full Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Overweight and Obesity" ], "start_date": "2024-03-28", "last_update": "2026-05-07" }, { "nct_id": "NCT06422143", "title": "Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Non-small Cell Lung Cancer", "NSCLC" ], "start_date": "2024-06-10", "last_update": "2026-10-06" }, { "nct_id": "NCT06422884", "title": "A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Endeavor Biomedicines, Inc.", "conditions": [ "Idiopathic Pulmonary Fibrosis", "Progressive Fibrosing Interstitial Lung Disease" ], "start_date": "2024-11-15", "last_update": "2026-02-24" }, { "nct_id": "NCT06424275", "title": "Prostate Cancer Awareness and Initiative for Screening in the European Union", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "European Association of Urology Research Foundation", "conditions": [ "Prostate Cancer" ], "start_date": "2024-06-01", "last_update": "2025-08-15" }, { "nct_id": "NCT06430801", "title": "A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Crohn's Disease" ], "start_date": "2024-06-05", "last_update": "2026-10-02" }, { "nct_id": "NCT06431893", "title": "A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)", "phases": [ "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Travere Therapeutics, Inc.", "conditions": [ "Homocystinuria" ], "start_date": "2024-04-30", "last_update": "2026-05-28" }, { "nct_id": "NCT06432920", "title": "A Wearable In-phase Chest Wall Vibration Device for Relief of Dyspnoea in COPD: a First-in-human Exploratory Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Elevre Medical Ltd.", "conditions": [ "Chronic Obstructive Pulmonary Disease", "Dyspnea" ], "start_date": "2023-07-06", "last_update": "2024-05-29" }, { "nct_id": "NCT06433557", "title": "A Phase 2 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of Navepegritide in Combination With Lonapegsomatropin in Children With Achondroplasia", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Ascendis Pharma Growth Disorders A/S", "conditions": [ "Achondroplasia" ], "start_date": "2024-07-26", "last_update": "2026-02-18" }, { "nct_id": "NCT06442930", "title": "EXtubation Related Complications - the EXTUBE Study (EXTUBE)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University Health Network, Toronto", "conditions": [ "Extubation" ], "start_date": "2025-04-14", "last_update": "2026-10-09" }, { "nct_id": "NCT06453330", "title": "A Randomised Control Clinical Trial Investigating the Effect of H-PRF on Implant Stability and Marginal Bone Levels", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Osseointegration Failure of Dental Implant" ], "start_date": "2024-05-17", "last_update": "2024-06-11" }, { "nct_id": "NCT06454656", "title": "A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cerebral Palsy", "Walking, Difficulty", "Spastic Diplegia", "Hemiplegic Cerebral Palsy" ], "start_date": "2024-08-12", "last_update": "2026-04-14" }, { "nct_id": "NCT06459180", "title": "A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Cervical Cancer" ], "start_date": "2024-07-24", "last_update": "2026-08-28" }, { "nct_id": "NCT06460090", "title": "Evaluating a Targeted Selective Speech, Language, and Communication Intervention at Scale - Protocol for the 'Happy Talk' Cluster Randomised Controlled Trial.", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Developmental Language Disorder and Language Impairment", "Deprivation" ], "start_date": "2024-06", "last_update": "2024-06-14" }, { "nct_id": "NCT06463418", "title": "Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP)", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Traumatic Spinal Cord Injury" ], "start_date": "2024-12-20", "last_update": "2026-05-01" }, { "nct_id": "NCT06468228", "title": "A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Hidradenitis Suppurativa" ], "start_date": "2024-06-27", "last_update": "2026-09-02" }, { "nct_id": "NCT06472856", "title": "Vasomotor Symptom Alleviation Through Acupuncture in Patients With Prostate Cancer", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Prostate Cancer" ], "start_date": "2024-08-30", "last_update": "2026-03-04" }, { "nct_id": "NCT06478147", "title": "Effect of a Novel Protein Ingredient Combined With Oral Nutritional Supplement on Appetite in Older Adults", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University College Dublin", "conditions": [ "Aging", "Appetite Loss", "Undernutrition" ], "start_date": "2023-12-02", "last_update": "2024-06-27" }, { "nct_id": "NCT06494878", "title": "The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Calgary", "conditions": [ "Venous Thromboembolism", "Postpartum Period", "Aspirin", "Low Molecular Weight Heparin" ], "start_date": "2026-06-04", "last_update": "2026-07-27" }, { "nct_id": "NCT06499285", "title": "A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Myelodysplastic Syndromes" ], "start_date": "2025-05-06", "last_update": "2026-10-08" }, { "nct_id": "NCT06500455", "title": "Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "NRG Oncology", "conditions": [ "Anatomic Stage IV Breast Cancer AJCC v8", "Metastatic Breast Carcinoma", "Metastatic Digestive System Carcinoma", "Metastatic Lung Non-Small Cell Carcinoma", "Metastatic Malignant Neoplasm in the Brain", "Metastatic Malignant Solid Neoplasm", "Metastatic Melanoma", "Metastatic Renal Cell Carcinoma", "Stage IV Lung Cancer AJCC v8", "Stage IV Renal Cell Cancer AJCC v8" ], "start_date": "2024-12-12", "last_update": "2026-09-14" }, { "nct_id": "NCT06505304", "title": "AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "University College Cork", "conditions": [ "Crohn Disease" ], "start_date": "2024-05-01", "last_update": "2024-07-18" }, { "nct_id": "NCT06505408", "title": "Impact of a MVM to Support Biomarkers Associated With Conception and Pregnancy in Healthy Women.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Perelel Inc.", "conditions": [ "Healthy Adult Women of Child Bearing Age" ], "start_date": "2024-10-02", "last_update": "2025-06-06" }, { "nct_id": "NCT06505915", "title": "Carbohydrate Loading Fasting Protocol Versus 'Sip Til Send'", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Elective Cesarean Delivery", "Fasting ( 6H for Solid ; 2H for Clear Fluid )" ], "start_date": "2024-02-12", "last_update": "2025-04-04" }, { "nct_id": "NCT06512454", "title": "A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Alpha1-Antitrypsin Deficiency" ], "start_date": "2024-09-25", "last_update": "2026-07-24" }, { "nct_id": "NCT06516263", "title": "Effect of L-PRF on Implant Stability and Marginal Bone Levels.", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "Dublin Dental University Hospital", "conditions": [ "Dental Implant", "Implant Stability", "Marginal Bone Levels", "L-PRF" ], "start_date": "2024-06-01", "last_update": "2024-07-23" }, { "nct_id": "NCT06520865", "title": "TIDE Project: Biomarker Discovery for Chronic Tinnitus Diagnosis", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University of Regensburg", "conditions": [ "Tinnitus" ], "start_date": "2024-08-01", "last_update": "2026-03-24" }, { "nct_id": "NCT06523374", "title": "A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University Hospital, Antwerp", "conditions": [ "Barrett's Esophagus", "Esophageal Adenocarcinoma" ], "start_date": "2025-08-13", "last_update": "2026-02-24" }, { "nct_id": "NCT06535633", "title": "Community-based Exercise for Older Adults With Chronic Musculoskeletal Pain", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Chronic Musculoskeletal Pain" ], "start_date": "2024-09-01", "last_update": "2024-12-12" }, { "nct_id": "NCT06535659", "title": "VitaFlow LIBERTY Europe", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Shanghai MicroPort CardioFlow Medtech Co., Ltd.", "conditions": [ "Aortic Valve Stenosis" ], "start_date": "2025-05-06", "last_update": "2026-10-01" }, { "nct_id": "NCT06544499", "title": "A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "argenx", "conditions": [ "Primary Immune Thrombocytopenia (ITP)" ], "start_date": "2024-10-18", "last_update": "2026-05-01" }, { "nct_id": "NCT06546631", "title": "Investigating Mechanistic Predictors of Interpatient Variability and Temozolomide (TMZ) Induced Haematological Toxicity for Glioma Patients", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Glioma" ], "start_date": "2024-08-22", "last_update": "2026-03-04" }, { "nct_id": "NCT06548542", "title": "Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Crohn's Disease" ], "start_date": "2024-09-04", "last_update": "2026-09-25" }, { "nct_id": "NCT06550063", "title": "HER2 Status in Esophagogastric Adenocarcinoma and Its Associations With Patient's Clinicopathological Outcomes", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Esophagus Cancer", "Gastric Cancer", "HER2-positive Cancer", "HER2-low Cancer" ], "start_date": "2024-08-20", "last_update": "2024-08-13" }, { "nct_id": "NCT06557551", "title": "Prophylactic Surfactant by Thin Endotracheal Catheter for Preterm Infants At Birth: the ProTeCt Trial", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Infant, Newborn, Diseases", "Prematurity", "Prematurity; Extreme", "Respiratory Distress Syndrome in Premature Infant" ], "start_date": "2024-08-19", "last_update": "2024-10-15" }, { "nct_id": "NCT06561386", "title": "A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-small Cell Lung Cancer" ], "start_date": "2024-10-07", "last_update": "2026-09-23" }, { "nct_id": "NCT06563895", "title": "Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Eidos Therapeutics, a BridgeBio company", "conditions": [ "Amyloidosis", "Amyloid Cardiomyopathy", "Transthyretin Amyloidosis", "Cardiomyopathies", "Heart Diseases", "Polyneuropathies" ], "start_date": "2025-05-12", "last_update": "2026-08-04" }, { "nct_id": "NCT06564142", "title": "Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Alpine Immune Sciences Inc, A Subsidiary of Vertex", "conditions": [ "Immunoglobulin A Nephropathy" ], "start_date": "2024-08-30", "last_update": "2026-05-15" }, { "nct_id": "NCT06576557", "title": "Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: KNEE-DEeP Study", "phases": [ "NA" ], "overall_status": "UNKNOWN", "lead_sponsor": "University of Limerick", "conditions": [ "Osteoarthritis, Knee", "Meniscus; Degeneration" ], "start_date": "2024-06-01", "last_update": "2024-08-28" }, { "nct_id": "NCT06580834", "title": "Newborn Brain Test (NBT)", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Professor Geraldine Boylan", "conditions": [ "Seizures Newborn", "Brain Injuries" ], "start_date": "2024-07-22", "last_update": "2025-04-09" }, { "nct_id": "NCT06585774", "title": "A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Chronic Graft-versus-host-disease" ], "start_date": "2025-01-21", "last_update": "2026-10-09" }, { "nct_id": "NCT06586515", "title": "MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Pancreatic Ductal Adenocarcinoma", "Non-small Cell Lung Cancer", "Colorectal Cancer" ], "start_date": "2024-09-12", "last_update": "2026-08-24" }, { "nct_id": "NCT06587321", "title": "Remote Assessment of Signs and Symptoms in Palliative Care", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Palliative Care", "Vital Signs", "Remote Monitoring" ], "start_date": "2024-04-01", "last_update": "2025-06-27" }, { "nct_id": "NCT06588933", "title": "TQ-PAL Development and Validation", "phases": [], "overall_status": "UNKNOWN", "lead_sponsor": "Prof Andrew Davies", "conditions": [ "Altered Taste" ], "start_date": "2023-09-01", "last_update": "2024-09-19" }, { "nct_id": "NCT06590077", "title": "Impact of Aromatherapy on Wellbeing and Relaxation in Gynae Oncology Patients Post Treatment", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Stress", "Wellbeing", "Relaxation" ], "start_date": "2024-08-19", "last_update": "2025-01-09" }, { "nct_id": "NCT06590467", "title": "Abbott Structural Heart Device Registry", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Heart Diseases", "ASD - Atrial Septal Defect", "VSD - Muscular Ventricular Septal Defect", "PFO - Patent Foramen Ovale", "PIVSD - Post Infarct Muscular Ventricular Septal Defect", "Valvular Heart Disease" ], "start_date": "2024-08-21", "last_update": "2026-09-01" }, { "nct_id": "NCT06598943", "title": "A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Ulcerative Colitis", "Ulcerative Colitis Chronic" ], "start_date": "2024-10-10", "last_update": "2026-10-07" }, { "nct_id": "NCT06602687", "title": "PICSI Impact on Euploidy in Assisted Reproduction", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Merrion Fertility Clinic", "conditions": [ "Infertility" ], "start_date": "2024-01-01", "last_update": "2024-09-19" }, { "nct_id": "NCT06608563", "title": "The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Dental Caries", "Fissure Sealant" ], "start_date": "2024-06-05", "last_update": "2026-09-15" }, { "nct_id": "NCT06616272", "title": "Cervical Spine Focused Treatment for Patients With Persistent Concussion Symptoms and Neck Pain", "phases": [ "NA" ], "overall_status": "TERMINATED", "lead_sponsor": "University of Pittsburgh", "conditions": [ "Brain Concussion", "Neck Pain" ], "start_date": "2025-08-28", "last_update": "2026-05-19" }, { "nct_id": "NCT06620653", "title": "Heart Failure Virtual Ward Research Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Heart Failure" ], "start_date": "2024-10-18", "last_update": "2026-04-15" }, { "nct_id": "NCT06623422", "title": "A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2024-10-21", "last_update": "2026-10-02" }, { "nct_id": "NCT06631469", "title": "Behaviour-focused Personalised Nutrition Intervention", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Dietary Behaviours", "Sustainable Healthy Diet", "Personalised Nutrition" ], "start_date": "2024-10-01", "last_update": "2025-04-18" }, { "nct_id": "NCT06635824", "title": "Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Genmab", "conditions": [ "PD-L1-positive, Locally Advanced (Unresectable Stage IIIB/C) or Metastatic NSCLC" ], "start_date": "2024-11-25", "last_update": "2026-10-06" }, { "nct_id": "NCT06643481", "title": "A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Novartis Pharmaceuticals", "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "start_date": "2024-10-17", "last_update": "2026-07-07" }, { "nct_id": "NCT06646861", "title": "Head and Neck Cancer Rehabilitation: The CaRe Feasibility Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Head and Neck Cancer Survivors" ], "start_date": "2024-11-01", "last_update": "2026-03-25" }, { "nct_id": "NCT06647290", "title": "ENVELOP: Wound Care Following Pilonidal Sinus Surgery", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Pilonidal Sinus", "Wound Healing" ], "start_date": "2024-10-01", "last_update": "2026-09-24" }, { "nct_id": "NCT06652438", "title": "Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Stichting Hemato-Oncologie voor Volwassenen Nederland", "conditions": [ "Acute Myeloid Leukemia, Adult" ], "start_date": "2025-05-05", "last_update": "2026-09-02" }, { "nct_id": "NCT06653049", "title": "An Evaluation of the Effect of App-Based Exercise Prescription Using RL on Satisfaction and Exercise Intensity", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Exercise", "Mobile Applications" ], "start_date": "2022-09-01", "last_update": "2024-10-22" }, { "nct_id": "NCT06659549", "title": "A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Galimedix Therapeutics Inc", "conditions": [ "Geographic Atrophy of the Macula" ], "start_date": "2025-01-10", "last_update": "2026-10-05" }, { "nct_id": "NCT06669754", "title": "Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Pharvaris Netherlands B.V.", "conditions": [ "Hereditary Angioedema (HAE)" ], "start_date": "2024-12-01", "last_update": "2026-02-13" }, { "nct_id": "NCT06678594", "title": "Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Myocardial Ischaemia", "Severely Calcified Coronary Stenoses", "Coronary Calcification" ], "start_date": "2024-09-24", "last_update": "2024-11-07" }, { "nct_id": "NCT06679101", "title": "A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Multiple Myeloma", "Newly Diagnosed Multiple Myeloma" ], "start_date": "2024-12-16", "last_update": "2026-04-22" }, { "nct_id": "NCT06679881", "title": "Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE", "phases": [ "PHASE3" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Pharvaris Netherlands B.V.", "conditions": [ "Hereditary Angioedema (HAE)" ], "start_date": "2025-02-01", "last_update": "2026-09-22" }, { "nct_id": "NCT06680817", "title": "A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Neovascular Age-related Macular Degeneration", "Diabetic Macular Edema" ], "start_date": "2025-02-05", "last_update": "2026-10-02" }, { "nct_id": "NCT06684847", "title": "A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "argenx", "conditions": [ "Primary Sjogrens Disease" ], "start_date": "2025-01-15", "last_update": "2026-04-16" }, { "nct_id": "NCT06690775", "title": "CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "TORL Biotherapeutics, LLC", "conditions": [ "Epithelial Ovarian Cancer", "Primary Peritoneal", "Fallopian Tube Cancer", "Endometrioid Ovarian Cancer" ], "start_date": "2024-11-20", "last_update": "2025-12-23" }, { "nct_id": "NCT06702228", "title": "Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Connective Tissue Diseases", "Interstitial Lung Disease", "Idiopathic Pulmonary Fibrosis", "Familial Idiopathic Pulmonary Fibrosis", "Pulmonary Fibrosis", "Pulmonary Fibrosis Interstitial" ], "start_date": "2021-09-28", "last_update": "2024-11-22" }, { "nct_id": "NCT06705582", "title": "OASIS Study: Vitamin D Deficiency Prevention Among Older Adults in Ireland", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2024-11-11", "last_update": "2025-04-30" }, { "nct_id": "NCT06708819", "title": "AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer", "phases": [], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Colorectal Surgery", "Colorectal Resection", "Anastomosis, Surgical", "Fluorescence Guided Surgery", "Indocyanine Green", "Perfusion Imaging", "Anastomotic Leaks" ], "start_date": "2025-01", "last_update": "2024-11-27" }, { "nct_id": "NCT06709209", "title": "AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Ulcerative Colitis (UC)" ], "start_date": "2024-11-04", "last_update": "2024-12-03" }, { "nct_id": "NCT06709651", "title": "Microbiome Immunotherapy Neoadjuvant Assessment", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Triple Negative Breast Cancer" ], "start_date": "2024-10-02", "last_update": "2026-03-04" }, { "nct_id": "NCT06713135", "title": "A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy", "phases": [ "PHASE4" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Santhera Pharmaceuticals", "conditions": [ "Duchenne Muscular Dystrophy" ], "start_date": "2024-11-10", "last_update": "2026-04-23" }, { "nct_id": "NCT06714279", "title": "Laparoscopic-Assisted Transversus Abdominus Plane Block Versus Intraperitoneal Irrigation of Local Anesthetic for Patients Undergoing Laparoscopic Cholecystectomy", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Laparoscopic Cholecystectomy", "TAP Block", "Local Anesthetic" ], "start_date": "2025-03-12", "last_update": "2025-08-14" }, { "nct_id": "NCT06718322", "title": "PIECES - Towards Large-Scale Adaptation and Tailored Implementation of Primary Cancer Prevention Programs", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Hidde van der Ploeg", "conditions": [ "Focus of Study: Tailored Implementation" ], "start_date": "2024-12-01", "last_update": "2025-04-09" }, { "nct_id": "NCT06723899", "title": "Testing the Effectiveness of a Work Rehabilitation Intervention for Women with Breast Cancer", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Breast Cancer" ], "start_date": "2024-11-13", "last_update": "2024-12-17" }, { "nct_id": "NCT06726265", "title": "Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Immutep S.A.S.", "conditions": [ "Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)" ], "start_date": "2025-03-21", "last_update": "2026-03-18" }, { "nct_id": "NCT06729671", "title": "A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Psychosis" ], "start_date": "2024-05-16", "last_update": "2024-12-11" }, { "nct_id": "NCT06732895", "title": "A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Ascendis Pharma A/S", "conditions": [ "Achondroplasia" ], "start_date": "2024-12-10", "last_update": "2026-04-21" }, { "nct_id": "NCT06739408", "title": "Protein Source and Resistance Training", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Healthy", "No Condition" ], "start_date": "2025-01-21", "last_update": "2026-04-29" }, { "nct_id": "NCT06740344", "title": "Neonatal Mask Seal; a Two-handed Versus One-handed Approach: The NeoSeal Study", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Neonatal Intensive Care" ], "start_date": "2025-01-27", "last_update": "2026-05-12" }, { "nct_id": "NCT06742346", "title": "Linguistically Tailored Health Messages to Encourage Plant-Based Food Choices in Adolescents", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Erasmus University Rotterdam", "conditions": [ "Food Consumption", "Sustainable Food Consumption", "Sustainable Healthy Eating Behaviour" ], "start_date": "2024-10-04", "last_update": "2025-08-12" }, { "nct_id": "NCT06749327", "title": "Dissecting the Roles of High-quality Diets and Ultra Processed Foods on Cardiometabolic Health", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Queen's University, Belfast", "conditions": [ "Cardiometabolic Risk Factors" ], "start_date": "2026-10-01", "last_update": "2026-05-18" }, { "nct_id": "NCT06750289", "title": "Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Eosinophilic Asthma" ], "start_date": "2025-03-28", "last_update": "2026-05-13" }, { "nct_id": "NCT06760637", "title": "Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Pfizer", "conditions": [ "Breast Cancer" ], "start_date": "2025-01-06", "last_update": "2026-05-19" }, { "nct_id": "NCT06764485", "title": "A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Celgene", "conditions": [ "Metastatic Castration-resistant Prostate Cancer" ], "start_date": "2025-03-13", "last_update": "2026-09-30" }, { "nct_id": "NCT06764693", "title": "An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Psoriatic Arthritis" ], "start_date": "2025-01-31", "last_update": "2026-02-17" }, { "nct_id": "NCT06781658", "title": "Rehab in Mild Stable DCM: Feasibility RCT Comparing Structured Rehabilitation to Clinical Surveillance", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Degenerative Cervical Myelopathy" ], "start_date": "2025-01-13", "last_update": "2025-01-17" }, { "nct_id": "NCT06784193", "title": "Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Olema Pharmaceuticals, Inc.", "conditions": [ "Advanced or Metastatic ER+ HER2- Breast Cancer (mBC)", "Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)", "Advanced or Metastatic Castration-Resistant Prostate Cancer (mCRPC)", "Metastatic Breast Cancer", "Fulvestrant", "Palazestrant" ], "start_date": "2024-12-16", "last_update": "2026-10-05" }, { "nct_id": "NCT06788990", "title": "FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Bicara Therapeutics", "conditions": [ "Metastatic Head and Neck Squamous Cell Carcinoma", "Recurrent Head and Neck Squamous Cell Carcinoma" ], "start_date": "2025-01-28", "last_update": "2026-10-02" }, { "nct_id": "NCT06789913", "title": "A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Relay Therapeutics, Inc.", "conditions": [ "PIK3CA-Related Overgrowth Spectrum (PROS)", "Lymphatic Malformations", "Vascular Malformations", "PIK3CA Mutation", "CLOVES Syndrome", "Klippel Trenaunay Syndrome", "Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)", "Vascular Anomalies" ], "start_date": "2025-06-13", "last_update": "2026-08-25" }, { "nct_id": "NCT06793215", "title": "A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Non-Small Cell Lung Cancer", "KRAS G12C Lung Cancer" ], "start_date": "2025-10-24", "last_update": "2026-10-06" }, { "nct_id": "NCT06793397", "title": "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Cybin IRL Limited", "conditions": [ "Major Depressive Disorder (MDD)", "Depression in Adults", "Depression - Major Depressive Disorder", "Depression Disorders", "Depression Disorder", "Depression" ], "start_date": "2025-12-10", "last_update": "2026-10-05" }, { "nct_id": "NCT06804629", "title": "The Resistance Exercise Training for Worry Trial: Replication and Expansion", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Analogue Generalized Anxiety Disorder" ], "start_date": "2023-10-09", "last_update": "2025-02-03" }, { "nct_id": "NCT06808217", "title": "A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Atrial Fibrillation", "Pulsed Field Ablation", "FARAPULSE" ], "start_date": "2025-07-30", "last_update": "2026-09-24" }, { "nct_id": "NCT06816862", "title": "SYMPHONY™ OCT System for Instabilities of the Upper Thoracic and Cervical Spine", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Cervical Instabilities Spine", "Spine; Instability" ], "start_date": "2024-12-01", "last_update": "2025-02-10" }, { "nct_id": "NCT06818539", "title": "Burnout and Resilience in Hospital-based Nursing and Medical Personnel and Trainees", "phases": [], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Stress", "Burnout" ], "start_date": "2025-02-01", "last_update": "2025-02-10" }, { "nct_id": "NCT06820008", "title": "Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Amyotrophic Lateral Sclerosis", "Motor Neurone Disease" ], "start_date": "2024-11-21", "last_update": "2025-02-11" }, { "nct_id": "NCT06821542", "title": "A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Chronic Graft-versus-host-disease" ], "start_date": "2025-06-04", "last_update": "2026-08-25" }, { "nct_id": "NCT06824467", "title": "A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Ovarian Cancer", "Fallopian Tube Cancer", "Primary Peritoneal Cancer" ], "start_date": "2025-04-09", "last_update": "2026-10-06" }, { "nct_id": "NCT06848088", "title": "A Study to Learn About the Long-Term Health of Adult Participants From a Previous Study of a New Melanoma Treatment", "phases": [ "PHASE2" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Regeneron Pharmaceuticals", "conditions": [ "Melanoma" ], "start_date": "2025-04-14", "last_update": "2026-07-13" }, { "nct_id": "NCT06850636", "title": "Higher vs Lower Lumber Epidural Catheter Insertion During Labour: A Randomised Trial to Compare Efficacy.", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Labour Analgesia, Epidural Anaesthesia" ], "start_date": "2025-02-25", "last_update": "2026-08-14" }, { "nct_id": "NCT06855329", "title": "PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Massachusetts, Worcester", "conditions": [ "Progressive Pulmonary Fibrosis", "Interstitial Lung Disease" ], "start_date": "2025-05-01", "last_update": "2026-08-18" }, { "nct_id": "NCT06857539", "title": "Assessing Intellectual and Motor Outcomes in High-risk Infants", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Cerebral Palsy", "Cerebral Palsy (CP)", "Cerebral Palsy Children", "High-risk Infants", "Intellectual and Developmental Disabilities", "Motor Impairment", "Cognitive Development", "HIE - Hypoxic - Ischemic Encephalopathy", "Preterm", "Prematurity; Extreme" ], "start_date": "2025-03-21", "last_update": "2026-05-13" }, { "nct_id": "NCT06863272", "title": "A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Castration-Resistant Prostatic Cancer", "Metastasis" ], "start_date": "2025-07-03", "last_update": "2026-10-09" }, { "nct_id": "NCT06864312", "title": "Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery", "phases": [ "PHASE4" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)", "Ankle Fracture - Lateral Malleolus", "Ankle Fracture - Medial Malleolus", "Rebound Pain" ], "start_date": "2023-10-16", "last_update": "2026-08-19" }, { "nct_id": "NCT06864650", "title": "Effectiveness of Ergonomic Training and Exercise in Automotive Factory Workers With Nonspecific Chronic Low Back Pain", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Uskudar University", "conditions": [ "Work-related Illness" ], "start_date": "2025-03-25", "last_update": "2025-08-29" }, { "nct_id": "NCT06865417", "title": "A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Alfasigma S.p.A.", "conditions": [ "Ulcerative Colitis" ], "start_date": "2025-09-29", "last_update": "2026-08-12" }, { "nct_id": "NCT06868277", "title": "A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Carcinoma, Non-Small Cell Lung" ], "start_date": "2025-04-10", "last_update": "2026-09-25" }, { "nct_id": "NCT06872892", "title": "The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Bronchiectasis" ], "start_date": "2025-06-09", "last_update": "2026-10-01" }, { "nct_id": "NCT06875310", "title": "A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Mirati Therapeutics Inc.", "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "start_date": "2025-04-24", "last_update": "2026-09-22" }, { "nct_id": "NCT06880744", "title": "A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "AbbVie", "conditions": [ "Ulcerative Colitis" ], "start_date": "2025-06-17", "last_update": "2026-08-04" }, { "nct_id": "NCT06881784", "title": "Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Revolution Medicines, Inc.", "conditions": [ "NSCLC (Non-small Cell Lung Cancer)", "Non-Small Cell Lung Cancer", "NSCLC", "NSCLC (Non-small Cell Lung Carcinoma)", "NSCLC (Advanced Non-small Cell Lung Cancer)" ], "start_date": "2025-05-06", "last_update": "2026-09-29" }, { "nct_id": "NCT06890884", "title": "A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Lymphoma, Large B-Cell, Diffuse" ], "start_date": "2025-04-11", "last_update": "2026-10-08" }, { "nct_id": "NCT06898450", "title": "A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Nimbus Wadjet, Inc.", "conditions": [ "Advanced Solid Tumors Cancer", "MSI-H Cancer" ], "start_date": "2025-03-31", "last_update": "2026-05-06" }, { "nct_id": "NCT06898801", "title": "An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Respiratory Distress Syndrome, Newborn", "Endotracheal Intubation", "Neonatal Intubation Performance", "Prematurity", "Neonate", "Education, Medical" ], "start_date": "2025-03", "last_update": "2025-03-27" }, { "nct_id": "NCT06906250", "title": "European Venous Registry", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "IRCCS San Raffaele", "conditions": [ "Deep Venous Disease of the Lower Limbs" ], "start_date": "2025-07-05", "last_update": "2025-09-08" }, { "nct_id": "NCT06906926", "title": "Harmony TPV EMEA PMS", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Medtronic Cardiovascular", "conditions": [ "Severe Pulmonary Valve Regurgitation" ], "start_date": "2025-07-30", "last_update": "2026-07-14" }, { "nct_id": "NCT06907147", "title": "SPYRAL GEMINI Pilot Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases", "Chronic Kidney Diseases", "Diabetes Mellitus" ], "start_date": "2025-05-01", "last_update": "2026-06-24" }, { "nct_id": "NCT06910358", "title": "Study of Bitopertin in Participants With EPP or XLP (APOLLO)", "phases": [ "PHASE3" ], "overall_status": "COMPLETED", "lead_sponsor": "Disc Medicine, Inc", "conditions": [ "Erythropoietic Protoporphyria (EPP)", "X-Linked Protoporphyria (XLP)" ], "start_date": "2025-04-04", "last_update": "2026-10-09" }, { "nct_id": "NCT06924970", "title": "A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Agios Pharmaceuticals, Inc.", "conditions": [ "Sickle Cell Disease" ], "start_date": "2025-05-01", "last_update": "2026-09-28" }, { "nct_id": "NCT06925737", "title": "A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Prostate Cancer", "Prostatic Neoplasms" ], "start_date": "2025-05-13", "last_update": "2026-10-08" }, { "nct_id": "NCT06931717", "title": "A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "ETOP IBCSG Partners Foundation", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2026-01-12", "last_update": "2026-09-28" }, { "nct_id": "NCT06932562", "title": "A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "European Myeloma Network B.V.", "conditions": [ "Multiple Myeloma" ], "start_date": "2025-12-23", "last_update": "2026-03-25" }, { "nct_id": "NCT06939231", "title": "Supporting University Students Transition Towards Sustainable and Healthy Dietary Behaviours: A Living Lab Approach.", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Dietary Behaviours", "Sustainable Healthy Diet", "Personalised Nutrition" ], "start_date": "2024-02-26", "last_update": "2026-02-09" }, { "nct_id": "NCT06940453", "title": "CONDUIT™ Anterior Lumbar Interbody Fusion (ALIF) Cage System in Lumbar Degenerative Disease", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Lumbar Degenerative Disease" ], "start_date": "2024-06-28", "last_update": "2025-04-23" }, { "nct_id": "NCT06940830", "title": "Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa", "phases": [ "PHASE4" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Swedish Orphan Biovitrum", "conditions": [ "Hemophilia A" ], "start_date": "2025-05-21", "last_update": "2026-09-30" }, { "nct_id": "NCT06943872", "title": "A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "BeOne Medicines", "conditions": [ "Chronic Lymphocytic Leukemia", "Small Lymphocytic Lymphoma" ], "start_date": "2025-06-11", "last_update": "2026-09-28" }, { "nct_id": "NCT06952504", "title": "A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Endometrial Cancer" ], "start_date": "2025-05-22", "last_update": "2026-10-06" }, { "nct_id": "NCT06953583", "title": "A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Biogen", "conditions": [ "Friedreich Ataxia" ], "start_date": "2025-06-09", "last_update": "2026-10-02" }, { "nct_id": "NCT06959095", "title": "Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Pulmonary Disease, Chronic Obstructive" ], "start_date": "2025-06-20", "last_update": "2026-10-05" }, { "nct_id": "NCT06959524", "title": "AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Coronary Arterial Disease (CAD)", "de Novo Lesions in Native Coronary Arteries" ], "start_date": "2025-08-21", "last_update": "2026-09-29" }, { "nct_id": "NCT06967805", "title": "WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Mediar Therapeutics", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "start_date": "2025-05-05", "last_update": "2026-08-10" }, { "nct_id": "NCT06981078", "title": "A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD", "phases": [ "PHASE2" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Upstream Bio Inc.", "conditions": [ "Chronic Obstructive Pulmonary Disease" ], "start_date": "2025-07-02", "last_update": "2026-07-20" }, { "nct_id": "NCT06982521", "title": "Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Relay Therapeutics, Inc.", "conditions": [ "PIK3CA Mutation", "HER2- Negative Breast Cancer", "Hormone Receptor Positive Tumor", "Breast Cancer", "Metastatic Breast Cancer", "Advanced Breast Cancer" ], "start_date": "2025-08-26", "last_update": "2026-10-05" }, { "nct_id": "NCT06983782", "title": "A Feasibility Randomised Controlled Trial of an Online Exercise Programme for Adults With Cerebral Palsy", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Cerebral Palsy", "Exercise", "Adults", "Fitness" ], "start_date": "2025-07-25", "last_update": "2026-08-12" }, { "nct_id": "NCT07003919", "title": "Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)", "phases": [ "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "DBV Technologies", "conditions": [ "Allergy", "Peanut Allergy" ], "start_date": "2025-06-24", "last_update": "2026-07-22" }, { "nct_id": "NCT07009964", "title": "An Exploratory Feasibility Study", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Well-Being", "Lifestyle, Healthy", "Young Adult", "Behavior and Behavior Mechanisms" ], "start_date": "2025-11-01", "last_update": "2025-06-19" }, { "nct_id": "NCT07013929", "title": "Spyral InSight Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases" ], "start_date": "2025-06-09", "last_update": "2026-05-04" }, { "nct_id": "NCT07023835", "title": "Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Zydus Therapeutics Inc.", "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "start_date": "2025-09-17", "last_update": "2026-09-01" }, { "nct_id": "NCT07024706", "title": "Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Chronic Lymphocytic Leukemia (CLL)", "Small Lymphocytic Lymphoma (SLL)" ], "start_date": "2026-06-04", "last_update": "2026-08-06" }, { "nct_id": "NCT07027241", "title": "Frailty Intervention in Postoperative Hip Fracture Inpatients", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Hip Fractures (ICD-10 72.01-72.2)", "Frailty at Older Adults", "Strength Training", "Resistance Training", "Exercise Training", "Protein Supplementation" ], "start_date": "2025-08-01", "last_update": "2025-06-18" }, { "nct_id": "NCT07032662", "title": "Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Immunovant Sciences GmbH", "conditions": [ "Chronic Inflammatory Demyelinating Polyneuropathy" ], "start_date": "2025-03-18", "last_update": "2026-09-30" }, { "nct_id": "NCT07046052", "title": "PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Hip Fracture", "Analgesia Post Fracture" ], "start_date": "2024-03-28", "last_update": "2025-07-01" }, { "nct_id": "NCT07051122", "title": "Personalised Nutrition for the Preterm Infant", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Preterm Infant Nutrition" ], "start_date": "2018-09-01", "last_update": "2025-07-03" }, { "nct_id": "NCT07052903", "title": "TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Alnylam Pharmaceuticals", "conditions": [ "Transthyretin Amyloidosis With Cardiomyopathy" ], "start_date": "2025-07-02", "last_update": "2026-09-16" }, { "nct_id": "NCT07055126", "title": "Nutritional Resources and Techniques for Young Children", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Healthy" ], "start_date": "2025-06-06", "last_update": "2026-06-24" }, { "nct_id": "NCT07055789", "title": "Is Combined Respiratory Muscle Training, Incorporating Inspiratory and Expiratory Training, Feasible in Adult Critical-care Patients?", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Critical Illness Myopathy", "Critical Illness" ], "start_date": "2024-10-01", "last_update": "2026-03-17" }, { "nct_id": "NCT07057817", "title": "The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Osteomyelitis", "Diabetes", "Calcanectomy" ], "start_date": "2026-01-01", "last_update": "2026-07-22" }, { "nct_id": "NCT07064473", "title": "EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Diabetes Mellitus, Type 2", "Hypertension", "Cardiovascular Diseases" ], "start_date": "2025-07-22", "last_update": "2026-09-30" }, { "nct_id": "NCT07068971", "title": "Sleep Well At Night", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Sleep Disturbance in Advanced Cancer" ], "start_date": "2024-08-19", "last_update": "2025-07-16" }, { "nct_id": "NCT07075016", "title": "Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Stichting Hemato-Oncologie voor Volwassenen Nederland", "conditions": [ "Acute Myeloid Leukemia" ], "start_date": "2025-08-05", "last_update": "2025-08-19" }, { "nct_id": "NCT07076121", "title": "A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Pancreatic Ductal Adenocarcinoma" ], "start_date": "2025-10-23", "last_update": "2026-06-03" }, { "nct_id": "NCT07084077", "title": "Investigating the Effects of a Short Narratology Education Module on Empathy and Patient-centred Communication in Early-stage Medical Students.", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Empathy", "Patient-centredness", "Narrative Medicine" ], "start_date": "2025-04-02", "last_update": "2025-08-07" }, { "nct_id": "NCT07085819", "title": "Sleep Promoting Properties of a Botanical Extract in a Population Complaining From Non-Restorative Sleep (NRS)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Kerry Group P.L.C", "conditions": [ "Non Restorative Sleep", "Sleep Disorder (Disorder)" ], "start_date": "2025-07-15", "last_update": "2025-08-26" }, { "nct_id": "NCT07088471", "title": "Cardiac Left Atrial Evaluation and Response in HFrEF With Sacubitril/Valsartan", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Heart Failure and Reduced Ejection Fraction" ], "start_date": "2024-11-01", "last_update": "2026-04-13" }, { "nct_id": "NCT07095660", "title": "RECANA OUS - Recana Thrombectomy Catheter System for Venous Obstruction and Occlusion Study (RECANA-OUS-IRL)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Intervene, Inc.", "conditions": [ "Venous Obstruction" ], "start_date": "2025-07-02", "last_update": "2026-05-27" }, { "nct_id": "NCT07099027", "title": "The Lung Health Check Pilot", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Non-Small Cell Lung Cancer" ], "start_date": "2025-05-19", "last_update": "2025-08-01" }, { "nct_id": "NCT07099898", "title": "A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "GlaxoSmithKline", "conditions": [ "Neoplasms, Lung" ], "start_date": "2025-08-11", "last_update": "2026-09-28" }, { "nct_id": "NCT07100691", "title": "Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery", "phases": [ "PHASE4" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Mater Misericordiae University Hospital", "conditions": [ "Pulmonary Aspiration During Anaesthetic Induction", "Gastric Emptying Time", "Preoperative Risk Assessment", "Obesity (Disorder)" ], "start_date": "2025-08", "last_update": "2025-08-06" }, { "nct_id": "NCT07102693", "title": "Left Atrial Strain Assessment in Ischemic Stroke Patients", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Connolly Hospital Blanchardstown", "conditions": [ "Ischemic Stroke", "Left Atrial Strain", "Sinus Rhythm" ], "start_date": "2024-07-15", "last_update": "2025-08-12" }, { "nct_id": "NCT07106632", "title": "Optimising Adjuvant Chemotherapy Prescription in Young Patients With Hormone-dependent Breast Cancer Using Genomic Tests", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "UNICANCER", "conditions": [ "Early Breast Cancer", "Premenopausal Breast Cancer", "HR+/HER2- Breast Cancer" ], "start_date": "2026-06-26", "last_update": "2026-07-31" }, { "nct_id": "NCT07106762", "title": "Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Urothelial Cancer" ], "start_date": "2025-09-30", "last_update": "2026-07-29" }, { "nct_id": "NCT07115004", "title": "Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Vega Therapeutics, Inc", "conditions": [ "Von Willebrand Disease (VWD)" ], "start_date": "2025-10-15", "last_update": "2026-09-14" }, { "nct_id": "NCT07115953", "title": "Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Medtronic Vascular", "conditions": [ "Hypertension", "Vascular Diseases", "Cardiovascular Diseases", "Chronic Kidney Diseases", "Diabetes Mellitus" ], "start_date": "2025-09-22", "last_update": "2026-06-30" }, { "nct_id": "NCT07140172", "title": "Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University Hospital, Basel, Switzerland", "conditions": [ "Breast Cancer" ], "start_date": "2026-01-01", "last_update": "2026-08-07" }, { "nct_id": "NCT07142304", "title": "The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Luminate Medical, Inc.", "conditions": [ "Chemotherapy Induced Peripheral Neuropathy (CIPN)" ], "start_date": "2025-10-03", "last_update": "2026-06-10" }, { "nct_id": "NCT07160868", "title": "Obstructive Sleep Apnoea and Difficult Asthma (OSADA)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Asthma (Diagnosis)", "OSA - Obstructive Sleep Apnea", "CPAP Treatment" ], "start_date": "2025-09-01", "last_update": "2026-05-26" }, { "nct_id": "NCT07164313", "title": "A Study of ZW251 in Participants With Advanced Solid Tumors", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Zymeworks BC Inc.", "conditions": [ "Hepatocellular Carcinoma", "Squamous Cell Non-Small Cell Lung Cancer", "Germ Cell Tumor" ], "start_date": "2025-10-21", "last_update": "2026-10-05" }, { "nct_id": "NCT07171697", "title": "Mindful-Med: the Evaluation of the Mindfulness-based Stress-coping and Burnout Prevention Programme for Medical Interns.", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Stress (Psychology)", "Burnout", "Mindfulness" ], "start_date": "2025-09-01", "last_update": "2025-09-12" }, { "nct_id": "NCT07174336", "title": "A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Breast Neoplasms", "Neoplasm Metastasis" ], "start_date": "2025-12-22", "last_update": "2026-10-08" }, { "nct_id": "NCT07179393", "title": "Evaluating the Efficacy of a Ladies Gaelic Football-Specific Injury Prevention Programme", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Dublin City University", "conditions": [ "Injury", "Physical Performances" ], "start_date": "2025-06-23", "last_update": "2025-12-26" }, { "nct_id": "NCT07181590", "title": "BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Paroxysmal AF", "Atrial Arrhythmia", "Atrial Fibrillation", "Persistent Atrial Fibrillation" ], "start_date": "2025-12-11", "last_update": "2026-05-26" }, { "nct_id": "NCT07182773", "title": "Pre-infusion Aerobic Cycling Exercise for CardioRespiratory Fitness in Cancer Patients", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Cancer" ], "start_date": "2025-09-24", "last_update": "2026-05-04" }, { "nct_id": "NCT07196020", "title": "Prediction of Venous Thrombosis During chemotherapy-the PINPOINT Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Venous Thromboembolism", "Cancer" ], "start_date": "2025-10-01", "last_update": "2026-05-15" }, { "nct_id": "NCT07204275", "title": "Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)", "phases": [ "PHASE2", "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Vertex Pharmaceuticals Incorporated", "conditions": [ "Primary Membranous Nephropathy" ], "start_date": "2025-09-30", "last_update": "2026-09-18" }, { "nct_id": "NCT07206446", "title": "A Prospective Evaluation of a Prescription Digital Therapeutic for Treatment of Overactive Bladder in Women: The RiSolve Trial", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Galway", "conditions": [ "Overactive Bladder (OAB)", "Over Active Bladder" ], "start_date": "2025-10-15", "last_update": "2026-06-11" }, { "nct_id": "NCT07207811", "title": "CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Novo Nordisk A/S", "conditions": [ "Transthyretin Amyloid Cardiomyopathy (ATTR CM)" ], "start_date": "2025-10-02", "last_update": "2026-09-22" }, { "nct_id": "NCT07208175", "title": "Effectiveness of Ultrasound-Guided Versus Traditional IV Insertion by Oncology Nurses in Adult Population Recieving Systemic Anti-cancer Therapy", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Galway", "conditions": [ "Cancer" ], "start_date": "2025-10-20", "last_update": "2026-04-29" }, { "nct_id": "NCT07209930", "title": "Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Exercise", "Healthy Participants", "Glucose Variability", "Type 1 Diabetes (T1D)" ], "start_date": "2025-01-28", "last_update": "2025-10-07" }, { "nct_id": "NCT07213700", "title": "InRAD Observational Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Stichting International Registry for Alzheimer's Disease and other Dementias Foundation", "conditions": [ "Alzheimer's Disease(AD)", "Mild Cognitive Impairment (MCI)", "Subjective Cognitive Decline (SCD)", "Non-Alzheimer Degenerative Dementia" ], "start_date": "2026-03-30", "last_update": "2026-10-06" }, { "nct_id": "NCT07213804", "title": "A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Ovarian Neoplasms", "Fallopian Tube Neoplasms", "Peritoneal Neoplasms", "Neoplasm Metastasis" ], "start_date": "2025-10-22", "last_update": "2026-10-08" }, { "nct_id": "NCT07214779", "title": "Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Incyte Corporation", "conditions": [ "Ovarian Cancer" ], "start_date": "2025-12-09", "last_update": "2026-10-09" }, { "nct_id": "NCT07216703", "title": "A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Cervical Cancer" ], "start_date": "2026-01-19", "last_update": "2026-10-06" }, { "nct_id": "NCT07218341", "title": "A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma", "phases": [ "PHASE4" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Chronic Lymphocytic Leukemia", "Lymphoma, Small Lymphocytic" ], "start_date": "2026-03-09", "last_update": "2026-09-22" }, { "nct_id": "NCT07218809", "title": "AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Epithelial Ovarian Cancer" ], "start_date": "2025-12-29", "last_update": "2026-07-21" }, { "nct_id": "NCT07223203", "title": "TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Alnylam Pharmaceuticals", "conditions": [ "Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy", "hATTR-PN" ], "start_date": "2026-02-03", "last_update": "2026-10-08" }, { "nct_id": "NCT07227402", "title": "A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Renal Cell Carcinoma" ], "start_date": "2025-11-26", "last_update": "2026-08-03" }, { "nct_id": "NCT07230535", "title": "Evaluation of Wellbeing and Patient Reported Outcomes After Open vs Robotic Mastectomy With DIEP Reconstruction", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Beaumont Hospital", "conditions": [ "Breast Cancer, Breast Neoplasms", "Breast Reconstruction", "DIEP Flap Breast Reconstruction", "Robotic Surgery" ], "start_date": "2025-12-01", "last_update": "2026-06-01" }, { "nct_id": "NCT07231783", "title": "The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Amazentis SA", "conditions": [ "Healthy Aging", "Muscle Function" ], "start_date": "2025-12-10", "last_update": "2026-03-31" }, { "nct_id": "NCT07237334", "title": "A Prospective Cohort Study of Clinical and Process Outcomes of Older Adults That Transition Through the Geriatric Emergency Medicine Unit(GEM-U)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty" ], "start_date": "2025-02-10", "last_update": "2025-11-19" }, { "nct_id": "NCT07244341", "title": "A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Daiichi Sankyo", "conditions": [ "Metastatic Castration-resistant Prostate Cancer" ], "start_date": "2025-12-03", "last_update": "2026-05-15" }, { "nct_id": "NCT07260981", "title": "Comprehensive Biomarker Profiling of the IFN-α Pathway in Amyotrophic Lateral Sclerosis Patient Biofluids", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "Ulysses Neuroscience LTD", "conditions": [ "ALS - Amyotrophic Lateral Sclerosis" ], "start_date": "2023-03-01", "last_update": "2025-12-03" }, { "nct_id": "NCT07266428", "title": "A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Ottimo Pharma Limited", "conditions": [ "Advanced Solid Tumors" ], "start_date": "2025-12-17", "last_update": "2026-10-09" }, { "nct_id": "NCT07267845", "title": "The Effect of α-GPC on Cognitive Function and Sports Performance", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Nanjing Nutrabuilding Bio-tech Co., Ltd.", "conditions": [ "Healthy Participants" ], "start_date": "2025-10-21", "last_update": "2025-12-09" }, { "nct_id": "NCT07268482", "title": "Assessing Sensor-Guided Compression Therapy for Venous Leg Ulcers Healing Outcomes", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Feeltect Limited", "conditions": [ "Venous Leg Ulcer (VLU)" ], "start_date": "2026-01-15", "last_update": "2025-12-05" }, { "nct_id": "NCT07276113", "title": "Enriched Eggs as a Sustainable Approach to Enhance Omega-3 Status in Elite Athletes", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Queen's University, Belfast", "conditions": [ "Suboptimal Omega-3 Index" ], "start_date": "2023-09-25", "last_update": "2025-12-10" }, { "nct_id": "NCT07287098", "title": "A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Eli Lilly and Company", "conditions": [ "Breast Neoplasms" ], "start_date": "2026-05-13", "last_update": "2026-10-08" }, { "nct_id": "NCT07292636", "title": "The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of Life", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Aslam Alkadhimi", "conditions": [ "CLASS II DIVISION 1 MALOCCLUSION", "Class II Malocclusion", "Growth", "Overjet", "Class II Buccal Segment Relationship", "Class II Growth Modification", "Distalization", "Oral Health-Related Quality of Life" ], "start_date": "2026-03", "last_update": "2025-12-18" }, { "nct_id": "NCT07293351", "title": "A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Other Agents in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Advanced Renal Cell Carcinoma (RCC)" ], "start_date": "2026-03-26", "last_update": "2026-09-23" }, { "nct_id": "NCT07293754", "title": "An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Repertoire Immune Medicines", "conditions": [ "Advanced Malignant Solid Tumor" ], "start_date": "2025-12-12", "last_update": "2026-09-28" }, { "nct_id": "NCT07303439", "title": "Randomised Trial of Dual Device Treatment Involving Drug-coated Balloon Angioplasty and Drug-eluting Stent Implantation Compared to Single Device Treatments in Patients With Diabetes Mellitus", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Diabetes Mellitus", "Coronary Arterial Disease (CAD)", "de Novo Coronary Lesions", "De Novo Stenosis" ], "start_date": "2025-08-06", "last_update": "2025-12-24" }, { "nct_id": "NCT07310914", "title": "Implementation of an Advanced Telerehabilitation Solution for People With Multiple Sclerosis", "phases": [ "PHASE2" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Danish Multiple Sclerosis Hospitals", "conditions": [ "Multiple Sclerosis" ], "start_date": "2026-02-01", "last_update": "2025-12-30" }, { "nct_id": "NCT07318558", "title": "A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Merck Sharp & Dohme LLC", "conditions": [ "Ovarian Neoplasms", "Ovarian Cancer" ], "start_date": "2026-02-16", "last_update": "2026-10-06" }, { "nct_id": "NCT07322003", "title": "Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Prilenia", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "start_date": "2026-02-01", "last_update": "2026-10-06" }, { "nct_id": "NCT07332091", "title": "Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "CSL Behring", "conditions": [ "Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis" ], "start_date": "2026-01-22", "last_update": "2026-09-16" }, { "nct_id": "NCT07335497", "title": "CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Crescent Biopharma, Inc.", "conditions": [ "Locally Advanced / Metastatic Solid Tumors" ], "start_date": "2026-02-17", "last_update": "2026-09-10" }, { "nct_id": "NCT07347912", "title": "Group-based Resistance Training for Adults With Down Syndrome", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Saint John of God Intellectual Disability Services - Dublin South East", "conditions": [ "Down Syndrome", "Healthy Aging", "Resistance Training" ], "start_date": "2024-10-01", "last_update": "2026-01-29" }, { "nct_id": "NCT07351526", "title": "Inpatient Post-Acute Rehabilitation For Patients in the Midwest: a Prospective Cohort Study of Clinical Characteristics and Process Outcomes", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Rehabilitation", "Frailty", "Complex Patients in Rehabilitation Phase" ], "start_date": "2025-02-22", "last_update": "2026-01-20" }, { "nct_id": "NCT07360847", "title": "Profiling Patients With Rotator Cuff Related Shoulder Pain: What Factors Influence Outcomes With Non-operative Care in a Secondary Care Specialist Shoulder Clinic?", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Rotator Cuff Related Shoulder Pain", "RCRSP" ], "start_date": "2026-01-05", "last_update": "2026-03-27" }, { "nct_id": "NCT07361497", "title": "A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Non-small Cell Lung Cancer (NSCLC)" ], "start_date": "2026-03-16", "last_update": "2026-09-30" }, { "nct_id": "NCT07363928", "title": "A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Dementia", "Mild Cognitive Impairment", "Insomnia", "Sleep" ], "start_date": "2025-01-01", "last_update": "2026-01-23" }, { "nct_id": "NCT07376746", "title": "Improving ADHD Symptoms and Quality of Life Through Diet", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "ADHD" ], "start_date": "2026-02", "last_update": "2026-02-12" }, { "nct_id": "NCT07386483", "title": "Strategic Timing of Resistance Training to Guard Against Antipsychotic-Induced Metabolic Syndrome", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Psychosis" ], "start_date": "2026-02-01", "last_update": "2026-02-09" }, { "nct_id": "NCT07393880", "title": "Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University of Dublin, Trinity College", "conditions": [ "Tinnitus, Subjective", "Tinnitus", "Chronic Tinnitus" ], "start_date": "2026-01-30", "last_update": "2026-04-03" }, { "nct_id": "NCT07397975", "title": "Speech-based Assessment of Relapse Risk in People With Psychosis", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Philipp Homan", "conditions": [ "Psychotic Disorder" ], "start_date": "2026-01-29", "last_update": "2026-02-09" }, { "nct_id": "NCT07401550", "title": "Assessment and Prediction of Cardiovascular Health and Disease Risk Using Wearable Biometrics.", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Cardiovascular Diseases (CVD)", "Cardiovascular Disease Prevention", "Cardiovascular Disease Risk Factor", "Coronary Artery Disease (CAD)" ], "start_date": "2025-12-09", "last_update": "2026-02-10" }, { "nct_id": "NCT07402915", "title": "Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "AstraZeneca", "conditions": [ "Fallopian Tube Cancer", "Ovarian Cancer", "Primary Peritoneal" ], "start_date": "2026-01-26", "last_update": "2026-09-29" }, { "nct_id": "NCT07407530", "title": "Comparison of 'Sip Til Send' Regimens Prior to Elective Caesarean Delivery Using Bedside Gastric Ultrasound", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "The Rotunda Hospital", "conditions": [ "Gastric Emptying", "Caesarean Delivery", "Pregnancy" ], "start_date": "2025-08-01", "last_update": "2026-02-12" }, { "nct_id": "NCT07411105", "title": "Cognition in Older Adults With Cancer Receiving Systemic Anti-Cancer Therapy", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Cancer", "Older Adults (65 Years and Older)", "Cognition" ], "start_date": "2024-05-21", "last_update": "2026-02-27" }, { "nct_id": "NCT07416604", "title": "A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Hoffmann-La Roche", "conditions": [ "Hemophilia A" ], "start_date": "2026-04-27", "last_update": "2026-10-06" }, { "nct_id": "NCT07417228", "title": "The Impact of Concurrent Training on Women Experiencing Symptoms of Menopause", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Menopause Symptoms" ], "start_date": "2025-12-12", "last_update": "2026-02-18" }, { "nct_id": "NCT07417254", "title": "Novel Personalised Nutrition Intervention With Tailored Behavioural Support", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Dublin", "conditions": [ "Behavior Change", "Dietary Behaviour", "Personalised Nutrition", "Sustainable Healthy Diet", "Behavior And Behavior Mechanism", "Behavior Change Interventions" ], "start_date": "2025-10-20", "last_update": "2026-07-27" }, { "nct_id": "NCT07420023", "title": "The Satiety Control Optimization by Nutritional Enhancement Study", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease" ], "start_date": "2025-08-18", "last_update": "2026-02-19" }, { "nct_id": "NCT07422480", "title": "A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Myelodysplastic Syndrome", "Anemia" ], "start_date": "2026-05-21", "last_update": "2026-09-18" }, { "nct_id": "NCT07422727", "title": "Impact of Cooling Mats on Vasomotor Symptoms in Patients Receiving Endocrine Therapy", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Sligo General Hospital", "conditions": [ "Hot Flashes", "Sleep", "Hormonal", "Cancer" ], "start_date": "2025-11-10", "last_update": "2026-02-20" }, { "nct_id": "NCT07425002", "title": "Precision Oncology Clinical Diagnostic Study In Primary and Metastatic Breast Cancer (PRISM)", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2025-11-11", "last_update": "2026-02-20" }, { "nct_id": "NCT07426809", "title": "Margin Optimisation Using Z-axis Assessment With Real-time Tomosynthesis (MOZART Study).", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2025-12-18", "last_update": "2026-04-03" }, { "nct_id": "NCT07426835", "title": "The PHARO Trial: The Incidence of Para-conduit Hernia With Closure of Hiatus Versus the Standard Approach in Robotic Oesophagectomy - A Randomised Controlled Pilot Trial", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Oesphageal Cancer", "Para-conduit Hernia" ], "start_date": "2025-12-19", "last_update": "2026-02-23" }, { "nct_id": "NCT07426848", "title": "OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Primary Brain Tumour", "Glioblastoma", "Brain Neoplasms" ], "start_date": "2025-12-18", "last_update": "2026-02-23" }, { "nct_id": "NCT07426861", "title": "Pre-Operative Nurse-Led Education With Direct Physiotherapy Referral to Reduce Post-Prostatectomy Incontinence", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Prostate Cancer", "Urinary Incontinence", "Postoperative Complications", "Radical Prostatectomy" ], "start_date": "2025-12-20", "last_update": "2026-02-23" }, { "nct_id": "NCT07426874", "title": "eHealth Support Tool to Improve Quality of Life in Head and Neck Cancer Survivors", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Head and Neck Cancer (H&N)" ], "start_date": "2025-09-01", "last_update": "2026-02-23" }, { "nct_id": "NCT07434804", "title": "Exploring the Feasibility of Using Virtual Reality as an Educational Tool in Chronic Pain Rehabilitation", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Pain", "Chronic Pain", "Chronic Pain (Back / Neck)", "Adults", "Virtual Reality", "Neuroscience Pain Education" ], "start_date": "2026-02-20", "last_update": "2026-02-27" }, { "nct_id": "NCT07441408", "title": "Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis", "phases": [ "PHASE3" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Pulmonary Fibrosis" ], "start_date": "2026-12-16", "last_update": "2026-08-14" }, { "nct_id": "NCT07443579", "title": "Optimal Mammography View Sequencing in Women With a History of Breast Cancer Undergoing Surveillance Mammography", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer", "Breast Cancer Recurrence", "Post Treatment Surveillance" ], "start_date": "2026-02-24", "last_update": "2026-03-02" }, { "nct_id": "NCT07453498", "title": "Evaluating the Efficacy of the Psoas Sheath Block for Post Operative Analgesia Following Hip Arthroplasty", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Hospital Galway", "conditions": [ "Total Hip Arthroplasty (THA)" ], "start_date": "2025-11-18", "last_update": "2026-03-06" }, { "nct_id": "NCT07453823", "title": "The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Chr Hansen - part of Novonesis", "conditions": [ "Gastrointestinal Microbiome (Focus)", "Gastrointestinal Symptoms" ], "start_date": "2026-03-18", "last_update": "2026-04-15" }, { "nct_id": "NCT07455422", "title": "A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University Hospital, Antwerp", "conditions": [ "Barrett Esophagus", "Barrett Esophagus Adenocarcinoma", "Adenocarcinoma - GEJ", "Gastroenterology", "Gastroenterological Cancer" ], "start_date": "2026-06-01", "last_update": "2026-03-06" }, { "nct_id": "NCT07457424", "title": "Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)", "phases": [], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Metabolic Disease", "Obesity & Overweight" ], "start_date": "2022-02-17", "last_update": "2026-05-15" }, { "nct_id": "NCT07472517", "title": "DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Boehringer Ingelheim", "conditions": [ "Small Cell Lung Cancer (SCLC)", "Extensive-stage Small Cell Lung Cancer (ES-SCLC)" ], "start_date": "2025-11-07", "last_update": "2026-09-29" }, { "nct_id": "NCT07476807", "title": "Telemedicine Rash Evaluation and Assessment of Toxicity in Skin in Acute Oncology and Haematology Care: A Pilot Study", "phases": [ "NA" ], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Sligo General Hospital", "conditions": [ "Rash", "Systemic Treatments", "Tele-assessment" ], "start_date": "2026-04-01", "last_update": "2026-04-28" }, { "nct_id": "NCT07477938", "title": "A Single-Arm Interventional Trial of Pepper- Robot Delivered Cancer Education for Adults With Intellectual Disability", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "Cancer Awareness and Prevention Education", "Breast Cancer Awareness", "Intellectual Disabilities (F70-F79)" ], "start_date": "2026-05-01", "last_update": "2026-03-17" }, { "nct_id": "NCT07481240", "title": "A Household-Based Dietary Intervention Study of Vitamin D Fortified Bread in Irish Families", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Vitamin D Deficiency" ], "start_date": "2025-11-17", "last_update": "2026-05-15" }, { "nct_id": "NCT07489521", "title": "Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis", "phases": [ "PHASE4" ], "overall_status": "RECRUITING", "lead_sponsor": "Cappagh National Orthopaedic Hospital", "conditions": [ "Osteo Arthritis Knee", "Osteoarthritis", "Intraarticular Injection" ], "start_date": "2026-01-29", "last_update": "2026-04-28" }, { "nct_id": "NCT07492680", "title": "A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Bristol-Myers Squibb", "conditions": [ "Solid Tumors" ], "start_date": "2026-07-27", "last_update": "2026-10-06" }, { "nct_id": "NCT07503704", "title": "A Prospective Study of the Genomic Landscape of Central Nervous System Disease Secondary to Breast Cancer Utilising Cell-free DNA Derived From Cerebrospinal Fluid (CSF)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2024-10-01", "last_update": "2026-03-31" }, { "nct_id": "NCT07503717", "title": "SURVEY-CNS: A Feasibility Study of Randomising Women and Men With HER2-Positive Metastatic Breast Cancer to Central Nervous System Surveillance Versus No Surveillance", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer", "HER2-Positive Metastatic Breast Cancer" ], "start_date": "2025-06-01", "last_update": "2026-03-31" }, { "nct_id": "NCT07505329", "title": "An Intervention Study in Healthy Infants Aged 0-6 Months With Probiotics Lacticaseibacillus Rhamnosus LRa05 (LRa05) and Bifidobacterium Animalis Subsp. Lactis BLa80 (BLa80) vs. Placebo, for Promoting Gut Microbiome Development.", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Less Than 3 Months Old", "Healthy Infants" ], "start_date": "2026-04", "last_update": "2026-04-01" }, { "nct_id": "NCT07507500", "title": "Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months", "phases": [ "PHASE4" ], "overall_status": "RECRUITING", "lead_sponsor": "Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz", "conditions": [ "Myocardial Infarction (MI)" ], "start_date": "2026-09-02", "last_update": "2026-09-09" }, { "nct_id": "NCT07508670", "title": "An Observational Study of the NeuroBell EEG Monitor", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "EEG", "Neonatology", "Seizure", "Neurology", "Hypoxic Ischaemic Encephalopathy (HIE)", "Neonatal Seizures", "Medical Devices" ], "start_date": "2024-09-02", "last_update": "2026-04-02" }, { "nct_id": "NCT07512505", "title": "Remote Vital Sign Monitoring in Palliative Care Patients Using a Wearable ECG Monitor", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Our Lady's Hospice and Care Services", "conditions": [ "Cancer", "Malignancies Multiple", "Terminal Care", "Hospice" ], "start_date": "2025-11-06", "last_update": "2026-04-06" }, { "nct_id": "NCT07519967", "title": "Efficacy of Lactobacillus Mucosae DPC6426 on Blood-lipids", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Cholesterol", "Hypercholesterolaemia" ], "start_date": "2016-05-30", "last_update": "2026-04-09" }, { "nct_id": "NCT07523620", "title": "Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Abbott Medical Devices", "conditions": [ "Atrial Fibrillation (AF)", "Paroxysmal AF", "Persistent Atrial Fibrillation" ], "start_date": "2026-03-31", "last_update": "2026-07-13" }, { "nct_id": "NCT07524517", "title": "NeoSHARK: Anatomical Versus Round Facemasks for Breathing Support in Preterm and Term Newborn Infants", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Neonatal Intensive Care" ], "start_date": "2026-05", "last_update": "2026-05-12" }, { "nct_id": "NCT07524595", "title": "Self-Expanding Hydra Transcatheter Heart Valve (THV) Series Versus Balloon-Expandable Devices for Valve-In-Valve Transcatheter Aortic Valve Implantation (TAVI) for Patients With Failed Surgical Aortic Bioprosthesis.", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "National University of Ireland, Galway, Ireland", "conditions": [ "AORTIC VALVE DISEASES", "Valve-in-valve Procedures", "Surgical Valve Replacement", "Valve Disease, Aortic" ], "start_date": "2026-04", "last_update": "2026-04-13" }, { "nct_id": "NCT07546500", "title": "A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc", "conditions": [ "Ovarian Cancer" ], "start_date": "2026-04-17", "last_update": "2026-08-12" }, { "nct_id": "NCT07552168", "title": "INSPIRE: INnovative SABR for Prostate Cancer All IREland", "phases": [ "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Prostate Adenocarcinoma" ], "start_date": "2026-04-23", "last_update": "2026-07-06" }, { "nct_id": "NCT07555483", "title": "A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Grifols Therapeutics LLC", "conditions": [ "Alpha 1 Antitrypsin Deficiency" ], "start_date": "2026-05-05", "last_update": "2026-08-11" }, { "nct_id": "NCT07558668", "title": "A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis", "phases": [ "PHASE1" ], "overall_status": "RECRUITING", "lead_sponsor": "Sitryx Therapeutics Ltd", "conditions": [ "Moderate to Severe Atopic Dermatitis" ], "start_date": "2025-02-26", "last_update": "2026-04-30" }, { "nct_id": "NCT07559643", "title": "The OAT Trail: The Obesity Anti-Coagulation Thromboprophylaxis Trial.", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Bariatric Surgery", "Anti-Xa Activity", "VTE (Venous Thromboembolism)", "Obesity & Overweight" ], "start_date": "2026-08-01", "last_update": "2026-05-18" }, { "nct_id": "NCT07561957", "title": "A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "St. James's Hospital, Ireland", "conditions": [ "Chronic Kidney Disease", "Proteinuria", "Blood Pressure Control", "Congenital Anomalies of the Kidneys and Urinary Tract", "Nephrotic Syndrome", "Sickle-Cell Nephropathy", "Tuberous Sclerosis Complex", "Cancer Survivors" ], "start_date": "2026-01-14", "last_update": "2026-05-01" }, { "nct_id": "NCT07566884", "title": "Safety and Tolerance of a Novel Three-Strain Probiotic in Healthy Adults", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Pendulum Therapeutics", "conditions": [ "Healthy Adults" ], "start_date": "2024-09-23", "last_update": "2026-05-11" }, { "nct_id": "NCT07572370", "title": "Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Breast Cancer", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2025-12-11", "last_update": "2026-05-07" }, { "nct_id": "NCT07575269", "title": "Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Boston Scientific Corporation", "conditions": [ "Paroxysmal Atrial Fibrillation (PAF)", "Persistent Atrial Fibrillation" ], "start_date": "2026-07-07", "last_update": "2026-09-24" }, { "nct_id": "NCT07577609", "title": "AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Galway", "conditions": [ "Coronary Artery Disease (CAD)", "Computed Tomography Angiography", "Biomarkers", "AI (Artificial Intelligence)", "Lipoprotein(a)", "Atheroscleroses, Coronary", "Myocardial Ischemia" ], "start_date": "2022-12-21", "last_update": "2026-05-11" }, { "nct_id": "NCT07581392", "title": "Reintervention Rates and Complications in Endovascular Aneurysm Repair (EVAR) and the Use of Colour Doppler Ultrasound (CDUS) and Computed Tomography Angiography (CTA) in Identifying Endoleak Complications", "phases": [], "overall_status": "COMPLETED", "lead_sponsor": "University Hospital of Limerick", "conditions": [ "Aneurysm Abdominal" ], "start_date": "2026-01-01", "last_update": "2026-05-12" }, { "nct_id": "NCT07585149", "title": "Generating Intervals of Reference FFor Early Life Brain Biomarkers.", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Reference Intervals", "Biomarker in Early Diagnosis", "Neonatal" ], "start_date": "2026-04-13", "last_update": "2026-05-13" }, { "nct_id": "NCT07586930", "title": "CP: Intestinal Permeability", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Rousselot BVBA", "conditions": [ "Intestinal Permability" ], "start_date": "2026-03-25", "last_update": "2026-05-27" }, { "nct_id": "NCT07592234", "title": "Chemokeyp: A Feasibility Study for Realtime Safety Data-Capture for Potential Serious Adverse Drug Events", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "St Vincent's University Hospital, Ireland", "conditions": [ "Serious Adverse Events", "Patient Safety", "Pharmacovigilance", "Oncology" ], "start_date": "2026-02-01", "last_update": "2026-05-18" }, { "nct_id": "NCT07600229", "title": "Barefoot Walking VS Standardised Conservative Care for Plantar Fasciopathy", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Elisabetta Brigo", "conditions": [ "Plantar Fasciopathy", "Plantar Fasciitis", "Plantar Fasciitis, Chronic", "Heel Pain" ], "start_date": "2026-05-07", "last_update": "2026-05-22" }, { "nct_id": "NCT07605936", "title": "Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University of Limerick", "conditions": [ "Frailty at Older Adults", "Prostate Cancer" ], "start_date": "2026-04-23", "last_update": "2026-05-26" }, { "nct_id": "NCT07609134", "title": "The Development of the Walsh Asthma Self-management Programme and Feasibility of Implementation in Adults With Asthma in Primary Care", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Asthma", "Self-management", "Asthma Control" ], "start_date": "2026-05", "last_update": "2026-05-27" }, { "nct_id": "NCT07616245", "title": "MCT Enteral Feeding to Reduce Chyle Leak After Oesophagectomy", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Oesphageal Cancer" ], "start_date": "2025-10-02", "last_update": "2026-06-01" }, { "nct_id": "NCT07616258", "title": "Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer" ], "start_date": "2025-10-02", "last_update": "2026-06-01" }, { "nct_id": "NCT07623161", "title": "A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib", "phases": [ "PHASE3" ], "overall_status": "RECRUITING", "lead_sponsor": "Takeda", "conditions": [ "Myelofibrosis", "Anemia" ], "start_date": "2026-09-10", "last_update": "2026-10-01" }, { "nct_id": "NCT07628608", "title": "Safety and User Experience of BP-CBB", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "Bactolife A/S", "conditions": [ "Safety and Tolerability in Healthy Volunteers" ], "start_date": "2026-06-16", "last_update": "2026-09-15" }, { "nct_id": "NCT07636395", "title": "Eating Behaviour Before, During, and After Obesity Medication", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Obesity Type 2 Diabetes Mellitus", "Obesity & Overweight" ], "start_date": "2026-05-25", "last_update": "2026-06-09" }, { "nct_id": "NCT07672392", "title": "The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Breast Cancer", "Exercise" ], "start_date": "2024-08-01", "last_update": "2026-06-26" }, { "nct_id": "NCT07679490", "title": "Probiotic in Fruit Snack", "phases": [ "NA" ], "overall_status": "ACTIVE_NOT_RECRUITING", "lead_sponsor": "University College Dublin", "conditions": [ "Colonization, Asymptomatic", "Probiotic Intervention", "Gut Microbiota Diversity and Composition", "Gut-brain Axis" ], "start_date": "2026-01-18", "last_update": "2026-07-01" }, { "nct_id": "NCT07721766", "title": "Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Technical University of Munich", "conditions": [ "Healthy Volunteers", "Muscle Hypertrophy", "Glycolysis", "Moderately Trainend" ], "start_date": "2026-05-04", "last_update": "2026-07-23" }, { "nct_id": "NCT07731555", "title": "Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "Patrick Morris", "conditions": [ "Glioblastoma" ], "start_date": "2022-03-01", "last_update": "2026-07-28" }, { "nct_id": "NCT07734532", "title": "Infant Formula Study With Pre- And Postbiotics", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Nutricia UK Ltd", "conditions": [ "Formula Milk", "Infants" ], "start_date": "2021-06-17", "last_update": "2026-08-28" }, { "nct_id": "NCT07746609", "title": "The Design and Evaluation of a Digital Physical Activity Intervention for Individuals With Severe Mental Illness in an Irish Mental Health Residential Setting", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "Munster Technological University", "conditions": [ "Severe Mental Illness", "Health Professionals" ], "start_date": "2024-02-01", "last_update": "2026-08-06" }, { "nct_id": "NCT07759908", "title": "Effects of a Synbiotic Intervention on Perimenopausal/Menopausal Symptoms", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University College Cork", "conditions": [ "Menopause", "Perimenopause", "Perimenopausal Women" ], "start_date": "2025-06-06", "last_update": "2026-08-12" }, { "nct_id": "NCT07761130", "title": "A Feasibility Study of the Improving Health and Lifestyle Programme After Stroke (iHeLP)", "phases": [ "NA" ], "overall_status": "COMPLETED", "lead_sponsor": "University of Limerick", "conditions": [ "Stroke" ], "start_date": "2026-02-09", "last_update": "2026-08-12" }, { "nct_id": "NCT07769021", "title": "Tracheostomy Practice in Adult Intensive Care Units", "phases": [], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Royal College of Surgeons, Ireland", "conditions": [ "Tracheostomy Patients", "Tracheostomy Decannulation", "Intensive Care (ICU)" ], "start_date": "2026-11-02", "last_update": "2026-08-17" }, { "nct_id": "NCT07770035", "title": "School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "University College Cork", "conditions": [ "Hypoxic-Ischemic Encephalopathy" ], "start_date": "2024-03-09", "last_update": "2026-08-18" }, { "nct_id": "NCT07777614", "title": "OPTIMISE Lung SABR", "phases": [ "PHASE2" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Cancer Trials Ireland", "conditions": [ "Non Small Cell Lung Cancer" ], "start_date": "2026-10", "last_update": "2026-08-20" }, { "nct_id": "NCT07789483", "title": "An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy", "phases": [ "PHASE3" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "Alexion Pharmaceuticals, Inc.", "conditions": [ "Transthyretin Amyloid Cardiomyopathy (ATTR-CM)" ], "start_date": "2027-11-23", "last_update": "2026-08-28" }, { "nct_id": "NCT07798674", "title": "TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias", "phases": [], "overall_status": "RECRUITING", "lead_sponsor": "Heidelberg University", "conditions": [ "Hereditary Spastic Paraplegia", "Spastic Ataxia" ], "start_date": "2024-07-16", "last_update": "2026-09-01" }, { "nct_id": "NCT07807111", "title": "Open-Label Study to Evaluate the Safety, Tolerability, and Efficacy of Gene Therapy (SPVN20) in Subjects With Rod-Cone Dystrophy", "phases": [ "PHASE1", "PHASE2" ], "overall_status": "RECRUITING", "lead_sponsor": "SparingVision", "conditions": [ "Retinitis Pigmentosa (RP)", "Rod Cone Dystrophy" ], "start_date": "2025-10-08", "last_update": "2026-09-08" }, { "nct_id": "NCT07840534", "title": "Patient-Initiated Follow-Up for Women After Early Breast Cancer Treatment (LYSA2PIFU)", "phases": [ "NA" ], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "University College Cork", "conditions": [ "Breast Cancer", "Breast Cancer Survivorship", "Cancer Survivorship", "Endocrine Therapy", "Early Stage Breast Cancer" ], "start_date": "2026-10-01", "last_update": "2026-09-25" }, { "nct_id": "NCT07852897", "title": "Evaluation of Commercially Available Heel Pads for the Prevention of Pressure Ulcers: An Observational Study of Incidence and Usability in Adult Surgical Patients.", "phases": [], "overall_status": "ENROLLING_BY_INVITATION", "lead_sponsor": "Trulife", "conditions": [ "Pressure Injury Prevention" ], "start_date": "2026-06-09", "last_update": "2026-10-01" }, { "nct_id": "NCT07854899", "title": "Natural History Study of Advanced RCD", "phases": [ "NA" ], "overall_status": "RECRUITING", "lead_sponsor": "SparingVision", "conditions": [ "Rod Cone Dystrophy" ], "start_date": "2026-09-11", "last_update": "2026-10-08" }, { "nct_id": "NCT07857070", "title": "Newborn Brain Assessment - CergenX Wave", "phases": [], "overall_status": "NOT_YET_RECRUITING", "lead_sponsor": "CergenX Limited", "conditions": [ "Neonatal Encephalopathy", "Neonatal Encephalopathy (Neonatal Hypoxic-ischemic Encephalopathy)", "Neonatal Encephalopathy, Unspecified" ], "start_date": "2026-09", "last_update": "2026-10-05" } ] }